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α-Linolenic Acid Inhibits RANKL-Induced Osteoclastogenesis In Vitro and Prevents Inflammation In Vivo
... 1 West China School of Public Health, West China Fourth Hospital, Sichuan University, Chengdu 610041, China
2 Department of Healthcare- ...
... also harvested for assessment. For all animal experimental procedures, we followed the Laboratory Animal and Protection Regulations, and the ...
Nanoencapsulation of Cyanidin 3-O-Glucoside: Purpose, Technique, Bioavailability, and Stability
... 1 Department of Food Engineering, Faculty of Engineering, Ondokuz Mayis University, 55139 Samsun, Turkey
2 Laboratory of Human Nutrition ...
... ]. The nano-C3G encapsulation within chitosan according to the animal experiment showed that nano-C3G could efficiently lower the levels of ...
Progressive Ataxia, Memory Impairments, and Seizure Episodes in Spna2 R1098Q Mouse Variant Affecting Alpha II Spectrin’s Scaffold Stability
... 1 Department of Tumor Immunology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 ...
... stability. 2. Materials and Methods 2.1. Mice Animal experimentation whose severity qualified it as a procedure according to European Union ...
The effect of temporal expectation on the correlations of frontal neural activity with alpha oscillation and sensory-motor latency
Abstract
In a dynamic environment, we seek to enhance behavioral responses by anticipating future events. Previous studies have shown that ...
National Institutes of Health Guide for the Care and Use of Laboratory Animals . All animals were not sacrificed after the experiment and ...
Phenolic Phytochemicals for Prevention and Treatment of Colorectal Cancer: A Critical Evaluation of In Vivo Studies
... 1 Division of Molecular Medicine, Bose Institute, Kolkata 700 054, India
2 Department of Biotechnology, National Institute of Technology, ...
... phenolic phytochemicals with anti-CRC activities demonstrated in animal experiments with the underlying molecular basis of their actions ( ...
Transcriptional Analysis of the Endostyle Reveals Pharyngeal Organ Functions in Ascidian
... 1 Fang Zongxi Center, MoE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, ...
... ascidians were sacrificed for the endostyle collection. The guidelines for animal experiments were approved by the Ocean University of China ...
The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model - Genome Biology
Abstract Background The CRISPR-Cas13 system is an RNA-guided RNA-targeting system and has been widely used in transcriptome engineering ...
... to the Guide for the Care and Use of Laboratory Animals of the Chinese Association for Laboratory Animal Science. All procedures of animal ...
Antioxidant Potential-Rich Betel Leaves (Piper betle L.) Exert Depigmenting Action by Triggering Autophagy and Downregulating MITF/Tyrosinase In Vitro and In Vivo
... 1 Department of Food Science and Biotechnology, Graduate School, Kyungpook National University, Daegu 41566, Republic of Korea
2 Food and ...
... ). Institutional Review Board Statement All animal experiments were conducted following the guidelines for animal experiments issued by the ...
Over supplementation with vitamin B12 alters microbe-host interactions in the gut leading to accelerated Citrobacter rodentium colonization and pathogenesis in mice - Microbiome
Background Vitamin B12 supplements typically contain doses that far exceed the recommended daily amount, and high exposures are generally ...
Research Council (US). Subcommittee on laboratory animal nutrition. Nutrient requirements of laboratory animals. 4th ed. Washington (DC): ...
Concept for Interactive Learning Platform “3Rs Info Hub PRO” Receives International Award for Humane Education
.flipboard { width:20px; height:20px; background: url("/images/flipboard_mbsw.png") no-repeat; background-size: 20px 20px; display: inline- ...
Burch in 1959: Animal experiments should be replaced with alternatives whenever possible, the number of animal experiments should be reduced ...
Neoadjuvant PD-1 blockade combined with chemotherapy is not superior to neoadjuvant chemotherapy alone in resectable locally advanced esophageal carcinoma
Abstract
Background
Neoadjuvant chemotherapy (nCT) or neoadjuvant chemoradiotherapy followed by surgery has been recommended as standard ...
... with esophageal cancer was also the direction of future research. The animal experiment showed that the expression of PD-L1 increased from ...
The Gene Expression of Proteins Involved in Intercellular Signaling and Neurodegeneration in the Substantia Nigra in a Mouse Subchronic Model of Parkinson’s Disease
Koltzov Institute of Developmental Biology, Russian Academy of Sciences, 26 Vavilova Street, 119334 Moscow, Russia
* Author to whom ...
... with the National Institutes of Health Guide for the Care and Use of Laboratory Animals (8th edition, 2011) and were approved by the Animal ...
Lysiphyllum strychnifolium (Craib) A. Schmitz Extracts Moderate the Expression of Drug-Metabolizing Enzymes: In Vivo Study to Clinical Propose
... 1 Faculty of Veterinary Medicine, Rajamangala University of Technology Tawan-ok, Chonburi 20110, Thailand
2 Department of Biochemistry, ...
... cells). The experiment was performed in triplicate. 4.5. Animal Experiment Male and female Wistar rats weighing 160–170 g were obtained from ...
Intranasal Administration of Dolutegravir-Loaded Nanoemulsion-Based In Situ Gel for Enhanced Bioavailability and Direct Brain Targeting
... 1 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia
2 Department of ...
Axioscope 5, Jena, Germany). 4.12. Animal Experiments The Institutional Animal Ethical Review Board examined and authorized the methodology ...
Identification of Key Biomarkers Associated with Immunogenic Cell Death and Their Regulatory Mechanisms in Severe Acute Pancreatitis Based on WGCNA and Machine Learning
... 1 Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116000, China
2 Institute (College) of ...
... (6–8 weeks old, approximately 220 g) were purchased from the Laboratory Animal Centre of Dalian Medical University (License No, SCXK (Liao) ...
Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity
Abstract
Despite rapid and ongoing vaccine and therapeutic development, SARS-CoV-2 continues to evolve and evade, presenting a need for ...
... to the principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 1996 edition. The sharks used in this ...
Next-Generation Sequencing (NGS) Market: Global Industry Outlook, Size (US$ 40.25 Billion), Share, Growth (CAGR of 19.5%), Top Companies Analysis and Research Report 2023-2028
Next-Generation Sequencing (NGS) Market: Global Industry Outlook, Size (US$ 40.25 Billion), Share, Growth (CAGR of 19.5%), Top Companies ...
... and Personalized Medicine • Genetic Screening • Diagnostics • Agriculture and Animal Research • Others Breakup by End-User: • Academic ...
Engineered tissue vascularization and engraftment depends on host model
Abstract
Developing vascular networks that integrate with the host circulation and support cells engrafted within engineered tissues ...
Committee (IACUC protocol #4388-02). Additionally, animal experiments were conducted and reported here in accordance with ARRIVE guidelines.
Gelatin/calcium chloride electrospun nanofibers for rapid hemostasis
Blood coagulation is the body's main defense to bleeding caused by trauma and is divided into endogenous and exogenous pathways. Calcium ...
... were also conducted on the tail vein and liver of mice. Animal experiments demonstrated that the incorporation of calcium ions into the ...
Iron from Co-Encapsulation of Defatted Nannochloropsis Oceanica with Inulin Is Highly Bioavailable and Does Not Impact Wheat Flour Shelf Life or Sensorial Attributes
... 1 Department of Food Science, Cornell University, Ithaca, NY 14853, USA
2 Tata-Cornell Institute for Agriculture and Nutrition, Cornell ...
... diets is provided in Table S1 (supplementary) . The animal experiment was approved by the Institutional Animal Care and Use Committee at ...
Lactobacillus gasseri NK109 and Its Supplement Alleviate Cognitive Impairment in Mice by Modulating NF-κB Activation, BDNF Expression, and Gut Microbiota Composition
... 1 Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea
2 Neurobiota Research Center, College of Pharmacy ...
... used in the experiments. All animal experiments were ethically approved by the Committee for the Care and Use of Laboratory Animals in the ...
Global Transfer Glove Box Industry Opportunities, Analysis & Forecasts, 2020-2029
Global Transfer Glove Box Industry Opportunities, Analysis & Forecasts, 2020-2029
02-03-2023 12:52 PM CET | Health & Medicine
Press ...
... -standing. The market by application is segmented into laboratory, animal research.
Regions Covered in the Global Transfer Glove Box Market ...
Ant-Neointimal Formation Effects of SLC6A6 in Preventing Vascular Smooth Muscle Cell Proliferation and Migration via Wnt/β-Catenin Signaling
Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College ...
... β-catenin pathway. 2. Materials and Methods 2.1. Animal Experiments Rat carotid balloon injury model was performed as described previously [ ...
Coronary Artery Disease and Inflammatory Activation Interfere with Peripheral Tissue Electrical Impedance Spectroscopy Characteristics—Initial Report
... 1 Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, 61-848 Poznan, Poland
2 Department of Computer ...
Similarly, differences between healthy and injured tissues were reported in animal experiments. Studies conducted on animals’ lungs by Dean ...
The Effect of Parity on the Quality of Colostrum of Holstein Dairy Cows in the Organic Production System
... 1 Institute of Animal Science, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland
2 Institute of Genetics and ...
The animal study protocol was approved by the Second Ethics Committee for Animal Experimentation in Warsaw (protocol number WAWA2/086/2018).
Projections from the Rostral Zona Incerta to the Thalamic Paraventricular Nucleus Mediate Nociceptive Neurotransmission in Mice
... 1 Department of Human Anatomy, College of Preclinical Medical Sciences, Zhengzhou University, Zhengzhou 450001, China
2 Department of ...
... 12-week-old) wild-type (WT) C57BL/6J (purchased from the Laboratory Animal Center of the Fourth Military Medical University), GAD2-Cre (JAX# ...
HERV-W ENV Induces Innate Immune Activation and Neuronal Apoptosis via linc01930/cGAS Axis in Recent-Onset Schizophrenia
... 1 State Key Laboratory of Virology, Department of Medical Microbiology, School of Basic Medical Sciences, Wuhan University, No. 185 Donghu ...
... support from the Animal Ethics Committee of Wuhan University Center for Animal Experiment/A3 Laboratory, Wuhan University. Cell transfection ...
Novel Zebrafish Patient-Derived Tumor Xenograft Methodology for Evaluating Efficacy of Immune-Stimulating BCG Therapy in Urinary Bladder Cancer
... 1 Department of Health, Medicine and Care, Division of Diagnostics and Specialist Medicine, Linköping University, SE-58185 Linköping, ...
... the ability to feed freely, and therefore did not require animal research ethical permission. All patient samples were collected with ...
Differential gene expression analysis using RNA-seq in the blood of goats exposed to transportation stress
Abstract
Transportation stress causes significant changes in physiological responses in goats; however, studies exploring the ...
. The animal care protocols were approved by the FVSU Agricultural and Laboratory Animal Care and Use Committee prior to beginning of the ...
Effects of Ventromedial Hypothalamic Nucleus (VMN) Aromatase Gene Knockdown on VMN Glycogen Metabolism and Glucoregulatory Neurotransmission
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA
* ...
... were in compliance with the NIH Guide for the Care and Use of Laboratory Animals, 8th Edition. 2.2. Experimental Design Individual animals, ...
The Development and Optimization of Lipid-Based Self-Nanoemulsifying Drug Delivery Systems for the Intravenous Delivery of Propofol
... 1 Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, ...
... with the recommendations of the “Guide for the Care and Use of Laboratory Animals” of the center that approved the study. This study was ...
Proteomic Identification of Plasma Components in Tachypleus tridentatus and Their Effects on the Longitudinal Bone Growth Rate in Rats
... 1 Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China
2 Guangxi Key Laboratory of Marine Drugs, ...
Wistar rats (weighting 90 ± 10 g) aged 28 days were purchased from SJA Laboratory Animal Co., Ltd (Changsha, China). These 140 Wistar rats ...
Advances in Animal Models for Studying Bone Fracture Healing
... 1 Rehabilitation Medicine Center and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, China ...
... , tissue insertion, impaired blood circulation, and infection. Animal experiments and clinical studies have shown that too large a gap at ...
The Protective Role of Scorias spongiosa Polysaccharide-Based Microcapsules on Intestinal Barrier Integrity in DSS-Induced Colitis in Mice
... 1 Sichuan Institute of Edible Fungi, Chengdu 610066, China
2 National-Local Joint Engineering Laboratory of Breeding and Cultivation of ...
... weeks, weighing 21~25 g) acquired from Chengdu Dashuo Laboratory Animal, were randomly allocated into five treatment groups with eight pens ...
Effect of Lifestyle Interventions during Pregnancy on Maternal Leptin, Resistin and Offspring Weight at Birth and One Year of Life
... 1 Cologne Center for Prevention in Childhood, Youth/Heart Center Cologne, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, ...
... to receptor function are possible; however, this would have to be tested in animal experiments. The assessment of fat area/fat mass and fat- ...
Enhanced bacterial clearance in early secondary sepsis in a porcine intensive care model
Abstract
Early secondary sepsis (ESS), occurring after recent inflammatory activation is associated with a reduced inflammatory response. ...
... handled in accordance with the Guide for the Care and Use of Laboratory Animals and reported in compliance with the ARRIVE guidelines 21 .
Evaluating the effects of giraffe skin disease and wire snare wounds on the gaits of free-ranging Nubian giraffe
Abstract
Giraffe skin disease (GSD), a condition that results in superficial lesions in certain giraffe ( Giraffa spp.) populations, has ...
... assumption—a technique commonly employed to detect lameness in domestic and laboratory animals 60 , 61 , 62 .
The decreased mobility and ...
Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response
Abstract
Several limitations of [ 18 F]FDG have been reported, such as nonspecific uptake of inflammation foci. Moreover, [ 11 C]MET has ...
... and Innovation (IBRI) hospital, Kobe, Japan.
All animal experimental protocols were approved by the RIKEN Animal Welfare Committee and were ...
Vertical Vibration of Mouse Osteoblasts Promotes Cellular Differentiation and Cell Cycle Progression and Induces Aging In Vitro
... 1 Department of Orthodontics, Tokyo Dental College, 2-9-18, KandaMisaki-Cho, Chiyoda-Ku, Tokyo 101-0061, Japan
2 Department of ...
FBS, 1% penicillin G, and 1% streptomycin. All animal experiments were performed in strict accordance with the guidelines of the animal care ...
Injection of Ultra-Purified Stem Cells with Sodium Alginate Reduces Discogenic Pain in a Rat Model
... 1 Department of Orthopedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N15W7, Sapporo 060-8638, ...
... and National Institutes of Health guide for the care and use of Laboratory animals. Figure 1 provides an overview of this study. Outbred ...
Ameliorating Effects of Vitamin K2 on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice
... 1 Department of Nutrition and Food Hygiene, School of Public Health, Qingdao University, Qingdao 266021, China
2 Institute of Nutrition ...
... 48 male C57BL/6J mice (7 weeks of age) from the Beijing Vital River Laboratory Animal Technology Co., Ltd. (Beijing, China; SCXK Jing 2021- ...
Comparative Analysis between Salmonella enterica Isolated from Imported and Chinese Native Chicken Breeds
... 1 Shandong Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Veterinary Medicine, ...
... of Salmonella All animal work was reviewed and approved by the Laboratory Animal Care Committee of Shandong Agricultural University (permit ...
Dietary Supplementation of Methyl Cedryl Ether Ameliorates Adiposity in High-Fat Diet-Fed Mice
... 1 Key Laboratory of Precision Nutrition and Food Quality, Key Laboratory of Functional Dairy, Ministry of Education, College of Food ...
... investigation. The China Agricultural University Laboratory Animal Welfare and Animal Experimental Ethical Committee authorized all ...
Detection of the Endangered Siamese Bat Catfish (Oreoglanis siamensis Smith, 1933) in Doi Inthanon National Park Using Environmental DNA
... 1 Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
2 School of Agriculture and Natural ...
... was approved by the Ethics Committee of Animal Care and Use (Laboratory Animal Center of Chiang Mai University) review (protocol code 2561/ ...
Radiolabelling of Polyclonally Expanded Human Regulatory T Cells (Treg) with 89Zr-oxine for Medium-Term In Vivo Cell Tracking
... 1 MRC Centre for Transplantation, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Science, King’s College ...
... not administered to animals and assessed their growth in vitro alongside the animal experiment. This included various control Tregs: (i) ...
Host Response of Syrian Hamster to SARS-CoV-2 Infection including Differences with Humans and between Sexes
... 1 Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, 35020 Legnaro, Italy
2 Laboratory for ...
... with the human host response. 2. Materials and Methods 2.1. Animal Experiment The study involved 60 8-week-old Syrian hamsters that were ...
Critical Role of the Sulfiredoxin-Peroxiredoxin IV Axis in Urethane-Induced Non-Small Cell Lung Cancer
... 1 Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40506, USA
2 Department of Biochemistry and Molecular ...
... the Policy on Humane Care and Use of Laboratory Animals, and the Guidelines of the Animal Care and Laboratory Animal Welfare (NIH). Mice, ...
The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer
... 1 Faculty of Medicine, University of Belgrade, dr Subotića 8, 11000 Belgrade, Serbia
2 Clinic of Urology, University Clinical Center of ...
According to several in vitro discoveries, corroborated by both in vivo animal research and early-phase human clinical trials, genistein can ...
Lacto-Fermented and Unfermented Soybean Differently Modulate Serum Lipids, Blood Pressure and Gut Microbiota during Hypertension
... 1 Department of Biological Models, Institute of Biochemistry, Life Science Center, Vilnius University, LT-10257 Vilnius, Lithuania
2 ...
... inhibitor. 2.4. Animal Handling and Preparation All the animal experiments were carried out in accordance with the ethical procedures and ...
Metagenomic Insights into the Anti-Obesity Effect of a Polysaccharide from Saccharina japonica
Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, College of Pharmaceutical Science & ...
... stored at −80 °C. All animal experiments comply with the regulations of the Ethics Committee for Animal Research of Zhejiang University of ...
Biotransformation of Penindolone, an Influenza A Virus Inhibitor
... 1 Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao ...
... rats (weight: 220 ± 20 g; age: 6–8 weeks) from Beijing Vital River Laboratory Animal Technology Co., Ltd. (NO. SCXK-2019-0009) were used.
STS1 and STS2 Phosphatase Inhibitor Baicalein Enhances the Expansion of Hematopoietic and Progenitor Stem Cells and Alleviates 5-Fluorouracil-Induced Myelosuppression
... 1 National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China
2 NMPA ...
... was stored at −20 °C. Baicalein (B20571) used in cell and animal experiments was purchased from Yuanye Bio-Technology (Shanghai, China), ...
Lens Epithelial Explants Treated with Vitreous Humor Undergo Alterations in Chromatin Landscape with Concurrent Activation of Genes Associated with Fiber Cell Differentiation and Innate Immune Response
... 1 Cell, Molecular and Structural Biology Program, Miami University, Oxford, OH 45056, USA
2 Department of Biology and Center for Visual ...
... with those published by the Institute for Laboratory Animal Research (Guide for the Care and Use of Laboratory Animals). FVB/N mice were ...
Immunotherapy with Cleavage-Specific 12A12mAb Reduces the Tau Cleavage in Visual Cortex and Improves Visuo-Spatial Recognition Memory in Tg2576 AD Mouse Model
... 1 European Brain Research Institute (EBRI), Viale Regina Elena 295, 00161 Rome, Italy
2 Institute of Translational Pharmacology (IFT), ...
. Materials and Methods 2.1. Animals and Ethical Approval All animal experiments complied with the ARRIVE guidelines and were carried out in ...
Hofmann vs. Paracelsus: Do Psychedelics Defy the Basics of Toxicology?—A Systematic Review of the Main Ergolamines, Simple Tryptamines, and Phenylethylamines
... 1 Unit of Toxicology, Clinical Science Department, Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe s/n, CP 35016 ...
... of mescaline and seven analogs to toxicity and behavior in five species of laboratory animals. Toxicol. Appl. Pharmacol. 1973 , 25 , 299–309 ...
Probing researchers strike gold to stop the trots in pigs
Gold nanorod probes combined with an optical microscope can now be used to detect signs of a highly contagious and lethal virus that poses ...
... /bios12121146
Method of Research
Data/statistical analysis
Subject of Research
Animal tissue samples
Article Publication Date
8-Dec- ...
Search for alternatives to animal testing in research continues to be promoted
A research association led by the MHH is developing chip-based replacement and supplementary methods to avoid animal experiments. To this ...
... the MHH is developing chip-based replacement and supplementary methods to avoid animal experiments. To this end, it is receiving 3.6 million ...
Erythropoietin in Glaucoma: From Mechanism to Therapy
Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
* Author to whom ...
... toxicity was first recognized in 1957 [ 30 ]. In animal experiments, mice with glaucoma had decreased expression of glutamate transporters [ ...
The Role of Cyclodextrins in COVID-19 Therapy—A Literature Review
... 1 Laboratory of Drug Development and Technologies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
2 LAQV-REQUIMTE ...
... -like receptors (TLRs) [ 60 ]. In cell culture and animal experiments, interferons have been shown to inhibit coronavirus replication. In ...
Sustained Release of Tacrolimus Embedded in a Mixed Thermosensitive Hydrogel for Improving Functional Recovery of Injured Peripheral Nerves in Extremities
... 1 Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
2 Department of Physical ...
... the Guide for the Care and Use of Laboratory Animals (Chang Gung Memorial Hospital Animal Research Guidelines). The mouse nerve transection ...
Crosstalk between Adipose Tissue and Hepatic Mitochondria in the Development of the Inflammation and Liver Injury during Ageing in High-Fat Diet Fed Rats
... 1 Department of Pharmaceutical Sciences, University of Perugia, 06126 Perugia, Italy
2 Centro Servizi Metrologici e Tecnologici Avanzati ( ...
... and national laws and policies (EU Directive2010/63/EU for animal experiments, ARRIVE guidelines, and the Basel declaration including the 3R ...
Hepatic Glucose Metabolism Disorder Induced by Adipose Tissue-Derived miR-548ag via DPP4 Upregulation
... 1 Medical College, Shihezi University, Shihezi 832000, China
2 Department of Medical Genetics, Medical College of Tarim University, Alaer ...
HUNAN SJA Laboratory Animal Co., Ltd. (Hunan, China). Lepr db/db and Lepr db/− male mice were procured from the Model Animal Research Center ...
Beyond Pellagra—Research Models and Strategies Addressing the Enduring Clinical Relevance of NAD Deficiency in Aging and Disease
... 1 Department of Animal, Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT 84322 ...
... associated with NAD deficiency. Unlike humans, commonly used laboratory animals are well protected from becoming NAD deficient, and these ...
Playtime is purr-fect for your cat’s welfare
Play is often considered an indicator and promotor of animal welfare. Playing with your cat may also nurture closer cat-human bonds. In a ...
.1017/awf.2023.2
Method of Research
Survey
Subject of Research
Animals
Article Title
Cats just want to have fun: Associations between ...
Fructose Stimulated Colonic Arginine and Proline Metabolism Dysbiosis, Altered Microbiota and Aggravated Intestinal Barrier Dysfunction in DSS-Induced Colitis Rats
... 1 Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China
2 Academy of National Food ...
... for the Care and Use of Laboratory Animals and were approved by the Ethical Committee for Animal Experimentation of the Academy of National ...
Solid-State Fermentation of Distiller’s Dried Grains with Solubles Improves Digestibility for European Seabass (Dicentrarchus labrax) Juveniles
... 1 Department of Biology, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal
2 CIMAR/CIIMAR Interdisciplinary Centre of ...
... conditions following the ARRIVE (Animal Research: Reporting of In Vivo Experiments) Guidelines for Reporting Animal Research. BOGA is an ...
The effects of Ginger (Zingiber officinale) roots on the reproductive aspects in male Japanese Quails (Coturnix coturnix japonica)
BMC Veterinary Research
volume 19, Article number: 34 (2023) Cite this article ...
... officinale) on improvement of biological and fertility indices of sperm in laboratory animals, poultry and humans. Vet Med Sci. 2021;7(5): ...
Ensiling Cyanide Residue and In Vitro Rumen Fermentation of Cassava Root Silage Treated with Cyanide-Utilizing Bacteria and Cellulase
... 1 Faculty of Natural Resources, Rajamangala University of Technology Isan, Sakon Nakhon 47160, Thailand
2 Tropical Feed Resources Research ...
... by Khon Kaen University. Institutional Review Board Statement The animal experimental protocols performed in this work were approved by the ...
Changes in biomarkers of redox status in serum and saliva of dogs with hypothyroidism
BMC Veterinary Research
volume 19, Article number: 33 (2023) Cite this article ...
... in regulations, as well as with ARRIVE guidelines for animal experimentation.
Consent for publication
Not applicable.
Competing interests ...
Rates of hatching failure in birds almost twice as high as previously estimated
Rates of hatching failure in birds almost twice as high as previously estimated ...
... /brv.12931
Method of Research
Literature review
Subject of Research
Animals
Article Title
Systematic review of avian hatching failure ...
Immunohistochemical Distribution and Neurochemical Characterization of Huntingtin-Associated Protein 1 Immunoreactive Neurons in the Adult Mouse Lingual Ganglia
... 1 Division of Neuroanatomy, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube 755- ...
University School of Medicine and the Ethics of Animal Experimentation guidelines and Government of Japan Animal Research law (No. 105, ...
Changes in Faecal and Plasma Amino Acid Profile in Dogs with Food-Responsive Enteropathy as Indicators of Gut Homeostasis Disruption: A Pilot Study
... 1 Departamento de Producción Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n., 28040 Madrid ...
Sample Collection All procedures and protocols were approved by the Animal Research Committee of the Veterinary Medicine Teaching Hospital, ...
Pamela Anderson defends unlikely friendship with Julian Assange and defends him as a 'truth seeker' and 'brave person': 'We had a close connection and he even said that I was the only person he's ever trusted'
Species-specific immunogenicity and protective efficacy of a vesicular stomatitis virus-based Sudan virus vaccine: a challenge study in macaques
Summary ...
Laboratories is an Association for Assessment and Accreditation of Laboratory Animal Care-accredited institution. All procedures followed ...
Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin - Journal of Translational Medicine
AbstractBackgroundEnterococcus faecalis (Efa) has been shown to be a “driver bacteria” in the occurrence and development of colorectal ...
... weeks, BALB/C) were obtained from Hangzhou Ziyuan Laboratory Animal Technology Company. All animal experiments received the approval of the ...
Better cancer treatment inspired by the foam on your latte
Inspired by the foam on top of lattes, as well as gummy bears and Pop Rocks candies, researchers at the University of Iowa are creating new ...
DOI
10.1002/advs.202205995
Method of Research
Experimental study
Subject of Research
Animals
Article Title
Low-Cost, High-Pressure- ...
Statistics framework to remove bias from debate about how well mouse models mimic human disease
Mice and other animals have been key to some of the biggest medical breakthroughs in human history. But animals aren't always good models ...
... 've developed a framework to determine how much congruence and discordance laboratory animals have with specific human diseases. The tool ...
Statistics remove bias from debate about how well mouse models mimic human disease
PITTSBURGH, 2/2/2022 — Mice and other animals have been key to some of the biggest medical breakthroughs in human history. But animals aren ...
... ’ve developed a framework to determine how much congruence and discordance laboratory animals have with specific human diseases. The tool ...
VPS35 promotes cell proliferation via EGFR recycling and enhances EGFR inhibitors response in gastric cancer
Summary ...
... xenograft models. Animal experiments were performed in accordance with the institution's guidelines and animal research principles, and ...
Sparse, small, but diverse neural connections help make perception reliable, efficient
The brain’s cerebral cortex produces perception based on the sensory information it’s fed through a region called the thalamus.
... 01253-9
Method of Research
Experimental study
Subject of Research
Animals
Article Title
Mapping thalamic innervation to individual L2/ ...
The human microbial exposome: expanding the Exposome-Explorer database with gut microbial metabolites
Abstract
Metabolites produced by the gut microbiota play an important role in the cross-talk with the human host. Many microbial ...
... metabolites are the forms detected in urine and plasma in human and animal experiments, but they are absent from the bacteria GSMM models.
The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling - Journal of Translational Medicine
AbstractBackgroundPatients suffering from chronic pain often also exhibit depression symptoms. Soluble epoxide hydrolase (sEH) inhibitors ...
... recommendations in the Guide for the Care and Use of Laboratory Animals and under protocols approved by the Experimental Animal Committee of ...
Animal Transportation Market Emerging Player Outperforming: Cargo, Amerijet International, Herfurth Logistics
Animal Transportation Market Emerging Player Outperforming: Cargo, Amerijet International, Herfurth Logistics
02-02-2023 06:34 PM CET | ...
... date segmented by Livestock, Pets, Zoo Animals, Aquarium Animals, Research Animals & Others, , Transportation by Land, Transportation by Sea ...
Reducing their natural signals: How sneaky germs hide from ants
Pathogens are disease-causing organisms. By natural selection, they develop evading mechanisms to outsmart the host’s immune system and to ...
... -01981-6
Method of Research
Experimental study
Subject of Research
Animals
Article Title
Pathogen evasion of social immunity
Article ...
Small molecule inhibitors show early-stage promise against YAP fusion-driven cancers
An unexpected discovery made by experts at the Brain Tumor Center at Cincinnati Children’s while studying a rare-but-deadly type of brain ...
... -022-01069-6
Method of Research
Experimental study
Subject of Research
Animal tissue samples
Article Title
Nuclear condensates of YAP ...
Regeneration: How the liver keeps itself in shape
Are you hungry? When was the last time you consciously chose not to eat? Does fasting change the way your major organs work? Researchers ...
... fluctuations in food supply. Comparing the human body to laboratory animals that are continuously fed is likely oversimplifying biology that ...
Effects of time-restricted feeding on letrozole-induced mouse model of polycystic ovary syndrome
Abstract
The present study aimed to investigate whether time-restricted feeding (TRF) ameliorates metabolic and reproductive phenotypes in ...
Animal Care and Use Committee of the Korea University College of Medicine Laboratory Animal Research Center (KOREA-2020–0003). All methods ...
Duke-NUS and NHCS scientists first in the world to regenerate diseased kidney
SINGAPORE, 1 February 2023 – In a world first, scientists at Duke-NUS Medical School, the National Heart Centre Singapore (NHCS) and ...
... -1
Method of Research
Experimental study
Subject of Research
Animals
Article Title
Targeting endogenous kidney regeneration using anti ...
Ecological Indicative Stressors of Native vs Non-Native Fish in an Ultra-Oligotrophic Region of the Mediterranean Sea
... 1 Department of Basic Sciences, Fisheries Faculty, Akdeniz University, Main Campus, 07058 Antalya, Turkey
2 Independent Researcher, 50060 ...
... the “Akdeniz Üniversitesi Hayvan Deneyleri Yerel Etik Kurulu” Animal Experiments Local Ethics Committee of Akdeniz University (protocol no: ...
Genetic Structure and Phylogeography of Commercial Mytilus unguiculatus in China Based on Mitochondrial COI and Cytb Sequences
National Engineering Research Center for Marine Aquaculture, Zhejiang Ocean University, Zhoushan 316022, China
* Author to whom ...
Review Board Statement All animal experiments were conducted under the guidance of and approved by the Animal Research and Ethics Committee ...
Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons
Abstract
Neurotransmitter-filled synaptic vesicles (SVs) mediate synaptic transmission and are a hallmark specialization in neuronal axons ...
... in accordance with the NIH Guide for the Care and Use of Laboratory Animals handbook. Protocols were reviewed and approved by the Animal ...
Chromium Nanoparticles Together with a Switch Away from High-Fat/Low-Fiber Dietary Habits Enhances the Pro-Healthy Regulation of Liver Lipid Metabolism and Inflammation in Obese Rats
... 1 Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10 Tuwima Street, 10-718 Olsztyn, Poland
2 Department of ...
Directive 2010/63/EU for animal experiments, and they were approved by the National Ethics Committee for Animal Experiments (Approval No. 73 ...
G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma
Abstract
Engineered T cells transiently expressing tumor-targeting receptors are an attractive form of engineered T cell therapy as they ...
Agri-Food & Veterinary Authority (AVA) and the National Advisory Committee for Laboratory Animal Research (NACLAR). NOD-SCID-IL2RGnull (NSG) ...
Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice
Abstract ...
... carried out in accordance with the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health (NIH ...
Arginase 1 is a key driver of immune suppression in pancreatic cancer
Abstract
An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic cancer. In this disease, it is well ...
... or the decision to submit the work for publication.
Ethics
Animal experimentation: All the animal studies and procedures were conducted in ...
High-Dose Primaquine Induces Proximal Tubular Degeneration and Ventricular Cardiomyopathy Linked to Host Cells Mitochondrial Dysregulation
... 1 Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Ratchawithi Road, Ratchathewi, Bangkok ...
... (Approval No. FTM-ACUC 006/2021). All animal experiments were conducted in accordance with Thailand’s Animal for Scientific Purposes Act, B.
Towards Developing Novel Prostate Cancer Recurrence Suppressors: Acute Toxicity of Pseurotin A, an Orally Active PCSK9 Axis-Targeting Small-Molecule in Swiss Albino Mice
... 1 School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, ...
... types of cancer with a plethora of clinical analyses and animal experiments that support the relationship between serum cholesterol levels ...
The Autotaxin-LPA Axis Emerges as a Novel Regulator of Smooth Muscle Cell Phenotypic Modulation during Intimal Hyperplasia
Department of Cellular Biology and Anatomy, Louisiana State University Health Sciences-Shreveport, Shreveport, LA 71130, USA
* Authors to ...
... were developed in accordance with the NIH Guide for Care and Use of Laboratory Animals. A carotid artery wire injury model, or sham, was ...
Comment: What does the FDA animal testing legislation mean for drug discovery?
As of late December 2022, the US Food and Drug Administration (FDA) no longer needs drugs to be tested in animals to receive approval, ...
... legislative and regulatory requirements for animal research could be strengthened to help prevent animal experiments and accelerate change.
Bone Growth Stimulator Market is Likely to Upsurge USD 1.88 Billion by 2029
Bone Growth Stimulator Market is Likely to Upsurge USD 1.88 Billion by 2029
02-02-2023 02:36 PM CET | Advertising, Media Consulting, ...
... fusion, and spinal fusion. There is substantial basic science, animal research, and clinical evidence to support the use of bone growth ...
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