Procedures with care
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Owner/Developer: Newcastle University
NC3Rs and Institute of Animal Technology
This section of the Procedures with Care website provides information to assist research workers to develop their skills in the administration of substances to laboratory animals. Initially, we have provided material dealing with rats and mice, since they are the animals most widely used in research. Further material will be added to expand the range of techniques and species.
This site focuses particularly on the manual skills needed to carry out the different procedures humanely and efficiently, and on the need to handle animals carefully to reduce any distress caused by the procedure.
Administering substances to animals, for whatever reason, can have a significant impact on their welfare. If carried out incorrectly, not only can animal welfare be compromised, but the scientific goals of study can be affected. If the administration is for a therapeutic purpose, then the incorrect administration can lead to a failure of the treatment.
The selection of a particular route of administration must balance a number of factors – for example the volume and physicochemical properties of the substance, the required speed of onset, and other factors such as the degree of tissue irritation that could be caused. These topics are discussed in more detail in guidelines from LASA (1998), BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement (2001) and Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider.
Optional / Voluntary
Technical College, Undergraduate
Carrying out procedures on animals, Designing procedures and projects
Full coverage (a dedicated course)
Mice (Mus musculus), Rats (Rattus norvegicus)
|Details on the topic or technology covered:||
oral gavage in the mouse
subcutaneous injection in the rat
intravenous injection in the rat
intramuscular injection in the rat
oral gavage in the rat
intraperitoneal injection in the rat
subcutaneous injection in the mouse
intravenous injection in the mouse
intraperitoneal injection in the mouse
handling and restraint of the animal
This section of the Procedures with Care website provides information to assist research workers to develop their skills in the administration of substances to laboratory animals
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