Alternative methods for assessing the safety of cosmetic ingredients and finished products (2) (Alternative methods for assessing the safety of cosmetic ingredients and finished products)
This record is part of
a dataset collected by the EU Commission in June-September 2018
. Some of these links will therefore die out with time.
Please see the
overview of courses maintained by ETPLAS
or contact Norecopa for more information.
Owner/Developer: Béatrice Le Varlet / Université Clermont Auvergne, Professional licence Bachelor's diploma, Mention: Bioindustries and biotechnologies (In Vitro Consultancy / BIOACT)
| Country: |
France |
|---|---|
| Languages: |
French |
| Created: |
01 February 2018 |
| Locations: |
France |
| City: |
Clermont Ferrand |
| Description: | Objectives: • Address the general procedure of risk assessment • Present the current status of validation of alternative methods in Europe (EC Regulation 1223/2009) and international recommendations (OECD Test Guidelines) • Present validated tests for cosmetic ingredients and valid tests for cosmetic products: technical aspects • Understand the advantages, disadvantages and limitations of each test method and the costs of achieving them |
| References: | Béatrice Le Varlet. Données sécurité des ingrédients : les tests in vitro. Lavoisier Tec & Doc (ed). Sécurité du Produit Cosmétique : De la Production à l’Utilisateur. In Press. Bart De Wever, Alan Goldberg, Chantra Eskes, Erwin Roggen, Philippe Vanparys, Klaus Schroder, Béatrice Le Varlet, Howard Maibach, Sonja Beken, Benoit De Wilde, Constantin Turchina, Ginette Bogaert, and Jean-Pierre Bogaert. ‘‘Open Source’’–Based Engineered Human Tissue Models: A New Gold Standard for Non animal Testing Through Openness, Transparency, and Collaboration, Promoted by the ALEXANDRA Association. Applied In Vitro Toxicol 1(1):5-9, 2016. Marc Vocanson, Amine Achachi, Virginie Mutez, Magalie Cluzel-Tailhardat, Béatrice Le Varlet, Aurore Rozières, Philippe Fournier, Jean-François Nicolas. Human T cell priming assay : depletion of peripheral blood lymphocytes in CD25(+) cells improves the in vitro detection of weak allergen-specific T cells. S.F. Martin (ed.), T Lymphocytes as Tools in Diagnostics and Immunotoxicology, Experientia Supplementum EXS 104: 89-100, 2014. N Alépée, S Bessou-Touya, J Cotovio, A de Smedt, B de Wever, C Faller, P Jones, B Le Varlet, M Marrec-Fairley, U Pfannenbecker, M Tailhardat, F van Goethem, P McNamee (2013). Cosmetics Europe multi-laboratory pre-validation of the SkinEthic™ reconstituted human corneal epithelium test method for the prediction of eye irritation. Toxicol In Vitro, 27, 2013. Pfannenbecker, U., Bessou-Touya, S., Faller, C., Harbell, J., Jacob, T., Raabe, H., Tailhardat, M., Alépée, N., De Smedt, A., De Wever, B., Jones, P., Kaluzhny, Y., Le Varlet, B., McNamee, P., Marrec-Fairley, M., Van Goethem, F., Cosmetics Europe Multi-Laboratory Pre-Validation of the EpiOcular™ . Reconstituted Human Tissue Test Method for the Prediction of Eye Irritation, Toxicology in Vitro. 27(2):619-26, 2013. B. Le Varlet, N. Alepee, S. Bessou-Touya, A. De Smedt, B. De Wever, J. Harbell, P. Jones, P. Mcnamee, M. Marrec-Fairley, U. Pfannenbecker, M. Tailhardat, F. Van Goethem. Update of the COLIPA eye irritation task force strategy and programme for development of in vitro methods. Toxicology Letters, 196, S143-S144, 2010. Meloni M, Pauly A, Servi BD, Le Varlet B, Baudouin C. Occludin gene expression as an early in vitro sign for mild eye irritation assessment. Toxicol In Vitro. 24(1):276-85, 2010. Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Le Varlet B, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, Goethem FV, Vassallo M, Vinardell P, Zuang V. A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches. Toxicol In Vitro. 24(1):1-9, 2010. McNamee P, Hibatallah J, Costabel-Farkas M, Goebel C, Araki D, Dufour E, Hewitt NJ, Jones P, Kirst A, Le Varlet B, Macfarlane M, Marrec-Fairley M, Rowland J, Schellauf F, Scheel J. A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: eye irritation. Regul Toxicol Pharmacol. 54(2):197-209, 2009. |
| Format: |
Computer assisted learning |
| Presence: |
Mandatory |
| Content type: |
Theoretical, Practical |
| Duration: |
3 hours |
| Group size: |
15.0 |
| Frequency: |
Recurrent event |
| Target audience: |
Students |
| Target sectors: |
Academia |
| Educational level: |
University (Bachelor) |
| 3rs relevance: |
Replacement |
| Topics covered: |
Designing procedures and projects, Computational methods, In vitro methods, Legislative aspects |
| 3rs coverage: |
Full coverage (a dedicated course) |
| Details on the topic or technology covered: |
Program : • Toxicology risk assessment: a step-by-step procedure • Predictive toxicology In Vitro: When, why and how to perform In Vitro tests in cosmetic industrial development? • Validation of alternative methods • Presentation of In Vitro tests, validation status and current developments, limits & benefits depending on the ingredient tested, test strategy, for the evaluation of: o Eye irritation: Organotypic tests Tests based on cytotoxicity and cellular function Methods using reconstructed tissues o Skin corrosion: Methods using reconstructed tissues Test using a barrier membrane Organotypic test o Skin irritation Methods using reconstructed tissues o Phototoxicity Cellular test Method using reconstructed tissues o Percutaneous absorption Organotypic test o Skin allergy: In Chemico Test In Vitro Cellular Tests o Genotoxicity Reverse bacterial mutation assay In Vitro Tests o Endocrine disruptors • Conclusions |
| Legislative framework: |
Directive 2010/63/EU or equivalent, CLP Regulation (EC) No 1272/2008, REACH Regulation (EC) No 1907/2006 or equivalent, Cosmetics Regulation (EC) No 1223/2009 or equivalent, Test guidelines (OECD, ISO, etc.) |
| Accreditation body and/or authority that approved the education or training: |
IUT, Université Clermont Auvergne 49, Bd François-Mitterrand - CS 60032 63001 Clermont-Ferrand Cedex 1 |
| Qualification received: |
Licence Pro BIOACT |
Did you find what you were looking for?
Yes, I found it! No, I did not!Thanks for your feedback! Please note that we cannot reply to you unless you send us an email.
What are you looking for?
We value your feedback so we can improve the information on the page. Please add your email address if you would like a reply. Thank you in advance for your help.!
Please contact us by email if you have any questions.