Guidelines for the welfare and use of animals in cancer research
|Record number:||0ca94 (legacy id: 15042)|
|Category:||Cancer research - Design - Disease research - Ethics & harm-benefit analysis - Humane killing - Procedures|
|Relevance:||Reduction - Refinement - Replacement|
Published in the British Journal of Cancer in 2010.
Focusing on animal welfare, the paper presents recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g. genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site; and publication of best practice.
The paper can be accessed here.
AAALAC International cites these guidelines as one of its reference resources (with a caveat), with the caveat that AAALAC Council recommends the use of performance-based clinical signs signalling the need for immediate intervention listed in Box 5 on page 1571, in lieu of a more prescriptive engineering standard. The report can be downloaded from AAALAC as a pdf file.
Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DA, Glennie MJ, Kelland LR, Robinson V, Stratford IJ, Tozer GM, Watson S, Wedge SR, Eccles SA; Committee of the National Cancer Research Institute. Guidelines for the welfare and use of animals in cancer research. Br J Cancer. 2010 May 25;102(11):1555-77. doi: 10.1038/sj.bjc.6605642. PMID: 20502460
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