| DOI: | https://doi.org/10.3389/fphar.2016.00183 |
|---|---|
| Reference: |
Computational Modeling Predicts Simultaneous Targeting of Fibroblasts and Epithelial Cells Is Necessary for Treatment of Pulmonary Fibrosis |
| Disease Area: | Pulmonary Fibrosis |
| Type: | See notes |
| Application: | Disease mechanism (exp/theor) |
| Biological Endpoints: | Cytokine Release |
| Throughput: | Not relevant (e.g. In silico) |
| Potential: | Mechanistic Studies |
| Notes: |
The study authors combined in vitro studies with a multi-scale hybrid agent-based computational model that describes fibroblasts and epithelial cells in co-culture. Within this model TGF-β1 represents a pro-fibrotic mediator and we include detailed dynamics of TGF-β1 receptor ligand signaling in fibroblasts. This in silico model captures the coregulation of fibroblasts and epithelial cells in vitro. There is substantial support for constructing agent-based models (ABMs) of in vitro co-culture systems. These models are used to study a wide range of processes including, but not limited to wound healing, tissue patterning, and tumor progression. |
| Authors: | Warsinske, Hayley C. - Wheaton, Amanda K. - Kim, Kevin K. - Linderman, Jennifer J. - Moore, Bethany B. - Kirschner, Denise E. |
| Year: | 2016 |
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