EPSim (Rat Brain Slice Epilepsy Simulation)

EPSim is a simulated experiment for investigating the effects of anti-epileptic drugs on the action potential firing of a neuron within a brain slice. The intracellular membrane potential of the neuron is recorded using a patch clamp amplifier via a  glass micropipette electrode attached to the cell body of the neuron and connected to an oscilloscope recording device. The neuron can also be stimulated via this route. Drugs can be applied to the to bath and the concentration of the Na, Ca and K ions in the bathing medium changed.

EPSim belongs to The Strathclyde Pharmacology Simulations package that simulates pharmacological experiments on isolated tissues or whole animals. A range of drugs in varying concentrations can be applied and the effects observed.

Installation information is available on this page.

Please see The Virtual Cat, The Virtual RatCVS, The Virtual Nerve, The Virtual Twitch, The Virtual NMJ (Nerve Muscle Junction) and OBSIM (Organ Bath Simulation) for the other simulations in this package.

Please read the Conditions under which the software may be used.

Computer program: Windows 95 or later

Version 1.0.7 (2021)

Price: Academic users, others working for non-commercial, non-profit making organisations: Free of charge. Commercial organisations: Purchase a license to use the software from the University of Strathclyde (contact the author for details).

See also the physiology and pharmacology programs produced by David Dewhurst for similar resources.