Advancing Adverse Outcome Pathways for Integrated Toxicology and Regulatory Applications
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Owner/Developer: International group
02 March 2014
American Chemistry Council, BioDetection Systems, European Centre for Ecotoxicology and Toxicology of Chemicals, Environment Canada, European Commission Directorate General Joint Research Center, Human Toxicology Project Consortium, International Life Sciences Institute - Health and Environmental Science Institute, Norwegian Institute for Water Research, Society for Environmental Toxicology and Ch
|Description:||This workshop focused on the use of the Adverse Outcome Pathway (AOP) concept as a framework to characterize, organize, and define predictive relationships between measurable key events that reflect the progression from a chemical-induced perturbation to an adverse outcome considered relevant to regulatory decision-making.|
Optional / Voluntary
Regulators and policy-makers, Researchers
Governmental bodies, Academia, Industry
Continuing Professional Development
Partial coverage (e.g. a module)
|Details on the topic or technology covered:||
Research priorities for development of AOPs
Strategic approaches to AOP development
Weight of evidence evaluation to define uncertainties associated with predictive relationships represented in an AOP
“Acceptance” of AOPs for regulatory applications
Applying AOPs to support Informed Approaches to Testing and Assessment
Test guidelines (OECD, ISO, etc.)
The objective of the present workshop was to build upon these previous efforts and provide consideration and expert opinion on the critical next steps required to advance the use and acceptance of the AOP framework to support integrated toxicology and regulatory decision-making
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