Experimental Design and Reproducibility in Preclinical Animal Studies

This book provides grounds on how to plan and conduct animal experiments that can be reproduced by others. It touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process.
 
The book addresses advanced undergraduates, graduate students and all scientists working with animals.

Contents:

1. The Animal and Its Environment

   1. Front Matter
   2. An Introduction to Reproducibility in the Context of Animal Research

      José M. Sánchez-Morgado, Aurora Brønstad

      Pages 3-10
   3. Rodent Genetics

      Fernando Benavides, Jean-Louis Guénet

      Pages 11-52
   4. Animal and Environmental Factors That Influence Reproducibility

      José M. Sánchez-Morgado, Aurora Brønstad, Kathleen Pritchett-Corning

      Pages 53-75
   5. Microbiology and Microbiome

      Axel Kornerup Hansen

      Pages 77-104
   6. Effects of Untreated Pain, Anesthesia, and Analgesia in Animal Experimentation

      Paulin Jirkof, Heidrun Potschka

      Pages 105-126

2. Statistics: Basics and Explanation of Different Designs and Tests

   1. Front Matter
   2. Why Do We Need a Statistical Experiment Design?

      Michael Parkinson, Carlos Oscar Sánchez Sorzano

      Pages 129-146
   3. Statistical Tests and Sample Size Calculations

      Michael Parkinson, Carlos Oscar Sánchez Sorzano

      Pages 147-164
   4. Design of Experiments

      Michael Parkinson, Carlos Oscar Sánchez Sorzano

      Pages 165-181

3. Systematic Reviews and Publishing

   1. Front Matter
   2. Scholarly Publishing and Scientific Reproducibility

      Arieh Bomzon, Graham Tobin

      Pages 185-211
   3. Systematic Reviews

      Janet Becker Rodgers, Merel Ritskes-Hoitinga

      Pages 213-261
   4. Planning Animal Experiments

      Adrian J. Smith

      Pages 263-277

Part of the Laboratory Animal Science and Medicine book series (LASM, volume 1).

ISBN: Softcover: 978-3-030-66149-6, Hardcover: 978-3-030-66146-5, eBook: 978-3-030-66147-2

Softcover: € 109.99, Hardcover: € 149.99, eBook: € 93.08