Human iPSC-derived Midbrain Dopaminergic Neurons for Parkinson’s Disease Modeling and Cell Therapy
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Owner/Developer: Cellular Dynamics (cdi)
United States of America
15 June 2017
Parkinson’s disease (PD) affects approximately 1% of people over the age of 65 and is the second most common neurodegenerative disorder after Alzheimer’s disease. The advent of induced pluripotent stem cell (iPSC) technology now grants us access to previously unattainable cell types in the human brain. In this presentation, we will discuss how stem cells are being used not only to study PD in the lab, but also to develop treatments for PD using cells as therapies. Specifically, we have created an isogenic disease model for PD using human iPSC-derived midbrain dopaminergic neurons and have developed in vitro assays for comparative analysis of mitochondrial bioenergetics, calcium handling, and network-level electrophysiology. In the regenerative medicine space, we are actively manufacturing cGMP HLA “superdonor” iPSC lines for universal utility and will provide an update on our progress in developing iPSC-derived cellular therapies, including our program to treat PD by engrafting human midbrain dopaminergic neurons.
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Coby Carlson and Chris McMahon from Cellular Dynamics International discuss the development, manufacture and therapeutic research programs incorporating iPSC-derived dopaminergic neurons aimed at therapeutic intervention in Parkinson's disease.
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