Read-across in REACH and its assessment
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a dataset collected by the EU Commission in June-September 2018
. Some of these links will therefore die out with time.
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Owner/Developer: Association of European Toxicologists & European Societies of Toxicology (EUROTOX)
| Country: |
Belgium |
|---|---|
| Languages: |
English |
| Url: |
http://www.eurotox-congress.com/2018/_medien/_content/files/180821_Eurotox-2018_Programm_WEB_final(1).pdf |
| Created: |
02 September 2018 |
| Founding source: |
citoxlab, TPL, UCB, Janssen, RTC, Elsevier, DouglasConnect, Knoell, Covance, MatTek, ToxMinds, Umicore, Charles River, Cosmetics Europe, Solvay, Envigo, Sysmex, OECD, EPAA, Cabot, Ecetoc, SOT, Hesi, FNRS, Team Mastery, Marshall, Ablynx |
| Locations: |
Belgium |
| City: |
Brussels |
| Description: | Read-across is an important scientific method for providing reliable information on the properties of substances, whilst minimising the use of animals. It is widely used in a variety of legislations, and this session seeks to develop overarching approaches to improved read-across in general, by focusing on the specific example of its use in REACH. The session starts by describing the nature of read-across in REACH, the extent of the use of read-across in REACH registration dossiers, and the use of the recently developed read-across assessment framework to evaluate read-across in a consistent way. Scientific challenges associated with the use of read-across for multi-constituent substances, and substances of Unknown or Variable composition, Complex reaction products or Biological materials (UVCBs) are mapped out. Novel and alternative methods can support the use of read-across, and novel frameworks for considering how this information can be applied to read-across will be discussed. The challenges of dealing with read-across for a variety of industrial chemicals will be discussed, making reference to uncertainty in the regulatory landscape and other challenges for successful read-across. The session aims to summarise key concepts for sucessful application of read-across in a variety of regulatory settings. |
| References: | go to page 39 of the provided link |
| Format: |
Lecture |
| Presence: |
Optional / Voluntary |
| Access: |
Fee-based |
| Content type: |
Theoretical |
| Duration: |
1 day |
| Frequency: |
Recurrent event |
| Target audience: |
Professionals (e.g. veterinarians), Scientific officers / Project managers, Managers, Technicians, Teachers and educators, Regulators and policy-makers, Researchers |
| Target sectors: |
SMEs, Consulting, Contract Research Organizations (CROs), Governmental bodies, Industry, Academia |
| Educational level: |
Continuing Professional Development |
| 3rs relevance: |
Replacement |
| Topics covered: |
Computational methods |
| 3rs coverage: |
Full coverage (a dedicated course) |
| Details on the topic or technology covered: |
1. Read-across in REACH and the read-across assessment framework (RAAF) 2. Scientific considerations for assessing read-across between multiconstituent or UVCB substances 3. Scientific Issues That Need to be Addressed for a Successful Read-Across Prediction 4. Quantitative assessment of mitochondrial toxicity and downstream cellular perturbations in Adverse Outcome Pathways. 5. Key issues for successful read-across - a user’s guide |
| Legislative framework: |
REACH Regulation (EC) No 1907/2006 or equivalent |
| Accreditation body and/or authority that approved the education or training: |
Eurotox Education Program |
| Qualification received: |
certificate of attendance |
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