Heart
|
Source |
Non-harmful / below threshold / severity degree 0 | Mild / severity degree 1 | Moderate / severity degree 2 | Severe / severity degree 3 |
| Examples: Monitoring ECG by non-invasive methods, leading to no or minimal impairment in habituated animals. | .Examples: Models with ECG recordings in the conscious dog after administration of test substances in non-toxic doses. Preterminal infarction models in the anaesthetised animal and euthanasia while under anaesthesia. Reperfusion models in the anaesthetised animal and euthanasia while under anaesthesia. | Examples: Models with telemetric heart-rate measurements in the conscious animal by means of catheters/transmitters implanted in the abdominal cavity, without clinical insufficiency. |
Models resulting in clinical insufficiency or interventions that may cause severe pain, extreme anxiety or death of the animal. Examples: Testing of cardiac support devices. Induction of clinically manifest cardiac insufficiency, myocardial infarction or endocarditis. Models with telemetric blood-pressure measurements in the conscious animal by means of catheters/transmitters implanted in the abdominal cavity. Models with experimentally induced hypertension in the animal. |
Circulation
|
Source |
Non-harmful / below threshold / severity degree 0 | Mild / severity degree 1 | Moderate / severity degree 2 | Severe / severity degree 3 |
| Federal Food Safety and Veterinary Office FSVO (2018) |
Examples: Oxygen measurement using pulse oximeter. | Examples: Models with invasive arterial blood-pressure measurements by means of catheters previously inserted under anaesthesia in practically freely mobile animals, with the exception of abdominal arterial catheters. Models with non-invasive blood-pressure measurements in conscious mice, rats or using the cuff method. | Examples: Goldblatt rats with organ failure DOCA rats. Blood-pressure measurements in pulmonary vessels. MCAO (middle cerebral artery occlusion). |
ECG measurements
|
Source |
Non-harmful / below threshold / severity degree 0 | Mild / severity degree 1 | Moderate / severity degree 2 | Severe / severity degree 3 |
| Directive 2010/63/EU, Annex VIII |
Monitoring ECG with non-invasive techniques with minimal or no restraint of habituated animals. |
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