New isogenic cell models created by CRISPR genome editing for drug discovery
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Owner/Developer: American Type Culture Collection (ATCC)
| Country: |
United States of America |
|---|---|
| Languages: |
English |
| Url: |
https://www.lgcstandards-atcc.org/About/News_and_Events/Events/Webinars/2017/New_isogenic_cell_models_created_by_CRISPR_genome_editing_for_drug_discovery_2.aspx |
| Created: |
28 September 2017 |
| Description: | The recent development of the CRISPR/Cas9 system provides a revolutionary gene-editing technology for basic research in biology and for development of targeted cancer therapies. In addition to enabling the identification of novel drug targets through functional screening, CRISPR/Cas9 facilitates the creation of disease models for drug discovery and development. In this webinar, ATCC experts will address how ATCC utilized this advanced technology to create novel human cell models that contain disease-relevant point mutations and gene rearrangements. In addition, we will introduce a new type of BRAF inhibitor-resistant cell line that was created by using CRISPR/Cas9 to insert the NRAS Q61K mutation. These human isogenic lines provide useful disease models for the identification and validation of new therapeutics. |
| Format: |
Webinars |
| Presence: |
Optional / Voluntary |
| Access: |
Free |
| Content type: |
Theoretical |
| Duration: |
52 min |
| Target audience: |
Students, Researchers, Regulators and policy-makers, Teachers and educators, Technicians, Managers, Scientific officers / Project managers, Professionals (e.g. veterinarians), General public |
| Target sectors: |
Academia, Industry, Governmental bodies, Contract Research Organizations (CROs), Consulting, SMEs |
| Educational level: |
University (Bachelor), University (Master), University (Doctoral education), Postdoctoral (teaching and research), Continuing Professional Development |
| 3rs relevance: |
Replacement |
| Topics covered: |
In vitro methods |
| 3rs coverage: |
Full coverage (a dedicated course) |
| Details on the topic or technology covered: |
Key Points: CRISPR/Cas9 gene editing technology is a powerful tool for drug discovery Gene editing technology can be used to create disease-relevant cell models for screening new anti-cancer drug targets CRISPR/Cas9 is a useful tool for creating new types of drug-resistant cell models |
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