Application of non-animal (toxico)kinetic data and tools in risk assessment from basic research to practice
This record is part of
a dataset collected by the EU Commission in June-September 2018
. Some of these links will therefore die out with time.
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Owner/Developer: Association of European Toxicologists & European Societies of Toxicology (EUROTOX)
02 September 2018
citoxlab, TPL, UCB, Janssen, RTC, Elsevier, DouglasConnect, Knoell, Covance, MatTek, ToxMinds, Umicore, Charles River, Cosmetics Europe, Solvay, Envigo, Sysmex, OECD, EPAA, Cabot, Ecetoc, SOT, Hesi, FNRS, Team Mastery, Marshall, Ablynx
|Description:||The use of integrated approaches based on non-animal data to assess chemical toxicity is becoming a common practice in risk assessment. In this new paradigm, the in vitro concentration of a chemical that triggers a response needs to be compared to a biologically effective dose at an in vivo target, which is mediated by the toxicokinetic (TK) behaviors. Use of TK data and tools to determine these target concentrations will therefore become essential for risk assessors in future. In addition, TK data and tools have been identified as an important current gap for the ability to perform read-across. This CEC will provide an overview of the use of TK data and tools, based on only alternative methods, to support risk assessment in several areas, such as food safety, cosmetics safety assessment and REACH. This CEC will start with a series of presentations to provide insights on developing alternatives and novel approaches, including in vitro and in silico methods for estimating TK properties, as well as predictive tools such as physiologically based kinetic models. In addition, these presentations will introduce various applications of these TK data and tools in supporting risk assessment. These presentations will then be followed by demonstrations of TK databases and tools, focusing on their roles in facilitating the incorporation of TK considerations in risk assessment. Attendees enrolled in this CEC will learn about the perspectives from various sectors, such as regulatory agencies and industries, on their use of alternative methods to incorporate TK considerations in risk assessment. Attendees will also learn about the availability of modeling tools and TK databases to help them address the need to efficiently integrate TK information with exposure and hazard data for more informed risk assessment.|
|References:||Please see page 36 of the above provided link or of the uploaded pdf file|
Optional / Voluntary
Professionals (e.g. veterinarians), Scientific officers / Project managers, Managers, Technicians, Teachers and educators, Regulators and policy-makers, Researchers
SMEs, Consulting, Contract Research Organizations (CROs), Governmental bodies, Industry, Academia
Continuing Professional Development
Full coverage (a dedicated course)
|Details on the topic or technology covered:||
1. Introduction to the course
2. Predictive Tools and Databases for Toxicokinetics
3. RVis: a freely available modelling platform
4. Incorporating TK data and tools to support regulatory decision making –
from the perspectives of RIVM
5. Incorporating toxicokinetic data and tools to support public health
6. Using TK data and tools to support regulatory decision making – from the
perspectives of cosmetic industry
7. Developing TK databases and tools to support food safety assessment
8. Q&A – interactive presentation activity
|Accreditation body and/or authority that approved the education or training:||
Eurotox Education Program
certificate of attendance
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