Reducing, Refining and Replacing the Use of Animals in Toxicity Testing
Owner/Developer: Royal Society of Chemistry
| Country: | United Kingdom |
|---|---|
| Languages: | English |
| Url: | http://pubs.rsc.org/en/content/ebook/9781849736527#!divbookcontent |
| Description: |
Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area. |
| Category: | Publication |
| Channel: | Website - Printed |
| Audience: | Students - Industry - Educators |
| User access: | Fee-based access |
| Updating frequency: | 2013 |
| Relevance: | Replacement - Reduction - Refinement |
| Purpose: | Documentation and information - Toxicological and safety evaluation |
| Technology/Tools: | Alternative test methods (in vitro) - Non-testing methods (in silico) - Animal testing (in vivo) |
Did you find what you were looking for?
Yes, I found it! No, I did not!Thanks for your feedback! Please note that we cannot reply to you unless you send us an email.
What are you looking for?
We value your feedback so we can improve the information on the page. Please add your email address if you would like a reply. Thank you in advance for your help.!
Please contact us by email if you have any questions.