Predicting long-term toxic effects using computer models based on systems characterization of organotypic cultures (NOTOX)
Owner/Developer: European Commission and Cosmetics Europe
NOTOX will develop and establish a spectrum of systems biological tools including experimental and computational methods for i) organotypic human cell cultures suitable for long term toxicity testing and ii) the identification and analysis of pathways of toxicological relevance. NOTOX will initially use available human HepaRG and primary liver cells as well as mouse small intestine cultures in 3D systems to generate own experimental data to develop and validate predictive mathematical and bioinformatic models characterizing long term toxicity responses.
|Channel:||Website - Audio / Video - Printed|
|Audience:||Scientists - Regulators - Industry - Researchers|
|User access:||Open access|
|Purpose:||Regulatory testing - Toxicological and safety evaluation - Method development|
|Technology/Tools:||Alternative test methods (in vitro) - Non-testing methods (in silico)|
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