Disease modeling and cancer therapy in stem cell-derived 3D organoid systems
This record is part of
a dataset collected by the EU Commission in June-September 2018
. Some of these links will therefore die out with time.
Please see the
overview of courses maintained by ETPLAS
or contact Norecopa for more information.
Owner/Developer: Labroots
| Country: |
United States of America |
|---|---|
| Languages: |
English |
| Url: |
https://www.labroots.com/webinar/disease-modeling-cancer-therapy-stem-cell-derived-3d-organoid-systems |
| Created: |
25 October 2018 |
| Founding source: |
Thermo Fisher Scientific/Gibco |
| Description: | While the significance of the microbiome is unprecedented, a thorough study to dissect the role of individual populations of the natural gut microbiome in healthy and diseased states is still lacking. Currently available in-vitro models of the human intestine have certain limitations, e.g., lack of immune cells or microbiota. Therefore, systems closely mirroring the human intestine are needed to gain a better understanding of intestinal dysfunction, host - pathogen interactions and for the development of more effective therapies for cancer. It is important to establish a patient derived, fast and efficient system which would mimic the in-vivo architecture in humans and permit precise studies on interactions of the gut microbes with the epithelium and the immune cells. The in-vitro 3D “mini-gut” system developed in the Clevers lab displays many important functions of the normal intestinal epithelium. Along with the developed toolbox for the analysis of these organoids (including FACS-based cell sorting, confocal imaging, RNA Sequencing, mass-spec proteomics and CRISPR-Cas9), it has proven to serve as a powerful system to investigate regulatory and pathological mechanisms of the intestinal epithelium on a molecular level. |
| Format: |
Webinars |
| Presence: |
Optional / Voluntary |
| Access: |
Free |
| Content type: |
Theoretical |
| Duration: |
3h |
| Target audience: |
Students, Researchers, Regulators and policy-makers, Teachers and educators, Managers, Scientific officers / Project managers |
| Target sectors: |
Academia, Industry, Governmental bodies, Contract Research Organizations (CROs), Consulting, SMEs |
| Educational level: |
Continuing Professional Development, University (Master), University (Doctoral education), Postdoctoral (teaching and research) |
| 3rs relevance: |
Replacement |
| Topics covered: |
In vitro methods |
| 3rs coverage: |
Full coverage (a dedicated course) |
| Details on the topic or technology covered: |
To this end, we are developing a triple co-culture system of epithelial cells, immune cells and microbes to better understand the functional role of the gut microbiota, enabling personalized healthcare for the benefit of patients suffering from GI tract diseases. It might be possible in the future to determine the microbiome composition of cancer patients and provide personalized immunotherapy drug treatment. |
| Learning outcome: |
Learning Objectives: Organoids can be used for studying cancer and hereditary diseases, as well as in the examination of host cell–microorganism interactions. Patient-derived organoids may enable personalized medicine. Identify categories of individuals at risk of acquiring HDV infection. |
Did you find what you were looking for?
Yes, I found it! No, I did not!Thanks for your feedback! Please note that we cannot reply to you unless you send us an email.
What are you looking for?
We value your feedback so we can improve the information on the page. Please add your email address if you would like a reply. Thank you in advance for your help.!
Please contact us by email if you have any questions.