Application of non-animal (toxico)kinetic data and tools in risk assessment from basic research to practice
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a dataset collected by the EU Commission in June-September 2018
. Some of these links will therefore die out with time.
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Owner/Developer: Association of European Toxicologists & European Societies of Toxicology (EUROTOX)
02 September 2018
citoxlab, TPL, UCB, Janssen, RTC, Elsevier, DouglasConnect, Knoell, Covance, MatTek, ToxMinds, Umicore, Charles River, Cosmetics Europe, Solvay, Envigo, Sysmex, OECD, EPAA, Cabot, Ecetoc, SOT, Hesi, FNRS, Team Mastery, Marshall, Ablynx
The use of integrated approaches based on non-animal data to assess chemical toxicity is
becoming a common practice in risk assessment. In this new paradigm, the in vitro concentration
of a chemical that triggers a response needs to be compared to a biologically
effective dose at an in vivo target, which is mediated by the toxicokinetic (TK) behaviors.
Use of TK data and tools to determine these target concentrations will therefore become
essential for risk assessors in future. In addition, TK data and tools have been identified as
an important current gap for the ability to perform read-across. This CEC will provide an
overview of the use of TK data and tools, based on only alternative methods, to support
risk assessment in several areas, such as food safety, cosmetics safety assessment and
REACH. This CEC will start with a series of presentations to provide insights on developing
alternatives and novel approaches, including in vitro and in silico methods for estimating
TK properties, as well as predictive tools such as physiologically based kinetic models. In
addition, these presentations will introduce various applications of these TK data and tools
in supporting risk assessment. These presentations will then be followed by demonstrations
of TK databases and tools, focusing on their roles in facilitating the incorporation of
TK considerations in risk assessment. Attendees enrolled in this CEC will learn about the
perspectives from various sectors, such as regulatory agencies and industries, on their use
of alternative methods to incorporate TK considerations in risk assessment. Attendees
will also learn about the availability of modeling tools and TK databases to help them
address the need to efficiently integrate TK information with exposure and hazard data for
more informed risk assessment.
Please see page 36 of the above provided link or of the uploaded pdf file
Optional / Voluntary
Professionals (e.g. veterinarians), Scientific officers / Project managers, Managers, Technicians, Teachers and educators, Regulators and policy-makers, Researchers
SMEs, Consulting, Contract Research Organizations (CROs), Governmental bodies, Industry, Academia
Continuing Professional Development
Full coverage (a dedicated course)
|Details on the topic or technology covered:||
1. Introduction to the course
2. Predictive Tools and Databases for Toxicokinetics
3. RVis: a freely available modelling platform
4. Incorporating TK data and tools to support regulatory decision making –
from the perspectives of RIVM
5. Incorporating toxicokinetic data and tools to support public health
6. Using TK data and tools to support regulatory decision making – from the
perspectives of cosmetic industry
7. Developing TK databases and tools to support food safety assessment
8. Q&A – interactive presentation activity
|Accreditation body and/or authority that approved the education or training:||
Eurotox Education Program
certificate of attendance
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