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Experimental Design and Reproducibility in Preclinical Animal Studies

By José M. Sánchez Morgado & Aurora Brønstad (Eds.)

Record number: 8619d
Sanchez Morgado Bronstad

This book provides grounds on how to plan and conduct animal experiments that can be reproduced by others. It touches on factors that may impact the reproducibility of animal studies including: the animal genetic background, the animal microbial flora, environmental and physiological variables affecting the animal, animal welfare, statistics and experimental design, systematic reviews of animal studies, and the publishing process.
 
The book addresses advanced undergraduates, graduate students and all scientists working with animals.

Contents:

  1. The Animal and Its Environment

    1. Front Matter
    2. An Introduction to Reproducibility in the Context of Animal Research
      José M. Sánchez-Morgado, Aurora Brønstad
      Pages 3-10
    3. Rodent Genetics
      Fernando Benavides, Jean-Louis Guénet
      Pages 11-52
    4. Animal and Environmental Factors That Influence Reproducibility
      José M. Sánchez-Morgado, Aurora Brønstad, Kathleen Pritchett-Corning
      Pages 53-75
    5. Microbiology and Microbiome
      Axel Kornerup Hansen
      Pages 77-104
    6. Effects of Untreated Pain, Anesthesia, and Analgesia in Animal Experimentation
      Paulin Jirkof, Heidrun Potschka
      Pages 105-126

  2. Statistics: Basics and Explanation of Different Designs and Tests

    1. Front Matter
    2. Why Do We Need a Statistical Experiment Design?
      Michael Parkinson, Carlos Oscar Sánchez Sorzano
      Pages 129-146
    3. Statistical Tests and Sample Size Calculations
      Michael Parkinson, Carlos Oscar Sánchez Sorzano
      Pages 147-164
    4. Design of Experiments
      Michael Parkinson, Carlos Oscar Sánchez Sorzano
      Pages 165-181

  3. Systematic Reviews and Publishing

    1. Front Matter
    2. Scholarly Publishing and Scientific Reproducibility
      Arieh Bomzon, Graham Tobin
      Pages 185-211
    3. Systematic Reviews
      Janet Becker Rodgers, Merel Ritskes-Hoitinga
      Pages 213-261
    4. Planning Animal Experiments
      Adrian J. Smith
      Pages 263-277

Part of the Laboratory Animal Science and Medicine book series (LASM, volume 1).

ISBN: Softcover: 978-3-030-66149-6, Hardcover: 978-3-030-66146-5, eBook: 978-3-030-66147-2

Softcover: € 109.99, Hardcover: € 149.99, eBook: € 93.08


Year: 2021

Publisher

Springer Nature

All articles from Springer Nature

This is one of our favourite textbooks within Laboratory Animal Science.
This page was updated on 28 November 2022

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