Principles of PBPK modeling and the application of this technique for in vitro to in vivo extrapolation (IVIVE)
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United States of America
01 September 2017
United States of America
This course was designed to teach how to apply an effective computational tool — physiologically based pharmacokinetic (PBPK) modeling — to translate the results of in vitro toxicity assays into estimates of safe human exposure
Computer assisted learning, Hands-on training, Lecture
Optional / Voluntary
WHO SHOULD ATTEND?
Industrial, pharmaceutical and regulatory scientists desiring to interpret the results of in vitro toxicity assays in terms of their implications for human health
Toxicologists and research scientists who develop or conduct in vitro toxicity assays
Individuals desiring to learn how to develop and apply PBPK models
Individuals interested in promoting the use of alternatives to live animal testing for regulatory requirements such as REACH
Professionals (e.g. veterinarians), Scientific officers / Project managers, Managers, Teachers and educators, Regulators and policy-makers, Researchers, Students
SMEs, Consulting, Contract Research Organizations (CROs), Governmental bodies, Industry, Academia
Postdoctoral (teaching and research), University (Doctoral education), Continuing Professional Development
In vitro methods, Computational methods
Full coverage (a dedicated course)
|Details on the topic or technology covered:||
This one-week course covered the principles of PBPK modeling and the application of this technique for in vitro to in vivo extrapolation (IVIVE) to support risk assessments based on non-animal methods. The course featured comprehensive lectures and extensive hands-on computer modeling practice.
REACH Regulation (EC) No 1907/2006 or equivalent
This course will prepare you to use state-of-the-art modeling & simulation techniques to assist in estimating acceptable human exposure guidelines from the results of in vitro toxicity assays.
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