Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1

Brain derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation of the CNS, including neuronal morphology...

the decision to submit the work for publication. Ethics Animal experimentation: All experiments were performed according to NIH guidelines

Velpolstret biotekselskab sætter kurs mod klinikken i 2020

Aarhusianske NMD Pharma har valgt det første udviklingsmolekyle og regner med at sætte gang i fase 1-forsøg i mennesker om under et år. Til...

udvikler, viser sig at virke lige så godt i mennesker som i dyreforsøg, er potentialet betydeligt, idet behandlingen måske kan anvendes til

Prolongation of The Activation Time in Ischemic Myocardium is Associated with J-wave Generation in ECG and Ventricular Fibrillation

J-wave pattern has been recognized as an arrhythmic risk marker, particularly in myocardial infarction patients. Mechanisms underlying...

The procedures conformed to the Guide for the Care and Use of Laboratory Animals, 8th Edition published by the National Academies Press (US)

Sexual experience has no effect on male mating or reproductive success in house mice

The ability to learn from experience can improve Darwinian fitness, but few studies have tested whether sexual experience enhances...

, Alexandra Raffetzeder  & Dustin J. Penn Institute of Laboratory Animal Science, Department for Biomedical Sciences, University of

Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms

Aneurysms and dissections affecting thoracic aorta are associated with smooth muscle cell (SMC) dysfunction. NO/cGMP signaling pathway in...

to the standards published in Guide for the Care and Use of Laboratory Animals. Experimental procedures involving mice were approved by the

Laser printing technology: Creating the perfect bioprinter

Scientists from Russia, China, and the US have drawn the attention of the scientific community to one of the newest and most promising...

cells). In some of the studies, printed tissues were implanted into laboratory animals. The authors of the review believe that with the

Global Nucleic Acid Isolation and Purification Industry

Global Nucleic Acid Isolation and Purification Industry

& Animal Research (Application) Historic Sales Analysis in US$ Million by Region/Country: 2009-2017 Table 24: Agriculture & Animal Research

Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence

The limited efficacy of current immunotherapy suggests low antigen-specific T cells and immunosuppressive factors in tumor microenvironment...

and Accreditation of Laboratory Animal Care International (AAALAC International) and abides by the Institute of Laboratory Animal Resources

Necrotizing Enterocolitis: State of the Art in Translating Experimental Research to the Bedside

Artikel einzeln kaufen Lizenzen und Reprints Abstract Necrotizing enterocolitis (NEC) is a devastating intestinal disease that continues...

(02) 308-314 52 Wolfensohn S, Lloyd M. Handbook of Laboratory Animal Management and Welfare. 3rd ed. Oxford: Blackwell Publishing; 2003 53

Norwegian Authority warns pregnant women to avoid ginger supplements

The Norwegian Food Safety Authority warns pregnant women and women planning to become pregnant to avoid ginger supplements and...

taking ginger shots and supplements with ginger. The report detailed one of the animal experiments, in which rats were given 20-50 grams (g

Inside China’s Play to Become the World’s CRISPR Superpower

In some ways, Hercules is pretty standard for the course where beagles are concerned. He likes to run around and generally looks as...

CRISPR China’s full-speed-ahead approach on CRISPR extends beyond animal research. There are at least 20 research groups across the country

Memory-guided microsaccades

Microsaccades are small-amplitude, fixational eye movements that are largely thought to be involuntary. Here, the authors demonstrate that...

line with European Union directives, and German laws, governing animal research. Human experiments were approved by ethics committees at the

Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

The Anaphase Promoting Complex adaptor protein Cdh1 tightly controls cell cycle progression to restrain tumorigenesis but the mechanism is...

. Mouse models All animal experiments were approved by the Beth Israel Deaconess Medical Center IACUC Committee on Animal Research. Pten+/−;

VIDEO: Hundreds enjoy Bridlington's second Vegan Festival at Spa

VIDEO: Hundreds enjoy Bridlington's second Vegan Festival at Spa - Bridlington Free Press

sent information on medical research avoiding the suffering involved in animal experimentation. The Samaritans, Care4Cats and Pet Respect

Ultrasound: The potential power for cardiovascular disease therapy

In the current issue of Cardiovascular Innovations and Applications volume 4, issue 2, pp. 125-134; DOI...

, hypertrophic cardiomyopathy, and myocardial infraction, is being explored in animal experiments and clinical trials. In this review, we

Monkey malaria breakthrough offers cure for relapsing malaria

A breakthrough in monkey malaria research by two University of Otago scientists could help scientists diagnose and treat a relapsing form...

this new method is in vitro, it reduces the need for animal research models. The finding is also significant for the penguin population. “

Veterinærinstituttet på AquaNor 2019

Under årets AquaNor-messe i Trondheim 20.–23. august stiller Veterinærinstituttet i år med stand på et felles forskningstorg Hall A 125-138...

organlignende cellemodeller (organ-on-a-chip) som kan erstatte dyreforsøk. Presentasjon av prosjektet BIO-DIRECT ved Maria K. Dahle Kl 15.00

Alternate subunit assembly diversifies the function of a bacterial toxin

Salmonella Typhi produces the typhoid toxin. Here, Fowler et al. show that S. Typhi produces two forms of typhoid toxin that are...

trafficking properties, elicit different effects when administered to laboratory animals, and are expressed using different regulatory

Morphological and Molecular Changes in Juvenile Normal Human Fibroblasts Exposed to Simulated Microgravity

The literature suggests morphological alterations and molecular biological changes within the cellular milieu of human cells, exposed to...

or countermeasures that can be translated to in vivo models, while sparing laboratory animals. In this regard, the science areas TE, cancer

Enhancing the Thermal Stability of Carbon Nanomaterials with DNA

Single-walled carbon nanotubes (SWCNTs) have recently been utilized as fillers that reduce the flammability and enhance the strength and...

-halogenated11 (primarily phosphorus-containing). Studies in laboratory animals and humans have linked the most widely used flame retardants

Gravide bør unngå ingefærshots og kosttilskudd med ingefær

Gravide og kvinner som planlegger å bli gravide bør unngå inntak av ingefærshots og kosttilskudd med ingefær, advarer Mattilsynet....

Tekniske Universitet (DTU). I følge vurderingen kan resultatene fra dyreforsøkene ikke utelukke at store mengder ingefær også kan gi økt

Zoos are outdated and cruel – it’s time to make them a thing of the past

Zoos do not play a significant role in the conservation of wildlife, their claims to educate are exaggerated and their research is...

day trip to a zoo, and have also probably provided more information for animal research than that which was carried out at zoos. If you can

Amygdala GABAergic neuron activity dynamic during cataplexy of narcolepsy

Recent studies showed activation of the GABAergic neurons in the central nucleus of the amygdala (CeA) triggered cataplexy of sleep...

, or the decision to submit the work for publication. Ethics Animal experimentation: All manipulations done to the mice followed the

Molecular and anatomical organization of the dorsal raphe nucleus

The dorsal raphe nucleus (DRN) is an important source of neuromodulators and has been implicated in a wide variety of behavioral and...

in the U.S. National Institutes of Health Guide for the Care and Use of Laboratory Animals (HMS IACUC protocol #IS00000571). All surgery was

PHLPP1 counter-regulates STAT1-mediated inflammatory signaling

Inflammation is an essential aspect of innate immunity but also contributes to diverse human diseases. Although much is known about the...

Training Grant T32 GM007752 from the NIGMS. Ethics Animal experimentation: All protocols for mouse experiments were conducted in

Survival-time dependent increase in neuronal IL-6 and astroglial GFAP expression in fatally injured human brain tissue

Knowledge on trauma survival time prior to death following a lethal traumatic brain injury (TBI) may be essential for legal purposes....

neurons and glial cells in the PCZ depending on the survival time Animal research demonstrated that IL-6 is expressed in neurons and glial

Nucleic Acid Isolation and Purification Market Size, Share, Growth and Trend Analysis Report, 2018 to 2025

The global nucleic acid isolation & purification market size is expected to reach USD 3.6 billion by 2025, according to a new report by...

Drug Discovery & Development Agriculture and Animal Research Others Nucleic Acid Isolation & Purification

Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA

RESEARCH Open Access Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded...

-93 and 2017-08) or by the Ethics Committee on Animal Experimentation of the Germans Trias i Pujol Research Institute and by the Generalitat

Whole Exome Sequencing Market: Ability to Offer End to End Solutions to Drive Market Growth

Exome sequencing is a technique for sequencing all of the exome and protein-coding genes in a genome. This technique includes selection of...

, drug discovery and development, personalized medicine, agriculture and animal research, and others. Diagnostics application segment is

De novo regulation of RD3 synthesis in residual neuroblastoma cells after intensive multi-modal clinical therapy harmonizes disease evolution

Most high-risk neuroblastomas that initially respond to therapy will ultimately relapse. Currently, no curative treatment is available....

-H). All animal experiments were performed in strict accordance with institutional guidelines on the handling of laboratory animals. Consent

Why mice are being used in the fight against ‘deepfakes’

The fight against so-called deepfakes has taken a strange twist as researchers turn to mice to help prevent the spread of misinformation....

yuan (14.7 thousand US dollars) per square meter at a laboratory animal center at the Sixth Affiliated Hospital of Sun Yat-sen University on

Tissue Model Reveals Role of Blood-brain Barrier in Alzheimer's

Study Finds that Alzheimer's Damage Allows Toxins to Enter the Brain, Further Harming Neurons

cell types and really solidify things that had been seen previously in animal experiments, but reproduce them in a model system that we can

AquaGen ansetter ny kundeansvarlig i region sør

Håvard Fauskanger er fra 1. august ansatt som ny kundeansvarlig i region sør. Han vil styrke AquaGens kundeoppfølging av settefisk- og...

sin karriere. Først som prosjektansatt og deretter forsøkskoordinator og ansvarlig for forsøksdyr innen vaksinering. «Vi ser frem til å få

Tissue model reveals role of blood-brain barrier in Alzheimer’s

Study finds that Alzheimer’s damage allows toxins to enter the brain, further harming neurons Beta-amyloid plaques, the protein aggregates...

cell types and really solidify things that had been seen previously in animal experiments, but reproduce them in a model system that we can

Har skapt verdens første apefoster med menneskeceller

Som et skritt på veien mot å dyrke menneskeorganer i dyr, har et spansk-amerikansk forskningsteam hatt suksess med å skape en ny kimære: et...

for å dyrke organer mer effektivt i griser. Kimærforskning kan gi bedre forsøksdyr En annen forklaring på ape/menneske-kimærene kan også

Høy dose D-vitamin under graviditeten forebygger emaljefeil hos barn

Forskerne oppfordrer myndigheter til å gå gjennom sine anbefalinger til gravide.

, blant annet nyresvikt. Men det er helt ubegrunnet og stammer fra dyreforsøk, sier Bisgaard. Han legger dessuten vekt på at det i de

GERMANY HEALTH DISEASE RESEARCH ANIMAL

View of the research facilities of the Friedrich Loeffler Institute (FLI), the Federal Research Institute for Animal Health, on the island...

GERMANY HEALTH DISEASE RESEARCH ANIMAL

Skal dyrke menneskeorganer ved hjelp av rotter

En japansk forsker har fått tillatelse til å sette inn menneskeceller i rotter. Målet er å gro organer til folk som lider av organsvikt.

at det finnes klare moral-etiske begrensninger knyttet til både teknologien og forsøksdyrene. – Det ene er dyrevelferd, der man frykter er

Science Policy – an in Depth Anaylsis on What Works and What Doesn’t

The extreme left is merely a different symptom of the identical issue. Until you are able to demonstrate that the scientific consensus is...

you are able to demonstrate that the scientific consensus is that animal experimentation isn’t needed, you might not pretend that we are

Rapid identification of species, sex and maturity by mass spectrometric analysis of animal faeces

METHODOLOGY ARTICLE Open Access Rapid identification of species, sex and maturity by mass spectrometric analysis of animal faeces Nicola B....

z) to maintain an accurate mass measurement during all analyses. Laboratory animal and storage studies were conducted using the beta version

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

Pathological cardiac fibrosis is a hallmark of diseases leading to heart failure. Here, the authors used systems genetics to identify a...

according to the guidelines issued by the National Advisory Committee on Laboratory Animal Research. Protocol with IACUC number 2016/SHS/

Nutritionists say it is 'far too early' to advise avoiding emulsifiers - added to ice cream and chocolate to create a smooth texture and extend shelf life

FDA Considers Imposing Penalties on Novartis over Data Manipulation

The FDA is reassessing Novartis’ approved gene therapy Zolgensma after the company admitted to submitting manipulated data in its approval...

, Novartis’ Zolgensma application contained manipulated data from animal experiments establishing the manufacturing process of the therapy.

GM humans are possible, but do we really want them?

■ James Davies, clinician scientist and consultant haematologist, University of Oxford WE ARE entering a new era as a species. For the...

molecules. This has been optimised to generate thousands of genetically modified laboratory animals, which has led to rapid advances in our

The impact of sseK2 deletion on Salmonella enterica serovar typhimurium virulence in vivo and in vitro

RESEARCH ARTICLE Open Access The impact of sseK2 deletion on Salmonella enterica serovar typhimurium virulence in vivo and in vitro Xiaojie...

mice were sacrificed by cervical dislocation. Then the corresponding animal experiments were started. All animals were humanely handled.

Generation Authentic: 5 Steps To Opinion Marketing In The Millennial Era

By Emily Rowell - Aug 6, 2019 To attract more young people, create your community and bolster their beliefs. Share this article...

Lush Prize which was in conjunction with the Ethical Consumer for ending animal research. Resonating with brands is more important now than

Generation Authentic: 5 Steps To Opinion Marketing In The Millennial Era

By Emily Rowell - Aug 6, 2019 To attract more young people, create your community and bolster their beliefs. Share this article...

Lush Prize which was in conjunction with the Ethical Consumer for ending animal research. Resonating with brands is more important now than

Generation Authentic: 5 Steps To Opinion Marketing In The Millennial Era

By Emily Rowell - Aug 6, 2019 To attract more young people, create your community and bolster their beliefs. Share this article...

Lush Prize which was in conjunction with the Ethical Consumer for ending animal research. Resonating with brands is more important now than

Generation Authentic: 5 Steps To Opinion Marketing In The Millennial Era

By Emily Rowell - Aug 6, 2019 To attract more young people, create your community and bolster their beliefs. Share this article...

Lush Prize which was in conjunction with the Ethical Consumer for ending animal research. Resonating with brands is more important now than

Generation Authentic: 5 Steps To Opinion Marketing In The Millennial Era

By Emily Rowell - Aug 6, 2019 To attract more young people, create your community and bolster their beliefs. Share this article...

Lush Prize which was in conjunction with the Ethical Consumer for ending animal research. Resonating with brands is more important now than

Generation Authentic: 5 Steps To Opinion Marketing In The Millennial Era

By Emily Rowell - Aug 6, 2019 To attract more young people, create your community and bolster their beliefs. Share this article...

Lush Prize which was in conjunction with the Ethical Consumer for ending animal research. Resonating with brands is more important now than

Generation Authentic: 5 Steps To Opinion Marketing In The Millennial Era

By Emily Rowell - Aug 6, 2019 To attract more young people, create your community and bolster their beliefs. Share this article...

Lush Prize which was in conjunction with the Ethical Consumer for ending animal research. Resonating with brands is more important now than

Generation Authentic: 5 Steps To Opinion Marketing In The Millennial Era

By Emily Rowell - Aug 6, 2019 To attract more young people, create your community and bolster their beliefs. Share this article...

Lush Prize which was in conjunction with the Ethical Consumer for ending animal research. Resonating with brands is more important now than

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Injectable hydrogels could be used to repair bone defects. Here the authors incorporate nanoclay particles into chitosan creating an...

defect model All animal experiments were performed in accordance with the guidelines of the Chancellor’s Animal Research Committee at the

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog

Individuals carrying a gain-of-function mutation in PKG1 develop thoracic aortic aneurysms and dissections. Here Schwaerzer et al. show...

wall homeostasis. Generation of PKG1RQ knock-in mice All animal experiments complied with ethical guidelines for the use of animals in

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

of highly thermostable strains like BSE. Ethics statement Animal experiments were performed in strict accordance with the recommendations of

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

of highly thermostable strains like BSE. Ethics statement Animal experiments were performed in strict accordance with the recommendations of

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

(Madrid) and authorized by the Committee on the Ethics of Animal Experiments (CEEA) of the Spanish Instituto Nacional de Investigación y

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

(Madrid) and authorized by the Committee on the Ethics of Animal Experiments (CEEA) of the Spanish Instituto Nacional de Investigación y

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

(Madrid) and authorized by the Committee on the Ethics of Animal Experiments (CEEA) of the Spanish Instituto Nacional de Investigación y

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

of highly thermostable strains like BSE. Ethics statement Animal experiments were performed in strict accordance with the recommendations of

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

of highly thermostable strains like BSE. Ethics statement Animal experiments were performed in strict accordance with the recommendations of

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

(Madrid) and authorized by the Committee on the Ethics of Animal Experiments (CEEA) of the Spanish Instituto Nacional de Investigación y

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

(Madrid) and authorized by the Committee on the Ethics of Animal Experiments (CEEA) of the Spanish Instituto Nacional de Investigación y

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

(Madrid) and authorized by the Committee on the Ethics of Animal Experiments (CEEA) of the Spanish Instituto Nacional de Investigación y

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

(Madrid) and authorized by the Committee on the Ethics of Animal Experiments (CEEA) of the Spanish Instituto Nacional de Investigación y

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

(Madrid) and authorized by the Committee on the Ethics of Animal Experiments (CEEA) of the Spanish Instituto Nacional de Investigación y

Thermostability as a highly dependent prion strain feature

Prion diseases are caused by the conversion of physiological PrPC into the pathogenic misfolded protein PrPSc, conferring new properties to...

of highly thermostable strains like BSE. Ethics statement Animal experiments were performed in strict accordance with the recommendations of