Applying refinement to the use of mice and rats in rheumatoid arthritis research
| Record number: | ae30b (legacy id: 15370) |
|---|---|
| Category: | Disease research |
| Type: | Guidelines |
| Relevance: | Reduction - Refinement - Replacement |
A report from a Working Group, focusing on identifying causes of suffering within commonly used mouse and rat models of rheumatoid arthritis (RA), describing practical refinements to help reduce suffering and improve welfare without compromising the scientific objectives.
The report also discusses other relevant topics including identifying and minimising sources of variation within in vivo RA studies, the potential to provide pain relief, welfare assessment, humane endpoints, reporting standards and the potential to replace animals in RA research. The report contains a list of adverse effects with recommendations on how to reduce them, welfare assessment indicators (including grimace scales) and humane endpoints, a list of advantages and disadvantages of parenteral versus self-administration of analgesics, a score sheet for mice and key recommendations to help refine the use of mice and rats in RA research.
The 20-page report was published online in Inflammopharmacology, July 2015 (DOI 10.1007/s10787-015-0241-4) and may be downloaded here.
This work is part of a project initiated by the RSPCA which focuses on severe suffering in laboratory animals.
Did you find what you were looking for?
Yes, I found it!
No, I did not!
Thanks for your feedback! Please note that we cannot reply to you unless you send us an email.
What are you looking for?
We value your feedback so we can improve the information on the page. Please add your email address if you would like a reply. Thank you in advance for your help.!
Please contact us by email if you have any questions.