Read-across in REACH and its assessment
This record is part of
a dataset collected by the EU Commission in June-September 2018
. Some of these links will therefore die out with time.
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Owner/Developer: Association of European Toxicologists & European Societies of Toxicology (EUROTOX)
02 September 2018
citoxlab, TPL, UCB, Janssen, RTC, Elsevier, DouglasConnect, Knoell, Covance, MatTek, ToxMinds, Umicore, Charles River, Cosmetics Europe, Solvay, Envigo, Sysmex, OECD, EPAA, Cabot, Ecetoc, SOT, Hesi, FNRS, Team Mastery, Marshall, Ablynx
|Description:||Read-across is an important scientific method for providing reliable information on the properties of substances, whilst minimising the use of animals. It is widely used in a variety of legislations, and this session seeks to develop overarching approaches to improved read-across in general, by focusing on the specific example of its use in REACH. The session starts by describing the nature of read-across in REACH, the extent of the use of read-across in REACH registration dossiers, and the use of the recently developed read-across assessment framework to evaluate read-across in a consistent way. Scientific challenges associated with the use of read-across for multi-constituent substances, and substances of Unknown or Variable composition, Complex reaction products or Biological materials (UVCBs) are mapped out. Novel and alternative methods can support the use of read-across, and novel frameworks for considering how this information can be applied to read-across will be discussed. The challenges of dealing with read-across for a variety of industrial chemicals will be discussed, making reference to uncertainty in the regulatory landscape and other challenges for successful read-across. The session aims to summarise key concepts for sucessful application of read-across in a variety of regulatory settings.|
|References:||go to page 39 of the provided link|
Optional / Voluntary
Professionals (e.g. veterinarians), Scientific officers / Project managers, Managers, Technicians, Teachers and educators, Regulators and policy-makers, Researchers
SMEs, Consulting, Contract Research Organizations (CROs), Governmental bodies, Industry, Academia
Continuing Professional Development
Full coverage (a dedicated course)
|Details on the topic or technology covered:||
1. Read-across in REACH and the read-across assessment framework (RAAF)
2. Scientific considerations for assessing read-across between multiconstituent
or UVCB substances
3. Scientific Issues That Need to be Addressed for a Successful Read-Across
4. Quantitative assessment of mitochondrial toxicity and downstream
cellular perturbations in Adverse Outcome Pathways.
5. Key issues for successful read-across - a user’s guide
REACH Regulation (EC) No 1907/2006 or equivalent
|Accreditation body and/or authority that approved the education or training:||
Eurotox Education Program
certificate of attendance
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