Alternative methods for regulatory toxicology – a state-of-the-art review
Owner/Developer: European Commission, Joint Research Centre (EC - JRC)
This state-of-the art review is based on the final report of a project carried out by the European Commission’s Joint Research Centre (JRC) for the European Chemicals Agency (ECHA). The aim of the project was to review the state of the science of non-standard methods that are available for assessing the toxicological and ecotoxicological properties of chemicals. Non-standard methods refer to alternatives to animal experiments, such as in vitro tests and computational models, as well as animal methods that are not covered by current regulatory guidelines. This report therefore reviews the current scientific status of non-standard methods for a range of human health and ecotoxicological endpoints, and provides a commentary on the mechanistic basis and regulatory applicability of these methods.
|Audience:||Regulators - Industry|
|User access:||Open access|
|Relevance:||Replacement - Reduction|
|Purpose:||Regulatory testing - Documentation and information|
|Legislative framework:||Cosmetics Regulation (EC) No 1223/2009 - REACH Regulation (EC) No 1907/2006 - CLP Regulation (EC) No 1272/2008 - Biocidal Products Regulation (EC) No 528/2012 - Plant Protection Products Regulation (EC) No 1107/2009|
|Technology/Tools:||Alternative test methods (in vitro) - Non-testing methods (in silico) - Integrated approaches to testing and assessment (IATA)|
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