The Effect of MUFA-Rich Food on Lipid Profile: A Meta-Analysis of Randomized and Controlled-Feeding Trials

Since the effects of mono-unsaturated fatty acids (MUFA) on lipid profile are still controversial, a meta-analysis of randomized controlled ...

group. The following exclusion criteria were used: (a) cell experiments, animal experiments, meta-analyses, reviews, conference papers, case

Fecal microbiota and their association with heat stress in Bos taurus

BackgroundHumans have been influencing climate changes by burning fossil fuels, farming livestock, and cutting down rainforests, which has ...

https://arriveguidelines.org ) for the reporting of animal experiments. Consent for publication Not provided. Competing interests The

Real-Time Image Processing Toolbox for All-Optical Closed-Loop Control of Neuronal Activities

Introduction Establishing a causal relationship between neural activity and behavior is central to understanding brain function, and this ...

YangYangLab/ORCA . Animals The C57BL/6 mice were purchased from Slac Laboratory Animals (Shanghai, China). Mice were housed and bred in a

Nootkatone, a Sesquiterpene Ketone From Alpiniae oxyphyllae Fructus, Ameliorates Metabolic-Associated Fatty Liver by Regulating AMPK and MAPK Signaling

Introduction With changing lifestyles, the incidence of nonalcoholic fatty liver disease (NAFLD) has increased. NAFLD has been newly ...

Co., Ltd. (Jiang Su, China). Mice were fed in the animal research center of Hainan Medical University (HMU). Our study was approved by the

Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro

Introduction Diabetic cardiomyopathy (DCM) is a myocardial microvascular complication of diabetes, characterized by cardiac insufficiency ...

University (No. 2000904) and followed the ethical standards of animal experiments. The mice were randomly divided into 2 groups with body

Construction and Application of Hepatocyte Model Based on Microfluidic Chip Technique in Evaluating Emodin

The current cytological evaluation technique of health food raw materials does not entirely meet the needs of evaluating health food. Our ...

, conventional cell culture in vitro, which is widely used to replace animal experiments, has its limitations because it is in a macroscopic

Insights into the Gut Microbial Communities of Broiler Chicken Fed Black Soldier Fly Larvae-Desmodium-Based Meal as a Dietary Protein Source

The utilization of insect-based diets to improve gastrointestinal function and gut health in poultry is gaining global attention as a ...

probiotic that has received the most attention in poultry production and animal research. This bacteria genus is predominant in the chicken’

Total Barley Maiya Alkaloids Prevent Increased Prolactin Levels Caused by Antipsychotic Drugs and Reduce Dopamine Receptor D2 via Epigenetic Mechanisms

Introduction Schizophrenia is among the global most disabling health conditions ( Lee et al., 2016 ) and affects about 21 million people ...

of The Third Hospital of Wuhan. All animal experiments complied with the Animal Research: Reporting of In Vivo Experiments guidelines and

The C-Terminal Repeat Units of SpaA Mediate Adhesion of Erysipelothrix rhusiopathiae to Host Cells and Regulate Its Virulence

Erysipelothrix rhusiopathiae is a causative agent of erysipelas in animals and erysipeloid in humans. However, current information ...

mutation of the spaA gene influenced E. rhusiopathiae virulence, an animal experiment was performed using C57BL/6 mice. The survival

Consumption of salmon fishmeal increases hepatic cholesterol content in obese C57BL/6 J mice

Abstract

Ethics approval Experimental use of animals was approved by the Norwegian Animal Research Authority (Mattilsynet, approvals FOTS id: #10902

Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis

Background Cold exposure is one of the most important risk factors for atrial fibrillation (AF), and closely related to the poor prognosis ...

Animals: The animal experiments in this study were performed according to the Guide for the Care and Use of Laboratory Animals and approved

Different Dose of Sucrose Consumption Divergently Influences Gut Microbiota and PPAR-γ/MAPK/NF-κB Pathway in DSS-Induced Colitis Mice

Sugar reduction and sugar control are advocated and gaining popularity around the world. Sucrose, as the widely consumed ingredient in our ...

of DSS-induced Colitis in Mice. ( A ) Schematic diagram of animal experiment design. ( B ) Oral glucose tolerance test (OGTT) after

Postischemic Neuroprotection of Aminoethoxydiphenyl Borate Associates Shortening of Peri-Infarct Depolarizations

Brain stroke is a highly prevalent pathology and a main cause of disability among older adults. If not promptly treated with recanalization ...

had free access to food and water. Animal experiments were performed according to the Animal Research: Reporting In Vivo Experiments (ARRIVE

Sex differences in heart mitochondria regulate diastolic dysfunction

Heart failure with preserved ejection fraction (HFpEF) exhibits a sex bias, being more common in women than men, and we hypothesize that ...

improvement following testosterone treatment 43 . Methods Mice All animal experiments were approved by the University of California Los

Flexible ultrasound-induced retinal stimulating piezo-arrays for biomimetic visual prostheses

Electronic visual prostheses, or biomimetic eyes, have shown the feasibility of restoring functional vision in the blind through electrical ...

current (DC) signal (monophasic pulses are often used in animal experiments for studying neuronal responses to the stimulations) by the

Benzylamines as highly potent inhibitors of the sterol biosynthesis pathway in Leishmania amazonensis leading to oxidative stress and ultrastructural alterations

Leishmaniasis is a neglected disease caused by protozoan parasites of the Leishmania genus. Benzylamines are a class of compounds ...

of Laboratory Animal Care” formulated by the National Society for Medical Research and the “Guide for the Care and Use of Laboratory Animals

Effect of oxidative aging of biochar on relative distribution of competitive adsorption mechanism of Cd2+ and Pb2+

In this study, aged biochar (CCB350 and CCB650) were obtained from pyrolysis of corn stalk biochar (CB350 and CB650) at the degree of 350 ° ...

6.5. Ethical approval This study did not involve human or animal research and did not require ethical approval. Results and discussion

Redox-sensitive doxorubicin liposome: a formulation approach for targeted tumor therapy

In this study redox-sensitive (RS) liposomes manufactured using 10,10′-diselanediylbis decanoic acid (DDA), an organoselenium RS compound, ...

from the Pasteur Institute (Tehran, Iran). All animal experiments were approved by the Institutional Ethical Committee and Research Advisory

Simiate and the focal adhesion kinase FAK1 cooperate in the regulation of dendritogenesis

Despite the crucial importance of dendritogenesis for the correct functioning of neurons, the molecular mechanisms underlying neuronal ...

accordance with the guidelines of the Federation of European Laboratory Animal Science Associations and the recommendations of the European

Generation of a live attenuated influenza A vaccine by proteolysis targeting

The usefulness of live attenuated virus vaccines has been limited by suboptimal immunogenicity, safety concerns or cumbersome manufacturing ...

Biotech Ltd. and Servicebio Ltd. for technical assistance with animal experiments, gene sequencing, plasmid construction, establishment of

Effects of chronic cannabidiol in a mouse model of naturally occurring neuroinflammation, neurodegeneration, and spontaneous seizures

Cannabidiol (CBD) has gained attention as a therapeutic agent and is purported to have immunomodulatory, neuroprotective, and anti-seizure ...

Google Scholar du Sert, N. P. et al. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 20. PLOS Biol.

The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice

SLC26A4 is a known iodide transporter, and is localized at the apical membrane of thyrocytes. Previously, we reported that SLC26A7 is also ...

conditions in a laboratory animal facility at Nagoya City University. All experiments comply with the ARRIVE (Animal Research: Reporting of

The genetic consequences of captive breeding, environmental change and human exploitation in the endangered peninsular pronghorn

Endangered species with small population sizes are susceptible to genetic erosion, which can be detrimental to long-term persistence. ...

Google Scholar Percie Du Sert, N. et al. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 20. PLOS

Therapeutic Effects of Quetiapine and 5-HT1A Receptor Agonism on Hyperactivity in Dopamine-Deficient Mice

Some diseases that are associated with dopamine deficiency are accompanied by psychiatric symptoms, including Parkinson’s disease. However ...

animals were cared for and humanely treated according to our institutional animal experimentation guidelines. All of the mice were housed in

Myotonic dystrophy RNA toxicity alters morphology, adhesion and migration of mouse and human astrocytes

Brain dysfunction in myotonic dystrophy type 1 (DM1), the prototype of toxic RNA disorders, has been mainly attributed to neuronal RNA ...

Paris Descartes Ethics Committee for Animal Experimentation (CEEA 34) and Charles Darwin Ethics Committee for Animal Experimentation (CEEA 5

Effects of Early Initiation of High-Dose Dexamethasone Therapy on Pro-Inflammatory Cytokines and Mortality in LPS-Challenged Mice

This study aims to explore the effects of early dexamethasone therapy at low to high doses on the survival and inflammatory responses in ...

). Institutional Review Board Statement All of the animal experiments were conducted in compliance with the bioethical standards for

Establishment of the Primary Avian Gonadal Somatic Cell Lines for Cytogenetic Studies

The last decade was marked by a steep rise in avian studies at genomic and cellular levels. Cell lines are important tools for in vitro ...

[ Google Scholar ] [ CrossRef ] ARRIVE. ARRIVE Guidelines: Animal Research: Reporting of In Vivo Experiments. Available online: https:

The Investigation of New Phosphate–Titanite Glasses According to Optical, Physical, and Shielding Properties

The melt-quenching approach was used to prepare phosphate–titanite glasses with the composition P 2 O 5 -Na 2 O-CaO-8KF-CaCl 2 -xTiO 2 ( ...

and osteointegration of metal implants between hydroxyapatite/Ti alloy coat: An animal experimental study. J. Med. Assoc. Thai. 2003 ,

Tooth Formation as Experimental Model to Study Chemotherapy on Tissue Development: Effect of a Specific Dose of Temozolomide/Veliparib

Background: Chemotherapy treatment of cancer in children can influence formation of normal tissues, leading to irreversible changes in ...

with Dutch legislation. All experiments with animals were approved by the animal experiment committee of the instituut [ 23 ]. Informed

A Deeper Insight into Evolutionary Patterns and Phylogenetic History of ORF Virus through the Whole Genome Sequencing of the First Italian Strains

Orf virus (ORFV) is distributed worldwide and is the causative agent of contagious ecthyma that mainly occurs in sheep and goats. This ...

were waived for this study, as this study did not involve any animal experiments. Samples were collected from sheep and goats using standard

Visualizing synaptic dopamine efflux with a 2D composite nanofilm

Chemical neurotransmission constitutes one of the fundamental modalities of communication between neurons. Monitoring release of these ...

the decision to submit the work for publication. Ethics Animal experimentation: Primary rat neuronal culture work was conducted according

Process- and product-related impurities in the ChAdOx1 nCov-19 vaccine

ChAdOx1 nCov-19 and Ad26.COV2.S are approved vaccines inducing protective immunity against SARS-CoV-2 infection in humans by expressing the ...

decision to submit the work for publication. Ethics Animal experimentation: Animal experiments were approved by the Animal Care Commission

Air France move on primates ‘worsens animal transport crisis’

Airline says it will stop transporting non-human primates for use in research The move by one of Europe’s largest airline companies, Air ...

is part of a perfect storm for the European biomedical sector,” the European Animal Research Association (Eara) said on 1 July. “[It] adds

HIF-1α Inhibition Improves Anti-Tumor Immunity and Promotes the Efficacy of Stereotactic Ablative Radiotherapy (SABR)

High-dose hypofractionated radiation such as SABR (stereotactic ablative radiotherapy) evokes an anti-tumor immune response by promoting a ...

Not applicable. Informed Consent Statement The animal experiments were performed following the animal experiment protocol (1410-31907A)

Clonal barcoding with qPCR detection enables live cell functional analyses for cancer research

Single-cell analysis methods are valuable tools; however, current approaches do not easily enable live cell retrieval. That is a particular ...

area under the curve (AUC) from the ROC curve. Animal experiments All animal studies were conducted in accordance with regulations of the

Evaluation of the Effects of Microgravity on Activated Primary Human Hepatic Stellate Cells

In recent years, research has been conducted to develop new medical treatments by simulating environments existing in space, such as zero- ...

-1-1, Ube 755-0046, Yamaguchi, Japan 5 Institute of Laboratory Animals, Science Research Center, Yamaguchi University, Yamaguchi 755-8505,

Effects of SNPs in AANAT and ASMT Genes on Milk and Peripheral Blood Melatonin Concentrations in Holstein Cows (Bos taurus)

Aralkylamine N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT), the two rate-limiting enzymes for melatonin ...

approved by the China Agricultural University Laboratory Animal Welfare and Animal Experimental Ethical Inspection Committee (AW92402202-1-1

Integrated Metabolomic and Transcriptomic Analysis of Acute Kidney Injury Caused by Leptospira Infection

Renal leptospirosis caused by leptospiral infection is characterised by tubulointerstitial nephritis and tubular dysfunction, resulting in ...

analysis. Animal biosafety level 2 conditions were required for all animal experiments, as well as adherence to all applicable rules for the

Novel Osmoprotective DOPC-DMPC Liposomes Loaded with Antihypertensive Drugs as Potential Strategy for Glaucoma Treatment

Glaucoma is a group of chronic irreversible neuropathies that affect the retina and the optic nerve. It is considered one of the leading ...

Review Board Statement The European Union regulations for the use of research animals, the Statement for the Use of Animals in Ophthalmic

Dangerous Bites

Mosquitoes are responsible for transmitting many disease-causing pathogens. In Switzerland, biting midges in particular make life difficult ...

, clarifies Verhulst, as obtaining a permit from the cantonal animal experimentation commission is a lengthy and expensive process. Instead

Diagnosis and Management of Acanthamoeba Keratitis: A Continental Approach

Acanthamoeba keratitis (AK) is a potentially blinding infection caused by protozoa found worldwide. The topical application of biguanides ...

of Nottingham University, School of Veterinary Medicine and Science Committee for Animal Research and Ethics (Approval No. 3590 220428).

A Pilot Study on Plasma and Urine Neurotransmitter Levels in Children with Tic Disorders

Background: Tic disorders (TDs), including Tourette syndrome, are childhood-onset neuropsychiatric disorders characterized by motor and/or ...

genetic and environmental factors. Available neurochemical, neuroimaging, animal experiments, drug treatment responses, and autopsy results

G6PD Deficiency Is Crucial for Insulin Signaling Activation in Skeletal Muscle

Glucose 6-P dehydrogenase (G6PD) is the first rate-limiting enzyme in pentose phosphate pathway (PPP), and it is proverbial that G6PD is ...

mice were conducted in accordance with the guidelines of the Animal Research Institute Committee at Nanjing Agricultural University (SYXK-

Recent Progress on Bioinspired Antibacterial Surfaces for Biomedical Application

Surface bacterial fouling has become an urgent global challenge that calls for resilient solutions. Despite the effectiveness in combating ...

–Dawley rats to evaluate their antibacterial performance in vivo. This animal experiment indicated that the number of bacteria on both the

Possible Metastatic Stage-Dependent ILC2 Activation Induces Differential Functions of MDSCs through IL-13/IL-13Rα1 Signaling during the Progression of Breast Cancer Lung Metastasis

Breast cancer is the most common cancer in women worldwide, and lung metastasis is one of the most frequent distant metastases. When breast ...

of age. The animal experimental procedures used in this study were approved by the Ethics Review Committee for Animal Experimentation at Mie

Prospective Role of Bioactive Molecules and Exosomes in the Therapeutic Potential of Camel Milk against Human Diseases: An Updated Perspective

Camel milk (CM) constitutes an important dietary source in the hot and arid regions of the world. CM is a colloidal mixture of nutritional ...

, 72 , 73 , 74 , 75 , 76 ]. In parallel, animal experimental data have also demonstrated the inhibitory potential of CM and its

Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver

Global obesity epidemics impacts human health and causes obesity-related illnesses, including the obesity-related kidney and liver diseases ...

approved by the Committee on Ethics in the Care and Use of Laboratory Animals of College of Life Sciences, Wuhan University. Animals Mouse

A Novel Ex Vivo Bone Culture Model for Regulation of Collagen/Apatite Preferential Orientation by Mechanical Loading

The anisotropic microstructure of bone, composed of collagen fibers and biological apatite crystallites, is an important determinant of its ...

Review Board Statement All animal experiments were performed with the approval of the Ethics Committee for Animal Experiments of Osaka

Promotion of Hair Regrowth by Transdermal Dissolvable Microneedles Loaded with Rapamycin and Epigallocatechin Gallate Nanoparticles

Interest in transdermal delivery methods for stimulating hair regrowth has been increasing recently. The microneedle approach can break the ...

formaldehyde, C57BL/6 mice (6 weeks old, Guangdong Medical Laboratory Animal Center). All mouse experiments were approved by the Animal Care

Effects of Oats, Tartary Buckwheat, and Foxtail Millet Supplementation on Lipid Metabolism, Oxido-Inflammatory Responses, Gut Microbiota, and Colonic SCFA Composition in High-Fat Diet Fed Rats

Coarse cereals rich in polyphenols, dietary fiber, and other functional components exert multiple health benefits. We investigated the ...

Sixty male Sprague Dawley rats (5 weeks old) were purchased from Vital River Laboratory Animal Technology Co., Ltd. (Beijing, China). After

Noninvasive NMR/MRS Metabolic Parameters to Evaluate Metabolic Syndrome in Rats

(1) Background: Ectopic fat deposition and its effects, metabolic syndrome, have been significantly correlated to lifestyle and caloric ...

). Institutional Review Board Statement The study was conducted following the Laboratory Animal Care and Use Committees at the Faculty of

Engineering probiotics to inhibit Clostridioides difficile infection by dynamic regulation of intestinal metabolism

Clostridioides difficile infection (CDI) results in significant morbidity and mortality in hospitalised patients. The pathogenesis of CDI ...

infection prognosis and outcomes of CDI in a murine model. A Animal experiment timeline. B Table of the groups used in this study and

Developmental Toxic Effects of Thiram on Developing Zebrafish (Danio rerio) Embryos

Thiram, an oxidized dimer of dithiocarbamate, has fungicidal and ectoparasiticidal roles. This study aimed to determine the effects of ...

studies of carbaryl, diazinon, norea, disulfiram, and thiram in small laboratory animals. Toxicol. Appl. Pharmacol. 1969 , 15 , 152–163

The splicing factor RBM17 drives leukemic stem cell maintenance by evading nonsense-mediated decay of pro-leukemic factors

Chemo-resistance in acute myeloid leukemia (AML) patients is driven by leukemic stem cells (LSCs) resulting in high rates of relapse and ...

Margaret Cancer Centre. All procedures received the approval of the Animal Research Ethics Board at McMaster University, HiREB (Hamilton

Advancing Key Gaps in the Knowledge of Plasmodium vivax Cryptic Infections Using Humanized Mouse Models and Organs-on-Chips

Background Human malaria is a disease caused by five species of plasmodia of which Plasmodium falciparum and Plasmodium vivax ...

use. Therefore, novel enabling technologies reducing the use of animal experimentation and widely available, are also needed to advance

Network Pharmacology–Based Prediction and Pharmacological Validation of Effects of Astragali Radix on Acetaminophen-Induced Liver Injury

Introduction Acetaminophen ( N -acetyl- p -aminophenol, APAP) is a widely utilized over-the-counter medication for relief of fever and ...

Male C57BL/6 mice weighing 25 ± 2 g were supplied by Beijing Vital River Laboratory Animal Technology Co., Ltd. [License No.: SCXK(Jing)2014

Applications of Hydrogels in Premature Ovarian Failure and Intrauterine Adhesion

Introduction In obstetrics and gynecology, both premature ovarian failure (POF) and intrauterine adhesion (IUA) are difficult diseases ...

in other diseases is still at the stage of animal experiment. In animal experiment the therapeutic effects and safety of hydrogels have been

Study of Mechanical Behavior in Epiphyseal Fracture Treated by Reduction and Cement Injection: No Immediate Post-Operative Weight-Bearing but Only Passive and Active Mobilization Should be Advised

1 Introduction Tibial plateau fractures (TPF) are known to be arthrogenic ( Honkonen, 1995 ; Rademakers et al., 2007 ). They result ...

Up to the present, no study has answered all these questions. Animal experimentation is the only way to quantify the effects of time on the

Zearalenone-14-Glucoside Is Hydrolyzed to Zearalenone by β-Glucosidase in Extracellular Matrix to Exert Intracellular Toxicity in KGN Cells

As one of the most important conjugated mycotoxins, zearalenone-14-glucoside (Z14G) has received widespread attention from researchers. ...

further explore the toxicity mechanism of Z14G in vivo through animal experiments, especially the difference in toxicity between Z14G and

Awards recognise remarkable achievements of Imperial staff | Imperial News

Staff at Imperial have been celebrated for their hard work with the Provost’s Awards. Winners of the Provost’s Awards in Excellence in ...

’s research earned him the Provost’s Award for Excellence in Animal Research. Animal use has been integral to research concerning drug

A kNGR Peptide-Tethered Lipid–Polymer Hybrid Nanocarrier-Based Synergistic Approach for Effective Tumor Therapy: Development, Characterization, Ex-Vivo, and In-Vivo Assessment

The present study aims to design, develop and characterize kNGR (Asn-Gly-Arg) peptide-conjugated lipid–polymer-based nanoparticles for the ...

, Sagar (M.P.), authorized the in-vivo experimental procedure for animal experiments through letter no. Animal Eths. Comm.11/10/87, and the

Identification of Bacterial Membrane Selectivity of Romo1-Derived Antimicrobial Peptide AMPR-22 via Molecular Dynamics

The abuse or misuse of antibiotics has caused the emergence of extensively drug-resistant (XDR) bacteria, rendering most antibiotics ...

government (NRF-2020R1A2C1012207). Institutional Review Board Statement The animal experiments were planned, approved (KOREA-2021-0210),

Mobile Cardiac Acoustic Monitoring System to Evaluate Left Ventricular Systolic Function in Pacemaker Patients

The mobile cardiac acoustic monitoring system is a promising tool to enable detection and assist the diagnosis of left ventricular systolic ...

and they argued against the necessity of correcting EMAT for heart rate based on animal experiments [ 23 ]. On the other hand, most of our

Tributes paid to neuroscientist Sir Colin Blakemore

Scientists and academics have paid tribute to the late professor Sir Colin Blakemore, following his death at the age of 78.

. Blakemore was also a determined defender of the principle of animal experimentation, a stance which earned him vehement criticism from

The Antifibrotic Effects of Inhaled Treprostinil: An Emerging Option for ILD

Abstract Interstitial lung diseases (ILD) encompasses a heterogeneous group of parenchymal lung diseases characterized by variable amounts ...

In addition to the previously described in vitro data and animal experiments, the antifibrotic effects of treprostinil have been brought to

Effect of Paulownia Leaves Extract Levels on In Vitro Ruminal Fermentation, Microbial Population, Methane Production, and Fatty Acid Biohydrogenation

Paulownia is a fast-growing tree that produces a huge mass of leaves as waste that can be used as a feed source for ruminants. The previous ...

performed following the guidelines of the National Ethical Commission for Animal Research (Ministry of Science and Higher Education, Warsaw,

Myocardial Injury Caused by Chronic Alcohol Exposure—A Pilot Study Based on Proteomics

Chronic alcohol exposure can cause myocardial degenerative diseases, manifested as cardiac insufficiency, arrhythmia, etc. These are ...

the “Guide for the Care and Use of Laboratory Animals” prepared by the Institute of Laboratory Animal Research and published by the National

[email protected] Nanoparticles with Aggregation-Induced Emission for Bioimaging In Vitro and In Vivo

Fluorescent materials based on aggregation-induced emission luminogens (AIEgens) have unique advantages for in situ and real-time ...

to give thanks to Henan Medical Research Center for having all animal experiments carried out. Conflicts of Interest The authors declare

Ethanol Extract of Pinus koraiensis Leaves Mitigates High Fructose-Induced Hepatic Triglyceride Accumulation and Hypertriglyceridemia

Pinus koraiensis is a valuable plant source of functional health foods and medicinal materials. Hypertriglyceridemia affects about 15–20% ...

to the Association for Assessment and Accreditation of Laboratory Animal Care International recommendations and protocols. Informed Consent

An Ecological Validity Model for the Prevention of Obesity: Non-Nutritive Sweetener Consumption in Rats and the Effects of Switching from Sugar-Sweetened to Diet Beverages

Reducing consumption of sugar-sweetened beverages (SSBs) has been encouraged due to its strong association with obesity. In parallel, ...

, U.; et al. The ARRIVE Guidelines 2.0: Updated Guidelines for Reporting Animal Research. J. Cereb. Blood Flow Metab. 2020 , 40 , 1769–

Engineering a 3D In Vitro Model of Human Gingival Tissue Equivalent with Genipin/Cytochalasin D

Although three-dimensional (3D) co-culture of gingival keratinocytes and fibroblasts-populated collagen gel can mimic 3D structure of in ...

, and eventually bridge the gap between 2D monolayer culture and animal experiment. Three-dimensional organotypic tissue models offer many

Extracellular Vesicles from BMSCs Prevent Glucocorticoid-Induced BMECs Injury by Regulating Autophagy via the PI3K/Akt/mTOR Pathway

Osteonecrosis of the femoral head (ONFH) is a common clinical disease with a high disability rate. Injury of bone microvascular endothelial ...

of China-Japan Friendship Hospital and was strictly conducted according to the animal experiment guidelines (Approval Code: Zryhyy12-20-01-7

AGE OLD PROBLEM I’m an anti-ageing expert – here’s the gym hack that really will make you live longer & common myths that need busting

WE all hope to live a long and healthy life, but working out how can be a frustrating experience. With so much conflicting advice around, ...

. But in reality, it doesn’t even extend the life of laboratory animals, let alone humans. In fact, resveratrol could even be harmful.

Prøver ut nye tilsetningsstoffer i iskrem etter forbrukerpress

.css-qf083p{box-sizing:border-box;border-bottom:1px solid #d7d3cf;display:-webkit-box;display:-webkit-flex;display:-ms-flexbox;display:flex ...

som cellulosegummi/cmc, med E-nummer E466, E467 Dyreforsøk har vist negative helseeffekter knyttet til tilsetningsstoffene. I Aftenposten

Ten organisations account for half of all animal research in Great Britain in 2021

Today, 30 June 2022, Understanding Animal Research (UAR) has published a list of the ten organisations that carry out the highest number of ...

, Chief Executive of Understanding Animal Research, which developed the Concordat on Openness, said: “Animal research remains a small but

Hvad skal vi lave i ferien? Tag børnene med på lokale eventyr både på land og til vands

Så er det sommerferie, og vi skal hygge med ungerne. Men sådan nogle størrelser sidder ikke stille ret længe, førend de keder sig. Melfar ...

så gale videnskabsmænd ikke får held med at bruge marsvinene i Lillebælt til dyreforsøg. Turen kan bookes på Visitmiddelfart.dk. 11 Klap en

Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

Omicron variant strains encode large numbers of changes in the spike protein compared to historical SARS-CoV-2 isolates. Although in vitro ...

with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocols were

A Review of Non-Invasive Sampling in Wildlife Disease and Health Research: What’s New?

In the last decades, wildlife diseases and the health status of animal populations have gained increasing attention from the scientific ...

(e.g., [ 13 ]) and is now widely applied to laboratory animals. Ethical advances in wildlife research have been comparably slower, but the

Rickettsia felis and Other Rickettsia Species in Chigger Mites Collected from Wild Rodents in North Carolina, USA

Chiggers are vectors of rickettsial pathogenic bacteria, Orientia spp., that cause the human disease, scrub typhus, in the Asian–Pacific ...

of Rickettsiae in Dermacentor variabilis ticks and tissue samples from humans and laboratory animals. J. Clin. Microbiol. 2016 , 54 ,

Roles of Reactive Oxygen Species in Vascular Complications of Diabetes: Therapeutic Properties of Medicinal Plants and Food

The rising prevalence of chronic metabolic disorders, such as obesity and type 2 diabetes, most notably associated with cardiovascular ...

properties of bioactive compounds from medicinal plants and food in animal experiments and clinical studies to provide insights for the

A 3D Analysis of Cleared Human Melanoma

Cutaneous melanoma is one of the most aggressive and deadliest cancers in human beings due to its invasiveness and other factors. ...

://arriveguidelines.org , accessed on 18 November 2021) for reporting animal experiments. All animal protocols/methods were carried out in

Evaluation of new and old biomarkers in dogs with degenerative mitral valve disease

BackgroundDogs with degenerative mitral valve disease are commonly presented to small animal clinicians. Diagnosis, clinical staging, and ...

DJ, et al. Cardiac troponin I is a sensitive, specific biomarker of cardiac injury in laboratory animals. Lab Anim. 2006;40(2):153–71. CAS

Prevention of Cell Death by Activation of Hydroxycarboxylic Acid Receptor 1 (GPR81) in Retinal Explants

Background: Progressive retinal ganglion cell (RGC) dysfunction and death are common characteristics of retinal neurodegenerative diseases ...

of the Declaration of Helsinki and performed according to the Danish Act on Animal Experiments (LBK No. 474 of 15 May 2014). Informed

Lipocalin-2 Deficiency Reduces Hepatic and Hippocampal Triggering Receptor Expressed on Myeloid Cells-2 Expressions in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

Background: Lipocalin-2 (LCN2) is an acute-phase protein that has been linked to insulin resistance, diabetes, and neuroinflammatory ...

C57BL/6J and LCN2 knockout (KO) mice were purchased from Central Laboratory Animal, Inc. (Seoul, South Korea) and The Jackson Laboratory (

Antioxidative Role of Hygrophila erecta (Brum. F.) Hochr. on UV-Induced Photoaging of Dermal Fibroblasts and Melanoma Cells

Antioxidants are an important strategy for treating photoaging because excessive reactive oxygen species (ROS) are produced during UV ...

34141, Korea 4 Longevity & Wellbeing Research Center and Laboratory Animals Resources Center, College of Natural Resources and Life

Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance

It is highly important and challenging to develop donor-acceptor-donor structured small-molecule second near-infrared window (NIR-II) dyes ...

guidelines for animal handling. All operations related to animal experiments follow the relevant requirements of the Institutional Animal

Metabolic Fate Is Defined by Amino Acid Nature in Gilthead Seabream Fed Different Diet Formulations

The sustainability of the Aquaculture industry relies on optimising diets to promote nitrogen retention and maximise fish growth. The aim ...

Council (Directive 2010/63/EU) and Portuguese legislation for the use of laboratory animals under project FICA: ALG-01-0247-FEDER-047175,

Why is airborne Covid spread the last pandemic taboo?

Covid is rising again in the UK - should we worry?

Image source, Getty Images You'd be forgiven for letting out a weary sigh. There's so much going on from Ukraine to the rising cost of ...

Omicron, but we don't know for sure. So far there is only laboratory and animal research. A study in Japan shows BA.4 and BA.5 can grow more

Utilization of dielectric properties for assessment of liver ischemia-reperfusion injury in vivo and during machine perfusion

There is a shortage of donor livers and patients consequently die on waiting lists worldwide. Livers are discarded if they are clinically ...

Research at Oslo University Hospital, for invaluable assistance during the animal experiments. Funding This study was funded by the South-

CCND1 Amplification Profiling Identifies a Subtype of Melanoma Associated With Poor Survival and an Immunosuppressive Tumor Microenvironment

Introduction Melanoma is one of the deadliest cancers due to its high recurrence rate and high metastatic potential ( 1 – 4 ). ...

, the results from our bioinformatic analysis and animal experiments confirm that CCND1 amplification facilitates an immunosuppressive

Are Phthalate Exposure Related to Oxidative Stress in Children and Adolescents with Asthma? A Cumulative Risk Assessment Approach

Childhood asthma has become one of the most common chronic diseases in children and adolescents. However, few case–control studies ...

we used the results of previous animal experiments on allergic or immune reactions for RfDs. In an animal experiment involving injection and

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD+ by Generating Dihydronicotinamide Riboside

Through evolution, eukaryote organisms have developed the ability to use different molecules as independent precursors to generate ...

(Irvine, CA, USA). 2.2. Animal Experiments All animal experiments were performed according to national Swiss and EU ethical guidelines and

Insights from one thousand cloned dogs

Animal cloning has been popularized for more than two decades, since the birth of Dolly the Sheep 25 years ago in 1996. There has been an ...

Foundation, Korea (permit no. C-12-01) and within Animal research: reporting of in vivo experiments (ARRIVE) guidelines. All data presented

Extracellular vesicles deliver sodium iodide symporter protein and promote cancer cell radioiodine therapy

Extracellular vesicles (EVs) are a promising carrier for various cargos with antitumor effects, but their capacity to transfer the ability ...

in vitro findings will need to be verified through in vivo animal experiments that include confirmation of sufficient tumor retainment of

Sexual Dimorphism in the Chinese Endemic Species Hynobius maoershanensis (Urodela: Hynobiidae)

Sexual dimorphism is common in most vertebrate species and has diverse manifestations. The study of sexual dimorphism has critical ...

Animal Care and Use Committee and were approved by the Laboratory Animal Care and Animal Ethics Committee of Guangxi Normal University (No.

A novel CREB5/TOP1MT axis confers cisplatin resistance through inhibiting mitochondrial apoptosis in head and neck squamous cell carcinoma

BMC Medicine volume 20, Article number: 231 (2022) Cite this article

-derived xenograft (PDX) model This experiment was approved by the laboratory animal care and use committee of the hospital. The PDX model

Molecular Mechanism of Equine Endometrosis: The NF-κB-Dependent Pathway Underlies the Ovarian Steroid Receptors’ Dysfunction

Endometrosis is a frequently occurring disease decreasing mares’ fertility. Thus, it is an important disease of the endometrium associated ...

retrieval after slaughter (decision of II Local Committee for Ethics in Animal Research WULS in Warsaw from 27 October 2021). Samples were

The Pharmacokinetics in Mice and Cell Uptake of Thymus Immunosuppressive Pentapeptide Using LC-MS/MS Analysis

Thymus immunosuppressive pentapeptide (TIPP) is a novel anti-inflammatory peptide with high efficacy and low toxicity. This study aims to ...

River Laboratory Animal Technology Co., Ltd. (Beijing, China). The animal experiment was carried out in accordance with Animal Experiment

Genomic and Immunological Characterization of Hypermucoviscous Carbapenem-Resistant Klebsiella pneumoniae ST25 Isolates from Northwest Argentina

In recent years, an increase in the prevalence hypermucoviscous carbapenem-resistant Klebsiella pneumoniae with sequence type 25 (ST25) was ...

performed in accordance with the guide for the care and use of laboratory animals and were approved by the CERELA-CONICET Animal Care and