Use of the Syrian hamster embryo (SHE) cell transformation assay for the in vitro testing of five pesticides
By Dusinska, M. - Slamenova, D. - Kolman, A.
| Record number: | 1667868 |
|---|---|
| Category: | animal use alternatives - pesticides |
The morphological transformation of Syrian hamster embryo (SHE) cells has been used for the in vitro testing of the transforming activity of five pesticides (Dual, Vucht 524, Piritione, Decemtione and Supercypermethrin). Morphological transformation with two known inducers, 3-methylcholanthrene and N-methyl-N'-nitro-N-nitrosoguanidine, was used as a positive control. It was found that only one of the tested pesticides, Dual, failed to induce morphological transformation in SHE cells, whereas the remaining four demonstrated varying degrees of positive response and could be regarded as potential carcinogenic chemicals.
Issued: Apr 1993
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 21 v. 2 no.
Pages: 202 - 205
Notes:
Paper presented at the tenth annual Scandinavian Society of Cell Toxicology conference on in vitro toxicology, Sept 10-13, 1992, Visby, Gotland, Sweden.
AGRICOLA identifier: IND20359615
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