The Akademie für Tierschutz is part of the Deutscher Tierschutzbund e.V.(
German Animal Welfare Federation ).
The Akademie has established a bibliographical database on alternatives.
Print-outs are published in hard copy in German as the "Gelbe Liste". The
database contains about 15,000 references. The database is available via PREX,
or on floppy disc, but the Akademie also answers individual queries.
Further details from:
Roman Kolar, Akademie für Tierschutz, Spechtstrasse 1, D-85579 Neubiberg,
Germany
Telephone: +49 89 603008
Telefax: +49 89 601 7078
Email: akademie.fuer.tierschutz@muenchen.org
APHIS (Animal and Plant Inspection Health Service), a division of the US Department of Agriculture, has its own home page.
The Alternatives in Education Database hosted by
the Association of
Veterinarians for Animal Rights (AVAR) contains thousands of entries of
alternatives to the harming or killing of animals at many levels of education.
Animal Welfare Information Center (AWIC) is part of the National
Agricultural Library, U.S. Department of Agriculture. The Center (AWIC) was
established by the United States Congress in 1986 with the mandate to
acquire and disseminate information on alternatives and improved
methodologies for the humane care, use, and handling of all animals in
research, testing, and education.
The Center provides a variety of information and referral services,
including computerized literature searching, expert referral, document
delivery, and the acquisition, production, and maintenance of materials
pertinent to the topic of animal welfare.
The National Agricultural Library maintains a collection of books, journals,
newsletters, proceedings, reports, news articles, slides, films, and video
recordings relevant to the various topics addressed by the Center. The
Library provides access to these materials via photocopy and interlibrary
loans.
AWIC publishes a series of bibliographic reference products, a quarterly
newsletter, resource guides, listings, and other publications related to
animal welfare. Currently, all publications are supplied free of charge.
AWIC provides online information retrieval services from the National
Agricultural Library's AGRICOLA database and selected databases available
through DIALOG. (Note that AGRICOLA is available from other sources
e.g. in CD form from Silver Platter and from PREX in the
Netherlands). Users, with the exception of U.S. Department of Agriculture
personnel, may be billed for information support services in excess of
one hour of staff time or $25 in online computer costs.
Of special note is Care-CD, an information product recently completed by Mike
Kreger of the AWIC staff. This is a CD ROM that contains 169 documents. Most
of these are the full text of U.S. Federal documents that are relevant
to animal care in research and testing settings. In addition, the CD contains
guidelines and statements from various professional organizations, among them the
Guide for the Care and Use of
Laboratory Animals produced by ILAR (see below), books,
manuals, and training manuals for laboratory personnel; 35 bibliographies,
resource guides, newsletter issues, fact sheets from AWIC and 18 zoo animal
bibliographies. The disk (stock #001-000-04634-9) can be purchased from:
U.S. Government Printing Office
Superintendent of Documents
PO Box 371954
Pittsburgh, PA 15250-7954
USA
The cost is $35.00 for those in the U.S. International customers need to
add 25% additional money for handling. Visa and Mastercard are accepted.
Many of the AWIC documents are also available in full text from the AWIC web
site.
For additional information or to contact a staff member, AWIC can be
reached in the following ways:
Animal Welfare Information Center
10301 Baltimore Avenue,
Beltsville,
Maryland 20705-2351
USA
Tel: +1-301-504-6212
Fax: +1-301-504-7125
Email: awic@nal.usda.gov
AWIC contact: Jean Larson, Coordinator
email: jlarson@nal.usda.gov
The documentation service of the Department of Animal Experimentation and
Alternative Methods (STA) maintains a database of all animal experiments performed
in Switzerland since 1992. There is no public access to this information, but
information is provided from a 2000-record database of literature on husbandry,
alternatives and the ethics of animal experimentation.
Further details from:
Michelle Howald, Swiss Federal Veterinary Office, Animal Welfare Division, Animal
Expermentation and Alternative Methods Section, Schwarzenburgstrasse 161, CH-3003
Bern, Switzerland
Telephone: +41 31 323 8563
Telefax: +41 31 323 8570
Email: michelle.howald@bvet.admin.ch
ECVAM has developed a database known as SIS (Scientific Information Service) to support
validation studies carried out under their auspices. This will initially provide
information on test development, prevalidation, test protocols and test chemicals,
data and data analysis, background documentation and the progress of regulatory
access. Some public access may later be permitted to data on completed studies.
A hotline datalink for exchange of data via the Internet between participating
laboratories is also planned, as is a register of scientists working in the area
of in vitro pharmatoxicology.
Further details from:
Annett Janusch, ECVAM, JRC Environmental Institute, I-21020 Ispra (VA), Italy
Telephone: +39 332 785 570
Telefax: +39 332 789 963
Email: annett.janusch@ei.jrc.it
The Food and Drug Administration has developed a
database called FIRST (FDA Information Retrieval System). They have plans
for the release of a CD-ROM containing information on drug carcinogenicity
studies.
The Galileo databank collects toxicology data of alternative studies, mostly
related to the field of cosmetics testing. The databank contains factual data on
over 800 ingredients, over 300 cosmetic formulations, 50 methods, 26 animal models
and over 100 biosystems, with a total of nearly 21,000 individual results. The
databank is not currently available online, but printouts are sent to
enquirers.
Further details from:
Gregorio Loprieno, Technical Services SAS,Via Vecchia Lucchese 59, I-56123 Pisa,
Italy
Telephone: +39 50 555 685
Telefax: +39 50 555 687
ILAR has published the Guide
for the Care and Use of Laboratory Animals. This Guide is also available on
the Care-CD to be released by AWIC in late October (see below). ILAR is planning
to place its own database of resources online in the future.
This service provides protocols for methods of in vitro toxicity testing at
a level of detail not normally found in the published literature. The 114
available protocols include SOP's from recent validation studies coordinated by
ECVAM. A total of 650 scientists, mainly from academia and industry, are
registered to use the services of INVITTOX. INVITTOX has been funded by DGXI and
by ECVAM, and the service is due to be transferred from FRAME in England to ECVAM in Italy. INVITTOX has also a web site.
Further details from:
Krys Ungar, FRAME / INVITTOX, Russell & Burch House, 96-98 North Sherwood Street,
Nottingham NG1 4EE, England
Telephone: +44 115 958 4740
Telefax: +44 115 950 3570
Email: krys@frame-uk.demon.co.uk
The MEIC project
(Multicentre Evaluation of In vitro Cytotoxicology) has involved 50
laboratories using 96 in vitro methods to test the toxicity of between 20
and 50 defined chemicals. The results are in the process of being published in
ATLA and will also be available via the Internet. MEIC has also collected data
on time-related high survived and lethal blood concentrations from cases of human
poisoning and has published this information in a monograph for each test chemical
to facilitate in vitro and in vivo comparison.
Further details from:
Bjørn Ekwall, CTLU, Pavals, När, S-62013 Stånga, Sweden
Telephone: +46 498 492259
Email: bjoern.ekwall@ctlu.se
The The Netherlands Centre for
Alternatives to Animal Use (NCA) is in the process of setting up a database on
the development and validation of alternative methods. The Centre plans to make
an overview of the in vitro methods currently being employed in the
Netherlands. The NCA publishes a newsletter.
Further details from:
Jan van der Valk, The Netherlands Centre for Alternatives to Animal Use, Yalelaan
17, NL-3584 CL Utrecht, The Netherlands
Telephone: +31 30 253 2186
Telefax: +31 30 253 9227
Email: valk@accu.uu.nl
.
NORINA (A Norwegian Inventory of Alternatives) provides information on over
3500 audiovisual aids and other alternatives such as computer programs to the use
of animals or animal products in teaching, at all levels from junior school to
university. NORINA is available online
on the Internet. There is a mirror site, in Sydney, Australia.
For more information please contact Karina
Smith (email: karina.smith@veths.no).
The OLAW, or Office of
Laboratoy Animal Welfare, implements the
Public Health Service (PHS) Policy on Humane Care and Use of Laboratory
Animals. The OLAW was previously known as OPRR-NIH (The Office of Protection from
Research Risks, National Institutes of Health). The OLAW is located
organizationally at the National Institutes of
Health in Bethesda, Maryland; however, OLAW's responsibility for
laboratory animal welfare extends beyond the NIH to all PHS supported
activities involving animals.
Compliance with the PHS Policy is a prerequisite to receiving PHS
(including NIH and FDA) funds for research involving laboratory animals.
The Policy requires institutional animal care and use programs to be
consistent with the Guide
for the Care and Use of Laboratory Animals. Institutions must also
submit an acceptable Animal Welfare Assurance to OLAW, establish an
appropriate Institutional Animal Care and Use Committee with authority
to review the institutional program and individual protocols, and
monitor the program and use of animals on a regular basis.
Specific OLAW responsibilities for laboratory animal welfare include:
implementation of the PHS Policy; interpretation of the PHS Policy;
negotiation of Animal Welfare Assurances; evaluation of compliance with
the PHS Policy; and education of institutions and investigators
receiving PHS support.
OLAW is also responsible for the Department of Health and Human
Services' regulations for the protection of human research subjects.
PREX is a collection of over 20 databases
containing information of relevance to Laboratory Animal Science and Alternatives.
The databases include MEDLINE, CAB Abstracts and Agricola, together with a number
of smaller specialized databases such as the alternatives database of the Akademie
für Tierschutz and NORINA. An annual subscription gives access to all the
databases, with no extra charge other than user connection costs.
Several of the other databases referred to below are available via subscription to
PREX. This is referred to where applicable.
The PREX database collection can be accessed via the Internet using Telnet. Full
access requires a subscription. Some of the databases may however be accessed
free of charge (but without the possibility of downloading information) at the
following Telnet address:
131.211.172.21
Log in as: guest (N.B. lower case)
Password: guest (N.B. lower case)
For further information, contact:
PREX,
Utrecht University,
P.O. Box 80166,
NL-3508 TD Utrecht,
The Netherlands
Telephone: +31 30 253 1583
Telefax: +31 30 253 6747
The Tree of Life is
an Internet project containing information about phylogeny and biodiversity. It
is designed to illustrate the diversity of living organisms, and to link
biological information available on the Internet in the form of a phylogenetic
navigator.
Dr. Henk van Wilgenburg is
developing a database. More details will be added here.
The UC Center
for Animal Alternatives serves the animal care community of the University of
California's nine campuses and laboratories, focussing mainly on alternatives in
education and the issues surrounding the third R, Refinement. It also acts as a
referral service, providing information on how best to search for required
information. The Center publishes a newsletter, UC Alert, and guides to
information resources.
These last guides include: Alternatives in
Higher Education, Internet
Resources, Bibliographies and
Recommended
Journals.
Further details from:
Mary W. Wood, UC Center for Alternatives, School of Veterinary Medicine,
University of California, Davis CA 95616-8684, USA
Telephone: +1 916 752 9016
Telefax: +1 916 754 8608
Email: mwwood@ucdavis.edu
VetBase is a database of literature references to over 12,000 doses of drugs for
800 veterinary drugs in 130 species. The species covered include traditional
farm and laboratory animals, zoo species, fish, birds, amphibians and reptiles.
Doses for primates are excluded. Over 4500 of these doses concern the relief or
prevention of pain. The doses are derived from British, American, French, German
and Dutch sources (journal articles, books, conference proceedings etc.). They
are included whether they are licensed for use for a particular species or not.
The classification of the drugs is an adapted version of the Anatomical
Therapeutical Classification System for veterinary medical products, which
classifies by site of action, therapeutic effects and chemical characteristics.
Generic drug names are used exclusively.
VetBase is produced by Dr. Hans Kuiper
and Dr. H.J. Kuiper in Utrecht, The Netherlands. The database is a custom-made
MS-Windows application, requiring Windows 3.1 or Windows 95. A free demo of
VetBase for IBM Windows is now available. The demo is fully functional for a
limited range of drugs (anthelmintics in rodents). Searches for other drug
categories return the number of references that the full version contains.
The demo can be downloaded
here.
This file (1.2 MB) must be unpacked using the
shareware program pkunzip. Type 'pkunzip vetbase.zip' on your local
computer. Then run the vbsetup.exe program and follow the instructions on the
screen.
The World Congress was held in Utrecht, The Netherlands, from Monday 20th to
Thursday 24th October 1996. A database containing all the abstracts of
presentations at the Congress is available for IBM Windows machines. The database may be downloaded from our
server. This file (1070 kB) must be unpacked using the shareware program pkunzip. Type 'pkunzip setup.zip'
on your local computer. Then run the Setup.exe program and follow the
instructions on the screen.
The database has been constructed by Dr. Hans
Kuiper (email: j.d.kuiper@accu.uu.nl) of the PREX project.
The ZEBET database contains documentation on about 300 alternatives in all fields
of biomedicine and contains a total of about 4000 bibliographical references.
ZEBET is used to provide advice and information to scientists and animal welfare
officers during the process of licensing applications for animal experimentation.
In controversial cases, ZEBET makes an official statement to the regional
authorities which may be used in court cases. ZEBET also handles more general
queries on alternatives from all sectors of society. A trial is in progress to
investigate the feasibility of offering public access to the database through
DIMDI.
Further details from:
Barbara Grune-Wolff, ZEBET, Postfach 33 00 13, D-14195 Berlin, Germany
Telephone: +49 30 84122 271
Telefax: +49 30 84 122 958
Email: zebet@bgvv.de
The following literature reference is also recommended:
Alternatives
to animal testing: information resources via the internet and world wide web,
by P.J. Hakkinen and D.K. Green, published in Toxicology, Vol. 173(1-2), 3-11,
April 2002.
Supporting organizations and companies
The Center for Alternatives to Animal Testing (CAAT), Johns Hopkins
University, Baltimore, Maryland, USA
CAAT is one of the organizations participating in the initiative to create a
global consortium of information on alternatives databases. They have their own
home page.
CAAT is developing a database on antibody production.
The Humane Society of the United States (HSUS)
The Humane Society of the United States is one of
the organizations participating in the initiative to create a global consortium of
information on alternatives databases. The HSUS is the United States' largest
animal protection organization. Their youth education division, the NAHEE
(National Association for Humane and Environmental Education), and the
international organization HSI (Humane Society International) are described in
more detail here.
Laboratory Animals Ltd.
Publisher of Laboratory Animals, the international journal of laboratory
science and welfare. The journal has its own home
page.
This page is provided by the server of the Laboratory Animal Unit, at the Norwegian School of Veterinary Science, Oslo.
