From in vivo models to cell models
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Owner/Developer: International Council for Laboratory Animal Science, Tunisian Association for Laboratory and Animal Science and ENMV (National School of Veterinary Medicine of Tunisia and CAAT-Europe, Episkin Academy and Biopredic International. (ICLAS, ATSAL, BPI, CAAT, Episkin)
23 February 2015
|Description:||-animal ethical bases and the evolution of man’s perception of animals through the ages and according to civilizations and countries; -an overview of different alternative methods and their status of validation. She introduced different international organisations for the validation of alternative methods, in particular EURL ECVAM (European Union Reference Laboratory for Alternatives to Animal Testing); -a new cell culture platform dedicated to teaching which is supported by the World Bank and started in 2012;|
Hands-on training, Lecture
Optional / Voluntary
Students, Researchers, Technicians, Professionals (e.g. veterinarians)
Academia, Industry, Governmental bodies
University (Bachelor), University (Master), University (Doctoral education), Postdoctoral (teaching and research), Continuing Professional Development
Taking care of animals, In vitro methods, Ethics
Substantial coverage (e.g. multiple modules)
|Details on the topic or technology covered:||
-3Rs principles and the international guiding principles for biomedical research involving animals (ICLAS/CIOMS) and OIE recommendations on laboratory animal welfare;
-new models (e.g., in silico, in vitro and organs-on-a-chip), current state-of-the-art in the EU, the
paradigm shift in toxicology (e.g., adverse outcome pathways), zebrafish embryo toxicity test as a low-cost but valuable model for academic research purposes;
-“3D models: Reconstructed Human Epidermis and Skin,” - an overview of the regulatory
context, the concept of alternative methods and how to validate them;
- industrial applications of tissue engineering to assess safety and efficiency of chemicals,
cosmetics, drugs or medical devices.
Directive 2010/63/EU or equivalent, REACH Regulation (EC) No 1907/2006 or equivalent, Test guidelines (OECD, ISO, etc.)
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