Adverse Outcome Pathways in environmental toxicology: practical applications, methods and challenges
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Owner/Developer: Norwegian University of Science and Technology (NTNU)
| Country: |
Norway |
|---|---|
| Languages: |
English |
| Url: |
https://swetox.se/wp-content/uploads/2018/08/phd-course-aop.pdf |
| Created: |
15 October 2018 |
| Locations: |
Norway |
| City: |
Trondheim |
| Description: | In this intensive, one-week course we will provide an advanced understanding of the Advanced Outcome Pathways (AOP) framework emerging in the field of environmental toxicology and chemistry. The AOP framework is a powerful conceptual tool to organize and integrate information on the action of a chemicals on different levels of biological organization. It thereby links interactions of chemicals on a molecular level (molecular initiating event) through a series of key events on tissue and organ level to adverse outcomes in individuals or populations. We will discuss the basic principles of the AOP concept, learn about its applications and critically reflect on advantages and shortcomings using several case studies. Working in groups, we will analyze existing AOPs and the scientific knowledge used to build them. Equipped with such deeper understanding, participants will work jointly on how to embed their PhD research in existing AOPs or construct new AOPs. This will enable the participants to place their own work into a larger toxicological perspective, identify critical knowledge gaps and built better hypotheses. |
| References: | old course description available here https://www.ntnu.edu/studies/courses/BI8071/ |
| Format: |
Computer assisted learning, Lecture |
| Presence: |
Optional / Voluntary |
| Access: |
Free, Fee-based |
| Content type: |
Theoretical, Practical |
| Duration: |
5 days |
| Frequency: |
Recurrent event |
| Prerequisites: |
Recommended previous knowledge Competence in Environmental toxicology and/or chemistry on a MSc level. Required previous knowledge Competence in Environmental toxicology and/or chemistry on a MSc level. |
| Target audience: |
Students |
| Target sectors: |
Academia, Industry |
| Educational level: |
University (Doctoral education) |
| 3rs relevance: |
Replacement |
| Topics covered: |
Computational methods |
| 3rs coverage: |
Full coverage (a dedicated course) |
| Details on the topic or technology covered: |
Learning methods and activities - using the AOPWiki (and similar tools) - identify gaps and challenges in the AOP framework - literature search - presenting and discussing selected case studies - place own research in existing AOPs - draft a new AOP for the own research - presenting the outcomes |
| Legislative framework: |
Test guidelines (OECD, ISO, etc.) |
| Learning outcome: |
Learning outcome - advanced understanding of the theoretical principles of the AOP framework - advanced understanding of the components of an AOP (molecular initiating events, key events, adverse outcome) based on existing case studies - embed the own PhD project in an AOP thinking Skills - use the AOPWiki and other relevant online platforms - critically assess existing AOP and generating new AOP - critically reflect and discuss scientific publications General competence - search, read and understand the relevant literature - present and discuss own analyses |
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