Mechanisms of action (MechoAs): In what way is your substance toxic?
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a dataset collected by the EU Commission in June-September 2018
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Owner/Developer: Chemical Watch (CW)
| Country: |
United Kingdom |
|---|---|
| Languages: |
English |
| Url: |
https://www.kreatis.eu |
| Description: | To predict the toxicity of substances using Read-Across or (Q)SAR models with confidence and reliability, the Mechanism of Action (MechoA) of substances, i.e. the molecular mechanism by which they exert their toxicity, must be identified. In the field of ecotoxicology, several classification methods to predict the Mode of Action (MoA) of substances exist, however, MoAs are generally not clearly defined. At KREATiS, we have developed a universal method of classification of MechoAs for use in both fields. MechoAs are a useful tool for hazard assessment to strengthen mechanistic interpretation, read-across justification and weight of evidence and QSAR approaches. We have launched the iSafeRat® Online platform, where MechoA predictions can be accessed for free. |
| Presence: |
Optional / Voluntary |
| Educational level: |
High school, Technical College, Undergraduate, University (Bachelor), University (Master), University (Doctoral education), Postdoctoral (teaching and research), Continuing Professional Development |
| 3rs relevance: |
Replacement |
| Topics covered: |
Computational methods |
| Details on the topic or technology covered: |
Predict the toxicity of substances using Read-Across or (Q)SAR models with confidence and reliability, the Mechanism of Action (MechoA) of substances, i.e. the molecular mechanism by which they exert their toxicity, must be identified. |
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