Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma

marine drugs Article Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma Shohei Tsuji 1, Shinsuke Nakamura 1,*, Takashi ...

with ARRIVE (Animal Research: Reporting in Vivo Experiments) guidelines. These experiments were approved by the animal ...

Animal Transportation Market Players Analysis: DSV, FedEx, IAG Cargo Logistics, United Parcel Service

Latest Market Analysis Research Report on “Global Animal Transportation Market 2020” has been added to Wise Guy Reports database.

by air Market segment by Application, split into Livestock Pets Research Animals Zoo Animals Aquarium Animals Others Market ...

Prepulse Inhibition of the Auditory Startle Reflex Assessment as a Hallmark of Brainstem Sensorimotor Gating Mechanisms

brain sciences Review Prepulse Inhibition of the Auditory Startle Reflex Assessment as a Hallmark of Brainstem Sensorimotor Gating ...

of the PPI-mediating circuits based on experiments carried out on laboratory animals. All the proposed human-related startle ...

IIAEK Targets Intestinal Alkaline Phosphatase (IAP) to Improve Cholesterol Metabolism with a Specific Activation of IAP and Downregulation of ABCA1

IIAEK (Ile-Ile-Ala-Glu-Lys, lactostatin) is a novel cholesterol-lowering pentapeptide derived from bovine milk β-lactoglobulin. ...

to the manufacturer’s protocol. The Ethics Committee on Animal Experiments at Gifu University approved all the experimental ...

Beneficial effect of STAT3 decoy oligodeoxynucleotide transfection on organ injury and mortality in mice with cecal ligation and puncture-induced sepsis

Abstract Sepsis is a major clinical challenge with unacceptably high mortality. The signal transducers and activators of transcription (...

by the Research Facility of Toyama University (A2018MED-30) and the Animal Research Facility of Nagoya University (20327, 31345). ...

Optimization of tamoxifen-induced Cre activity and its effect on immune cell populations

Abstract Tamoxifen (TAM) inducible Cre recombinase system is an essential tool to study gene function when early ablation or overexpression...

**p ≤ 0.001, ****p ≤ 0.0001. Ethics statement Animal experiments were carried out at the Columbia Center for Translation ...

A dietary anthocyanin cyanidin-3-O-glucoside binds to PPARs to regulate glucose metabolism and insulin sensitivity in mice

Jia, Wu, Kim et al. show that cyanidin-3-O-glucoside (C3G), a major dietary anthocyanin, functions as a ligand for PPARalpha to regulate ...

80 °C for further use. All animal experiments were performed according to a protocol approved by the Animal Experiment ...

Technological approaches to streamline vaccination schedules, progressing towards single-dose vaccines

Abstract Vaccines represent the most successful medical intervention in history, with billions of lives saved. Although multiple doses of ...

responses induced by human and chimpanzee adenovirus vectors differs between laboratory animals and a target species. Vaccine 33, ...

Adeno-associated virus-mediated gene delivery promotes S-phase entry-independent precise targeted integration in cardiomyocytes

Abstract Post-mitotic cardiomyocytes have been considered to be non-permissive to precise targeted integration including homology-directed ...

, 2011) and were approved by the Osaka University Committee for Laboratory Animal Use. gRNA and repair template constructs gRNA ...

Ultrasound neuromodulation depends on pulse repetition frequency and can modulate inhibitory effects of TTX

Abstract Ultrasound is gaining traction as a neuromodulation method due to its ability to remotely and non-invasively modulate neuronal ...

established by the National Research Council, the Guide for the Care and Use of Laboratory Animals. In brief, mice (both male and ...

Investigation into the effect of divergent feed efficiency phenotype on the bovine rumen microbiota across diet and breed

Abstract The relationship between rumen microbiota and host feed efficiency phenotype, for genetically divergent beef cattle breeds is ...

(2019) (in submission). Download references Acknowledgements The animal experiment was funded through a Department of Agriculture...

Nitro-fatty acids suppress ischemic ventricular arrhythmias by preserving calcium homeostasis

Abstract Nitro-fatty acids are electrophilic anti-inflammatory mediators which are generated during myocardial ischemic injury. Whether ...

Protection (LANUV), NRW, Germany) and follow ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines. Left anterior ...

antioxidants-922204-FC done

Antioxidants 2020, 9, 885; doi:10.3390/antiox9090885 www.mdpi.com/journal/antioxidants Article Retinoprotective Effect of Wild Olive (...

(RD 53/2013) guidelines for the care and use of laboratory animals, and was approved by the competent Institutional Animal Care ...

DsbA-L mediated renal tubulointerstitial fibrosis in UUO mice

DsbA-L upregulation prevents lipid-induced renal injury in diabetic nephropathy. Here, the authors show that DsbA-L knockout attenuates ...

at a dose of 15 mg/kg, with saline as a control. Animal experiments were performed in accordance with guidelines approved by the ...

SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells

Cancer stem cells can evade treatment. Here, the authors perform an in vitro screen to identify proteins that are involved in protecting ...

5% CO2. All intracranial studies were carried out according to Danish Welfare Law on Animal Experiments Act no 1306, protocol: ...

A 12-storey pig farm: has China found a way to stop future pandemics?

Nucleic Acid Isolation & Purification Market Research Report by Product, by Method, by Type, by Application, by End User - Global Forecast to 2025 - Cumulative Impact of COVID-19

Nucleic Acid Isolation & Purification Market Research Report by Product (Instruments, Kits, and Reagents), by Method (Column-based ...

Nucleic Acid Isolation & Purification Market studied across Agriculture & Animal Research, Diagnostics, Drug Discovery & ...

Forsker vil forbinde danske ræve med rumstation

Det nye forskningsprojekt Icarus overvåger dyr fra rummet. En dansk forsker vil videreudvikle teknologien og blandt andet spore danske ræve...

med det tysk-russiske forskningsprojekt Icarus (International Cooperation for Animal Research Using Space). I denne måned ...

Tackling respiratory diseases with advanced non-animal models

A new JRC study describes almost 300 non-animal models used for research on respiratory diseases and the development of new drugs and ...

for scientific purposes, the final goal of EU policy is the full replacement of animal experiments as soon as scientifically ...

Study shows SARS-CoV-2 jumped between people and mink, providing strong evidence of zoonotic transmission

A study investigating SARS-CoV-2 infections across 16 mink farms in the Netherlands, being presented at the ESCMID Conference on ...

is still unknown, although various theories have been put forward. Animal experiments have shown that non-human primates, ferrets...

Involvement of Capsaicin-Sensitive Lung Vagal Neurons and TRPA1 Receptors in Airway Hypersensitivity Induced by 1,3–D-Glucan in Anesthetized Rats

International Journal of Molecular Sciences Article Involvement of Capsaicin-Sensitive Lung Vagal Neurons and TRPA1 Receptors in Airway ...

the recommendations found in the “Guide for the Care and Use of Laboratory Animals” published by the National Institutes of Health...

Nucleic Acid Isolation & Purification Market Research Report by Product, by Method, by Type, by Application, by End User - Global Forecast to 2025 - Cumulative Impact of COVID-19

Nucleic Acid Isolation & Purification Market Research Report by Product (Instruments, Kits, and Reagents), by Method (Column-based ...

Nucleic Acid Isolation & Purification Market studied across Agriculture & Animal Research, Diagnostics, Drug Discovery & ...

Stearoyl-CoA Desaturase 1 Activity Determines the Maintenance of DNMT1-Mediated DNA Methylation Patterns in Pancreatic -Cells

International Journal of Molecular Sciences Article Stearoyl-CoA Desaturase 1 Activity Determines the Maintenance of DNMT1-Mediated DNA ...

used in this study were approved by the First Local Ethical Committee for Animal Experiments in Warsaw (Permit number: 37/2016, ...

Oxidative Stress in Rats is Modulated by Seasonal Consumption of Sweet Cherries from Different Geographical Origins: Local vs. Non-Local

Sweet cherries (Prunus avium L.) are a source of bioactive compounds, including phenolic compounds, which are antioxidants that contribute ...

at −80 °C until use. The Ethical Committee of Animal Experimentation of the Rovira i Virgili University approved the experimental ...

Anti-inflammatory activities of puerarin in high-fat diet-fed rats with streptozotocin-induced gestational diabetes mellitus

Abstract To investigate the effect of puerarin on insulin resistance and inflammation in rats with gestational diabetes mellitus (GDM). ...

Hospital Affiliated to Nanjing University of Chinese Medicine. All animal experiments performed in this study were in accordance ...

1,4-Disubstituted-1,2,3-Triazole Compounds Induce Ultrastructural Alterations in Leishmania amazonensis Promastigote: An in Vitro Antileishmanial and in Silico Pharmacokinetic Study

The current standard treatment for leishmaniasis has remained the same for over 100 years, despite inducing several adverse effects and ...

in accordance with the National Council for Control of Animal Experimentation (Conselho Nacional de Controle de Experimentação ...

Study shows SARS-CoV-2 jumped between people and mink, providing strong evidence of zoonotic transmission

A study investigating SARS-CoV-2 infections across 16 mink farms in the Netherlands, being presented at the ESCMID Conference on ...

is still unknown, although various theories have been put forward. Animal experiments have shown that non-human primates, ferrets...

Scavenging by threatened turtles regulates freshwater ecosystem health during fish kills

Abstract Humans are increasing the frequency of fish kills by degrading freshwater ecosystems. Simultaneously, scavengers like freshwater ...

-3.0, and Western Sydney University Animal Ethics Committee Animal Research Authority approval A12390, observing all relevant ...

Photoacoustic Imaging for Assessing Tissue Oxygenation Changes in Rat Hepatic Fibrosis

Chronic liver inflammation progressively evokes fibrosis and cirrhosis resulting in compromised liver function, and often leading to cancer...

, 3620 Hamilton Walk, Philadelphia, PA 19104, USA 2 University Laboratory Animal Resources, University of Pennsylvania, 3800 ...

applsci-892346-FC done

Appl. Sci. 2020, 10, 6493; doi:10.3390/app10186493 www.mdpi.com/journal/applsci Article Establishing Correlations between Breast Tumor ...

‐imaged, and tumors were outlined as depicted in Figure 1. All animal experiments were approved by the Institution of Animal Care...

Antibody escape by polyomavirus capsid mutation facilitates neurovirulence

JCPyV polyomavirus, a member of the human virome, causes Progressive Multifocal Leukoencephalopathy (PML), an oft-fatal demyelinating brain...

is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC). The ...

Discovery and preclinical efficacy of HSG4112, a synthetic structural analog of glabridin, for the treatment of obesity

Abstract Background HSG4112 is a clinical-stage drug candidate for the treatment of obesity. Here, we report its discovery and preclinical ...

detect sufficient statistical significance in the main study. All animal experiment procedures were in compliance with the Animal ...

Low-Dose Nicotine Activates EGFR Signaling via 5-nAChR and Promotes Lung Adenocarcinoma Progression

International Journal of Molecular Sciences Article Low-Dose Nicotine Activates EGFR Signaling via α5-nAChR and Promotes Lung ...

) of Taiwan. We thank Ming-Long Tsai for technical support in animal experiments. Conflicts of Interest: The authors declare no ...

antibiotics-937022-FC done

Antibiotics 2020, 9, 614; doi:10.3390/antibiotics9090614 www.mdpi.com/journal/antibiotics Article Antimicrobial Resistance Genes in ...

experimental procedures were approved by the Ethics Committee for Animal Experimentation of the University of Lleida and...

3D Bioprinting Gains a Foothold in Biomedicine

3D printing has revolutionized manufacturing by reducing costs and giving designers and engineers immense flexibility. Could 3D bioprinting...

expectations, such as 3D printing organs for transplantation or replacing animal research. Such breakthroughs may still be far ...

Using C-doped TiO2 Nanoparticles as a Novel Sonosensitizer for Cancer Treatment

Sonodynamic therapy is an effective treatment for eliminating tumor cells by irradiating sonosentitizer in a patient’s body with ...

suspended in 200 μL 1X PBS into the right thigh. All the animal experiments were approved by National Health Research Institutes (...

Enhanced Chemotherapy for Glioblastoma Multiforme Mediated by Functionalized Graphene Quantum Dots

Glioblastoma is the most aggressive and lethal brain cancer. Current treatments involve surgical resection, radiotherapy and chemotherapy. ...

, with national laws (Legislative Decree 116/ 1992) and European Union guidelines on animal research (No. 86/609/EEC) [32]. ...

Critical Perspective of Animal Production Specialists on Cell-Based Meat in Brazil: From Bottleneck to Best Scenarios

Recently, many studies regarding consumer perception of cell-based meat have been published. However, the opinion of the professionals ...

on Animal Welfare: An OIE* Initiative, ALTEX-Alternatives to Animal Experimentation; ELSEVIER: Amsterdam, The Netherlands, 2004; ...

The phosphoproteomic responses of duck (Cairna moschata) to classical/novel duck reovirus infections in the spleen tissue

Abstract Duck reovirus (DRV) is a fatal member of the genus Orthoreovirus in the family Reoviridae. The disease caused by DRV leads to huge...

applied in protein phosphorylation level analysis. Ethics statement Animal experiments were performed in the Institute of Animal ...

Effects of different social experiences on emotional state in mice

Abstract A comprehensive understanding of animals’ emotions can be achieved by combining cognitive, behavioural, and physiological measures...

. Ethics statement All procedures complied with the regulations covering animal experimentation within Germany (Animal Welfare Act...

Transcriptomic sex differences in sensory neuronal populations of mice

Abstract Many chronic pain conditions show sex differences in their epidemiology. This could be attributed to sex-dependent differential ...

gonadal hormones44,87,88. Materials and methods Mouse lines and tissues All animal experiments conformed to APS's Guiding ...

Evaluation of a Bacterial Single-Cell Protein in Compound Diets for Rainbow Trout (Oncorhynchus mykiss) Fry as an Alternative Protein Source

A 60-day trial was conducted in rainbow trout (Oncorhynchus mykiss) fry (initial weight = 2.5 ± 0.6 g) to evaluate the potential use...

at 15 °C for 10 min in cooler after extrusion. Animal experimentation procedures were approved by the Ethics Committee in the ...

Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing

bioengineering Review Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing Patrick Bédard 1,2, ...

. 1.4.2. Reduction In 2018, 780,070 animals were used for animal research in the United States [10]. This number excludes many ...

Abatement of the Stimulatory Effect of Copper Nanoparticles Supported on Titania on Ovarian Cell Functions by Some Plants and Phytochemicals

The application of nanoparticles has experienced a vertiginous growth, but their interaction with food and medicinal plants in organisms, ...

of CuNPs that can be ingested and that have been applied in previous animal experiments, both in vivo and in vitro [20,58,59,60,61...

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells

How lipid metabolism can affect cancer recurrence is still unclear. Here, the authors show that the lysophospholipase D Gdpd3 maintains ...

M. and K.S. provided viable BMMNCs from a human CML patient. Y.S. supported animal experiments. D.-W.K. supported CML research. A....

Punica granatum L.-derived omega-5 nanoemulsion improves hepatic steatosis in mice fed a high fat diet by increasing fatty acid utilization in hepatocytes

Abstract Pomegranate seed oil (PSO) is mainly composed of punicic acid (PA), a polyunsaturated fatty acid also known as omega-5 (ω-5), a ...

at week 14 by indirect calorimetry using the Oxymax CLAMS system (Comprehensive Laboratory Animal Monitoring System, Columbus, OH...

Somatostatin 1.1 contributes to the innate exploration of zebrafish larva

Abstract Pharmacological experiments indicate that neuropeptides can effectively tune neuronal activity and modulate locomotor output ...

the modulatory circuits involved. Methods Animal care All animal experimental procedures were approved by the Institutional Ethics...

Endothelial dysfunction in small arteries and early signs of atherosclerosis in ApoE knockout rats

Abstract Endothelial dysfunction is recognized as a major contributor to atherosclerosis and has been suggested to be evident far before ...

Food of Denmark for animal experiments, approval number 2018–15-0,201–01,477. All studies were performed in accordance with ...

The influenza virus NS1A binding protein gene modulates macrophages response to cytokines and phagocytic potential in inflammation

Abstract Macrophages show remarkable phenotypic plasticity in response to environmental signals. Although it is generally less considered, ...

with the approved European Union guidelines for the handling and care of laboratory animals. We used Sprague Dawley rats (225–250 ...

Downregulation of the CCL2/CCR2 and CXCL10/CXCR3 axes contributes to antitumor effects in a mouse model of malignant glioma

Abstract Glioblastoma multiforme involves glioma stem cells (GSCs) that are resistant to various therapeutic approaches. Here, we studied ...

Keyence, Osaka, Japan) equipped image analysis system. Animal experiments Experiments were performed according to the National ...

Bone-on-a-chip device could lessen need for animal experiments

Engineers have developed a bone-on-a-chip device that grows human bone tissue in the laboratory, an advance that could reduce the need for ...

a human-on-a-chip that would remove the need for animal research when developing new medical treatments. In vitro testing of new ...

Enhanced Intestinal Absorption and Pharmacokinetic Modulation of Berberine and Its Metabolites through the Inhibition of P-Glycoprotein and Intestinal Metabolism in Rats Using a Berberine Mixed Micelle Formulation

pharmaceutics Article Enhanced Intestinal Absorption and Pharmacokinetic Modulation of Berberine and Its Metabolites through the Inhibition...

cycle. Food and water were supplied ad libitum for 1 week prior to the animal experiment. 2.7.2. Pharmacokinetic Study The rats ...

Transdermal Fentanyl Uptake at Two Different Patch Locations in Swiss White Alpine Sheep

When using animals in biomedical research, investigators have the responsibility to ensure adequate analgesia. Currently, transdermal ...

] Carbone, L.; Austin, J. Pain and laboratory animals: Publication practices for better data reproducibility and better animal ...

Methylglyoxal Decoration of Glutenin during Heat Processing Could Alleviate the Resulting Allergic Reaction in Mice

nutrients Article Methylglyoxal Decoration of Glutenin during Heat Processing Could Alleviate the Resulting Allergic Reaction in Mice Yaya ...

All mice were allowed free access to food and purified water. All animal experiments began one week after feeding. 2.7. ...

Coronavirus masks may be providing IMMUNITY - Experts make 'viral load' discovery

CORONAVIRUS is still a threat to people's wellbeing. The notorious virus is still lingering, and it could attack you in the street, the ...

in China hinted at a connection between dose and disease with their animal experiment. Using hamsters, they found that those ...

Socheongryongtang Modulates Asthma-Related Changes via Modulation of TNF-α and T-bet as well as IFN-γ in an Asthma Murine Model

In 2017 the World Health Organization (WHO) reported that 235 million people suffered from asthma, and that 383,000 deaths were due to ...

The analytical conditions are described in Table 1. 2.2. Animal Experiments Animal experiments were done based on our ...

Socheongryongtang Modulates Asthma-Related Changes via Modulation of TNF- and T-bet as well as IFN- in an Asthma Murine Model

processes Article Socheongryongtang Modulates Asthma-Related Changes via Modulation of TNF-α and T-bet as well as IFN-γ in an Asthma Murine...

0 21 100 0 55 15 85 25 10 90 30 10 90 2.2. Animal Experiments Animal experiments were done based on our previous study [9...

Monkeys have 'penises electroshocked until they ejaculate' in sick experiments

The Wisconsin National Primate Research Center was fined in April 2020 for depriving animals of basic care. PETA claims nothing has changed...

and personnel training to maximise the societal benefit of our vital animal research and to minimise risks to animals." According ...

Scientists 'electroshock restrained monkey's penises' in depraved lab experiments

An investigation by the People for the Ethical Treatment of Animals have produced a report into the Wisconsin National Primate Research ...

and personnel training to maximize the societal benefit of our vital animal research and to minimize risks to animals." According ...

Scientists updated genome editing technology

Researchers from Peter the Great St.Petersburg Polytechnic University (SPbPU) in collaboration with colleagues from the Pavlov University, ...

is at the stage of pre-clinical studies and is being tested on laboratory animals ", - mentioned Igor Radchenko, director of the "...

Three-Dimensional Cell Cultures as an In Vitro Tool for Prostate Cancer Modeling and Drug Discovery

In the last decade, three-dimensional (3D) cell culture technology has gained a lot of interest due to its ability to better recapitulate ...

(2D) cultures and have provided an interesting link between the latter and animal experiments. Indeed, 3D cell cultures represent ...

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

The cellular organelles peroxisomes contribute to the sensitivity of cells to ferroptosis by synthesizing polyunsaturated ether ...

interpretation. J.K.E. performed the DPPH assay. F.R. assisted with animal experiments. V.D. and P.A.C. developed GeLiNEA and ...

Scientists updated genome editing technology

Researchers from Peter the Great St.Petersburg Polytechnic University (SPbPU) in collaboration with colleagues from the Pavlov University, ...

is at the stage of pre-clinical studies and is being tested on laboratory animals ", - mentioned Igor Radchenko, director of the "...

Evidence for cephalic phase insulin release in humans: A systematic review and meta-analysis

Abstract The initial release of insulin in response to food stimuli acting on receptors in the head and oropharynx is called the cephalic ...

may contribute to these functions. Though well documented in laboratory animals, the existence of cephalic phase insulin release ...

HCV Glycoprotein Structure and Implications for B-Cell Vaccine Development

Despite the approval of highly efficient direct-acting antivirals in the last decade Hepatitis C virus (HCV) remains a global health burden...

self-assembling protein from Helicobacter pylori, but humoral responses from animal experiments have not yet been reported [126]. ...

Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy

Intratumoural spatial heterogeneity is crucial to enhance therapeutic resistance in glioblastoma. Here, the authors show a paracrine ...

8-weeks were used for intracranial implantation of GBM cells. All animal experiments were carried out under an Institutional ...

An engineered antibody binds a distinct epitope and is a potent inhibitor of murine and human VISTA

Abstract V-domain immunoglobulin (Ig) suppressor of T cell activation (VISTA) is an immune checkpoint that maintains peripheral T cell ...

and animal experiments performed in accordance with policies approved by the Stanford University Administrative Panel on ...

Experimental autoimmune encephalomyelitis is associated with changes of the microbiota composition in the gastrointestinal tract

Abstract The gut microbiome is known to be sensitive to changes in the immune system, especially during autoimmune diseases such as ...

L. reuteri or MRS culture broth as described18. All animal experiments were approved and complied with regulations of the ...

Simultaneous molecular MRI of extracellular matrix collagen and inflammatory activity to predict abdominal aortic aneurysm rupture

Abstract Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease with an up to 80% mortality in case of rupture. Current ...

approach and enabled in vivo characterization of AAAs. Methods Animal experiments and study design All procedures and protocols ...

Animal model of intrahepatic metastasis of hepatocellular carcinoma: establishment and characteristic

Abstract One of the most important and striking characteristics of hepatocellular carcinoma (HCC) with intrahepatic metastasis, is that it ...

and their body weight ranged from 18 to 22 g. All animal experimental procedures were in accordance with ARRIVE guidelines. Cell ...

Mechanisms of indigo naturalis on treating ulcerative colitis explored by GEO gene chips combined with network pharmacology and molecular docking

Abstract Oral administration of indigo naturalis (IN) can induce remission in ulcerative colitis (UC); however, the underlying mechanism ...

and tryptanthrin are the other two main components of IN. Animal experiments show that indirubin can significantly inhibit DSS-...

Biomedical Application of a Herbal Product Based on Two Asteraceae Species

Background: Species belonging to the Asteraceae family have been widely studied for their healing properties. The paper introduces STOMAPET...

by FELASA (Federation of European Laboratory Animal Science Associations) and ARSAL (Romanian Association for Laboratory ...

Anti-Diabetic Obesity Effects of Wasabia Japonica Matsum Leaf Extract on 45% Kcal High-Fat Diet-Fed Mice

The present study examined the effects of Wasabi leaf (WL) on 45% Kcal high-fat diet (HFD)-fed mild diabetic obese mice. In particular, the...

weight. All laboratory animals were treated in accordance with the national regulations regarding the use and welfare of ...

Prevalence and Distribution of Lesions in the Nasal Bones and Mandibles of a Sample of 144 Riding Horses

Restrictive nosebands are used in equestrian sports to hold the bit in place and reduce mouth-opening, a response that can attract ...

the guidance of the National Guide for the Production, Care and Use of Laboratory Animals, Mexico (Norma Oficial Mexicana NOM-062–...

Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption

Organs-on-a-Chip (OOAC) is a disruptive technology with widely recognized potential to change the efficiency, effectiveness, and costs of ...

-third of the participants. A systematic toxicology review of the animal experimental data at the time concluded that the adverse ...

Obese Adipose Tissue Secretion Induces Inflammation in Preadipocytes: Role of Toll-Like Receptor-4

In obesity, the dysfunctional adipose tissue (AT) releases increased levels of proinflammatory adipokines such as TNFα, IL-6, and IL-...

. The animal study was approved by the Committee on the Ethics of Animal Experiments of the Federal University of Rio de Janeiro (...

Using Soy-Based Compounds To Improve Bone Cancer Treatment

Researchers in recent years have demonstrated the health benefits of soy, linking its consumption to reduced risk of cardiovascular disease...

technology. More detailed long-term studies are needed, using animal research as well as other malignant cells, she said. ...

Metastatic status of sentinel lymph nodes in breast cancer determined with photoacoustic microscopy via dual-targeting nanoparticles

Fluorescent nanoparticles designed by researchers in China will help surgeons detect key sites where breast cancer spreads around the body...

and in compliance with the experimental guidelines of the Animal Experimentation Ethics Committee of Huazhong University of ...

Role of TRP Channels in Shaping the Gut Microbiome

Transient receptor potential (TRP) channel family proteins are sensors for pain, which sense a variety of thermal and noxious chemicals. ...

procedures were performed in accordance with the North Carolina State University laboratory animal care. The KO mice were ...

Development and Optimization of a High Sensitivity LC-MS/MS Method for the Determination of Hesperidin and Naringenin in Rat Plasma: Pharmacokinetic Approach

The purpose of this study was to develop, optimize, and fully validate a high-sensitivity methodology using UHPLC-MS/MS to simultaneously ...

. Animal procedures were conducted in accordance to the Mexican Federal Regulations for Animal Experimentation and Care (NOM-062-...

Fluidigm Joins Global Consortium of Cancer Prevention Experts

CANCERPREV Cross-Disciplinary Program Expands Knowledge of Cancer Development to Deliver New Insights into Prevention Strategies ...

academic, government, pharmaceutical, biotechnology, and plant and animal research laboratories worldwide. Together with them, we ...

ImmunoGenomics and Vero Diagnostics Providing COVID-19 Testing with Saliva-Based Advanta Dx SARS-CoV-2 RT-PCR Assay on Biomark HD Platform

SOUTH SAN FRANCISCO, Calif., Sept. 16, 2020 (GLOBE NEWSWIRE) -- Fluidigm Corporation (Nasdaq:FLDM), an innovative biotechnology tools ...

academic, government, pharmaceutical, biotechnology, plant and animal research, and clinical laboratories worldwide. Together with...

applsci-891542

Appl. Sci. 2020, 10, 6431; doi:10.3390/app10186431 www.mdpi.com/journal/applsci Article Influence of NOM on the Stability of Zinc Oxide...

exposure period. In this project (NIER−19‐2), the animal experiments were performed in accordance with the Code of Ethics of the...

Bidirectional Ductal Shunting and Preductal to Postductal Oxygenation Gradient in Persistent Pulmonary Hypertension of the Newborn

Background: The aim was to evaluate the relationship between the direction of the patent ductus arteriosus (PDA) shunt and the pre- and ...

of Laboratory Animal Care, International (AAALAC). UCD has an Animal Welfare Assurance on file with the Office of Laboratory ...

Iggy Pop donates new song 'Free' to help end cruel monkey experiments

"Anyone can see the pain and terror in these monkeys' eyes. No one should have to suffer like this," says Iggy Pop, who has just donated ...

-for-hire" Covance. Numerous published studies have shown that animal experimentation wastes resources and lives, as more than 90...

UPLC-qTOF-MS Phytochemical Profile and Antiulcer Potential of Cyperus conglomeratus Rottb. Alcoholic Extract

Cyperus has been commonly used as a multi-use medicinal plant in folk medicine worldwide. The objectives of our study were to determine the...

and in accordance with the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health in compliance ...

Animal observation project Icarus begins via space station

Stuttgart (dpa) - The German-Russian animal observation project Icarus, supported by data-collection equipment on the International Space ...

, a spokesperson said on Tuesday. Icarus (International Cooperation for Animal Research Using Space) is to observe the migration ...

ReviewIvermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?David A. Jans 1

Cells 2020, 9, 2100; doi:10.3390/cells9092100 www.mdpi.com/journal/cells Review Ivermectin as a Broad-Spectrum Host-Directed Antiviral: ...

human serum from standard parasitic treatment dosing and robust large animal experiments where lung levels of ivermectin can be ...

Influence of host genetics in shaping the rumen bacterial community in beef cattle

Abstract In light of recent host-microbial association studies, a consensus is evolving that species composition of the gastrointestinal ...

refers to animals that were fed at either the U.S. Meat Animal Research Center and UNL refers to animals fed at the University of ...

Viromers as carriers for mRNA-mediated expression of therapeutic molecules under inflammatory conditions

Abstract Therapeutic mRNA delivery has been described for several treatment options, such as vaccination and cancer immunotherapy. However...

Lipocalyx). The mRNA IN VIVO reagent was used for all animal experiments. The applied mRNAs were synthesized by TriLink ...

Modulation of contractions in the small intestine indicate desynchronization via supercritical Andronov–Hopf bifurcation

Abstract The small intestine is covered by a network of coupled oscillators, the interstitial cells of Cajal (ICC). These oscillators ...

All procedures were approved and carried out in accordance with regulations of the Animal Research Ethics Board (approval no. AUP ...

Network science characteristics of brain-derived neuronal cultures deciphered from quantitative phase imaging data

Abstract Understanding the mechanisms by which neurons create or suppress connections to enable communication in brain-derived neuronal ...

with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. (Animal ...

Regulatory Functions of L-Carnitine, Acetyl, and Propionyl L-Carnitine in a PCOS Mouse Model: Focus on Antioxidant/Antiglycative Molecular Pathways in the Ovarian Microenvironment

Polycystic ovary syndrome (PCOS) is a complex metabolic disorder associated with female infertility. Based on energy and antioxidant ...

40, 18 February 1992; National Institutes of Health Guide for the Care and Use of Laboratory Animals, NIH publication no. 85–23, ...

Effects of quercetin-conjugated with superparamagnetic iron oxide nanoparticles on learning and memory improvement through targeting microRNAs/NF-κB pathway

Abstract Quercetin-conjugated superparamagnetic iron oxide nanoparticles (QCSPIONs) have an ameliorative effect on diabetes-induced memory ...

done according to the guidelines for the use and care of research laboratory animals (USA National Institute of Health Publication...

Knee osteoarthritis in young growing rats is associated with widespread osteopenia and impaired bone mineralization

Abstract Osteoarthritis (OA) leads to joint pain from intraarticular inflammation with articular cartilage erosion, deterioration of joint ...

-old female Sprague–Dawley rats were obtained from the National Laboratory Animal Centre of Thailand, Mahidol University. The ...

Behavioral and trophic segregations help the Tahiti petrel to cope with the abundance of wedge-tailed shearwater when foraging in oligotrophic tropical waters

Abstract Two species breeding in sympatry are more likely to coexist if their ecological niches are segregated either in time, space or in ...

and analysed using R v3.4.072. Ethical statement All animal experimentation met the ABS/ASAB guidelines for ethical treatment of ...

Gene signatures and prognostic values of m1A-related regulatory genes in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) ranks fourth in cancer-related mortality worldwide. N1-methyladenosine (m1A), a methylation ...

-related regulatory genes. Following, relevant validations via cell and animal experiment are crucial to carry out to reveal how ...

Advantage of fat-derived CD73 positive cells from multiple human tissues, prospective isolated mesenchymal stromal cells

Abstract Somatic stem cells have been isolated from multiple human tissues for their potential usefulness in cell therapy. Currently, ...

N.I. conducted the cell processing, culturing, cell surface analysis, and animal experiments. Y.N. conducted cell surface analysis...

Iggy Pop Donates ‘Free’ to Help End Cruel Monkey Experiments

PETA

-for-hire” Covance. Numerous published studies have shown that animal experimentation wastes resources and lives, as more than 90...

A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis

RNF43 is frequently mutated in cancers and negatively regulates Wnt signalling. Here, the authors report that RNF43 phosphorylation at a ...

was approved by NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY PROVISIONS ON ANIMAL EXPERIMENTS. Tumours arising from Cle-H3 ...