Read-across in REACH and its assessment (Read-across in REACH and its assessment)
Owner/Developer: Association of European Toxicologists & European Societies of Toxicology (EUROTOX)
02 September 2018
citoxlab, TPL, UCB, Janssen, RTC, Elsevier, DouglasConnect, Knoell, Covance, MatTek, ToxMinds, Umicore, Charles River, Cosmetics Europe, Solvay, Envigo, Sysmex, OECD, EPAA, Cabot, Ecetoc, SOT, Hesi, FNRS, Team Mastery, Marshall, Ablynx
Read-across is an important scientific method for providing reliable information on the
properties of substances, whilst minimising the use of animals. It is widely used in a
variety of legislations, and this session seeks to develop overarching approaches to improved
read-across in general, by focusing on the specific example of its use in REACH.
The session starts by describing the nature of read-across in REACH, the extent of the
use of read-across in REACH registration dossiers, and the use of the recently developed
read-across assessment framework to evaluate read-across in a consistent way. Scientific
challenges associated with the use of read-across for multi-constituent substances, and
substances of Unknown or Variable composition, Complex reaction products or Biological
materials (UVCBs) are mapped out. Novel and alternative methods can support the use of
read-across, and novel frameworks for considering how this information can be applied to
read-across will be discussed. The challenges of dealing with read-across for a variety of
industrial chemicals will be discussed, making reference to uncertainty in the regulatory
landscape and other challenges for successful read-across. The session aims to summarise
key concepts for sucessful application of read-across in a variety of regulatory settings.
go to page 39 of the provided link
Optional / Voluntary
Professionals (e.g. veterinarians), Scientific officers / Project managers, Managers, Technicians, Teachers and educators, Regulators and policy-makers, Researchers
SMEs, Consulting, Contract Research Organizations (CROs), Governmental bodies, Industry, Academia
Continuing Professional Development
Full coverage (a dedicated course)
|Details on the topic or technology covered:||
1. Read-across in REACH and the read-across assessment framework (RAAF)
2. Scientific considerations for assessing read-across between multiconstituent
or UVCB substances
3. Scientific Issues That Need to be Addressed for a Successful Read-Across
4. Quantitative assessment of mitochondrial toxicity and downstream
cellular perturbations in Adverse Outcome Pathways.
5. Key issues for successful read-across - a user’s guide
REACH Regulation (EC) No 1907/2006 or equivalent
|Accreditation body and/or authority that approved the education or training:||
Eurotox Education Program
certificate of attendance
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