Target Organ Toxicity in Marine and Freshwater Teleosts, Volume 1: Organs

This book addresses the numerous gaps in current information, all the chapters are written by researchers who are internationally recognized for their work in mechanistic aspects of aquatic toxicology. This volume is devoted to specific organs with coverage of the gill, kidney, skin, liver and gut. Each chapter focuses on a specific target organ or physiological system and describes how various agents disrupt the normal physiological system and processes. The companion volume, Systems, provides coverage of toxic effects in the central nervous, immune, neurobehavioural and reproductive systems as well as describing general mechanisms of toxicity.  

Table of Contents: List of contributors; Foreword; Copyright acknowledgments; 1 Toxic responses of the gill; Functional anatomy; Basic physiology; General responses to toxicants; Specific responses to selected toxicants; 2 Target organ toxicity in the kidney; Functional morphology of the teleost kidney; Overall kidney function; Urine formation; Control of kidney function; Concluding remarks on teleost kidney physiology; Nephrotoxicity; Concluding remarks on nephrotoxicity; 3 Toxic responses of the skin; Structure - function of fish skin; Skin absorption of xenobiotics; Toxic responses of the skin; Research needs; 4 Toxic responses of the liver; Important aspects of fish liver anatomy related to interpretation of toxicity; Important aspects of fish liver physiology related to interpretation of toxicity; Studies with reference hepatotoxicants in fish; Hepatocellular adaptation; Hepatobiliary system; In vitro model systems; Chronic toxicity - liver carcinogenesis studies; Information gaps and future directions; 5 Response of the teleost gastrointestinal system to xenobiotics; Structure of the gastrointestinal tract; Gastrointestinal tract physiology; Xenobiotic absorption and disposition; Elimination; Gastrointestinal tract toxicity; Index.

382 pages. Paperback, Hardback & eBook. Please see record number 7926 for Volume 2 in this series.

ISBN-13: 9780367455309, Hardback: 9780415248389, eBook: 9781315109244

Paperback: £54.99, Hardback: £170.00, eBook: £49.49