Principles of PBPK modeling and the application of this technique for in vitro to in vivo extrapolation (IVIVE)
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Owner/Developer: SCITOVATION
| Country: |
United States of America |
|---|---|
| Languages: |
English |
| Url: |
http://www.scitovation.com |
| Created: |
01 September 2017 |
| Locations: |
United States of America |
| City: |
North Carolina |
| Description: | This course was designed to teach how to apply an effective computational tool — physiologically based pharmacokinetic (PBPK) modeling — to translate the results of in vitro toxicity assays into estimates of safe human exposure |
| Format: |
Computer assisted learning, Hands-on training, Lecture |
| Presence: |
Optional / Voluntary |
| Access: |
Fee-based |
| Content type: |
Theoretical, Practical |
| Duration: |
1 week |
| Frequency: |
Recurrent event |
| Prerequisites: |
WHO SHOULD ATTEND? Industrial, pharmaceutical and regulatory scientists desiring to interpret the results of in vitro toxicity assays in terms of their implications for human health Toxicologists and research scientists who develop or conduct in vitro toxicity assays Individuals desiring to learn how to develop and apply PBPK models Individuals interested in promoting the use of alternatives to live animal testing for regulatory requirements such as REACH |
| Target audience: |
Professionals (e.g. veterinarians), Scientific officers / Project managers, Managers, Teachers and educators, Regulators and policy-makers, Researchers, Students |
| Target sectors: |
SMEs, Consulting, Contract Research Organizations (CROs), Governmental bodies, Industry, Academia |
| Educational level: |
Postdoctoral (teaching and research), University (Doctoral education), Continuing Professional Development |
| 3rs relevance: |
Replacement |
| Topics covered: |
In vitro methods, Computational methods |
| 3rs coverage: |
Full coverage (a dedicated course) |
| Details on the topic or technology covered: |
This one-week course covered the principles of PBPK modeling and the application of this technique for in vitro to in vivo extrapolation (IVIVE) to support risk assessments based on non-animal methods. The course featured comprehensive lectures and extensive hands-on computer modeling practice. |
| Legislative framework: |
REACH Regulation (EC) No 1907/2006 or equivalent |
| Learning outcome: |
This course will prepare you to use state-of-the-art modeling & simulation techniques to assist in estimating acceptable human exposure guidelines from the results of in vitro toxicity assays. |
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