Reproducibility: From the Tank/Cage Side for Better Research and 3Rs
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Owner/Developer: American Association for Laboratory Animal Science (AALAS)
United States of America
United States of America
This seminar will consider practical options to achieve better research reporting and reproducibility.
Optional / Voluntary
2 h 15 min
Students, Researchers, Regulators and policy-makers, Teachers and educators, Technicians, Managers, Scientific officers / Project managers, Professionals (e.g. veterinarians)
Academia, Industry, Governmental bodies, Contract Research Organizations (CROs), Consulting, SMEs
University (Bachelor), University (Master), University (Doctoral education), Postdoctoral (teaching and research), Continuing Professional Development
Other, Taking care of animals
Full coverage (a dedicated course)
Rodents, Zebrafish (Danio rerio)
|Details on the topic or technology covered:||
Study Reproducibility Overview
Guidelines for Reporting: What, Where, When?
Environmental Summary Reporting: A Tool for Improving the Reproducibility of Zebrafish Studies
Innovation and Quality Initiatives for Reproducibility of Studies
Cage Side Care that Impacts Consistency and Reproducibility of Rodent Research
Participants will learn about reporting of environmental conditions for animal research models and next steps to ensure more rigorous reporting. We will review historical concerns and contemporary issues going forward. Last year's AALAS meeting included much discussion on research reproducibility and opportunities for improvements. We will review developments and usage of reporting guidance and update a 2017 survey on the use of these guidelines. An area with minimal reporting has been laboratory fish housing, husbandry practices, and environmental parameters, which are highly variable and are under-reported. Environmental factors are under-recognized as contributors to experimental variation, and this information is rarely shared or requested. The problem was addressed by 1) developing a summary environmental report for research fish facilities, and 2) disseminating these data by depositing this document into an accessible web-based platform for data sharing called protocol.io. In addition, pharmaceutical companies and CROs contend with regulatory requirements that involve extensive QA QC and documentation that includes macro- and micro-environmental data collection and reporting. We will present examples of the practical application of digital information within a unit, and across a global organization, and its effects on study reproducibility. Husbandry impact on reproducibility and data consistency is addressed by the last speaker. While “meets Guide standards” is the company line, the details of daily care vary among institutions. Differences in cage components, housing density, cage changing frequency, and practices are all recognized to impact animal development, physiology, and behavior. Suggestions to improve reproducibility of rodent research will be presented. A discussion based on audience questions will end the session.
The target audience includes all individuals engaged in research involving animal models including animal facility managers, lab animal and research technicians, staff, veterinarians, IACUC members, scientists, and editors, reviewers, and authors.
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