ELISA for guinea-pig IgG1: an alternative to the PCA test fo r relative allergenicity
By Prento, A.
| Record number: | 1655258 |
|---|---|
| Category: | animal use alternatives - hypersensitivity - enzyme-linked immunosorbent assay |
An ELISA method to replace the PCA (passive cutaneous anaphylaxis) test has been developed for use in the evaluation of relative allergenicity in guinea-pigs (Dunkin-Hartley). The method detects antigen-specific IgG1 antibodies formed in the guinea-pig during sensitisation, and correlates well with the corresponding PCA test. The relative importance of IgG1 and IgE for relative allergenicity in the Dunkin-Hartley guinea-pig strain is discussed.
Issued: Feb 1991
Journal Title: Alternatives to laboratory animals
ISSN: 0261-1929
Volume issue: 19 v. 1 no.
Pages: 8 - 14
AGRICOLA identifier: IND20337477
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