Reproductive Toxicology (1) (Reproductive Toxicology)
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Owner/Developer: Postgraduate education in toxicology (PET)
| Country: |
Netherlands |
|---|---|
| Languages: |
English |
| Url: |
http://www.toxcourses.nl/courses/reproductive-toxicology/ |
| Founding source: |
Wageningen, Utrecht, Radbourd, Maastricht, Leiden, Vrije Amsterdam, Groningen Universities, NVT Toxicologie, EUROTOX and LinkedIn |
| Locations: |
Netherlands |
| City: |
Utrecht |
| Description: | Aim of the course This postgraduate course introduces the field of reproductive toxicology from the viewpoint of a variety of contributing disciplines. Starting from basic toxicological and embryological concepts it covers subjects from experimental research to clinical studies and epidemiology. Specific topics include advice on drugs use in pregnancy, the teratology of antiepileptic drugs, folic acid deficiency and neural tube defects, and the classical and still topical DES saga. Special attention is given to the interpretation of animal reproductive toxicity studies which form the basis for human risk assessment of chemicals. Students will receive timely subjects for self-study in subgroups culminating in presentations on Friday. |
| Format: |
Lecture |
| Presence: |
Optional / Voluntary |
| Access: |
Fee-based |
| Content type: |
Theoretical |
| Duration: |
5 days |
| Frequency: |
Recurrent event |
| Prerequisites: |
minimum basic knowledge in toxicology |
| Target audience: |
Students, Researchers, Regulators and policy-makers, Teachers and educators, Managers, Scientific officers / Project managers |
| Target sectors: |
Academia, Industry, Governmental bodies, Contract Research Organizations (CROs), Consulting, SMEs |
| Educational level: |
Continuing Professional Development, University (Doctoral education), Postdoctoral (teaching and research) |
| 3rs relevance: |
Replacement |
| Topics covered: |
Other |
| 3rs coverage: |
Partial coverage (e.g. a module) |
| Details on the topic or technology covered: |
Content of the course -General Introduction. -The reproductive cycle: definitions, history, disciplines, human and animal studies. -Fundamental and applied research, risk evaluation and risk management. -Alternatives to animal experimentation. -The DES Saga: Pathology and epidemiology of DES effects, mothers and sons/daughters. -Clinical Teratology: genetic predisposition versus exogenous exposures, clinical research and counselling. -Drugs use in Pregnancy: safety evaluation, exposures in pregnancy, post-marketing surveillance of drugs, risk communication. -Epidemiology of congenital malformations: study types with pros and cons, birth defects registries, examples of congenital anomalies. -Folic acid and neural tube defects, nutrition and pregnancy, folic acid requirements, epidemiology. -Risk assessment in Reproductive Toxicology: overview of guideline-based animal study test protocols, their use in testing strategies, parental versus fetal toxicity. -Risk assessment in Reproductive Toxicology: Workshop with practical examples of animal study results -Presentation of self study reports |
| Learning outcome: |
Outcomes (competences, skills) -knowledge of the general principles of reproductive toxicology; -knowledge of selected human teratogens and their epidemiology and clinical teratology; -knowledge of modes and mechanisms of action of selected reproductive toxicants; -knowledge of innovative approaches towards mechanisms of reproductive toxicity; -knowledge of regulatory hazard assessment methodologies in reproductive toxicology; -knowledge of alternative methods to animal testing in reproductive toxicology; -knowledge of internationally harmonized testing strategies in reproductive toxicology. |
| Accreditation body and/or authority that approved the education or training: |
EUROTOX NVT (Netherlands Society of Toxicology) |
| Qualification received: |
1,5 ECTS credits |
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