PBPK modelling for quantitative in vitro-in vivo extrapolation
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a dataset collected by the EU Commission in June-September 2018
. Some of these links will therefore die out with time.
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Owner/Developer: Altertox Academy
| Country: |
Belgium |
|---|---|
| Languages: |
English |
| Url: |
http://academy.altertox.be/ |
| Locations: |
Belgium |
| City: |
Leuven |
| Description: | Physiology-based (pharmaco)kinetic PB(P)K modelling has become a promising tool to predict plasma and/or tissue exposure to xenobiotics based on in vitro disposition data. While physiological parameters that characterize the target population have been largely implemented in several PB(P)K platforms, further consensus building is needed with respect to the quality requirements of in vitro data used for a successful bottom-up modelling approach. Therefore, this workshop will focus on improved integration of in vitro drug disposition assessments with the latest developments in the field of PB(P)K-based prediction. Special attention will also be given to prediction of (tissue) partition coefficients. |
| Format: |
Hands-on training, Lecture, Webinars |
| Presence: |
Optional / Voluntary |
| Access: |
Fee-based |
| Content type: |
Theoretical, Practical |
| Duration: |
2 days |
| Group size: |
20.0 |
| Frequency: |
One-time event |
| Target audience: |
Students, Researchers, Regulators and policy-makers, Teachers and educators, Technicians, Managers, Scientific officers / Project managers, Professionals (e.g. veterinarians) |
| Target sectors: |
Academia, Industry, Governmental bodies, Contract Research Organizations (CROs), Consulting, SMEs |
| Educational level: |
Technical College, Undergraduate, University (Bachelor), University (Master), University (Doctoral education), Postdoctoral (teaching and research), Continuing Professional Development |
| 3rs relevance: |
Replacement |
| Topics covered: |
Computational methods |
| 3rs coverage: |
Full coverage (a dedicated course) |
| Details on the topic or technology covered: |
General Introduction to PBPK models PBPK modelling equations, model input and software Inclusion of the partition coefficients and metabolic clearance data from the day before in the PBPK model in Berkeley Madonna, evaluation of the model performance and use of the model for QIVIVE of toxicity data. Inclusion of the data in Simcyp and comparison with the outcomes of Berkeley Madonna. Drug-drug interaction Population (DNT) |
| Legislative framework: |
Directive 2010/63/EU or equivalent |
| Learning outcome: |
Understand new toxicological models Practice side-by-side with the experts Integrate and transfer these tools in your daily working environment or your future job Increase your expertise on the regulatory context of REACH, Cosmetics ban, the EU Pharmacopoeia etc.. Discover new aspects and develop your skills for continuous education |
| Accreditation body and/or authority that approved the education or training: |
The French Society of Toxicology (SFT) |
| Qualification received: |
Certificate of participation |
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