Application of non-animal approaches for decision-making in chemical safety assessment
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Owner/Developer: National Center for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs)
10 December 2018
In collaboration with Unilever, the NC3Rs is jointly hosting a two-day workshop in central London on 10-11 December 2018.
Optional / Voluntary
Professionals (e.g. veterinarians), Scientific officers / Project managers, Managers, Technicians, Teachers and educators, Regulators and policy-makers, Researchers
SMEs, Consulting, Contract Research Organizations (CROs), Governmental bodies, Industry, Academia
Continuing Professional Development
In vitro methods, Computational methods, Legislative aspects
Full coverage (a dedicated course)
|Details on the topic or technology covered:||
Non-animal approaches (i.e. in vitro and in silico) can provide useful information to inform decision-making for chemical safety assessment in product development programmes. However, there can be a lack of confidence in these methods, particularly within a regulatory setting. Methods that focus on mechanistic approaches and incorporation of exposure science can make non-animal approaches more useful for decision-making purposes, and can therefore support a reduction in the current reliance on data from animal tests.
The meeting will bring together academic and industry researchers across multiple disciplines to share their knowledge and experiences in applying non-animal (i.e. in vitro and in silico) methods for decision-making for efficacy and safety assessment. The workshop will be attended by expert scientists from academia, government and regulatory agencies and the (agro)chemicals, consumer products, and pharmaceutical industries.
The key objectives of the workshop are to:
Showcase how non-animal approaches (i.e. in vitro and in silico) are currently being used to enable and improve decision-making for chemical safety assessment, including the use of AOPs/mechanistic approaches and incorporation of exposure science.
Increase awareness and acceptance of non-animal approaches to accelerate their uptake to support decision-making, particularly in a regulatory setting.
Identify scientific gaps that if addressed could have a significant impact on the application and uptake of non-animal approaches.
Encourage collaboration between sectors, to share knowledge and ‘lessons learned’ to maximise the impact of non-animal approaches and to improve safety and efficacy decision-making.
Directive 2010/63/EU or equivalent
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