Cell-based metabolomics for assessing chemical exposure and toxicity of environmental surface waters
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Owner/Developer: Society of Environmnetal Toxicology and Chemistry (SETAC)
United States of America
11 November 2014
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In vitro methods
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Waste water treatment plants (WWTPs), concentrated animal feeding operations (CAFOs), mining activities, and agricultural operations release contaminants that negatively affect surface water quality. Traditional methods using live animals/fish to monitor/assess contaminant exposure and impacts in affected ecosystems are both resource and time intensive and are not sustainable in the long term. This study describes an optimized cell culture-based method employing metabolomics combined with high throughput NMR spectroscopic analysis to obtain multi-endpoint cellular responses to stressor exposure. We also report results of applying cell culture-based metabolomics using Zebrafish (Danio rerio) liver cells (ZFL) to determine biomarkers of exposure following exposure with surface waters from contaminated and pristine sites. Detailed chemical characterization of the test surface waters combined with the metabolomic analysis will provide insight on stressor exposure and impacts.
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