Microbial and Phenotypic Definition of Rats and Mice: Proceedings of the 1998 US/Japan Conference

US-Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US-Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic of Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes published in 1991. In addition to these publications, these meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.

Table of Contents: Front Matter; Opening Remarks (Ota); Opening Remarks (Vaitukaitis); The Need for Defined Rats and Mice in Biomedical Research: Problems, Issues, and the Current State of Affairs (Nomura); The Need for Defined Rats and Mice in Biomedical Research: Problems, Issues, and the Current State of Affairs (Tamaoki); The Biological Integrity of Laboratory Rodents; Quality Testing System for SPF Animals in Japan and Problems in the Management of Such Systems; Definition of Microbiological Status of Rats and Mice/The Need for Methods of Defining Flora/International Standards for Terminology; Development of Rodent Pathogen Profiles and Adequacy of Detection Technology; Current Status of Pathogen Status in Mice and Rats; Genetic Background and Phenotypes in Animal Models of Human Diseases; Genetic and Phenotypic Definition of Laboratory Mice and Rats/What Constitutes an Acceptable Genetic-Phenotypic Definition (Katoh); Phenotype Assessment Requires More Than a Casual Observation; Genetic and Phenotypic Definition of Laboratory Mice and Rats/What Constitutes an Acceptable Genetic-Phenotypic Definition (Davisson); Genetic and Phenotypic Definition of Laboratory Mice and Rats/What Constitutes an Acceptable Genetic-Phenotypic Definition (DeGeorge); CIEA/NCRR/NIH Genetic and Microbiological Monitoring of Mouse and Rat Resources: Directions for the Future (Nomura); CIEA/NCRR/NIH Genetic and Microbiological Monitoring of Mouse and Rat Resources: Directions for the Future (West); Closing Comments/Summary of Presentations; Summary of Presentations (Pakes); Summary of Presentations (Nomura); Appendix A: US/Japan Meeting Agenda; Appendix B: Meeting Participants.

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