Computational Modeling Predicts Simultaneous Targeting of Fibroblasts and Epithelial Cells Is Necessary for Treatment of Pulmonary Fibrosis
|Disease Area:||Pulmonary Fibrosis|
|Application:||Disease mechanism (exp/theor)|
|Biological Endpoints:||Cytokine Release|
|Throughput:||Not relevant (e.g. In silico)|
The study authors combined in vitro studies with a multi-scale hybrid agent-based computational model that describes fibroblasts and epithelial cells in co-culture. Within this model TGF-β1 represents a pro-fibrotic mediator and we include detailed dynamics of TGF-β1 receptor ligand signaling in fibroblasts.
This in silico model captures the coregulation of fibroblasts and epithelial cells in vitro. There is substantial support for constructing agent-based models (ABMs) of in vitro co-culture systems. These models are used to study a wide range of processes including, but not limited to wound healing, tissue patterning, and tumor progression.
|Authors:||Warsinske, Hayley C. - Wheaton, Amanda K. - Kim, Kevin K. - Linderman, Jennifer J. - Moore, Bethany B. - Kirschner, Denise E.|
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