Toxicogenomics
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Owner/Developer: Postgraduate education in toxicology (PET)
| Country: |
Netherlands |
|---|---|
| Languages: |
English |
| Url: |
http://www.toxcourses.nl/courses/toxicogenomics/ |
| Founding source: |
Wageningen, Utrecht, Radbourd, Maastricht, Leiden, Vrije Amsterdam, Groningen Universities, NVT Toxicologie, EUROTOX and LinkedIn |
| Locations: |
Netherlands |
| City: |
Maastricht |
| Description: | Aim of the course In this course, an introduction will be provided on genomics technologies, i.e. gene expression profiling by RNA sequencing and microarray technologies, focussing on its application in toxicology. Content of the course During this course, participants will be familiarized with the theoretical and practical background of toxicogenomics. Through lectures in the mornings, knowledge will be provided about the basic principles of gene expression profiling by RNA sequencing and DNA microarrays, its technologies, the main approaches for statistical analyses and visualisation of gene expression data, and its application in toxicology. In the afternoon, practical experience with the main data analyses approaches and applications will be provided by computer trainings and a plenary discussion. |
| Format: |
Hands-on training, Lecture |
| Presence: |
Optional / Voluntary |
| Access: |
Fee-based |
| Content type: |
Theoretical, Practical |
| Duration: |
5 days |
| Frequency: |
Recurrent event |
| Prerequisites: |
minimum basic toxicology knowledge |
| Target audience: |
Students, Researchers, Regulators and policy-makers, Teachers and educators, Technicians, Managers, Scientific officers / Project managers, Professionals (e.g. veterinarians) |
| Target sectors: |
Academia, Industry, Governmental bodies, Contract Research Organizations (CROs), Consulting, SMEs |
| Educational level: |
Continuing Professional Development, University (Doctoral education), Postdoctoral (teaching and research) |
| 3rs relevance: |
Replacement |
| Topics covered: |
Legislative aspects, Computational methods |
| 3rs coverage: |
Partial coverage (e.g. a module) |
| Details on the topic or technology covered: |
List of subjects Basic principles of genomics -Methods for gene expression profiling (RNA sequencing, microarrays) -Data pre-processing -Data analysis: statistical approaches and visualisations -Data mining to understand biology -Other technologies: proteomics, metabolomics, and epigenomics Applied toxicogenomics -Unravelling toxic mechanisms -Biomarkers for toxic effects -Predictive toxicology -Regulatory aspects Practical training -Pre-processing of RNA sequencing -Data analysis to identify differentially expressed genes and to compare toxic exposure by gene expression profiles (including clustering approaches and visualisations) -Identification of affected pathways and processes -In silico drug target prediction and biological interpretation |
| Learning outcome: |
Outcomes (competences, skills) Following this course the participants should: -be familiar with the theoretical and practical background of toxicogenomics, especially transcriptomics by RNA sequencing and DNA microarrays; -have knowledge about the basic principles of gene expression profiling, especially: -the various technologies and platforms -the main approaches for statistical analyses and visualisations -the various options for data mining in order to understand the biology -the main application areas in toxicology (mechanistic, predictive, and epidemiological); -have practical experience for initial data analysis/visualization/mining approaches of gene expression data; -have basic knowledge about other ‘omics’ technologies. |
| Accreditation body and/or authority that approved the education or training: |
EUROTOX NVT (Netherlands Society of Toxicology) |
| Qualification received: |
1,5 ECTS credits |
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