Principles of Toxicology Testing, Second Edition

This book begins with an introduction into the fundamentals of toxicology, to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. The introductory material is useful in understanding the applications of toxicology testing. The basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs, prepare readers for these subsequent topics. The book then continues with in vivo and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD₅₀. The book examines other short-and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. Mutagenicity and carcinogenicity studies are also discussed in a separate chapter. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasises cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity and local toxicity. The contributors present the advantages and disadvantages of alternative methods. For more information on this book, please click here.

Second Edition. 362 pages. Available as a Paperback and as an eBook (available through VitalSource). For Librarians: Available on CRCnetBASE.

ISBN: Paperback: 978-1-8421-4528-9; Hardback; 9781138457065; eBook: 978-1-8421-4529-6

Price: Hardback; £128.00; eBook: £96.00