Advanced Models of Parkinson’s Disease
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Owner/Developer: American Type Culture Collection (ATCC)
| Country: |
United States of America |
|---|---|
| Languages: |
English |
| Url: |
https://www.lgcstandards-atcc.org/About/News_and_Events/Events/Webinars/2018/Advanced_Models_of_Parkinsons_Disease.aspx |
| Created: |
22 February 2018 |
| Description: | Optimized cell lines are essential for modeling neurodegenerative diseases such as Parkinson’s disease, screening novel therapeutics for preclinical studies, and testing the neurotoxicity of environmental compounds. Neural progenitor cells (NPCs) derived from induced pluripotent stem cells (iPSCs) are excellent in vitro models as they can be induced to differentiate down all three neural lineages. ATCC has recently added a line of NPCs developed from a donor with Parkinson’s disease to its collection of neurological research tools. This webinar will describe how ATCC NPCs can be differentiated into three neural fates and used in toxicological studies, focusing on the performance of the Parkinson’s disease-derived NPCs. |
| Format: |
Webinars |
| Presence: |
Optional / Voluntary |
| Access: |
Free |
| Content type: |
Theoretical |
| Duration: |
47 min |
| Target audience: |
Students, Researchers, Regulators and policy-makers, Teachers and educators, Technicians, Managers, Scientific officers / Project managers, Professionals (e.g. veterinarians), General public |
| Target sectors: |
Academia, Industry, Governmental bodies, Contract Research Organizations (CROs), Consulting, SMEs |
| Educational level: |
University (Bachelor), University (Master), University (Doctoral education), Postdoctoral (teaching and research), Continuing Professional Development |
| 3rs relevance: |
Replacement |
| Topics covered: |
In vitro methods |
| 3rs coverage: |
Full coverage (a dedicated course) |
| Details on the topic or technology covered: |
Key Points: ATCC has a wide range of whole-cell models of Parkinson’s disease NPCs cultured in ATCC Dopaminergic Neuron Differentiation Media express tyrosine hydroxylase and TuJ1 Parkinson’s disease patient-derived NPCs can be induced to differentiate into all three major neural lineages Parkinson’s disease patient-derived NPCs can be used to screen compounds for toxicity |
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