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Dihydromyricetin ameliorates liver fibrosis via inhibition of hepatic stellate cells by inducing autophagy and natural killer cell-mediated killing effect
Background
This study investigated the mechanisms underlying the preventive effect of dihydromyricetin (DHM) against liver fibrosis ...
°C. All efforts were made to minimize animal suffering. The animal experiments were approved by the Animal Care and Use Committee of Third
Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted by BMSCs Regulates Activated Astrocytes by Inhibiting NF-κB Signaling Pathway to Ameliorate Blood Brain Barrier Damage After Intracerebral Hemorrhage
Abstract
To investigate the influence of tumor necrosis factor-stimulated gene-6 (TSG-6) secreted by bone mesenchymal stem cells (BMSCs) on ...
Ethical Approval
This study was approved by the animal experiment ethics committee of the First Affiliated Hospital of
Targeted Micellar Phthalocyanine for Lymph Node Metastasis Homing and Photothermal Therapy in an Orthotopic Colorectal Tumor Model
Highlights
Small-sized trastuzumab-targeted ...
) were provided by Shanghai Laboratory Animal Center (Chinese Academy of Sciences, Shanghai, China). The animal experiment designed in this
External auditory exostoses in wind-dependent water sports participants: German wind- and kitesurfers
Abstract
Purpose
Cold water and wind are known to cause exostoses of the external auditory canal. Different prevalences in different sports ...
, other authors corroborated this hypothesis in swimmers [29,30,31] and in animal experiments [32, 33]. According to Harrison [33], the most
Clinical evaluation of a robotic system for precise CT-guided percutaneous procedures
Abstract
Purpose
To assess accuracy and compare protocols for CT-guided needle insertion for clinical biopsies using a hands-free robotic ...
Robotic Insertion of Various Ablation Needles Under Computed Tomography Guidance: Accuracy in Animal Experiments. Eur J Radiol 105:162-167.
How Communication Technology Fosters Individual and Social Wellbeing During the Covid-19 Pandemic: Preliminary Support For a Digital Interaction Model
Abstract
The aim of the present study was to test an explanatory model for individual and social wellbeing which incorporates the ...
number: 3540). The study did not involve human and/or animal experimentation and conformed to all guidelines according to the Declaration of
In-air hearing in Hawaiian monk seals: implications for understanding the auditory biology of Monachinae seals
Abstract
The auditory biology of Monachinae seals is poorly understood. Limited audiometric data and certain anatomical features suggest ...
Google Scholar
Heffner HE, Heffner RS (2007) Hearing ranges of laboratory animals. J Am Assoc Lab Anim Sci 46:20–22
CAS
Psychological Distress and Physical Health Symptoms in the Latinx Population During the COVID-19 Pandemic: Exploring the Role of Anxiety Sensitivity
Abstract
Objective
The outbreak of the novel 2019 SARS2-Coronavirus disease (COVID-19) has led to substantial physical and mental health ...
to participating in the current study.
Animal Research
No animals took part in the
Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats
Abstract
Injection therapy for diabetes has poor patient compliance, and the pain occurring at the site of subcutaneous injections causes ...
All institutional and national guidelines for the care and use of laboratory animals were followed. All the animal procedures were reviewed
Exclusive: Joni Ernst Joins Watchdog Group to End U.S. Funding of ‘Cruel and Dangerous Animal Experiments’ in Wuhan Lab
Sen. Joni Ernst (R-IA) and Justin Goodman of the
White Coat Waste Project
joined Thursday’s edition of SiriusXM’s
Breitbart News Daily
...
billion a year that the federal government wastes on cruel and dangerous animal experiments, like the stuff we’re talking about in Wuhan.”
Mathematical media literacy in the COVID-19 pandemic and its relation to school mathematics education
Abstract
In the first months of 2020, as the COVID-19 pandemic became a top concern worldwide, media coverage became full of information ...
. Expressions of science literacy in online public discussions of animal experimentation. International Journal of Science Education, Part B
Fear of the dark: substrate preference in Amazonian tadpoles
Abstract
Due to the importance of camouflage to avoid detection by predators, predation pressure can cause coupled evolution of skin colour ...
institution or practice at which the studies were conducted. Ethics committee on animal experimentation (CEUA) protocol # 011/2017—CEUA/UFAM
Induction of Tertiary Phase Epileptiform Discharges after Postasphyxial Infusion of a Toll-Like Receptor 7 Agonist in Preterm Fetal Sheep
International Journal of
Molecular Sciences
Article
Induction of Tertiary Phase Epileptiform Discharges after
Postasphyxial Infusion of a ...
D.G. Improving bioscience research reporting: The ARRIVE
guidelines for reporting animal research. PLoS Biol. 2010, 8, e1000412. [CrossRef]
ELF5 inhibits the proliferation and invasion of breast cancer cells by regulating CD24
Abstract
E74-like factor five (ELF5) is a basic transcription factor that plays a key role in breast tissue and gland development. However ...
Ethical approval
There were no human tissues or animal experiments in this study.
Additional information
Publisher's Note
Preclinical Evaluation of 89Zr-Df-IAB22M2C PET as an Imaging Biomarker for the Development of the GUCY2C-CD3 Bispecific PF-07062119 as a T Cell Engaging Therapy
Abstract
Purpose
A sensitive and specific imaging biomarker to monitor immune activation and quantify pharmacodynamic responses would be ...
of The Guide for the Care and Use of Laboratory Animals (“The Guide,” Institute of Laboratory Animal Resources, National Academy Press,
The erythropoietin receptor expressed in skeletal muscle is essential for mitochondrial biogenesis and physiological exercise
Abstract
Erythropoietin (EPO) is a haematopoietic hormone that regulates erythropoiesis, but the EPO-receptor (EpoR) is also expressed in ...
1583–02-011, 1583–02-014). In addition, all animal experiments followed the protocols from Directive 2010/63/EU of the European Parliament.
Fetal Zone Steroids and Estrogen Show Sex Specific Effects on Oligodendrocyte Precursor Cells in Response to Oxidative Damage
Oxygen causes white matter damage in preterm infants and male sex is a major risk factor for poor neurological outcome, which speculates ...
the international FELASA, national GVsolas and local University Medicine Greifswald animal research guidelines. Crl:CD-1 (ICR) mice were
Combined OX40 Agonist and PD-1 Inhibitor Immunotherapy Improves the Efficacy of Vascular Targeted Photodynamic Therapy in a Urothelial Tumor Model
Purpose: Vascular targeted photodynamic therapy (VTP) is a nonsurgical tumor ablation approach used to treat early-stage prostate cancer ...
are in accordance with our institution’s Research Animal Resource Center’s Recommended Methods of Euthanasia for laboratory Animals and the
Astragalus (Astragalus membranaceus Bunge): botanical, geographical, and historical aspects to pharmaceutical components and beneficial role
Abstract
Medicinal plants always are part of folk medicine and are nowadays receiving worldwide attention for prophylaxis, management, and ...
number of health conditions indicate the need to use observational animal experiments for pharmacokinetic characterization. Health-promoting
A New Dermal Substitute Containing Polyvinyl Alcohol with Silver Nanoparticles and Collagen with Hyaluronic Acid: In Vitro and In Vivo Approaches
The experimental use of poly (alcohol-vinyl) (PVA) as a skin curative is increasing widely. However, the use of this hydrogel is ...
, R.; De Figueiredo, L.F.P. Fundamentals aspects of animal experimentation-applications in experimental surgery. Rev. Ass. Med. Bras. 2010,
An Astrocyte Structural Organization Analysis Based on Fluorescent Microscopy with 2D and 3D Quantitative Approaches
Abstract
According to the obtained data over the last decades, astrocytes play a crucial role in neuronal homeostasis. Therefore, the ...
the Declaration of Helsinki and the Rules for the Care and Use of Laboratory Animals (Addendum to Order of the Soviet Ministry of Health no.
Potential Biomarkers in Diagnosis of Renal Acanthamoebiasis
International Journal of
Molecular Sciences
Article
Potential Biomarkers in Diagnosis of Renal Acanthamoebiasis
Karolina Kot 1 , Patrycja ...
2016) were
obtained to conduct the experiment on laboratory animals. All animal experiments were
performed in a strict agreement with good
The Antioxidant Effects of Whey Protein Peptide on Learning and Memory Improvement in Aging Mice Models
nutrients
Article
The Antioxidant Effects of Whey Protein Peptide on Learning
and Memory Improvement in Aging Mice Models
Xiao-Chen Yu, ...
of Laboratory Animal Science at Peking
University (Laboratory animal production license No.: SCXK (Jing) 2016-0010; laboratory
animal use
Advokat Sysette Vinding Kruse er død
Advokat Sysette Vinding Kruse er død i en alder af 67 år.
fra 1989-2005 var hun formand for Fonden til Sygdomsbekæmpelse uden Dyreforsøg.
Hun var tilmed medstifter af en klinik for stofmisbrugere i
Biomedical Applications of Scutellaria edelbergii Rech. f.: In Vitro and In Vivo Approach
molecules
Article
Biomedical Applications of Scutellaria edelbergii Rech. f.:
In Vitro and In Vivo Approach
Muddaser Shah 1,2, Waheed Murad ...
.C.; Dirnagl, U.; Emerson, M.; et al.
Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0. PLoS Biol. 2020,
Myeloid-Specific Acly Deletion Alters Macrophage Phenotype In Vitro and In Vivo without Affecting Tumor Growth
Cancer cells rely on ATP-citrate lyase (Acly)-derived acetyl-CoA for lipid biogenesis and proliferation, marking Acly as a promising ...
Kruijssen, Eelco D. Keuning and Kelly Boelaars for their help with animal experiments. We further thank Jo A. Van Ginderachter and Damya
FMRP Interacts with RAR in Synaptic Retinoic Acid Signaling and Homeostatic Synaptic Plasticity
International Journal of
Molecular Sciences
Article
FMRP Interacts with RARα in Synaptic Retinoic Acid
Signaling and Homeostatic Synaptic ...
following standard procedures approved by the Stanford University Administrative Panel
on Laboratory Animal Care. Fmr1 knock-out mice (JAX:
Klumme: En lige højre til verdenssituationen
Klummer på 24NYT er udelukkende udtryk for skribentens mening.
24NYT er ikke nødvendigvis enig med skribenten.
Udenrigspolitik
Kineserne ...
m.fl. destabiliserer menneskets naturlige immunsystem. Test på forsøgsdyr har vist allehånde skrækscenarier i form af høje dødsrater og
Blocking IL-11 signaling can promote liver regeneration after paracetamol-induced damage
Scientists at Duke-NUS Medical School and National Heart Centre Singapore (NHCS), in collaboration with colleagues in Singapore and the UK ...
an animal model conducted according to the National Advisory Committee for Laboratory Animal Research (NACLAR) guidelines, they found high
Struggling to eat Low Carb or KETO when dining out in Sydney? Check this out
As if struggling to find a restaurant or cafe in Sydney that caters to the growing list of dietary requirements people have wasn’t hard ...
. Although some of the evidence is from case studies and animal research, results from human controlled studies are also promising.
Medical
Kasakhstansk covid-19 vaksine kan bli godkjent av WHO
Kasakhstans QazVac-vaksine mot COVID-19 kan bli inkludert i listen over vaksiner som er godkjent for nødbruk av WHO, sier president Kassym- ...
to ganger. For tiden stimulerer det immuniteten i kroppen til vaksinerte forsøksdyr på den 14. dagen etter injeksjonen av den andre dosen.
I
Can Optimizing the Mechanical Environment Deliver a Clinically Significant Reduction in Fracture Healing Time?
The impact of the local mechanical environment in the fracture gap on the bone healing process has been extensively investigated. Whilst it ...
weight-bearing approach appears to contradict the findings from animal experiments that early mechanical stimulation is critical. Therefore,
Cytoprotective effect of ginger extract on cisplatin-induced hepatorenal toxicity in rats via modulation of oxidative stress, inflammation and apoptosis: histopathological, biochemical and immunohistochemical study
Abstract
Cisplatin (CP) as a potent chemotherapeutic agent is restricted due to its hepatotoxicity, nephrotoxicity, and multiple organ ...
Ethics approval
The Research Ethical Committee of Animal Experiments of faculty of veterinary medicine at University of Sadat
Kan være «gift» for kroppen
Så farlig kan svidd grillmat være for helsa. Men det er ikke for farlig.
enn den høyeste mengden av stoffet som ikke gir økning i kreftrisiko hos forsøksdyr, regnes risikoen som tilstrekkelig lav. For mange av de
microRNA-181a promotes the oncogene S100A2 and enhances papillary thyroid carcinoma growth by mediating the expression of histone demethylase KDM5C
Abstract
Background and purpose
Papillary thyroid carcinoma (PTC) is an endocrine malignancy. Increasing evidence highlights microRNAs ( ...
in line with the Guide for the Care and Use of Laboratory Animals to minimize the suffering and discomfort of experimental animals.
Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice
Abstract
A strong animal survival instinct is to approach objects and situations that are of benefit and to avoid risk. In humans, a large ...
Shanghai Jiao Tong University), and C57BL/6J mice (Guangdong Medical Laboratory Animal Center, Guangzhou, China). To generate the DISC1-NTM
Immunologically relevant aspects of the new COVID-19 vaccines—an ÖGAI (Austrian Society for Allergology and Immunology) and AeDA (German Society for Applied Allergology) position paper
Summary
Background
The vaccines against the coronavirus disease 2019 (COVID-19) approved in the European Union represent a decisive step in ...
the 1st injection and 94% after the 2nd injection [9]. In animal experiments, a sharp drop in virus-neutralising antibodies was observed
Activation of the DDR Pathway Leads to the Down-Regulation of the TGFβ Pathway and a Better Response to ICIs in Patients With Metastatic Urothelial Carcinoma
Immune checkpoint inhibitors (ICIs) have changed the treatment paradigm of metastatic urothelial carcinoma (mUC), a dominant type of ...
in other cancers. We hope to perform corresponding cell experiments or animal experiments in the future to determine the influence of the
mRNA vaccine yields full protection against malaria in mice
Scientists from the Walter Reed Army Institute of Research and Naval Medical Research Center partnered with researchers at the University ...
adheres to principles stated in the Guide for the Care and Use of Laboratory Animals, NRC Publication, 2011 edition.
About the Walter Reed
Schisandrin B Attenuates Airway Inflammation and Airway Remodeling in Asthma by Inhibiting NLRP3 Inflammasome Activation and Reducing Pyroptosis
Abstract
Asthma is a chronic inflammatory disorder of the airways. Schisandrin B (SB) is the main effective component. This ...
of Longhua Hospital. All the animal experiments were implemented on the guide for the care and use of laboratory animals and on minimized
"Hidden": Animals Struggling to Coexist in the Anthropocene
An unflinching book of photography about our global conflicts with non-humans.
we’re eating a calf, for example, we say we’re eating veal. And in animal research, an animal is “sac’ed”—sacrificed—when they are finished
pharmaceuticals-1207786
Pharmaceuticals 2021, 14, 590. https://doi.org/10.3390/ph14060590 www.mdpi.com/journal/pharmaceuticals
Article
Dextran Sodium Sulphate‐ ...
gastrointestinal anatomy, physiology, and biochemistry of humans and commonly
used laboratory animals. Biopharm. Drug Dispos. 1995, 16, 351
Single-Oocyte Gene Expression Suggests That Curcumin Can Protect the Ovarian Reserve by Regulating the PTEN-AKT-FOXO3a Pathway
International Journal of
Molecular Sciences
Article
Single-Oocyte Gene Expression Suggests That Curcumin Can
Protect the Ovarian Reserve ...
the 30 6-to-8-month-old mice were provided by the Shandong University Laboratory
Animal Center.
4.2. Custom TaqMan Array Cards
A total of 91
Evaluation of Allicin Against Alveolar Echinococcosis In Vitro and in a Mouse Model
Abstract
Purpose
At present, the chemotherapy for alveolar echinococcosis (AE) is mainly based on albendazole (ABZ). However, more than 20 ...
of China and the Measures of Qinghai Province for the Administration of Laboratory Animals and were approved by the Ethics Committee of the
ijms-1182890
Int. J. Mol. Sci. 2021, 22, 6565. https://doi.org/10.3390/ijms22126565 www.mdpi.com/journal/ijms
Article
The Anti‐Tumor Activity ...
Pharmaceutical Company.
Institutional Review Board Statement: All animal experiments were approved by the Baylor
College of
Paradoxical changes in mood-related behaviors on continuous social isolation after weaning
Abstract
Continuous social isolation (SI) from an early developmental stage may have different effects in youth and adulthood. Moreover, SI ...
, employment status, and other covariates (Ge et al. 2017). In animal experiments, SI-induced rats have been used as a model of depression.
HDAC Inhibitor Abrogates LTA−Induced PAI-1 Expression in Pleural Mesothelial Cells and Attenuates Experimental Pleural Fibrosis
Lipoteichoic acid (LTA) stimulates pleural mesothelial cell (PMC) to overproduce plasminogen activator inhibitor-1 (PAI-1), and thus may ...
Rat Model
The animal research was conducted following the National Research Council Guide for the Care and use of Laboratory Animals, and
ijms-1209351-FC done
Int. J. Mol. Sci. 2021, 22, 6559. https://doi.org/10.3390/ijms22126559 www.mdpi.com/journal/ijms
Article
Is the Jaw Bone Micro‐ ...
. It is yet to be seen if the results from the
osteoporosis animal experiment can be extrapolated to humans [26]. Furthermore, the
pathogens-1253033 - FC done
Pathogens 2021, 10, 768. https://doi.org/10.3390/pathogens10060768 www.mdpi.com/journal/pathogens
Article
Evaluation of Lesions ...
pigs presented in this study have
been previously described [35]. Animal experiments were carried out in the biosafety level
3 (BSL3)
ijms-1249686
Int. J. Mol. Sci. 2021, 22, 6553. https://doi.org/10.3390/ijms22126553 www.mdpi.com/journal/ijms
Article
In Vitro and In Vivo ...
ad libitum.
4.3.2. Ethical Approval
All animal experiments were done in accordance with the German Law on the
protection of
Photobiomodulation Therapy as a Possible New Approach in COVID-19: A Systematic Review
COVID-19 is a viral disease characterized as a pandemic by the World Health Organization in March 2020. Since then, researchers from all ...
COVID-19.
Pinto et al., 2020 [32]
Experimental, in vivo research
Animal/mice
This study aimed to characterize the PDT associated with the
ijms-1244445 - FC done
Int. J. Mol. Sci. 2021, 22, 6551. https://doi.org/10.3390/ijms22126551 www.mdpi.com/journal/ijms
Review
Estrogen Receptor ...
in COVID−19 patients. This principle was
proposed and tested in animal experiments and in a limited clinical study performed in
COVID−19
Inhibition of Oxidative Stress and ALOX12 and NF-B Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury
antioxidants
Article
Inhibition of Oxidative Stress and ALOX12 and NF-κB
Pathways Contribute to the Protective Effect of Baicalein on
...
Animal Care and Use Committee at the China Agricultural University
approved all animal experiments in this study. Male C57 BL/6 mice (8
Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease
Previous studies have shown that the CD40L-CD40 signaling axis plays a role in atherosclerosis. Here the authors investigate the cell- ...
following institutional guidelines. All animal experiments were approved by the local ethical committee for animal experimentation (TVA #55.
The pan-cancer lncRNA PLANE regulates an alternative splicing program to promote cancer pathogenesis
Genomic amplification of chromosome 3q often encodes proteins that contribute to cancer development. Here the authors identify a non-coding ...
of 4-week-old female nude mice (6 mice per group, Shanghai SLAC Laboratory Animal Co. Ltd., China). Tumour growth was measured every 3 days
The LIM domain protein nTRIP6 modulates the dynamics of myogenic differentiation
Abstract
The process of myogenesis which operates during skeletal muscle regeneration involves the activation of muscle stem cells, the so- ...
animals were handled according to German regulations for animal experimentation and experiments were authorized by the Regierungspräsidium
Combined Exposure to Metals in Drinking Water Alters the Dopamine System in Mouse Striatum
Environmental exposure to arsenic (As), lead (Pb), and cadmium (Cd) frequently occurs; however, data on the specific effects of combined ...
were conducted according to NIH guidelines for the care and use of laboratory animals. Animals were housed in a specific pathogen-free (SPF)
Inhibition of discoidin domain receptors by imatinib prevented pancreatic fibrosis demonstrated in experimental chronic pancreatitis model
Abstract
Discoidin domain receptors (DDR1 and DDR2) are the collagen receptors of the family tyrosine kinases, which play significant role ...
. The Animal experiments were designed, conducted and reported as per the ARRIVE guidelines19. Specifically, all the animal experiments were
Low-intensity pulsed ultrasound attenuates replacement root resorption of avulsed teeth stored in dry condition in dogs
Abstract
This study aimed to investigate the effects of low-intensity pulsed ultrasound (LIPUS) on replacement root resorption after ...
daily for the duration of the study in the Department of Laboratory Animal Resources, Yonsei Biomedical Research Institute, Seoul, Republic
Basement membrane collagen IV deficiency promotes abdominal aortic aneurysm formation
Abstract
Abdominal aortic aneurysm (AAA) is a complex disease which is incompletely accounted for. Basement membrane (BM) Collagen IV ( ...
with protocols approved by the local authorities (the Danish Animal Experiments Inspectorate) and conform to the guidelines from Directive
Neonatal administration of a subanaesthetic dose of JM-1232(−) in mice results in no behavioural deficits in adulthood
Abstract
In animal models, neonatal exposure of general anaesthetics significantly increases apoptosis in the brain, resulting in ...
Google Scholar
48.
Smith, W. Responses of laboratory animals to some injectable anaesthetics. Lab. Anim. 27, 30–39 (1993)
Combination of 131I-trastuzumab and lanatoside C enhanced therapeutic efficacy in HER2 positive tumor model
Abstract
Lanatoside C has a promising anti-tumor activity and is a potential candidate for radiosensitizers. In this study, we have ...
/c nude mice were obtained from Dooyeol Biotech, Korea. All animal experiments were approved by the Committee for the Handling and Use of
How Different Personalities Affect the Reaction to Adoption of Dogs Adopted from a Shelter
Dog shelters provide a valuable service by housing homeless dogs and seeking subsequent adoption for these dogs. Few studies have aimed to ...
Gosling, S.D. From mice to men: What can we learn about personality from animal research? Psychol. Bull. 2001, 127, 45–86. [Google Scholar]
Exosomes Derived from Fisetin-Treated Keratinocytes Mediate Hair Growth Promotion
Enhanced telomerase reverse transcriptase (TERT) levels in dermal keratinocytes can serve as a novel target for hair growth promotion. ...
hair growth was evaluated. Animal experiments were conducted in accordance with the “Guide for the Care and Use of Laboratory Animals” and
Untangling the influence of biotic and abiotic factors on habitat selection by a tropical rodent
Abstract
Understanding how animal populations respond to environmental factors is critical because large-scale environmental processes (e.g ...
: SF010079) in accordance with the international ‘Principles of Laboratory Animal Care’.
Results
Temperature
Removing the lower foliage
Early-adolescent antibiotic exposure results in mitochondrial and behavioral deficits in adult male mice
Abstract
Exposure to antibiotic treatment has been associated with increased vulnerability to various psychiatric disorders. However, a ...
, D. G. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. PLoS Biol. 8, e1000412. https://doi.
Preventing post-surgical cardiac adhesions with a catechol-functionalized oxime hydrogel
Postsurgical adhesions are a problem during routine cardiothoracic procedures. Here, the authors report on a catechol functionalised ...
S09168) and performed in an American Association for Accreditation of Laboratory Animal Care (AAALAC) accredited facility (No. 00503). Pigs
High-throughput screening and rational design of biofunctionalized surfaces with optimized biocompatibility and antimicrobial activity
Optimizing the concentration of different functional peptides on a surface can be a complex process. Here, the authors report on the use of ...
were approved by the Institutional Animal Care and Use Committee of Guangdong Medical Laboratory Animal Center (Foshan, China). Overall, 40
ijms-1245268-FC done
Int. J. Mol. Sci. 2021, 22, 6542. https://doi.org/10.3390/ijms22126542 www.mdpi.com/journal/ijms
Article
P2X7 Receptors and ...
procedures complied with official European guidelines for the care
and use of laboratory animals (Directive 2010/63/UE) and were approved
Estradiol regulates intestinal ABCG2 to promote urate excretion via the PI3K/Akt pathway
Objectives
The study of sex differences in hyperuricemia can provide not only a theoretical basis for this clinical phenomenon but also new ...
All animal procedures were approved by the ethics committee of the Animal Experiments Committee of Fudan University.
The hyperuricemia mouse
The Effect of Adding Modified Chitosan on the Strength Properties of Bacterial Cellulose for Clinical Applications
Currently, several materials for the closure of the dura mater (DM) defects are known. However, the long-term results of their usage reveal ...
versus a cadaveric dura graft for the repair of dural defects–a comparative animal experimental study. Acta Neurochir. 2005, 147, 877–887. [
Cannabidiol promotes neurogenesis in the dentate gyrus during an abstinence period in rats following chronic exposure to methamphetamine
Abstract
Chronic methamphetamine (meth) abuse can lead to certain deficits in the hippocampal function by affecting the hippocampal ...
accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals (NIH Publication No. 80–23, revised 1996)
Kildare finalists shine bright for Miss Ireland 2021
A dreamy enchanted castle, an optimistic rainbow of colours, an ambitious philanthropic goal and excited smiles marked the announcement of ...
in UCD with the goal of someday going on to study veterinary or go into animal research.
Miss Kildare North is Alannah Pardy, a 20-year-old
Methylglyoxal-Derived Advanced Glycation End Product (AGE4)-Induced Apoptosis Leads to Mitochondrial Dysfunction and Endoplasmic Reticulum Stress through the RAGE/JNK Pathway in Kidney Cells
Advanced glycation end products (AGEs) are formed via nonenzymatic reactions between reducing sugars and proteins. Recent studies have ...
using a microplate reader (HIDEX, Turku, Finland).
4.3. In Vivo Animal Experiments
C57BL/6N mice (4 weeks of age, male) were purchase from
Fundamental dietary specialisation explains differential use of resources within a koala population
Abstract
The diets of individual animals within populations can differ, but few studies determine whether this is due to fundamental ...
koalas. The study was approved by the Australian National University Animal Experimentation Ethics Committee (protocol A2017/03), and was
MiR-93 inhibits the vascular calcification of chronic renal failure by suppression of Wnt/β-catenin pathway
Abstract
Objective
To explore the effect of miR-93-mediated Wnt/β-catenin pathway on the vascular calcification (VC) of chronic renal ...
.
Bayne K (1996) Revised guide for the care and use of laboratory animals available. American physiological society. Physiologist 39(4):199,
Effects of chronic voluntary alcohol consumption on PDE10A availability: a longitudinal behavioral and [18F]JNJ42259152 PET study in rats
Abstract
Purpose
Phosphodiesterase 10A (PDE10A) is a dual substrate enzyme highly enriched in dopamine-receptive striatal medium spiny ...
Ethics declarations
Ethics approval
All animal experiments were conducted according
Effects of Zinc Lactate Supplementation on Growth Performance, Intestinal Morphology, Serum Parameters, and Hepatic Metallothionein of Chinese Yellow-Feathered Broilers
Abstract
In poultry, organic zinc compounds have higher bioavailability than inorganic zinc sources. However, as an organic zinc source, ...
Foshan University, which were in accordance with ethical standards in Laboratory animal-guideline for ethical review of animal welfare (The
Characterization of βN-Octadecanoyl-5-hydroxytryptamide Anti-Inflammatory Effect
Background: N-octadecanoyl-5-hydroxytryptamide (C18-5HT) is an amide that can be obtained by the coupling of serotonin and octadecanoic ...
by the National Council for the Control of Animal Experimentation (CONCEA), approved by the Ethical Committee for Animal Research (no. 35/19
Introduction of Mouse Embryonic Fibroblasts into Early Embryos: From Confusion to Constructive Discussion. Comment on Savatier, P. Introduction of Mouse Embryonic Fibroblasts into Early Embryos Causes Reprogramming and (Con)fusion. Cells 2021, 10, 772
We would like to address the issues raised by Pierre Savatier in “Introduction of Mouse Embryonic Fibroblasts into Early Embryos Causes ...
no. 58/2006 of the Third Local Ethical Committee on Animal Experimentation in Warsaw and in a designated facility of the University of
Sublethal effects of propiconazole on the metabolism of lambari Deuterodon iguape (Eigenmann 1907), a native species from Brazil
Abstract
The objective of this study was to analyze the sublethal effects of propiconazole on Deuterodon iguape, a native fish common in ...
This study followed the ethical principles for animal experimentation adopted by the Brazilian School of Animal Experimentation (COBEA) and
Automatic chronic degenerative diseases identification using enteric nervous system images
Abstract
Studies recently accomplished on the Enteric Nervous System have shown that chronic degenerative diseases affect the Enteric Glial ...
work is virtually insurmountable. It involves the induction of diseases to the research animals. It also needs to be approved in a long-term
Cigarette smoke extract-treated airway epithelial cells-derived exosomes promote M1 macrophage polarization in chronic obstructive pulmonary disease
Highlights
•
TREM-1 expression was increased in ExoCSE compared to ExoPBS.
•
ExoCSE promoted M1 macrophage polarization by upregulating ...
partly reversed by TREM-1 knockdown. The results of animal experiments showed that ExoCSE administration aggravated CS-induced impairment in
Stress during first gestation of ewes impairs memory and learning of male offspring
Abstract
This study aimed to investigate the influence of gestational stress induced by lipopolysaccharide (LPS, Escherichia coli) on the ...
as with the rules issued by the National Council for Control of Animal Experimentation (CONCEA), and was approved by the Ethic Committee on
CBD Advantages: Full Information and 6 Greatest Manufacturers – NEWPAPER24
advertising
advertising
This text incorporates affiliate hyperlinks to merchandise. Uncover could obtain a fee for purchases made via these ...
lot of the proof out there right now is anecdotal and based mostly on animal research. There’s a rising want for a lot of extra human-based
Superior adsorptive removal of brilliant green and phenol red dyes mixture by CaO nanoparticles extracted from egg shells
Abstract
Calcium oxide (CaO) is an up-and-coming adsorbent, effectively accessible and extractable from natural resources. In this paper, ...
– Satnam Singh
– Bonamali Pal
Animal research
There is no harm
Effect of short-term mild salinity stress on physiological and hematological parameters in sheep
Abstract
Contamination of water through salinization will affect the well-being of livestock. Therefore, it is necessary to understand how ...
licenses for experiments on animals approved the animal experimentations.
Consent for publication
Ursula K. Le Guin skriver galgenhumoristisk fra forsøgsdyrets perspektiv
Endnu et øjenåbnende kortprosaværk udkommer på Forlaget Virkelig
Ursula K. Le Guin skriver galgenhumoristisk fra forsøgsdyrets perspektiv
Moving Away from Individual Responsibility: A Comment
Abstract
In this comment, we suggest there has been a crusade among some gambling stakeholders to move the field away from personal ...
Rights
This article does not contain human subjects or animal research.
Additional information
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Springer
Pharmacokinetic–pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies
Abstract
Background
CGM097 inhibits the p53-HDM2 interaction leading to downstream p53 activation. Preclinical in vivo studies support ...
to the ethical principles of the Declaration of Helsinki. All animal experiments were performed according to procedures covered by permit
Cattle In Vitro Induced Pluripotent Stem Cells Generated and Maintained in 5 or 20% Oxygen and Different Supplementation
The event of cellular reprogramming into pluripotency is influenced by several factors, such as in vitro culture conditions (e.g., culture ...
Council for Control of Animal Experimentation (CONCEA) and were approved by the Ethics Committee on Animal Experimentation of the Faculty of
The B Chromosomes of Prochilodus lineatus (Teleostei, Characiformes) Are Highly Enriched in Satellite DNAs
B or supernumerary chromosomes are dispensable elements that are widely present in numerous eukaryotes. Due to their non-recombining nature ...
animals were carried out in accordance with the international rules on animal experimentation followed by the Ethics Committee on the Use of
Mitigating the Growth, Biochemical Changes, Genotoxic and Pathological Effects of Copper Toxicity in Broiler Chickens by Supplementing Vitamins C and E
This experiment was carried out to explore the efficiency of an individual or combined doses of vitamin C (Vit. C) and vitamin E (Vit. E) ...
). All animal experiments were performed following the recommendations described in “The Guide for the Care and Use of Laboratory Animals in
Genotyping Assay Market Analysis 2021 along with Global Research Report
Global Genotyping Assay market gives essential information, objective insights regarding global market top key players analysis, and much ...
Assay Market is segmented into:
Pharmacogenomics
Diagnostic Research
Animal Genetics
Agricultural Biotechnology
Others
Geographically,
Might This Millennia-Outdated Treatment Turn out to be a Pharmaceutical Marvel? – NEWPAPER24
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The black cumin or Nigella sativa plant has been used for greater than 2,000 years in conventional treatments all ...
drugs techniques like Ayurveda and Unani, each cell tradition and animal research (together with a smaller variety of human ones) have
Methamphetamine Exposure During Development Causes Lasting Changes to Mesolimbic Dopamine Signaling in Mice
Abstract
Methamphetamine (MA) abuse remains a public health issue. Prenatal MA exposure (PME) poses a significant health problem, as we ...
the National Research Council’s Guide for the Care and Use of Laboratory Animals.
Additional information
Publisher's Note
Springer Nature
Progesterone and Allopregnanolone Neuroprotective Effects in the Wobbler Mouse Model of Amyotrophic Lateral Sclerosis
Abstract
Progesterone regulates a number of processes in neurons and glial cells not directly involved in reproduction or sex behavior. ...
in this review followed the Guide for the Care and Use of Laboratory Animals (NIH Guide, Instituto de Biologia y Medicina Experimental
Kildare is represented by two contestants in this year's Miss Ireland pageant
Kildare is well represented this year at Miss Ireland with two contenders for the coveted Miss Ireland crown. Miss Kildare is Fiona Ni ...
in UCD with the goal of someday going on to study veterinary or go into animal research.
Miss Kildare North is Alannah Pardy, a 20-year-old
Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance
Polθ has been recently identified as a therapeutic target in cancer but specific inhibitors are currently unavailable. Here, the authors ...
the National Research Council Guide for the Care and Use of Laboratory Animals.
Real time cell proliferation and apoptosis assay
Cells in
Protective Effects of Small-Molecule Oligopeptides Isolated from Tilapia Fish Scale on Ethanol-Induced Gastroduodenal Injury in Rats
Peptic ulcer has a serious impact on people’s health around the world, and traditional medicines can cause adverse reactions. This study ...
freely during the experiment. Laboratory animal production license number: SCXK (Beijing) 2016-0010, Laboratory animal use license number:
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