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Cytotoxic and estrogenic activity of chlorpyrifos and its metabolite 3,5,6-trichloro-2-pyridinol. Study of marine yeasts as potential toxicity indicators
Abstract
Chlorpyrifos (CP) is one of the organophosphate insecticides most used worldwide today. Although the main target organ for CP is ...
Mushtaq S, Kursad Y, Aksoy A (2018) Alternative methods to animal experiments. Turkiye Klinikleri J Med Sci 38:161–170. https://doi.org/10.
Supplementary File 1 (PDF, 1695 KiB)
Cancers 2020, 12, 3566; doi:10.3390/cancers12123566 www.mdpi.com/journal/cancers
Article
Combined CDK2 and CDK4/6 Inhibition Overcomes
...
week. After 23
days, all mice were sacrificed according to the animal experimental guidelines, and the xenografted
tumors were excised and
Evaluation of the Effectiveness of Mesenchymal Stem Cells of the Placenta and Their Conditioned Medium in Local Radiation Injuries
Background: The search for an effective therapy for local radiation injuries (LRI) is urgent; one option is mesenchymal stem cells (MSC) ...
of conditioned MSCs (CMPL group) in severe LRI in laboratory animals accelerates the transition of the wound process to the stage of
RIP1/RIP3/MLKL-mediated necroptosis contributes to vinblastine-induced myocardial damage
Abstract
Vinblastine (VBL) has been considered as a first-line anti-tumor drug for many years. However, vinblastine-caused myocardial ...
and MLKL, respectively.
Animal experiments
Male Sprague-Dawley (SD) rats (200 g–220 g) were purchased from Hunan SJA Laboratory Animal Co.,
Reversion mutation of cDNA CA8-204 minigene construct produces a truncated functional peptide that regulates calcium release in vitro and produces profound analgesia in vivo
Abstract
Intracellular calcium is critical in orchestrating neuronal excitability and analgesia. Carbonic anhydrase-8 (CA8) regulates ...
the Update of the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Research (U.S.) and National Academies
Inhibition of 11β-HSD1 Expression by Insulin in Skin: Impact for Diabetic Wound Healing
Chronic, non-healing wounds impose a great burden on patients, professionals and health care systems worldwide. Diabetes mellitus (DM) and ...
the shaved backs of the mice as described [25]. All animal experiments were performed according to institutional and state guidelines (T26/
The Creation of a Multiallele Knockout Genotype in Rabbit Using CRISPR/Cas9 and Its Application in Translational Medicine
applied
sciences
Article
The Creation of a Multiallele Knockout Genotype in
Rabbit Using CRISPR/Cas9 and Its Application in
Translational ...
. Thromb. 2018, 25, 213–220. [CrossRef]
46. Faggion, C.M. Animal research as a basis for clinical trials. Eur. J. Oral Sci. 2015, 123, 61–64
Activity-Based Anorexia Dynamically Dysregulates the Glutamatergic Synapse in the Nucleus Accumbens of Female Adolescent Rats
Intense physical activity and dieting are core symptoms of anorexia nervosa (AN). Their combination evolves into compulsivity, leading the ...
out in the following laws, regulations, and policies governing the care and use of laboratory animals: Italian Governing Law (D.lgs 26/2014;
Covid-19-vaccine rummer en skjult etisk omkostning
Det er forsøgsdyr, der betaler prisen i kapløbet om at komme først med en ny vaccine.
vaccine og i mange andre sammenhænge.
I sommer florerede et opslag om dyreforsøg bredt på sociale medier. På billeder sås små aber af arten
CBD Oil: What are 9 Established or Possible Health Benefits?
CBD has been credited with relieving several medical conditions, including epilepsy, anxiety, inflammation, insomnia, and pain. Despite the ...
anti-stress effect following either acute or repeated administration.16
Animal research have shown that CBD features a positive impact on
The role of dopamine D1 receptors in MDMA-induced memory impairments
Highlights
•
MDMA impairs working memory performance by increasing perseveration in rats.
•
Rats with compromised D1 receptor function ...
serotonin systems. However, recent evidence from non-human animal experimental studies suggests that acute MDMA may indirectly impair memory
Bank of America – COCP Stock price Will increase 111.17% Over The Previous Week: Why It Occurred
Bank of America – COCP Stock price Will increase 111.17% Over The Previous Week: Why It Occurred
The stock price of Cocrystal Pharma, Inc ...
patent portfolio round these molecules, conducting a proof of idea animal research, initiating preclinical research, and figuring out extra
Regenerative medicine for anal incontinence: a review of regenerative therapies beyond cells
Abstract
Introduction and hypothesis
Current treatment modalities for anal sphincter injuries are ineffective for many patients, prompting ...
, supported by NIH Post-doctoral T32 Institutional Training Grant “Laboratory Animal and Comparative Medicine Research” (NIH T32 OD010957).
An Interview With Tim Ewins - Author Of
Tim Ewins is a debut novelist who defies classification. His first book,
is a diverting, assiduously modulated musing upon fate, human ...
in and realised that that is what I’d been doing, possibly because animal research is a great way to spend your time. I found myself with a
Curcumin Improves Human Umbilical Cord-Derived Mesenchymal Stem Cell Survival via ERK1/2 Signaling and Promotes Motor Outcomes After Spinal Cord Injury
Abstract
Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) transplantation is thought to be a promising strategy for treating ...
of interests.
Ethical Approval
All animal experiments and care conditions were
3 science-backed benefits of CBD oil and how to use it safely
Oral consumption is the healthiest way to use CBD oil.
nikkimeel/Getty Images
The health benefits of CBD oil include reducing pain, ...
as an alternative to opioids for patients with severe pain.
While animal research found CBD to be a promising treatment for nerve-based (
Arterial branching pattern of the rabbit femoral artery
Abstract
Rabbits have highly developed hindlimb muscles, whereas their bones are fragile, thus resulting in frequent hindlimb fractures. To ...
Rajtová V, Horák J (2002) A colour atlas of anatomy of small laboratory animals, vol 1. Saunders, London
Google Scholar
Modelling gestational diabetes mellitus: large animals hold great promise
Abstract
Gestational diabetes mellitus (GDM) characterized by hyperglycemia during pregnancy is a risk factor for various maternal and ...
Google Scholar
39.
Florence BD, Hau J. Chapter 1 - laboratory animals. In: Delves PJ, editor. Cellular Immunology. United
animals-1014631-fc done
Animals 2020, 10, 2234; doi:10.3390/ani10122234 www.mdpi.com/journal/animals
Article
Combined Supplementation of Nano‐Zinc Oxide and
...
the guidelines contained in the Guide for the
Care and Use of Laboratory Animals (2011).
Table 1. Ingredient and chemical composition
Enhanced neural differentiation of neural stem cells by sustained release of Shh from TG2 gene-modified EMSC co-culture in vitro
Abstract
As a promising cell therapy, neural crest-derived ectoderm mesenchymal stem cells (EMSCs) secrete high amounts of extracellular ...
University Animal Care and Ethics Committee, and the International Guidelines for Animal Research were strictly followed in this study.
Virulence of Francisella tularensis Subspecies holarctica Biovar japonica and Phenotypic Change during Serial Passages on Artificial Media
Francisella tularensis (F. tularensis) is the etiological agent of the zoonotic disease tularemia. F. tularensis subspecies holarctica ...
in an animal BSL3 laboratory in strict accordance with the Animal Experimentation Guidelines of NIID and the protocols were approved by the
Hematology and Blood Chemistry Reference Values of Captive Adult Black-Faced Ibis (Theristicus melanopis melanopis)
animals
Communication
Hematology and Blood Chemistry Reference Values
of Captive Adult Black-Faced Ibis
(Theristicus melanopis melanopis)
...
, D.G. Improving Bioscience Research Reporting:
The ARRIVE Guidelines for Reporting Animal Research. Plos Biol. 2010, 8, 1–5. [CrossRef]
19.
Hybrides of Alkaloid Lappaconitine with Pyrimidine Motif on the Anthranilic Acid Moiety: Design, Synthesis, and Investigation of Antinociceptive Potency
molecules
Article
Hybrides of Alkaloid Lappaconitine with Pyrimidine
Motif on the Anthranilic Acid Moiety: Design,
Synthesis, and ...
requirements
and recommendations of the Guide for the Care and Use of Laboratory Animals and was approved
by the Ethic Committee of the N.N.
En af dyrenes store forkæmpere fylder 20 år
Dyreværnsforeningen Anima kan i år fejre 20-års jubilæum. Foreningen arbejder for at sikre bedre forhold for dyr, uanset om det handler om ...
om det handler om kæledyr, landbrugsdyr, pelsdyr, forsøgsdyr eller dyr i underholdningsindustrien.
Fra græsrodsaktivisme til international
Development and biochemical characterization of the monoclonal antibodies for specific detection of the emerging H5N8 and H5Nx avian influenza virus hemagglutinins
Abstract
The highly pathogenic avian influenza (HPAI) H5N8 virus has been detected in wild birds and poultry worldwide. The threat caused ...
no conflict of interest.
Ethical approval
The animal experiment was approved by the
Microelectrophysiological Studies of the Ratio of Excitatory to Inhibitory Synaptic Processes in the Corticonigral Projection in a Model of Parkinson’s
Experiments on 23 white male rats (250 g) analyzed the spike activity of individual neurons in the substantia nigra pars compacta (SNc, 242 ...
, et al., “Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research,” PLoS Biol., 8, No. 6, e1000412 (
Specific Controlling Essential Oil Composition of Basil (Ocimum basilicum L.) Involving Low-Temperature, Low-Pressure Glow Plasma of Low Frequency
water
Article
Specific Controlling Essential Oil Composition of
Basil (Ocimum basilicum L.) Involving
Low-Temperature, Low-Pressure Glow ...
substance in food. It was found that methyl eugenol induced cancer in laboratory
animals [30]. From 2021 any product containing over 0.01%
Effects of dietary n-3-PUFA supplementation, post-insemination plane of nutrition and pregnancy status on the endometrial transcriptome of beef heifers
Abstract
Supplementation of cattle diets with n-3-polyunsaturated fatty acids (PUFA) can improve reproductive efficiency. Conversely, short ...
Community Directive 86/609/EC and was sanctioned by the Animal Research Ethics Committee of University College Dublin. The work carried out
MCPIP1 reduces HBV-RNA by targeting its epsilon structure
Abstract
Hepatitis B virus (HBV) is the major causative factor of chronic viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. ...
-based gene delivery was performed as described previously11,13,31. The animal experiment was approved by the ethical committee of the
Recognising global animal welfare excellence
By Georgina Mills
The World Veterinary Association has presented its annual global animal welfare awards for 2020, recognising vets, vet ...
. She is also a member of the Sri Lankan Association of Laboratory Animal Sciences. The Sri Lankan Veterinary Association is also planning
Avocado Creole Peel Ameliorates Metabolic Alterations Caused by a High Sucrose Fat Diet in a Wistar Rats Model
Abstract
High-sucrose high-fat diets are one of the causes of malnutrition, and may induce metabolic alterations such as dyslipidemia, ...
Research Council (US) (2011) Guide for the care and use of laboratory animals. National Academies Press, Washington, DC, pp 11–40
8.
Guzmán
Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease
Pathogenic IgA1 metalloproteases block the initial host immune response by cleaving host IgA1. Using cryoEM, the authors here provide ...
Committee, accredited by the Association for Assessment and Accreditation of Laboratory Animal Care—File Number 00235. We have complied with
Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry
Myo-Inositol phosphates (InsPs) and pyrophosphates (PP-InsPs) are important second messengers but their analysis remains challenging. Here ...
subjected to titanium dioxide extraction as described above. All animal experiments were approved by the UCL Animal Welfare and Ethical
CRISPR based editing of SIV proviral DNA in ART treated non-human primates
Removal of integrated HIV DNA remains a roadblock for HIV cure. Here, Mancuso et al. show that intravenous administration of an adeno- ...
Methods
Study approval
All experimental protocols involving the use of laboratory animals were approved by the Institutional Animal Care and
An expanded palette of improved SPLICS reporters detects multiple organelle contacts in vitro and in vivo
The authors have previously reported split-GFP-based contact site sensors (SPLICS) to document endoplasmic reticulum/mitochondria contact ...
macro-enabled Excel workbook.
Zebrafish husbandry and transgenic lines
All animal experiments were conducted on wild-type fish. Adult fish
Changes in hemodynamics, renal blood flow and urine output during continuous renal replacement therapies
Abstract
Continuous renal replacement therapies (CRRT) affect hemodynamics and urine output. Some theories suggest a reduced renal blood ...
protocol was approved by the Gregorio Marañon University Hospital Ethics Committee for Animal Research (4-2/2012). Animal studies were
Diet induces parallel changes to the gut microbiota and problem solving performance in a wild bird
Abstract
The microbial community in the gut is influenced by environmental factors, especially diet, which can moderate host behaviour ...
-gut-brain axis affecting behaviour is limited to experiments on model laboratory animals and to correlational studies on mental health in
Evaluation of an antibody-PNA conjugate as a clearing agent for antibody-based PNA-mediated radionuclide pretargeting
Abstract
Radionuclide molecular imaging of cancer-specific targets is a promising method to identify patients for targeted antibody therapy ...
animal studies were approved by the Local Ethics Committee for Animal Research in Uppsala (Uppsala djurförsöksetiska nämnd).
The dose (30 μg
Weak acids induce PGE2 production in human oesophageal cells: novel mechanisms underlying GERD symptoms
Abstract
The role of weak acids with pH values in the range of 4–7 has been implicated in the symptoms of gastroesophageal reflux disease ( ...
(in vivo)
Animal experimental procedures were performed according to the Guidelines for the Care and Use of Laboratory Animals and approved
Salidroside regulates inflammatory pathway of alveolar macrophages by influencing the secretion of miRNA-146a exosomes by lung epithelial cells
Abstract
The purpose of this study was to explore the investigative mechanism of salidroside (SAL) on LPS-induced acute lung injury (ALI)/ ...
the Guide for the Care and Use of Laboratory Animals issued by the Institute of Laboratory Animal Resources of the Life Science Committee of
Novel multimodal molecular imaging of Vitamin H (Biotin) transporter activity in the murine placenta
Abstract
Vitamin H (biotin) is delivered to the fetus transplacentally by an active biotin-transport mechanism and is critical for fetal ...
underwent MRI scans on gestational day E14.5. All animal experiments were reviewed and approved by the Weizmann Institutional Animal Care
Assessment of the hepatic tumor extracellular matrix using elastin-specific molecular magnetic resonance imaging in an experimental rabbit cancer model
Abstract
To investigate the imaging performance of an elastin-specific molecular magnetic resonance imaging (MRI) probe with respect to the ...
van Gieson
FELASA:
Federation of Laboratory Animal Science Associations
GRE:
Differential Sex-Dependent Regulation of the Alveolar Macrophage miRNome of SP-A2 and co-ex (SP-A1/SP-A2) and Sex Differences Attenuation after 18 h of Ozone Exposure
antioxidants
Article
Differential Sex-Dependent Regulation of the
Alveolar Macrophage miRNome of SP-A2 and co-ex
(SP-A1/SP-A2) and Sex ...
guidelines of
the National Institute of Health on the care and use of laboratory animals.
Abbreviations
AGO2: Argonaute 2; AKT1: AKT Serine/
A consideration in the experimental design of pig nutrition studies
All kind of influencing factors in feeding trials must be considered, otherwise results may be useless.
design to use, first consult with somebody experienced with the principles of animal experimentation. Such an up-front investment is usually
Nanoparticle System Based on Amino-Dextran as a Drug Delivery Vehicle: Immune-Stimulatory CpG-Oligonucleotide Loading and Delivery
The aim of this study is to prepare and characterize an amino-dextran nanoparticle (aDNP) platform and investigate two loading strategies ...
Research Facility, University of Otago, Dunedin, New Zealand. Animal experiments were performed according to ethical permits provided by the
Changes in Acute Phase Proteins in Bitches after Laparoscopic, Midline, and Flank Ovariectomy Using the Same Method for Hemostasis
Acute phase proteins (APP) are biomarkers of systemic inflammation, which allow monitoring the evolution of diseases, the response to ...
.5 and 51 kg. The study was approved by the Ethics Committee for Animal Experimentation of the University CEU-Cardenal Herrera (2018/VSC/PEA
Photobiomodulation invigorating collagen deposition, proliferating cell nuclear antigen and Ki67 expression during dermal wound repair in mice
Abstract
The present investigation focuses on understanding the role of photobiomodulation in enhancing tissue proliferation. Circular ...
, Manipal School of Life Sciences (MSLS), MAHE, Manipal, during animal experiments. The authors are also thankful to Dr. K. Satyamoorthy,
Impaired speed encoding and grid cell periodicity in a mouse model of tauopathy
Dementia is associated with severe spatial memory deficits which arise from dysfunction in hippocampal and parahippocampal circuits. For ...
Eli Lilly provided all the mice used in this study.
Ethics
Animal experimentation: All procedures were carried out in accordance with the
Corona-vacciner: Her opdaterer vi løbende og svarer på de vigtigste spørgsmål
De første vacciner mod coronavirussen er ved at være i mål. Følg med i kapløbet og læs alt, hvad du skal vide, om de nye vacciner.
at teste den på mennesker, efter at vaccinen har virket i dyreforsøg.
Læs mere om vaccineteknologierne i denne artikel:
Svækkede virusser:
Toxicology partner in two research projects of the Dutch Research Agenda (NWA)
The Toxicology department of Wageningen University & Research is a partner in two large research projects that have been awarded funding ...
and medicines can be performed in the future without the use of laboratory animals. It will be explored how substances interact with human
ArticleANIMAL SAFETY
Cancers 2020, 12, 3536; doi:10.3390/cancers12123536 www.mdpi.com/journal/cancers
Article
Animal Safety, Toxicology, and Pharmacokinetic
...
manuscript has no intention to take a general position on ethics of animal experiments, nor
on the strengths and pitfalls of certain model
Expression of Eya1 in mouse taste buds
Abstract
Taste substances are detected by taste receptor cells in the taste buds in the oral epithelium. Individual taste receptor cells ...
All mouse studies were approved by the Institutional Animal Experiment Committee of the Tokyo Institute of Technology and were performed in
Improvement in identification of pro-estrous mice by using a novel method of detecting vaginal mucous cells
Abstract
Accurate identification of the murine estrous cycle using vaginal exfoliative cytology is the initial and crucial step for ...
of interest.
Ethical approval
All animal experimental work was approved by the
Comparison of bone regenerative capacity of donor-matched human adipose–derived and bone marrow mesenchymal stem cells
Abstract
Adipose-derived stem cells (ASC) have been used as an alternative to bone marrow mesenchymal stem cells (BMSC) for bone tissue ...
with informed parental consent. Animal experiment approval was obtained from the Norwegian Animal Research Authority (Approval number:
biomedicines-989081
Biomedicines 2020, 8, 544; doi:10.3390/biomedicines8120544 www.mdpi.com/journal/biomedicines
Article
Chronic Treatment with A Phytosomal ...
Italian Health Ministry in full accordance with the Italian legislation
in animal experimentation (DL 26/2014) and conformed to EU
Targeting the RhoGEF PIX/COOL-1 in Glioblastoma: Proof of Concept Studies
cancers
Article
Targeting the RhoGEF βPIX/COOL-1 in Glioblastoma:
Proof of Concept Studies
Kate Connor 1,† , David W. Murray 1,†, Monika A ...
by the Royal College of Surgeons
in Ireland Animal Research Ethics Committee. Animal experiments were carried out under Directive
2010/63/EU
New EU open peer review system stirs debate
EU research chief is urging grantees to use the newly created ‘Open Research Europe.’ But there are doubts about the open review method and ...
to all researchers. Anna Olsson, researcher and coordinator of the Laboratory Animal Science group at the Institute for Molecular and Cell
Efficacy of Iopamidol for Sealing an Injured Thoracic Duct: Pilot Experiments in a Large Animal
applied
sciences
Article
Efficacy of Iopamidol for Sealing an Injured Thoracic
Duct: Pilot Experiments in a Large Animal
Hyo Yeong Ahn 1 ...
once after the experiment.
2.4. Experimental Procedure
All animal experiments were conducted in Pusan National University Yangsan Hospital,
Growth Outlook: How COVID-19 change the picture of Next-generation Sequencing (NGS) Market
Pune, New York, USA, November 26 2020 (Wiredrelease) Research Dive –:The report aims to offer a clear picture of the current scenario and ...
Market By Applications:
Diagnostics, Drug Discovery, Agriculture & Animal Research, Other Applications
Global Next-generation Sequencing (
Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension
Abstract
A recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control ...
, D. G. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLOS Biol. 8, e1000412. https://doi.
ZnAl nano layered double hydroxides for dual functional CRISPR/Cas9 delivery and enhanced green fluorescence protein biosensor
Abstract
Evaluation of the effect of different parameters for designing a non-viral vector in gene delivery systems has great importance. ...
independent sets of experiments.
Ethical concern
There are no human or animal experiments in this work; and all methods were carried out in
Mirtazapine exerts astrocyte-mediated dopaminergic neuroprotection
Abstract
Mirtazapine, a noradrenergic and specific serotonergic antidepressant (NaSSA), is known to activate serotonin (5-HT) 1A receptor. ...
cycle) and had free access to food and water. All animal experiments were conducted in accordance with the National Institutes of Health’s
Impairment of motor coordination and interneuron migration in perinatal exposure to glufosinate-ammonium
Abstract
Glufosinate-ammonium (GLA) is a broad-spectrum herbicide for agricultural weed control and crop desiccation. Due to many GLA- ...
and comply with the Association for Assessment and Accreditation of Laboratory Animal Care International Animal Care Policies (Approval No.
Ischial tuberosity: new donor site for bone grafts in animal cleft research
Abstract
In the context of cleft repair in animal research in rat models, different areas can be used for bone grafting. The aim of the ...
Ms. Leonie Zieglowski (Institute for Laboratory Animal Science and Central Laboratory for Laboratory Animal Science, University Hospital of
Activation of p38 MAPK participates in the sulbactam-induced cerebral ischemic tolerance mediated by glial glutamate transporter-1 upregulation in rats
Abstract
Our previous studies have shown that sulbactam can play a neuroprotection role in hippocampal neurons by upregulating the ...
‘ARRIVE’ guidelines and accepted by the Committee of Ethics on Animal Experiments of Hebei Medical University. All efforts were conducted to
TRPM2 promotes autophagic degradation in vascular smooth muscle cells
Abstract
Transient receptor potential channel M2 (TRPM2) is a Ca2+-permeable channel that is activated by reactive oxygen species (ROS). In ...
.
Animal ethics and experimental methods
All animal experiments were approved by Animal Experimentation Ethics Committee, The Chinese
Systemic and sustained thioredoxin analogue prevents acute kidney injury and its-associated distant organ damage in renal ischemia reperfusion injury mice
Abstract
The mortality of patients with acute kidney injury (AKI) remains high due to AKI associated-lung injury. An effective strategy for ...
am–8 pm) and freely provided with food and water. All animal experiments were conducted using procedures approved by the experimental animal
Maternal DOT1L is dispensable for mouse development
Abstract
A battery of chromatin modifying enzymes play essential roles in remodeling the epigenome in the zygote and cleavage stage embryos ...
All animal experiments were performed according to the National Institutes of Health Guide for the Care and Use of Laboratory animals, with
Redesigned reporter gene for improved proton exchange-based molecular MRI contrast
Abstract
Reporter gene imaging allows for non-invasive monitoring of molecular processes in living cells, providing insights on the ...
(IACUC) of the Brigham and Women’s Hospital. All animal experiments were carried out in accordance with approved IACUC guidelines and
Effect of different levels of hydrolysable tannin intake on the reproductive hormones and serum biochemical indices in healthy female rats
Abstract
The present work aimed to find out the effect of different levels of hydrolysable tannin (HT) on serum hormonal profile, ...
, 2014).
Google Scholar
12.
Nutrient Requirements of Laboratory Animals: Fourth Revised Edition (n.d.
Perilipin 4 Protein: an Impending Target for Amyotrophic Lateral Sclerosis
Abstract
The pathogenesis of amyotrophic lateral sclerosis (ALS) might exist some relationships with the abnormal lipidomic metabolisms. ...
Renshi Xu.
Ethics declarations
Animal experiments were approved by the Animal Experiment Committee of the Animal
MiR-215-5p Reduces Liver Metastasis in an Experimental Model of Colorectal Cancer through Regulation of ECM-Receptor Interactions and Focal Adhesion
Background: Growing evidence suggests that miR-215-5p is a tumor suppressor in colorectal cancer (CRC); however, its role in metastasis ...
, Italy) with ad libitum access to water and feeding. Animal experiments were performed in accordance with national and EU animal welfare
A Four-Inflow Construction to Ensure Thermal Stability and Uniformity during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Rats
cancers
Article
A Four-Inflow Construction to Ensure Thermal
Stability and Uniformity during Hyperthermic
Intraperitoneal Chemotherapy ( ...
.5 g. All experiments were approved
by the Dutch Central Committee of Animal Experiments with approval code AVD1180020174184,
received on 14
Emerging Neuroblastoma 3D In Vitro Models for Pre-Clinical Assessments
The potential of tumor three-dimensional (3D) in vitro models for the validation of existing or novel anti-cancer therapies has been ...
(2D) followed by in vivo validations in zebrafish, mice, or other small laboratory animals (4). The highly standardized protocols, well-
Fatty Acid Conjugation Leads to Length-Dependent Antimicrobial Activity of a Synthetic Antibacterial Peptide (Pep19-4LF)
The increasing number of infections caused by multidrug-resistant bacteria requires an intensified search for new antibiotics. Pep19-4LF is ...
by LC–MS.
4.5. In Vivo Experiments in Female Wistar Rats
The animal experiments were approved by the Animal Care and Use Committee at
Animal-free method predicts nanoparticle toxicity for safer industrial materials
A step closer to safe-by-design material development
Currently, safety testing relies heavily on animal studies. While animal experimentation is still indispensable for mechanistic and chronic
Acute caffeine reverses the disruptive effects of chronic fluoxetine on the sexual behavior of female and male rats.
Abstract
Rationale
Sexual side effects of chronic treatment with selective serotonin reuptake inhibitors (SSRIs) in humans include ...
for Animal Care. All procedures were approved by the Concordia University Animal Research Ethics Committee (Protocol #30000300 to JGP).
Monitoring Endothelin-A Receptor Expression during the Progression of Atherosclerosis
biomedicines
Article
Monitoring Endothelin-A Receptor Expression during
the Progression of Atherosclerosis
Miriam Stölting 1, Christiane ...
murine models. The lack of age-matched controls in
the animal experiments might lead to a diverse interpretation of resulting data,
Covid-19 : With global push for COVID-19 vaccines, China aims to win friends and cut deals | Science
Covid-19 : With global push for COVID-19 vaccines, China aims to win friends and cut deals | Science
Beijing-based Sinovac, which makes a ...
syncytial virus given to children in the 1960s, and in animal experiments with vaccines against SARS and another coronavirus disease, Middle
Walgreens Boots Alliance (WBA) Beneficial properties As Market Dips: What You Ought to Know
TipRanks
Which stocks are both a fan favourite or a must-avoid? Penny stocks. These tickers going for lower than $5 apiece are ...
over the previous few months. In August, preclinical animal research of coronavirus antiviral compounds, which constituted potential
Effects of Curcumin and Boric Acid Against Neurodegenerative Damage Induced by Amyloid Beta (1-42)
Abstract
Synaptosomes are used as an ex vivo model in the investigation of neuronal transmission and neurodegenerative processes. In this ...
in accordance with the approval of the Eskişehir Osmangazi University Animal Experiments Local Ethics Committee (decision dated 24 July 2018
uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells
Abstract
Exosomes (Exos) have been reported to promote pre-metastatic niche formation, proliferation, angiogenesis and metastasis. We have ...
the legal mandates and Italian guidelines for the care and maintenance of laboratory animals. Five hundred µl of Matrigel (BD Biosciences)
The pulmonary toxicity of carboxylated or aminated multi-walled carbon nanotubes in mice is determined by the prior purification method
RESEARCH Open Access
The pulmonary toxicity of carboxylated or
aminated multi-walled carbon nanotubes in
mice is determined by the prior ...
in an AAALAC (Association for Assess-
ment and Accreditation of Laboratory Animal Care)
accredited, pathogen-free animal facility, with
Developing the Cyberostracism Scale and Examining its Psychometric Characteristics
Abstract
This study aims to develop the Cyberostracism Scale (CS) to assess university students’ perceptions of virtual social exclusion. ...
included in the study.
Human and Animal Research
Formal approval related to the
Macromorphological findings in cases of death in water: a critical view on “drowning signs”
Abstract
Death in water is a challenging issue in forensic pathology since from natural death to homicide all circumstances of death in ...
U (2019) Can pulmonary foam arise after postmortem submersion in water? An animal experimental pilot study. J Forensic Legal Med 61:40–44.
Shared extracellular vesicle miRNA profiles of matched ductal pancreatic adenocarcinoma organoids and blood plasma samples show the power of organoid technology
Abstract
Extracellular vesicles (EV) are considered as a promising diagnostic tool for pancreatic ductal adenocarcinoma (PDAC), a disease ...
authority) approved the maintenance and experiments with mice. Animal experiments followed the principles of the Declaration of Helsinki.
TRF2-independent chromosome end protection during pluripotency
Experiments in mouse pluripotent embryonic and epiblast stem cells show that TRF2 is dispensable for telomere protection specifically ...
(CMRI) for microscopy infrastructure; the Crick BRF and GEMs for support with animal experiments; and T. de Lange for advice on G-overhang
Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway
Ubiquitin-specific protease 39 (USP39), a member of the deubiquitinating enzyme family, has been reported to participate in cytokinesis and ...
were performed according to the institutional and national guidelines for animal experiments.
4.11. In Vivo Metastasis Experiment
The A549
NAIP expression increases in a rat model of liver mass restoration
Abstract
The neuronal apoptosis inhibitory protein (NAIP) is a constituent of the NLRC4 inflammasome, which plays a key role in innate ...
the guidelines for animal research of the University of Granada (Spain) and the Ethics Committee for Animal Experimentation of Junta de
Scientists are harnessing viruses to treat tumours
Could viruses such as the one used in the measles vaccine be used to treat multiple myeloma?
— many different types of cancer are sensitive to it in cell and animal experiments.
Pichiorri was involved in the first human trial of
How Germany retains one of the world’s strongest research reputations
Thanks to steady funding, Germany’s national research organizations are thriving. But there are concerns that some universities are being ...
on the International Space Station. Called ICARUS (International Cooperation for Animal Research Using Space), the project aims to monitor
ArticleRecombinant Lactococcus expressing a novel variant of infectious bursal disease virus VP
Viruses 2020, 12, 1350; doi:10.3390/v12121350 www.mdpi.com/journal/viruses
Article
Recombinant Lactococcus Expressing a Novel Variant
of ...
in a negative-pressure isolator fitted with an air filter. All animal
experiments were approved by the HVRI of CAAS and carried out by
Semen Modulates Inflammation and Angiogenesis in the Reproductive Tract of Female Rabbits
animals
Article
Semen Modulates Inflammation and Angiogenesis in
the Reproductive Tract of Female Rabbits
Jaume Gardela 1,2 , Amaia Jauregi ...
; inflammation;
angiogenesis; rabbit
1. Introduction
Considered either laboratory animals, pets, invasive species or livestock, the rabbit
(
Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3–CCR5 axis
Inflammatory cytokines and chemokines are involved in the development of abdominal aortic aneurysm (AAA). Here the authors show that CCL3& ...
were approved by the Animal Research and Ethics Committee of Wakayama Medical University (approval No. 885). All animal experiments in this
Immunogenicity and protective efficacy of enterotoxigenic Escherichia coli (ETEC) total RNA against ETEC challenge in a mouse model
Abstract
Enterotoxigenic Escherichia coli (ETEC), an essential cause of post-weaning diarrhea (PWD) in piglets, leads to significant ...
be further studied.
Materials and methods
Animal ethics statement
The animal experiment in this study was approved by the Animal Ethical and
Label-free X-ray estimation of brain amyloid burden
Abstract
Amyloid plaque deposits in the brain are indicative of Alzheimer’s and other diseases. Measurements of brain amyloid burden in ...
\(\beta \)-sheet rich structures.
Animals
All animal experimental procedures and protocols were approved by the Indiana University School of
Regulation of microRNAs in high-fat diet induced hyperlipidemic hamsters
Abstract
Dyslipidemia is a documented risk factor for cardiovascular diseases and other metabolic disorders. Therefore, the analysis of ...
EU-CardioRNA COST Action CA17129
Contributions
Study designed by L.S.N.; animal experiments, samples processing and analysis by T.B., M.D.
Investigation of intraocular pressure of the anterior chamber and vitreous cavity of porcine eyes via a novel method
Abstract
To evaluate a new method of measuring the intraocular pressure (IOP) in the vitreous cavity. IOPs in the anterior chamber and ...
the progression of myopia with axial elongation has been reported in animal experiments using young guinea pigs10, suggesting that IOP has
Nod2 protects mice from inflammation and obesity-dependent liver cancer
Abstract
Nod2 is a pattern recognition receptor that modulates host innate immune responses and protects from inflammation, steatosis, and ...
and Use Committee. All animal work was performed in accordance with Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines
Automated measurement of long-term bower behaviors in Lake Malawi cichlids using depth sensing and action recognition
Abstract
In the wild, behaviors are often expressed over long time periods in complex and dynamic environments, and many behaviors include ...
flakes (Pentair Aquatic Eco-Systems).
Behavioral trials
All animal experiments were reviewed and approved by IACUC under the protocol #
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