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Seed- and Soil-Dependent Differences in Murine BreasTumor Microenvironments Dictate Anti-PD-L1 IgGDelivery and Therapeutic Efficacy
pharmaceutics
Article
Seed- and Soil-Dependent Differences in Murine Breas
Tumor Microenvironments Dictate Anti-PD-L1 IgG
Delivery and ...
Methodist Research Institute approved by the American Association for Accreditation of
Laboratory Animals.
Pharmaceutics 2021, 13, 530 3 of
Effects of aqueous extract of Anogeissus leiocarpus (DC) guill. Et Perr. (Combretaceae) leaves on acetic acid‐induced ulcerative colitis in rats
Abstract
Colitis are one of the worldwide increasing inflammatory bowel diseases. Colitis was induced by intrarectal administration of 1 mL ...
Review of Animal Experiments across Europe: Summary of the Report of a Felasa Working Group on Ethical Evaluation of Animal Experiments. Lab
Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Extensively Differentiate to Tyrosine-Hydroxylase-Expressing Dopamine-Secreting Neurons
Hair-follicle-associated pluripotent (HAP) stem cells are located in the bulge area of hair follicles from mice and humans and have been ...
Institutes of Health (NIH) and were approved by the Animal Experimentation and Ethics Committees of Kitasato University School of Medicine [
Universitetshospitalets ny stald til forsøgsdyr flytter på landet
Foto: Anne-Marie Fog Larsen, Region Nordjylland
Af Klaus Hansen
Universitetshospitalets ny stald til forsøgsdyr flytter på landet
Når ...
dyrlæge. Al forskning foregår i et veletableret samarbejde med Rådet for Dyreforsøg og overholder gældende regler på området.
Ældre nyhed >
Brain organoids uncover various mechanisms of virus-induced microcephaly
Researchers at IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences - demonstrate that different viruses can ...
direct research on human fetuses, and second, the unsuitability of laboratory animal models, as they are neither the natural hosts of the
Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates
Abstract
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused more than 96 million infections and over 2 million deaths ...
.
Animal and Human Right
All animal experiments were approved by the Institutional
Scientists produce new cancer therapy without animal experimentation
Professor Yaakov Nahmias seen holding the biological chip. (Image Credit: Hebrew University) I've always had a problem with testing on ...
for humans. Now, drug development and testing without animal experimentation have been introduced. Scientists at the Hebrew University of
Soluble IL-6R-mediated IL-6 trans-signaling activation contributes to the pathological development of psoriasis
Abstract
IL-6 has been suggested to function as an autocrine mitogen in the psoriatic epidermis. The biological activity of IL-6 relies on ...
participation. All animal experiments were conducted in compliance with the Guide for the Care and Use of Laboratory Animals published by
SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer
Abstract
The small nuclear ribonucleoprotein polypeptides B And B′ (SNRPB) is a core component of spliceosome and plays a key role in pre- ...
Ethical approval
All the procedures of animal experiments were approved by the Animal Care Committee of Xuzhou Medical
animals-1140150
Animals 2021, 11, 1079. https://doi.org/10.3390/ani11041079 www.mdpi.com/journal/animals
Article
Social Nesting, Animal Welfare ...
, D.G. Improving bioscience research reporting: The ARRIVE
guidelines for reporting animal research. PLoS Biol. 2010, 8, e1000412. 10.1371
Sensorimotor Perturbation Induces Late and Transient Molecular Synaptic Proteins Activation and Expression Changes
Abstract
Plasticity of the cerebral cortex following a modification of the sensorimotor experience takes place in several steps that can ...
2010/63/UE, and were approved by Regional Committee on Ethics of Animal Experiments of Nord Pas-de-Calais region (CEEA 75, reference Number:
Enhanced Solubility and Bioavailability of Dolutegravir by Solid Dispersion Method: In Vitro and In Vivo Evaluation—a Potential Approach for HIV Therapy
Abstract
Being a candidate of BCS class II, dolutegravir (DTG), a recently approved antiretroviral drug, possesses solubility issues. The ...
34.
Nair A, Morsy MA, Jacob S. Dose translation between laboratory animals and human in preclinical and clinical phases of drug development.
animals-1175271
Animals 2021, 11, 1076. https://doi.org/10.3390/ani11041076 www.mdpi.com/journal/animals
Article
The Efficacy of a Long‐Acting ...
carried out in accordance with the established standards
for animal experimentation.
Differences across treatment groups were estimated
Toxicity testing on animals at Vivotecnia, Spain
WARNING: GRAPHIC IMAGES
Sign the petition and join us in demanding that the Comunidad de Madrid immediately withdraw Vivotecnia’s ...
Comunidad de Madrid immediately withdraw Vivotecnia’s authorisation to carry out animal experiments, and the facility be closed down now!
biomedicines-1142379
Biomedicines 2021, 9, 407. https://doi.org/10.3390/biomedicines9040407 www.mdpi.com/journal/biomedicines
Article
DSIP‐Like KND ...
and Use of Laboratory Animals of BIBCh RAS and were carried out in accordance
with the EU Directive 2010/63/EU for animal experiments and
Sepsis Induces Physical and Mental Impairments in a Mouse Model of Post-Intensive Care Syndrome
Post-intensive care syndrome (PICS) is a physical, cognitive, and mental impairment observed in intensive care unit (ICU) survivors. ...
.
2. Materials and Methods
All animal experiments were approved by the Committee on the Ethics of Animal Experiments of Kobe University
Tumour draining lymph node-generated CD8 T cells play a role in controlling lung metastases after a primary tumour is removed but not when adjuvant immunotherapy is used
Abstract
Surgical resection of cancer remains the frontline therapy for millions of patients annually, but post-operative recurrence is ...
of interest.
Ethical approval
Animal experiments were conducted in accordance with
ijms-1150854
Int. J. Mol. Sci. 2021, 22, 3898. https://doi.org/10.3390/ijms22083898 www.mdpi.com/journal/ijms
Article
Sustained Hypoxia ...
commencing the experimental protocol. All animal experiments were con‐
ducted in accordance with the animal research guidelines of the Kyoto
viruses-1135116
Viruses 2021, 13, 652. https://doi.org/10.3390/v13040652 www.mdpi.com/journal/viruses
Article
Transmission of Bluetongue Virus ...
) and INRAE (France) for their help with the animal experiments
and their assistance in carrying out the biological sample collection. We
Application of portable real-time recombinase-aided amplification (rt-RAA) assay in the clinical diagnosis of ASFV and prospective DIVA diagnosis
Abstract
African swine fever, a serious infectious disease, has been found in many countries around the world over the last nearly 100 ...
sampled were handled following established procedures of the Chinese Laboratory Animal Administration Act of 2017. The research protocol was
A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment
Long-term infection of the stomach with Helicobacter pylori can cause gastric cancer. Here, Kinoshita-Daitoku et al. show that a small non- ...
for the care and use of laboratory animals and were approved by the Ethics Committee for Animal Experiments at the University of Tokyo or
foods-1165284 fc done
Foods 2021, 10, 818. https://doi.org/10.3390/foods10040818 www.mdpi.com/journal/foods
Article
The Effect of Ilex × meserveae S. ...
I. paraguariensis and I. meserveae were prepared day by day (across the
animal experiment period) in the same manner by adding 50.0 g
Experimental Infection of North American Sheep with Ehrlichia ruminantium
Ehrlichia ruminantium, a tick-borne rickettsial, causes heartwater in ruminants resulting from vascular damage. Severity of heartwater ...
Health Service (PHS) Policy on the Humane Care and Use of Laboratory Animals, the USDA Animal Welfare Act & Regulations (9CFR Chapter 1, 2.
pharmaceutics-1138557 - FC done
Pharmaceutics 2021, 13, 523. https://doi.org/10.3390/pharmaceutics13040523 www.mdpi.com/journal/pharmaceutics
Article
...
; Morsy, M.A.; Jacob, S. Dose translation between laboratory animals and human in preclinical and clinical phases of
drug development. Drug
Development of EST-SSRs from the ark shell (Scapharca broughtonii) transcriptome and their application in genetic analysis of four populations
Abstract
Background
The ark shell (Scapharca broughtonii) is one of the most economically important mollusks in the Bohai Sea and Yellow ...
. The research was conducted in the absence of any ethical issue on animal research.
Additional information
Publisher's Note
Springer Nature
viruses-1123720-fc done
Viruses 2021, 13, 648. https://doi.org/10.3390/v13040648 www.mdpi.com/journal/viruses
Article
Treatment with the Immunomodulator ...
, W.E.; Roth, L.; Tennant, B.C. Woodchucks as laboratory animals. In Laboratory
Animal Medicine, 2nd ed.; Elsevier Science: Amsterdam, The
Acute toxicity assessment of produced water effluent stream on selected local organisms in Delta state, Nigeria
Abstracts
This study evaluated toxicity level of produced water effluent on indigenous organisms in Delta state, Nigeria. Four test ...
S. (2010). Toxicity of roundup (a glyphosate product) to fingerlings of Clarias gariepinus. Animal Research International, 7(2), 1184–1193.
PFOS og andre flourstoffer er ekstremt farlige
Af Philippe Grandjean, professor i miljømedicin, Syddansk Universitet
Det var lidt af et chok, da jeg en morgen for nogle uger siden læste ...
liste over uønskede stoffer et par år senere. Efterhånden viste dyreforsøg øget risiko for kræft og påvirkning af hormonsystemet og
Musashi-1 Regulates MIF1-Mediated M2 Macrophage Polarization in Promoting Glioblastoma Progression
Glioblastoma (GBM) is the most malignant brain tumor which is characterized by high proliferation and migration capacity. The poor survival ...
/6 mice (National Laboratory Animal Center, Taipei, Taiwan) bred and maintained according to the Guidelines for Laboratory Animals at Taipei
‘Harry Potter’ star Evanna Lynch joins lawsuit to protect owls from deadly experiments
“There is overwhelming evidence that the results of most experiments on animals can’t be applied to humans. There can be no ethical ...
animal health needs, has been the result of insights learned from laboratory animals,” spokeswoman Karen Lancaster said in an email to
ijms-1172664 - fc done
Int. J. Mol. Sci. 2021, 22, 3893. https://doi.org/10.3390/ijms22083893 www.mdpi.com/journal/ijms
Article
Therapeutic Efficacy of ...
week‐old male C57BL/6J mice were purchased from Central Laboratory Animal
and then maintained in a specific pathogen free facility in Seoul
Global Nucleic Acid Isolation and Purification Market Report 2021: Market was valued at $3359.84 Million in 2020 - Forecast to 2026
Dublin, April 09, 2021 (GLOBE NEWSWIRE) -- The "Global Nucleic Acid Isolation and Purification Market - Analysis By Product Type, ...
Medicine - Market Size and Forecast (2016-2026)
5.2.4 Agriculture & Animal Research - Market Size and Forecast (2016-2026)
5.2.5 Others -
SLPI is a critical mediator that controls PTH-induced bone formation
The mechanism by which parathyroid hormone mediates the switch from bone resorption to bone formation is unclear. Here, the authors ...
relevant ethical regulations for animal testing and research. Animal experiments were performed in accordance with the experimental animal
Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes
The molecular identity of renal glomerular cells is poorly characterized and rodent glomerulopathy models translate poorly to humans. Here ...
protocols were approved by The Linköping Ethical Committee for Research Animals (“Linköpings djurförsöksetiska nämnd”), Linköping, Sweden (
The ameliorative role of Physalis pubescens L. against neurological impairment associated with streptozotocin induced diabetes in rats
Abstract
Neuropathy is considered a critical complication of diabetes mellitus (DM). Scientific studies are needed to relieve these painful ...
according to the international guidelines of the laboratory animal care and use.
Consent to
Essential Oils for Bone Repair and Regeneration—Mechanisms and Applications
Although bone possesses a remarkable capacity for self-remodeling and self-healing of small defects, the continuously increasing growth of ...
the literature are still limited, with most studies only focusing on animal experiments. Thereby, further studies are required in order to
Aalborg Universitetshospitals forsøgsdyr flytter på landet
I forbindelse med at det nye universitetshospital åbner, betyder det også, at der skal findes nye steder, hospitalets forsøgsdyr kan ...
med, når det nye universitetshospital i Aalborg åbner.
Det gør også de forsøgsdyr, der indtil nu befinder sig i en stald under Sygehus Nord.
Conditional RAC1 knockout in motor neurons restores H-reflex rate-dependent depression after spinal cord injury
Abstract
A major complication with spinal cord injury (SCI) is the development of spasticity, a clinical symptom of hyperexcitability ...
the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals and in compliance with ARRIVE guidelines. All animal
Endovascular repair and open repair surgery of thoraco-abdominal aortic aneurysms cause drastically different types of spinal cord injury
Abstract
Both endovascular repair (EVR) and open repair (OR) surgery of thoraco-abdominal aortic aneurysms cause spinal cord (SC) injury ...
, USA
Michele Basso
Department of Veterinary Preventive Medicine, University Laboratory Animal Resources, The Ohio State University, 111
Reproductive performance in houbara bustard is affected by the combined effects of age, inbreeding and number of generations in captivity
Abstract
Although captive breeding programs are valuable for conservation, they have been shown to be associated with genetic changes, such ...
Sert, N. et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLOS Biol. 18, e3000410 (2020).
CAS
PubMed
Comparative Transcriptomes of the Body Wall of Wild and Farmed Sea Cucumber Isostichopus badionotus
Overfishing of sea cucumber Isostichopus badionotus from Yucatan has led to a major population decline. They are being captured as an ...
Care and Use of Laboratory Animals (NOM-062-ZOO-1999) and the rules of the Internal Committee for the Care and Use of Laboratory Animals of
How safe is it to use ultrasound in prenatal medicine? Facts and contradictions – Part 2 – Laboratory experiments regarding non-thermal effects and epidemiological studies
Wie sicher ist Ultraschall in der Pränatalmedizin? Fakten und Widersprüche – Teil 2 – Laborversuche zu nichtthermischen Effekten und ...
with ultrasound exposure conditions similar to those causing lung hemorrhage in laboratory animals. J Am Soc Echocardiogr 1998; 11: 57-60 .
Therapeutic Effects of Decursin and Angelica gigas Nakai Root Extract in Gerbil Brain after Transient Ischemia via Protecting BBB Leakage and Astrocyte Endfeet Damage
Angelica gigas Nakai root contains decursin which exerts beneficial properties such as anti-amnesic and anti-inflammatory activities. Until ...
] [CrossRef]
Council, N.R. Guide for the Care and Use of Laboratory Animals; National Academies Press: Washington, DC, USA, 2010. [Google
Wound Healing Activity of Topical Formulations Containing Mauritia flexuosa Oil
Abstract
The wound healing potential of a topical herbal formulation containing “buriti” oil (Mauritia flexuosa L.f., Arecaceae) in a ...
The experiments with rats were approved by the Ethics and Animal Experimentation Committee of Universidade Federal do Oeste do Pará,
Effects of penconazole enantiomers exposure on hormonal disruption in zebrafish Danio rerio (Hamilton, 1822)
Abstract
PEN is a widely used triazole fungicide, usually used to control grape white rot. In the process of agricultural use, PEN will be ...
.
Ethics declarations
Ethics approval
All animal experiments were in accordance with
Investigation of metals accumulation in soil dumpsites using proton-induced X-ray emission
Abstract
This work was designed to examine the elemental constituents and physiochemical parameters of dumpsites in four local government ...
their consent to publish the manuscript.
Animal research
Not applicable.
Additional
The Bioactive Compound Contents and Potential Protective Effects of Royal Jelly Protein Hydrolysates against DNA Oxidative Damage and LDL Oxidation
antioxidants
Article
The Bioactive Compound Contents and Potential Protective
Effects of Royal Jelly Protein Hydrolysates against DNA
...
such as the antioxidant activities of RJ have already been
confirmed by animal experiments. The results in Table 1 show that the 10-HDA
Pectin Influences the Absorption and Metabolism of Polyphenols from Blackcurrant and Green Tea in Rats
Consumption of polyphenols and dietary fiber as part of a normal diet is beneficial to human health. In this study, we examined whether ...
experimental diets.
2. Materials and Methods
2.1. Animal Experiment
This study was carried out with approval from AgResearch Grasslands
Isofuranodiene, a Natural Sesquiterpene Isolated from Wild Celery (Smyrnium olusatrum L.), Protects Rats Against Acute Ischemic Stroke
The myrrh-like furanosesquiterpene isofuranodiene (IFD) is the main constituent of wild celery (Smyrnium olusatrum L., Apiaceae), an ...
is 989843). They also complied with the NIH guide for the care and use of laboratory animals (NIH Publication No. 80-23; revised 1978).
The
The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-O-desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs
molecules
Article
The Impact of Dextran Sodium Sulfate-Induced
Gastrointestinal Injury on the Pharmacokinetic Parameters of
Donepezil and ...
the gastrointestinal anatomy, physiology and biochemistry of humans and commonly used laboratory
animals. Biopharm. Drug. Dispos. 1995, 16,
Effects of intranasal guanosine administration on brain function in a rat model of ischemic stroke
Abstract
Ischemic stroke is a major cause of morbidity and mortality worldwide and only few affected patients are able to receive treatment ...
Guide for the Care and Use of Laboratory Animals.
Conflict of interest
The authors
TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer
The treatment and prognosis of advanced colorectal cancer (CRC) remain a challenging clinical research focus. Here, we describe a new CRC ...
Ashland, OR, USA) was used to analyze the data.
Animal Experiments
The animal study was reviewed and approved by the Animal Ethics Committee
Machine Learning-Based Energy System Model for Tissue Paper Machines
With the global energy crisis and environmental pollution intensifying, tissue papermaking enterprises urgently need to save energy. The ...
Statement
I promise that this study not involve human or animal research.
Informed Consent Statement
Informed consent was obtained from all
Urinary placental growth factor as a predictor of complications in hypertensive disorders in pregnancy: a protocol for systematic review and meta-analysis
Abstract
Introduction Preeclampsia is an important cause of maternal and fetal morbidity and mortality. Although the diagnostic and ...
on article and editorials will be excluded. Study focusing only on animal research, on PlGF quantification in serum or plasma or study
Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression
Abstract
Background
Aberrant activation of the WNT/β-catenin and STAT3 signaling pathways plays a critical role in cancer progression. ...
All institutional and national guidelines for the care and use of laboratory animals were followed.
Additional information
Publisher's Note
Is It Possible to Treat Infertility with Stem Cells?
Abstract
Infertility is a major health problem, and despite improved treatments over the years, there are still some conditions that cannot ...
Wharton’s jelly-derived mesenchymal stem cells using a chronic salpingitis model: an animal experiment. Stem Cell Res Ther. 2017;8(1):232.
Empiricism Must, but Cannot, Presuppose Real Causation
Abstract
In this article, I put forward a basic philosophical claim: empirical scientific knowledge, that is, knowledge generated in ...
. The apparatus may also be, or include, a model organism, a laboratory animal, a research subject, or the human observer itself. The basic
Response to correspondence on “Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation”
Author information
Affiliations
Mouse Genome Engineering Core Facility, Vice Chancellor for Research Office, University of Nebraska ...
and Innovation, Kobe, Japan
Yo-ichi Nabeshima
Department of Laboratory Animal Science, Support Center for Medical Research and Education,
New pig brain maps facilitate human neuroscience discoveries
URBANA, Ill. - When scientists need to understand the effects of new infant formula ingredients on brain development, it's rarely possible ...
But there's a lot to be said for pigs as an important biomedical research animal.
"You can study brain development in a mouse, but for some
Altered immunolocalization of FGF23 in murine femora metastasized with human breast carcinoma MDA-MB-231 cells
Abstract
Introduction
After the onset of bone metastasis, tumor cells appear to modify surrounding microenvironments for their benefit, and ...
T, Yamada T, HH, and MA under the guidance by Hiraga T performed animal experiments, such as preparation of cultured MDA-MB-231 cells, their
Effects of dietary Bacillus licheniformis on growth performance, intestinal morphology, intestinal microbiome, and disease resistance in common carp (Cyprinus carpio L.)
Abstract
This study was to evaluate the growth, intestinal morphology, intestinal flora, and anti-infection activity against Aeromonas ...
University Research Council’s “Guide for the Care and Use of Laboratory Animals” and “Policy on Humane Care and Use of Laboratory Animals.”
Law and the Laboratory: The British Vivisection Inspectorate in the 1890s
The 1876 British Cruelty to Animals Act introduced an unprecedented administrative system to supervise any experiment “calculated to give ...
“experiment.” Without concrete guidelines for the detection of pain in laboratory animals, the civil servants used a mixture of intuition,
Parental Lead Exposure Promotes Neurobehavioral Disorders and Hepatic Dysfunction in Mouse Offspring
Abstract
Lead (Pb) induces neurotoxicity in both children and adults. Children are more vulnerable to Pb toxicity than adults. Little is ...
: 127/320/IAMEBBC/IBSc) was received for the animal experiment from the Institute of Biological Sciences, University of Rajshahi, Bangladesh
Garlic (Allium sativum) and Fu-ling (Poria cocos) mitigate lead toxicity by improving antioxidant defense mechanisms and chelating ability in the liver of grass carp (Ctenopharyngodon idella)
Abstract
The heavy metal lead (Pb) is a contaminant widely distributed in the food chain. In this study, eight weeks of feeding containing ...
of the authors. All animal experimental procedures were carried out in accordance with the Regulations for Animal Experimentation of South
The first-line cluster headache medication verapamil alters the circadian period and elicits sex-specific sleep changes in mice
ABSTRACT
ABSTRACT
Verapamil is the first-line preventive medication for cluster headache, an excruciating disorder with strong circadian ...
Dirnagl U, et al. 2020. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol. 18(7):e3000410. doi:10.1371/
LINGO-1 shRNA protects the brain against ischemia/reperfusion injury by inhibiting the activation of NF-κB and JAK2/STAT3
Abstract
LINGO-1 may be involved in the pathogenesis of cerebral ischemia. However, its biological function and underlying molecular ...
) and carried out following the guidelines for the Care and Use of Laboratory Animals.
Establishment of MCAO/R model
The modified Zea Longa
jcm-1144422
J. Clin. Med. 2021, 10, 1581. https://doi.org/10.3390/jcm10081581 www.mdpi.com/journal/jcm
Article
Association of Myocardial ...
MVO2 [30], especially in steady‐state
conditions [31] and validated in animal experiments [32,33]. Our method for the estima‐
tion of MEEi,
Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment
Abstract
In view of the need to enhance the assessment of consumer products called for in the EU Chemicals Strategy for Sustainability, we ...
ECVAM—DB-ALM: The ECVAM Database Service on Alternative Methods to Animal experimentation (DB-ALM)—Online, which provides also the INVITTOX
animals-1141100
Animals 2021, 11, 1063. https://doi.org/10.3390/ani11041063 www.mdpi.com/journal/animals
Article
Effects of Cornus and its ...
.
2. Materials and Methods
2.1. Ethics Guidelines of the Animal Research
This trial was carried out according to the regulations of the
Eksisterende medisin kan ha effekt på Alzheimer
Amerikanske forskere kan ha funnet en ledetråd til medisin mot Alzheimer. Best av alt: Medisinen finnes allerede på markedet.
negative avleiringer i hjernen og fått dårlig hukommelse tilbake til normal hos forsøksdyrene på få uker.
Kan bli godkjent raskere
Ettersom
Animal rights protest at Oxford University lab
Protest group Support Animal Free Research International staged a demo outside Oxford University’s Biomedical Sciences Building today.
...
We can and will create a new movement to speak up for laboratory animals everywhere.
"Please support World Day for Animals in Laboratories
The early embryonic heart regenerates by compensation of proliferating residual cardiomyocytes after cryoinjury
Abstract
The adult mammalian heart is non-regenerative because cardiomyocytes withdraw from the cell cycle shortly after birth. Embryonic ...
in the NIH Guide for the Care and Use of Laboratory Animals (Eighth Edition).
Conflict of Interest
Deeper Insights on Cnesmone javanica Blume Leaves Extract: Chemical Profiles, Biological Attributes, Network Pharmacology and Molecular Docking
This study assessed the anxiolytic and antidepressant activities of a methanol leaves extract of Cnesmone javanica (CV) in Swiss albino ...
, M.; Altman, D.G.; NC3Rs Reporting Guidelines Working Group. Animal research: Reporting in vivo experiments: The ARRIVE guidelines. Br. J.
ijms-1141367-fc done
Int. J. Mol. Sci. 2021, 22, 3864. https://doi.org/10.3390/ijms22083864 www.mdpi.com/journal/ijms
Article
Acid‐Sphingomyelinase ...
after irradiation.
4.2. Mouse Tumor Model
All animal experiments were conducted in compliance with Institutional Animal
Care and
Anticancer Effects of Sublingual Type I IFN in Combination with Chemotherapy in Implantable and Spontaneous Tumor Models
Salivary gland tumors are a heterogeneous group of neoplasms representing less than 10% of all head and neck tumors. Among salivary gland ...
Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy
4
Animal Research and Welfare Centre, Istituto Superiore di Sanità, 00161 Rome,
Efficacy and Underlying Mechanism of Acupuncture in the Treatment of Posttraumatic Stress Disorder: A Systematic Review of Animal Studies
Journal of
Clinical Medicine
Review
Efficacy and Underlying Mechanism of Acupuncture in the
Treatment of Posttraumatic Stress Disorder: A ...
of the included studies was assessed using Systematic Review Cen-
tre for Laboratory Animal Experimentation (SYRCLE)’s risk of bias tool [19
The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus
Abstract
The hydrogen-rich water (HW) has been reported to possess a beneficial role in patients with diabetes. However, a systemic ...
National Institutes of Health Guidelines for the Care and Use of Laboratory Animals.
Additional information
Publisher's Note
Springer Nature
pharmaceuticals-1169938-FC done
Pharmaceuticals 2021, 14, 343. https://doi.org/10.3390/ph14040343 www.mdpi.com/journal/pharmaceuticals
Review
Toward Homogenous ...
, THIOMABs achieved a better therapeutic index in animal
experiments and showed improved serum stability than conventional ADCs [
Undercover footage shows ‘gratuitous cruelty’ at Spanish animal testing facility
Campaigners call for the closure of the Madrid research firm, after whistleblower video allegedly captures unacceptable treatment
animal experiments in Europe.”
In its statement to the Guardian, König said: “We would like to stress that at Vivotecnia Research animal
brainsci-1156202-FC done
Brain Sci. 2021, 11, 473. https://doi.org/10.3390/brainsci11040473 www.mdpi.com/journal/brainsci
Systematic Review
Effects of ...
[13,14].
In addition, in recent years, evidence from animal research and human studies has
accumulated indicating a potential role of
Next Generation Sequencing (NGS) Market Trends, Growth, Structure, Scope, Drivers and Opportunities by 2026
According to IMARC Group’s new report, titled “Next-Generation Sequencing (NGS) Market: Global Industry Trends, Share, Size, Growth, ...
in the fields of personalized and genetic medicines, agriculture and animal research, and clinical diagnostics.
The growing prevalence of
Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia
High myopia is associated with lens changes, but the underlying mechanisms are unclear. Here, the authors show increased equatorial ...
Song, Yanjun Liu, and Bing Chen for their help in animal experiments.
Author information
Author notes
These authors contributed equally:
NF-κB and TNF Affect the Astrocytic Differentiation from Neural Stem Cells
The NF-κB signaling pathway is crucial during development and inflammatory processes. We have previously shown that NF-κB activation ...
Union Directive and with the local Committee for Care and Use of Laboratory Animals.
2.2. Cell Culture
Primary cultures of neurospheres (
Lumican Inhibits In Vivo Melanoma Metastasis by Altering Matrix-Effectors and Invadopodia Markers
It was reported that lumican inhibits the activity of metalloproteinase MMP-14 and melanoma cell migration in vitro and in vivo. Moreover, ...
the “The French Animal Welfare Act” and “The French Board for Animal Experiments”. Experiments were conducted under approval of the French “
Dabrafenib Promotes Schwann Cell Differentiation by Inhibition of the MEK-ERK Pathway
Schwann cell differentiation involves a dynamic interaction of signaling cascades. However, much remains to be elucidated regarding the ...
Gyeonggi provincial government.
Institutional Review Board Statement
All animal experiments were approved by the Institutional Animal Care
A Novel Combination Therapy Using Rosuvastatin and Lactobacillus Combats Dextran Sodium Sulfate-Induced Colitis in High-Fat Diet-Fed Rats by Targeting the TXNIP/NLRP3 Interaction and Influencing Gut Microbiome Composition
pharmaceuticals
Article
A Novel Combination Therapy Using Rosuvastatin and
Lactobacillus Combats Dextran Sodium Sulfate-Induced Colitis
in ...
and the associated guidelines of EU directive
2010/63/EU for animal experiments. The study utilized adult male Sprague-Dawley rats
obtained
Dual Role of TNF and LT in Carcinogenesis as Implicated by Studies in Mice
cancers
Review
Dual Role of TNF and LTα in Carcinogenesis as Implicated by
Studies in Mice
Ekaterina O. Gubernatorova 1,2,*, Almina I. ...
out in accordance with
recommendations in the Guide for the Care and Use of Laboratory Animals (NRC 2011), the European
Convention for the
biology-1174058-FC done
Biology 2021, 10, 310. https://doi.org/10.3390/biology10040310 www.mdpi.com/journal/biology
Article
Insight into Liver lncRNA ...
transferred to a freezer at –80 ℃ for
RNA extraction. All animal experiments in this study were approved by the Institutional
Animal Care
Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man
Abstract
GABAA-α5 subunit-containing receptors have been shown to play a key modulatory role in cognition and represent a promising drug ...
Roche (Basel) complied with the Swiss Federal and Cantonal laws on animal research and AAALAC regulations and received prior approval by the
Oncogenic role of MiR-130a in oral squamous cell carcinoma
Abstract
Aberrant activation of the PI3K/AKT/mTOR pathway is attributed to the pathogenesis of oral squamous cell carcinoma (OSCC). In ...
. Animal experiments were performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals
Lipids and organic acids in three gut locations affect feed efficiency of commercial pigs as revealed by LC–MS-based metabolomics
Abstract
Feed efficiency (FE) is an important economic indicator in pig production. Improving the FE of commercial pigs is an important ...
for providing laboratory animals and phenotype records.
Thanks to Guangdong Wen's Foodstuffs Group for providing laboratory animals and
Ileal transposition helps to regulate plasma hepatokine levels in obese Zucker (Crl:ZUC(ORL)-Leprfa) rats
Abstract
We studied the long-term effect of ileal transposition (IT) metabolic surgery on the hepatokines: retinol-binding protein-4 (RBP4 ...
use of animals were followed (directive 2010/63/EU). All animal experimental protocols were approved by the Local Ethics Committee (58/2014)
Sulforaphane ameliorates lipid profile in rodents: an updated systematic review and meta-analysis
Abstract
Sulforaphane (SFN), a naturally-occurring isothiocyanate enriched in cabbage and broccoli, has been provided as food supplements ...
lipid profile. Moreover, our meta-analysis is based on animal experiments rather than RCTs. Results obtained through animal models are not
Making the choice between bioelectrical impedance measures for body hydration status assessment
Abstract
Situational or persistent body fluid deficit (i.e., de- or hypo-hydration) is considered a significant health risk factor. ...
, L. P. Anesthesia and restraint of laboratory fish. In Anesthesia and Analgesia in Laboratory Animals (Second Edition) (eds. Fish, R. E.,
Adolescent fluoxetine treatment mediates a persistent anxiety-like outcome in female C57BL/6 mice that is ameliorated by fluoxetine re-exposure in adulthood
Abstract
The objective of this study was to evaluate whether juvenile fluoxetine (FLX) exposure induces long-term changes in baseline ...
procedures complied with the Guide for the Care and Use of Laboratory Animals66, the Animal Research: Reporting In Vivo Experiments (ARRIVE)
Robenacoxib shows efficacy for the treatment of chronic degenerative joint disease-associated pain in cats: a randomized and blinded pilot clinical trial
Abstract
The main objective of this pilot clinical trial was to evaluate outcome measures for the assessment of the nonsteroidal anti- ...
variables were analyzed using ANOVA.
Ethics declarations and approvals for animal experiments
This study was approved by the Animal Care and
NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks
Abstract
Reduced NREM sleep in humans is associated with AD neuropathology. Recent work has demonstrated a reduction in NREM sleep in ...
these mouse data for our analyses in the present study, and all animal experiments that generated these data were approved in advance by the
The requirement of glycoprotein C (gC) for interindividual spread is a conserved function of gC for avian herpesviruses
Abstract
We have formerly shown that glycoprotein C (gC) of Gallid alphaherpesvirus 2, better known as Marek’s disease (MD) ...
UIUC are accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). All experimental procedures were
A comparative study of Helicobacter pylori infection in hamsters experimentally infected with liver flukes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis
Abstract
Helicobacter pylori causes a wide range of human diseases including cancer. Carcinogenic foodborne trematodes Opisthorchis ...
in compliance with the EU Directive 2010/63/EU for animal experiments and with the ARRIVE guidelines. Study design protocols and standard
Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand
Abstract
When exposed to nutrient excess and insulin resistance, pancreatic β-cells undergo adaptive changes in order to maintain glucose ...
, D. G. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. PLoS Biol. 8, e1000412 (2010).
PubMed
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