Literature searches and Systematic Reviews of published animal studies

Good literature searches are an integral part of planning animal research and testing, as indicated in the PREPARE guidelines. Some core resources are cited here. The section of the Norecopa website on databases and guidelines will also be helpful.

Systematic reviews of published animal experiments are a useful aid in planning research and can also be used to extract new conclusions from experiments which have already been performed (so-called Synthesis of Evidence), thereby avoiding the need for new ones.

(SYstematic Review Centre for Laboratory animal Experimentation) at Radboud Medical University Center, Nijmegen has produced an excellent video explaining the principles behind systematic reviews.
The rationale behind systematic reviews is explained by Professor Merel Ritskes-Hoitinga.

Benefits of preclinical systematic reviews (webinar by Merel Ritskes-Hoitinga, 27 October 2020)

Two presentations about systematic reviews from members of SYRCLE at the EUSAAT 2016 congress :

Systematic Review Toolbox (SR Toolbox)

Systematic reviews in animal research: Launch of the CAMARADES-NC3Rs Systematic Review Facility (SyRF) 

Free e-learning on systematic reviews (use the registration code: syrcle)

The Evidence-Based Research Network
Evidence Synthesis International

Examples of Systematic Reviews of relevance to animal research

The University of Bergen's Vivarium and Norecopa arranged a workshop in Voss, Norway on 27-28 May 2015 entitled Systematic Reviews and Harm-Benefit Assessment of Animal ExperimentsThe workshop gave theoretical and practical training in how to conduct literature searches and systematic reviews of the laboratory animal science literature. In addition, it gave an introduction to the harm-benefit assessment of animal experiments. Documentation of literature searches and harm-benefit assessment are two requirements of EU's Directive 2010/63. The theoretical and practical training in systematic reviews were led by representatives of SYRCLE. The discussion of harm-benefit assessment was led by Dr. Penny Hawkins, Head of the Research Animals Department at the RSPCA, UK and Dr. Aurora Brønstad, University of Bergen, who was the co-chair of an AALAS-FELASA working group on this subject. Advice on literature searching and available databases was provided by Adrian Smith. Several of these resources have been produced by Norecopa. The workshop took place at Fleischer's Hotel, Voss (more information about the workshop). Participants brought their own personal computers with the program Review Manager 5 from the Cochrane Collaboration installed.
The organisers gratefully acknowledge financial support for this workshop from the Research Council of Norway.

Searching for information on 3Rs and 3Rs Resources is the title of a presentation that was included in the FRAME/VetBioNet Training School in Experimental Design and Statistical Analysis of Bioscience and Biomedical Experiments, held on 9-11 January 2019 at the University of Nottingham, U.K. It aims to give scientists an awareness of the need to conduct effective searches and the problems associated with searching, as well as basic search skills and increased knowledge of available resources. Norecopa has been given permission to publish the presentation here. A slightly older version is available on YouTube.
The author, Dr. Michelle Hudson-Shore, is dedicated to improving training provision and contributing to learning and development within organisations and institutions through her work with colleagues at the Centre for Applied Bioethics (CAB), University of Nottingham. CAB is very interested in developing and providing training in 3Rs, ethics, implementation of animal experimentation legislation and the social impact of research, both for animal related studies and scientific research more broadly. If you feel that you and your research group could benefit from professional development in these areas please get in touch with Dr Michelle Hudson-Shore or Dr Kate Millar.

Other references

This page was updated on 07 July 2021

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