In Vitro-In Vivo Extrapolation (IVIVE) to Support Accurate Prediction of Hepatic Drug Disposition
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Owner/Developer: Center for Alternatives to Animal Testing Academy (CAAT Academy)
| Country: |
Belgium |
|---|---|
| Languages: |
English |
| Url: |
https://media.wix.com/ugd/389a36_c3318f8062d64b5483697be46158adc2.pdf |
| Created: |
14 September 2017 |
| Locations: |
Belgium |
| City: |
Leuven |
| Description: | The goal of this workshop is to make attending scientists familiar with the design and conduct of typical in vitro experiments that are performed to profile the hepatic disposition characteristics of new drug candidates and/or xenobiotics. |
| Format: |
Hands-on training, Lecture |
| Presence: |
Optional / Voluntary |
| Access: |
Fee-based |
| Content type: |
Theoretical, Practical |
| Duration: |
2 days |
| Group size: |
7 |
| Frequency: |
One-time event |
| Target audience: |
General public, Professionals (e.g. veterinarians), Scientific officers / Project managers, Managers, Technicians, Teachers and educators, Regulators and policy-makers, Researchers, Students |
| Target sectors: |
SMEs, Consulting, Contract Research Organizations (CROs), Governmental bodies, Industry, Academia |
| Educational level: |
Postdoctoral (teaching and research), University (Doctoral education), University (Master), Continuing Professional Development |
| 3rs relevance: |
Replacement |
| Topics covered: |
Computational methods |
| 3rs coverage: |
Full coverage (a dedicated course) |
| Details on the topic or technology covered: |
Focus will be on sound protocols for generating high quality in vitro data that can subsequently be used as input in physiologically-based pharmacokinetic (PBPK) models. Importantly, the workshop program will also cover adequate in vitro data processing as required before input into PBPK. Combination of data from various in vitro models will also aid in getting novel and mechanistic insights in drug disposition. For instance, combining rich in vitro data sets obtained in liver microsomes and hepatocytes supports determination of intrahepatic drug exposure as well as phenotyping in terms of disposition pathways. The workshop will offer opportunities for attendees to become familiar with recently developed in vitro model systems and their applications. As the workshop will focus on the IVIVE part of IVIVE-PBPK, it is relevant to scientists working in the field of ‘classical’ PBPK as well as scientists working with in vitro models. |
| Legislative framework: |
Directive 2010/63/EU or equivalent |
| Accreditation body and/or authority that approved the education or training: |
CAAT Academy |
| Qualification received: |
certificate of attendance |
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