Consensus Report on the Future of Animal-Free Systemic Toxicity Testing
Owner/Developer: Alternatives to Animal Experimentation (ALTEX)
Since March 2013, animal use for cosmetics testing for the European market has been banned. This requires a renewed view on risk assessment in this field. However, in other fields as well, traditional animal experimentation does not always satisfy requirements in safety testing, as the need for human-relevant information is ever increasing. A general strategy for animal-free test approaches was outlined by the US National Research Council’s vision document for Toxicity Testing in the 21st Century in 2007. It is now possible to provide a more defined roadmap on how to implement this vision for the four principal areas of systemic toxicity evaluation: repeat dose organ toxicity, carcinogenicity, reproductive toxicity and allergy induction (skin sensitization), as well as for the evaluation of toxicant metabolism (toxicokinetics). [...] Finally, quantitative information on all factors and key events will be fed into systems biology models that allow a probabilistic risk assessment with flexible adaptation to exposure scenarios and individual risk factors.
|Channel:||Website - Printed|
|Audience:||Scientists - Policy-makers - Regulators - Industry - Researchers - Students|
|User access:||Open access|
|Purpose:||Toxicological and safety evaluation - Documentation and information - Validation|
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