Acute Toxicity Testing Without Animals
Owner/Developer: European Coalition to End Animal Experiments (ECEAE)
Since the early days of the REACH proposals, it has been accepted by all parties that the numbers of animals used to gain toxicity information on chemicals should be kept to an absolute minimum.
In this report, we argue specifically that acute toxicity data should not be sought from animal tests. The underlying principle of such tests on rats and mice is that the results can be effectively extrapolated to humans. In fact, after nearly 80 years of use of these tests, the predictivity of rodent data for human acute toxic effects has been disputed but never proven.
|Audience:||Scientists - Policy-makers - Regulators - Industry|
|User access:||Open access|
|Purpose:||Documentation and information|
|Legislative framework:||REACH Regulation (EC) No 1907/2006|
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