In Vitro-In Vivo Extrapolation (IVIVE) to Support Accurate Prediction of Hepatic Drug Disposition
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Owner/Developer: Center for Alternatives to Animal Testing Academy (CAAT Academy)
14 September 2017
The goal of this workshop is to make attending scientists familiar with the design and
conduct of typical in vitro experiments that are performed to profile the hepatic disposition
characteristics of new drug candidates and/or xenobiotics.
Hands-on training, Lecture
Optional / Voluntary
General public, Professionals (e.g. veterinarians), Scientific officers / Project managers, Managers, Technicians, Teachers and educators, Regulators and policy-makers, Researchers, Students
SMEs, Consulting, Contract Research Organizations (CROs), Governmental bodies, Industry, Academia
Postdoctoral (teaching and research), University (Doctoral education), University (Master), Continuing Professional Development
Full coverage (a dedicated course)
|Details on the topic or technology covered:||
Focus will be on sound protocols for generating high quality in vitro data that can
subsequently be used as input in physiologically-based pharmacokinetic (PBPK) models.
Importantly, the workshop program will also cover adequate in vitro data processing as
required before input into PBPK. Combination of data from various in vitro models will
also aid in getting novel and mechanistic insights in drug disposition.
For instance, combining rich in vitro data sets obtained in liver microsomes and hepatocytes
supports determination of intrahepatic drug exposure as well as phenotyping in terms
of disposition pathways. The workshop will offer opportunities for attendees to become
familiar with recently developed in vitro model systems and their applications. As the
workshop will focus on the IVIVE part of IVIVE-PBPK, it is relevant to scientists working in
the field of ‘classical’ PBPK as well as scientists working with in vitro models.
Directive 2010/63/EU or equivalent
|Accreditation body and/or authority that approved the education or training:||
certificate of attendance
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