Rat Blood Pressure
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Owner/Developer: Sheffield Bioscience Programs
01 January 2008
an interactive computer simulation of experiments to study the effects of a number of pharmacological agents on rat blood pressure in vivo
Computer assisted learning
Optional / Voluntary
Carrying out procedures on animals, Computational methods
Full coverage (a dedicated course)
Rats (Rattus norvegicus)
|Course level on animal species:||
|Details on the topic or technology covered:||
The main menu allows students to access sections covering different aspects of the laboratory class;
Introduction: Home Office Licence requirements,
Preparation: anaesthesia/anaesthetization, cann-ulation of trachea, jugular vein and carotid artery,
Apparatus: equipment used to maintain body temperature, record blood pressure and heart rate,
Measurements: describes how to take measurements from the simulated chart recorder and how to calculate mean BP and pulse pressure,
Experiments: provides typical data for 16 different experiments selected to teach the essential pharmacology: catecholamines; pressor agents ; acetylcholine; ganglion stimulants ; uptake1-blockers; alpha-blockers ; beta-blockers; adrenaline reversal ; guanethidine ; sympathetic nerve stimulation; depressor drugs ; ganglion blockade; quantitative effects of alpha-blockade; quantitative effects of beta-blockade; reserpine; pithing.
Students are expected to record and tabulate data from the screen display and to then complete student assignments e.g. a series of MCQ questions, with feedback, to assess accuracy of data collection and data interpretation; a student task (typical of a traditional lab-class report) to be completed in their own time. In addition there is a section containing a selection of MCQ's with feedback covering cardiovascular pharmacology which students can use for revision.
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