In silico systems pharmacology to assess drug's therapeutic and toxic effects
Owner/Developer: Current Pharmaceutical Design
| Country: | United States of America |
|---|---|
| Languages: | English |
| Url: | http://www.ncbi.nlm.nih.gov/pubmed/27604605 |
| Description: |
For many years, the "one target, one drug" paradigm has been the driving force behind developments in pharmaceutical research. With the recent advances in molecular biology and genomics technologies, the focus is shifting toward "drug-holistic" systems based approaches (i.e. systems pharmacology). The integration of large and diverse amount of data from chemistry and biology coupled with the development and the application of network-based approaches to cope with these data is the next paradigm of drug discovery. Systems pharmacology offers a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets and their modification by drugs. Studying drug action across multiple scales of complexity from molecular and cellular to tissue and organism levels may help identify new druggable disease genes and to design new drugs with a better efficacy and clinical safety. |
| Category: | Publication |
| Channel: | Website |
| Audience: | Researchers - Scientists - Industry |
| User access: | Restricted access |
| Updating frequency: | 2016 |
| Relevance: | Replacement |
| Purpose: | Method development - Documentation and information - Toxicological and safety evaluation |
| Technology/Tools: | Non-testing methods (in silico) |
Fant du det du lette etter?
Ja, jeg fant det! Nei, jeg fant det ikke!Takk for din tilbakemelding! Vær oppmerksom på at vi ikke kan kontakte deg hvis ikke du oppgir din epostadresse.
Hva lette du etter?
Gi oss gjerne en tilbakemelding slik at vi kan forbedre informasjonen på siden. På forhånd takk for hjelpen! Vennligst skriv inn din epostadresse hvis du vil ha et svar.
Kontakt oss gjerne på e-post hvis du har spørsmål.