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Montane Palustrine Wetlands of Lesotho: Vegetation, Ecosystem Services, Current Status, Threats and Conservation
Abstract
Although palustrine wetlands cover only about 6% of the earth’s surface, they are among the most productive and socio-economically ...
to the content of this article.
Animal Research (Ethics)
Not applicable.
Ensuring reliability and trust in quality of Research Ethics expertise in the context of new/emerging technologies
Ensuring reliability and trust in quality of Research Ethics expertise in the context of new/emerging technologies
TOPIC ID: HORIZON-WIDERA ...
(e.g. on personal data protection, clinical trials, animal research etc.) and ethics principles. Assessing the compatibility with ethics
Preliminary evidence for a forestomach washing mechanism in llamas (Lama glama)
Abstract
Dust and grit are ingested by herbivores in their natural habitats along with the plants that represent their selected diet. Among ...
with approval of the Swiss Cantonal Animal Care and Use Committee Zurich (animal experiment licence 003/2019). Six mature (older than 5
I’m pregnant, and I want to use CBD to ease my stress and discomfort. Is it safe?
Crystal Cox/Insider
There's no strong human research on CBD in pregnancy, so the FDA "strongly advises" against it.
But some moms find ...
guidance is to avoid CBD use in pregnancy
The FDA points to animal research showing high doses of CBD in pregnancy leads to reproductive
Molecular and Functional Analysis of Sunitinib-Resistance Induction in Human Renal Cell Carcinoma Cells
Resistance in clear cell renal cell carcinoma (ccRCC) against sunitinib is a multifaceted process encompassing numerous molecular ...
) and University of Geneva.
Institutional Review Board Statement
All animal experiments were performed in accordance with the Institutional
GLIS1, a potential candidate gene affect fat deposition in sheep tail
Abstract
Fat deposition in sheep tails is as a result of a complicated mechanism. Mongolian sheep (MG) and Small Tail Han sheep (STH) are ...
collected were immediately stored in liquid nitrogen. The animal experimental procedures were performed according to the guidelines set by
Working memory gates visual input to primate prefrontal neurons
Visually guided behavior relies on the integration of sensory input and information held in working memory (WM). Yet it remains unclear how ...
National Institutes of Health Guide for the Care and Use of Laboratory Animals, the Society for Neuroscience Guidelines and Policies, and
circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis
Emerging evidence demonstrates the important role of circular RNAs (circRNAs) in regulating pathological processes in various diseases ...
), and informed consent was obtained from each participant.
Animal experimentation: All mouse procedures were approved by the Institutional
Oral Mucositis in Patients with Hematologic Malignancies Undergoing Chemotherapy
Abstract
The aim of this study was to evaluate the frequency of oral mucositis in patients with hematologic malignancies and relating to ...
, Sarmento VA. Evaluation of bone repair after radiotherapy by photobiomodulation-an animal experimental study. Laser Phys. 2011;21:958–64.
Veterinary Injectable Devices Market Share, Development by Companies Outlook, Growth Prospects and Key Opportunities by 2027 | Says FMI Analyst
Animals have always been a part of human life and they still play an important role in human life. It is important to keep the animals ...
be segmented into:
Veterinary Hospitals
Veterinary Clinics
Animal Research Institutes
Product Segmentation
The investigation offers a
Bayesian Binary Mixture Models as a Flexible Alternative to Cut-Off Analysis of ELISA Results, a Case Study of Seoul Orthohantavirus
Serological assays, such as the enzyme-linked immunosorbent assay (ELISA), are popular tools for establishing the seroprevalence of various ...
seropositivity. Both studies were approved by the Dutch Central Animal Experiments Committee (project number AVD3260020172104). The third
viruses-1239479-fc done
Viruses 2021, 13, 1154. https://doi.org/10.3390/v13061154 www.mdpi.com/journal/viruses
Review
Mosquito Vector Competence for ...
, K.; Asada, J. Study on Japanese Encephalitis
Virus. Animal Experiments and Mosquito Transmission Experiments. Kansai Iji 1936, 1, 260–261
Tumor Microenvironment-Responsive Shell/Core Composite Nanoparticles for Enhanced Stability and Antitumor Efficiency Based on a pH-Triggered Charge-Reversal Mechanism
High systemic stability and effective tumor accumulation of chemotherapeutic agents are indispensable elements that determine their ...
(No. 20180551167).
Institutional Review Board Statement
All the animal research was approved by Institutional Animal Care and Use Committee-
Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections
antibiotics
Article
Evaluation of Benzguinols as Next-Generation Antibiotics for
the Treatment of Multidrug-Resistant Bacterial Infections
...
(approval number S-2015-151) reviewed and approved all animal experiments. The study was
conducted in compliance with the Australian Code of
Genomics Market Newer Segments of Application 2030
Introduction:
Genomics refers to the study of structure, function and inheritance of the genome of an organism. Genomic technology offer ...
By Application:
Drug Discovery and Development
Diagnostics
Agriculture and Animal Research
Other Applications
By End User:
Hospitals and
Pics: Meet the 30 finalists vying for the Miss Ireland 2021 crown
© Provided by Extra.ie
The announcement of the finalists for the Miss Ireland 2021 was a rainbow of colours.
This year’s contestants ...
in UCD with the goal of going on to study Veterinary or move into animal research.
Miss Kildare North – Alannah Pardy
© Provided by Extra.ie
polymers-1245769-fc done
Polymers 2021, 13, 1977. https://doi.org/10.3390/polym13121977 www.mdpi.com/journal/polymers
Review
Thiophene‐Based Trimers and ...
HL60 and MCF‐7 human tumor cell lines, but in the in vivo animal experiment it
was not observed any significant anti‐tumor activity [527].
Development of Radiofluorinated Nicotinamide/Picolinamide Derivatives as Diagnostic Probes for the Detection of Melanoma
Regarding the increased incidence and high mortality rate of malignant melanoma, practical early-detection methods are essential to improve ...
4.7. Establishment of Melanoma-Bearing Mouse Models
All animal experiments were approved by the Institutional Animal Care and Use Committee
A Candidate Gene Association Study for Economically Important Traits in Czech Dairy Goat Breeds
Milk production is influenced by many factors, including genetic and environmental factors and their interactions. Animal health, ...
GAJU028/2019/ Z.
Institutional Review Board Statement
All animal experiments were under the supervision of the Institutional Animal Care and
Pharmacokinetics in Zebrafish Embryos (ZFE) Following Immersion and Intrayolk Administration: A Fluorescence-Based Analysis
Zebrafish embryos (ZFE) have increasingly gained in popularity as a model to perform safety screenings of compounds. Although immersion of ...
]. Moreover, this model adheres to the 3Rs principle of animal experimentation by providing refinement and partial replacement over higher
Nucleic Acid Isolation and Purification Market to Register Unwavering Growth During 2030
Nucleic Acid Isolation and Purification Market: Overview
The growing influence of technology across the life science research, molecular ...
acid isolation and purification process in diagnostics, agriculture research, animal research, precision medicine, drug discovery, drug
PICS: From GAA stars to showjumpers, here are the Miss Ireland 2021 finalists
© Provided by Evoke.ie
This year’s Miss Ireland 2021 finalists have finally been unveiled.
A beautiful outdoor show will take place on 5 ...
UCD with the goal of someday going on to study veterinary or go into animal research.
Miss Laois
© Provided by Evoke.ie
Miss Ireland 2021
Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccine
Abstract
Inactivated poultry vaccines are subject to routine potency testing for batch release, requiring large numbers of animals. The ...
/63/EU) experiments with embryonated chicken eggs are not considered animal experiments, the study was carried out in compliance with the
A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models
Abstract
CRISPR/Cas9 represents a valuable tool to determine protein function, but technical hurdles limit its use in challenging settings ...
with the current ethical standards of the official committee on animal experimentation (written approval by the Regierung von Oberbayern,
Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration
Abstract
Caspase-6 (Casp6) is implicated in Alzheimer disease (AD) cognitive impairment and pathology. Hippocampal atrophy is associated ...
, Ipswich, MA, USA) as described46.
Electrophysiology
All animal experimentation was approved by the McGill University Animal Care Committee
A distributed saccade-associated network encodes high velocity conjugate and monocular eye movements in the zebrafish hindbrain
Abstract
Saccades are rapid eye movements that redirect gaze. Their magnitudes and directions are tightly controlled by the oculomotor ...
out on the tuning curves using the Matlab command ttest2.
Animal experiments and all experimental protocols were approved by the responsible
Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina
Abstract
Ischemic stroke is a major cause of long-term disabilities, including vision loss. Neuronal and blood vessel maturation can affect ...
the National Institutes of Health Guide for the Care and Use of Laboratory Animals and approved by the Institutional Animal Care and Use
Interventricular Differences of Signaling Pathways-Mediated Regulation of Cardiomyocyte Function in Response to High Oxidative Stress in the Post-Ischemic Failing Rat Heart
antioxidants
Article
Interventricular Differences of Signaling Pathways-Mediated
Regulation of Cardiomyocyte Function in Response to High
...
.
2. Materials and Methods
2.1. Animal Model
Animal experimental procedures were permitted by the Animal Care Committee
of the University of
Blockade of HVEM for Prostate Cancer Immunotherapy in Humanized Mice
The herpes virus entry mediator (HVEM) delivers a negative signal to T cells mainly through the B and T lymphocyte attenuator (BTLA) ...
European legislation. All protocols were approved by the Ethics Committee for Animal Experimentation Charles Darwin (Ce5/2012/025).
Informed
Superoxide Dismutase 3-Transduced Mesenchymal Stem Cells Preserve Epithelial Tight Junction Barrier in Murine Colitis and Attenuate Inflammatory Damage in Epithelial Organoids
Superoxide dismutase 3 (SOD3), also known as extracellular superoxide dismutase, is an enzyme that scavenges reactive oxygen species (ROS ...
animal research was conducted in accordance with the Laboratory Animals Welfare Act, the guide for the care and use of laboratory animals,
Simulation-based optimisation to quantify heterogeneity of specific ventilation and perfusion in the lung by the Inspired Sinewave Test
Abstract
The degree of specific ventilatory heterogeneity (spatial unevenness of ventilation) of the lung is a useful marker of early ...
and AD. Royal Academy of Engineering Enterprise Fellowship funded the animal experiments to PP. Medical Research Council (MC_PC_17164) and
Preclinical study to improve microbubble-mediated drug delivery in cancer using an ultrasonic probe with an interchangeable acoustic lens
Abstract
Focused ultrasound with microbubbles (FUS-MBs) has shown that it can lead to an efficient drug delivery system (DDS) involving the ...
tumor mass among any of the groups (all P > 0.05).
Figure 4
Animal experiment. (a) Photograph of the subcutaneous hepatoma rat model. (b) An
Toxicity evaluation of ConvitVax breast cancer immunotherapy
Abstract
ConvitVax is a personalized vaccine for the treatment of breast cancer, composed of autologous tumor cells, bacillus Calmette- ...
by Instituto de Estudios Avanzados (IDEA) and maintained in the animal research facility of Fundación Jacinto Convit (FJC) in computerized
Evidence of a new hidden neural network into deep fasciae
Abstract
It is recognized that different fasciae have different type of innervation, but actually nothing is known about the specific ...
of the Italian Department of Health, and in compliance with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines. The
Null cyp1b1 Activity in Zebrafish Leads to Variable Craniofacial Defects Associated with Altered Expression of Extracellular Matrix and Lipid Metabolism Genes
CYP1B1 loss of function (LoF) is the main known genetic alteration present in recessive primary congenital glaucoma (PCG), an infrequent ...
All animal husbandry and experiments were approved by the Institutional Animal Research Committee of the University of Castilla–La Mancha (
Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus
Abstract
Aims/hypothesis
People with diabetes have an increased cardiovascular risk with an accelerated development of atherosclerosis and ...
the Care and Use of Laboratory Animals of the National Institutes of Health (Bethesda, MD, USA). All animal experiments were approved by the
Dietary Vitamin C and Age-Induced Lipid and Hormonal Metabolic Changes in a Humanized Mouse Model Not Synthesizing Vitamin C and Producing Lipoprotein(a) [Gulo (−/−); Lp(a)+]
AbstractThe lack of ability to produce vitamin C innately and the ability to synthesize human lipoprotein(a) (Lp(a)) are two unique ...
-PCR at Transnetyx (Cordova, TN) using mouse tail clips. All animal experiments were conducted with humane and customary care and followed a
A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study
Engineered nanomaterials (ENMs) are of significant relevance due to their unique properties, which have been exploited for widespread ...
, 120, S1–S7. [Google Scholar] [CrossRef]
Ipsos. Public Attitudes to Animal Research in 2018. 2018, pp. 1–36. Available online: https://www
Using the Tea Bag Index to determine how two human pharmaceuticals affect litter decomposition by aquatic microorganisms
Abstract
This study demonstrates that independent additive effects of two human pharmaceuticals, the antibiotic trimethoprim and the ...
The authors declare no competing interests.
Animal research
No animals were used in
Transdifferentiation of Human Fibroblasts into Skeletal Muscle Cells: Optimization and Assembly into Engineered Tissue Constructs through Biological Ligands
The development of robust skeletal muscle models has been challenging due to the partial recapitulation of human physiology and ...
vitro human skeletal muscle model, as an alternative to animal experimentation that more closely represents human physiology, necessitates
A review of proficiency exercises offered by the Veterinary Laboratory Investigation and Response Network (Vet-LIRN) and Moffett Proficiency Testing Laboratory from 2012 to 2018
Abstract
The Food and Drug Administration’s Veterinary Laboratory Investigation and Response Network is comprised of more than 40 animal ...
with the principles stated in the Guide for the Care and Use of Laboratory Animals [18]. The contaminated catfish were prepared by feeding
Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis
Abstract
Background
Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has ...
Balb/c mice (6–8 weeks, 18–20 g) from Guangdong Medical Laboratory Animal Center (Benxi, Liaoning, China) were bred in an aseptic-specified
Cancer cells fight for their footing by using an ageing gene
Researchers at the University of Helsinki and the Beatson Institute for Cancer Research in Glasgow have discovered how mutated cells ...
led by Katajisto has previously used a compound for this purpose in aged research animals to enhance the function of aged stem cells. In the
Mathematical Model Predicts that Acceleration of Diabetic Wound Healing is Dependent on Spatial Distribution of VEGF-A mRNA (AZD8601)
Abstract
Introduction
Pharmacologic approaches for promoting angiogenesis have been utilized to accelerate healing of chronic wounds in ...
, and MW designed the animal studies; AB and MW performed all animal experiments and quantification; JA developed the PK model; MR wrote the
Evaluation of efficacy and toxicity of nivolumab combined with or without docetaxel in patients with advanced NSCLC
Abstract
Background
The combination of PD-1/PD-L1 inhibitor and chemotherapy has been clinically confirmed to be beneficial as the first- ...
outlined in the Declaration of Helsinki for all human or animal experimental investigations.
Additional information
Publisher's Note
Ureteroscopic Cryoablation for Patients with Upper Tract Urothelial Carcinoma of a Solitary Kidney: A Porcine Model and Our Pilot Clinical Experience
Abstract
Purpose
To investigate the safety and efficacy of ureteroscopic cryoablation by a liquid-nitrogen system in a porcine model and ...
tract urothelial carcinoma (UTUC) of a solitary kidney.
Methods
In the animal experiment, the right-sided ureter was frozen in nine pigs.
Alzheimer disease research results over-hyped if science papers omit mice from the title
Scientists call for accurate reporting of animal studies to avoid misleading the public with exaggerated news headlines
A study of media ...
.
This is of concern because scientific findings obtained from animal experiments should be reported with caution due to their limited
Alzheimer's research gets more attention if scientists leave out the word 'mice' from study titles
News media are more likely to report on a novel scientific finding about Alzheimer’s disease if the authors fail to disclose in their paper ...
careful in communicating results to the public.
‘The reporting of animal research needs to be addressed with far greater caution and more
News media are 30% more likely to report on Alzheimer's research if scientists leave out the word 'mice' from study titles
If a study title fails to include that Alzheimer's research was done in mice, the study tends to get more media attention, a new pape found ...
the paper, Triunfol and her colleague Dr Fabio Gouveia point to the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines as
A broadly cross-reactive monoclonal antibody against hepatitis E virus capsid antigen
Abstract
To generate a hepatitis E virus (HEV) genotype 3 (HEV-3)–specific monoclonal antibody (mAb), the Escherichia coli–expressed ...
with good animal practice as defined by the Federation of European Laboratory Animal Science Associations (FELASA). All animal protocols
Elevated Anti-Müllerian Hormone Levels in Newborns of Women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis Based on Observational Studies
Abstract
We performed this updated systematic review and meta-analysis to evaluate anti-Müllerian hormone levels (AMH) in newborns of ...
excluded if they (1) were letters, case reports, editorials, animal experiments, or conference abstracts; (2) included individuals of twin
Veterinary Teleradiology Market Value Predicted To Reach US$ 437.6 Million By 2027 Covering COVID-19 Impact: Acumen Research and Consulting
Acumen Research and Consulting, a global provider of market research studies, in a recently published report titled “Veterinary ...
in the United States and Canada, and increased healthcare spending on animal research. During the forecast period, these factors are also
PFOS Inhibited Normal Functional Development of Placenta Cells via PPARγ Signaling
Perfluorooctane sulfonic acid (PFOS), a persistent environmental pollutant, has adverse effects on gestation pregnancy. Peroxisome ...
for the Care and Use of Laboratory Animals released by the US National Institute of Health. Animal experiments and procedures were approved
Breeding and Maintenance of Immunodeficient Mouse Lines under SPF Conditions—A Call for Individualized Severity Analyses and Approval Procedures
In the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience ...
the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience pain
molecules-1247276
Molecules 2021, 26, 3660. https://doi.org/10.3390/molecules26123660 www.mdpi.com/journal/molecules
Article
Phytochemical and In‐ ...
reviewed the man‐
uscript; Z.Y.A. performed the animal experiments and data curation. All authors have read and
agreed to the published
Case reportDeaths Due to Mixed Infections with Passalurus ambiguus
Pathogens 2021, 10, 756. https://doi.org/10.3390/pathogens10060756 www.mdpi.com/journal/pathogens
Case Report
Deaths Due to Mixed ...
in recent years [1], while
they continue to be used as laboratory animals in experiments [2]. Commercially, rabbits
are farmed for their
ijms-1241787
Int. J. Mol. Sci. 2021, 22, 6418. https://doi.org/10.3390/ijms22126418 www.mdpi.com/journal/ijms
Review
Pathophysiological ...
treatments for TBI‐induced cytotoxic edema.
A large number of animal experiments have been performed to develop novel therapeu‐
tic drugs
ijms-1217028-fc done
Int. J. Mol. Sci. 2021, 22, 6416. https://doi.org/10.3390/ijms22126416 www.mdpi.com/journal/ijms
Article
Is PTSD‐Phenotype ...
and guidelines of the NIH Guide for the Care and Use of Laboratory Animals.
All treatment and testing procedures were approved by the
Microbots Gene Delivery System Based on Bifidobacteria in a Tumor Model
In cancer, the use of microbots based on anaerobic bacteria as specific transporters targeting tumor tissues has been explored since most ...
-ZOO-1999, technical specifications for the production care, and use of laboratory animals.
2.7. Fluorescence and Luminescence Analysis
NCs
Protective Effect of Lutein/Zeaxanthin Isomers in Traumatic Brain Injury in Mice
Abstract
Previous studies revealed that oxidative stress and inflammation are the main contributors to secondary injury after traumatic ...
Participate
The experimental protocol was approved by the Animal Research Ethics Committee of Istanbul Medipol University (37
molecules-1209726 - revised
Molecules 2021, 26, 3654. https://doi.org/10.3390/molecules26123654 www.mdpi.com/journal/molecules
Article
Anti‐Helicobacter ...
protocols were approved by
the Ethics Committee for the Care and Use of Laboratory Animals, Faculty of Medicine,
UNAM, Mexico City, Mexico
A Novel Model for Nephrotic Syndrome Reveals Associated Dysbiosis of the Gut Microbiome andExtramedullary Hematopoiesis
cells
Article
A Novel Model for Nephrotic Syndrome Reveals Associated
Dysbiosis of the Gut Microbiome and
Extramedullary Hematopoiesis
...
to the
National Institutes of Health Guide for the Care and Use of Laboratory Animals as well as the German
Cells 2021, 10, 1509 18 of 21
PDLIM2 Suppression Inhibit Proliferation and Metastasis in Kidney Cancer
We evaluated the expression of PDLIM2 in human kidney cancer cell lines from primary or metastatic origins and found that PDLIM2 expression ...
at 20× magnification.
4.7. Animal Studies
All animal experiments were performed in accordance with the Seoul National University Hospital
Inhibitory control in neuronal networks relies on the extracellular matrix integrity
Abstract
Inhibitory control is essential for the regulation of neuronal network activity, where excitatory and inhibitory synapses can act ...
European Union (Directive 2010/63/EU) guidelines for the care and use of laboratory animals. C57BL/6j mice (Envigo, Indianapolis, IN, U.S.A.
Next Generation Sequencing Market Predicted to Exhibit Explosive Growth in Near Future
The global Next Generation Sequencing market which projected a CAGR of approximately 18% in the midst of the estimate time span of 2020- ...
Personalized Medicine and Genetic Screening
Disease Diagnosis
Agriculture and Animal Research
Others
By End User:
Hospital
Research Centers
Effects of Exogenous 6-Phytase (EC 3.1.3.26) Supplementation on Performance, Calcium and Phosphorous Digestibility, and Bone Mineralisation and Density in Weaned Piglets
animals
Article
Effects of Exogenous 6-Phytase (EC 3.1.3.26) Supplementation
on Performance, Calcium and Phosphorous Digestibility, and
...
Agrifood Research & Technology (IRTA) after approval by IRTA’s Ethical Committee on
Animal Experimentation (CEEA); Experiment codes P-504/P-
Viable 3D bioprinted tissues: an animal testing substitute or still years from reality?
Over the last decade, 3D bioprinting has come on leaps and bounds, with significant advances being made in the development of viable, ...
cell-culturing microstructures, which could help reduce the number of animal experiments behind clinical trials in the longer term.
In fact
Osteoclast-Mediated Cell Therapy as an Attempt to Treat Elastin Specific Vascular Calcification
Inflammation and stiffness in the arteries is referred to as vascular calcification. This process is a prevalent yet poorly understood ...
were performed according to protocols approved by the Clemson University Animal Research Committee. Animal care was provided by trained
Peptides from Liza aurata: Natural Source Attenuate Paracetamol Induced Nephrotoxicity by Modulation of the Inflammatory Response and DNA Damage
Abstract
The present study investigates the nephroprotective and the molecular mechanisms effects of Liza aurata protein hydrolysates ( ...
3.5, PB No 1171-14, 3000, Sfax, Tunisia
Sabah Dhibi
Laboratory Animal Eco Physiology, Faculty of Sciences, Sidi Ahmed Zarrouk, PB 11, 2112
ijms-1231808-FC done
Int. J. Mol. Sci. 2021, 22, 6399. https://doi.org/10.3390/ijms22126399 www.mdpi.com/journal/ijms
Article
Cardioprotective ...
Use of Laboratory Animals’’ published by US National Institutes of Health (NIH, Guide,
NRC 2011) and the ‘‘Principles of laboratory animal
Comparative Pathogenesis, Genomics and Phylogeography of Mousepox
viruses
Article
Comparative Pathogenesis, Genomics and Phylogeography
of Mousepox
Carla Mavian 1,† , Alberto López-Bueno 1, Rocío Martín 1 ...
.
Acknowledgments: We thank Juan Alonso Lobo for his help with the animal experiments and
the Genomics and NGS Core Facility at Centro de
Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation
Abstract
We recently reported that cyclin-dependent kinase inhibitor 1 (p21) deficiency induces osteoarthritis susceptibility. Here, we ...
with the recommendations of the Guide for the Care and Use of Laboratory Animals published by the National Institutes of Health (Bethesda,
Fish From Toxic Water Pass Down Epigenetic Mutations to Freshwater Offspring
You can take a fish out of toxic water, but its epigenetic mutations will remain for at least two generations.
A research team led by ...
in the Galapagos and the New Zealand mud snail as well as laboratory animals, showing that epigenetic changes resulting from environmental
Vimentin Promotes the Aggressiveness of Triple Negative Breast Cancer Cells Surviving Chemotherapeutic Treatment
Tremendous data have been accumulated in the effort to understand chemoresistance of triple negative breast cancer (TNBC). However, ...
were handled according to the European Union guidelines for the handling of laboratory animals (Directive 2010/63/EU of the European
SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury
Abstract
In the adult pancreas, the presence of progenitor or stem cells and their potential involvement in homeostasis and regeneration ...
. All experimental protocols were also approved by Zhejiang University Animal Experiment Facility. We confirm that all experiments were
Deficiency of myostatin protects skeletal muscle cells from ischemia reperfusion injury
Abstract
Ischemia reperfusion (IR) injury plays a pivotal role in many diseases and leads to collateral damage during surgical ...
every participant, and participants were identified by numbers. All animal experiments were approved by the IACUC LANUV NRW (The Ministry
Fatty acids suppress the steroidogenesis of the MA-10 mouse Leydig cell line by downregulating CYP11A1 and inhibiting late-stage autophagy
Abstract
Obese men have lower circulating testosterone than men with an optimal body mass index. Elevated fatty acids (FAs) caused by ...
performed according to the Guide for the Care and Use of Laboratory Animals and ARRIVE guidelines.
The concentrations of progesterone in the
CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma
Abstract
Malignant mesothelioma is a cancer with a poor survival rate. It is difficult to diagnose mesotheliomas because they show a ...
for Medical and Health Research involving Human Subjects.
Animal experiments
The experiments conducted using animals strictly adhered to the
Lack of detectable genetic isolation in the cyclic rodent Microtus arvalis despite large landscape fragmentation owing to transportation infrastructures
Abstract
Although roads are widely seen as dispersal barriers, their genetic consequences for animals that experience large fluctuations in ...
in compliance with the ARRIVE guidelines for how to report animal experiments.
DNA extraction and microsatellite genotyping
Total genomic
Plasma metabolomic profiles as affected by diet and stress in Spanish goats
Abstract
The effects of high-condensed tannin (CT) diet combined with preslaughter stress have not been studied at the metabolome level in ...
. The animal care protocols were approved by the FVSU Agricultural and Laboratory Animal Care and Use Committee prior to beginning of the
Determining the effect of aging, recovery time, and post-stroke memantine treatment on delayed thalamic gliosis after cortical infarct
Abstract
Secondary injury following cortical stroke includes delayed gliosis and eventual neuronal loss in the thalamus. However, the ...
in accordance with NIH guidelines for the care and use of laboratory animals and were approved by the Institutional Animal care and use
Functional ultrasound imaging of the spreading activity following optogenetic stimulation of the rat visual cortex
Abstract
Optogenetics has revolutionized neurosciences by allowing fine control of neuronal activity. An important aspect for this control ...
was carried out in compliance with the ARRIVE guidelines.
All animal experiments and procedures were approved by the Local Animal Ethics
Measurement of S-glutathionylated proteins by HPLC
Abstract
S-glutathionylated proteins (GSSP), i.e., protein-mixed disulfides with glutathione (GSH), are considered a suitable biomarker of ...
in accordance with the European Community guidelines for the use of laboratory animals. The experiments were authorized by the local ethical
Neuronal variability reflects probabilistic inference tuned to natural image statistics
The neural sampling theory suggests that neuronal variability encodes the uncertainty of probabilistic inferences. This paper shows that ...
States Public Health Service Guide for the Care and Use of Laboratory Animals.
Visual stimuli were generated with custom software (EXPO V1.5
Intertypic reassortment of mammalian orthoreovirus identified in wastewater in Japan
Abstract
Mammalian orthoreovirus (MRV), a non-enveloped virus with a ten-segmented double-stranded RNA genome, infects virtually all ...
Kouichi Kitamura & Tomoichiro Oka
Management Department of Biosafety and Laboratory Animal, National Institute of Infectious Diseases, Tokyo
Acrolein contributes to human colorectal tumorigenesis through the activation of RAS-MAPK pathway
Abstract
Colorectal cancer (CRC) is one of the most well-known malignancies with high prevalence and poor 5-year survival. Previous studies ...
out in accordance with the Declaration of Helsinki principles. All animal experiments were approved by the Institutional Animal Care and Use
Clinical Characteristics, Treatments and Outcomes of 18 Lung Transplant Recipients with COVID-19
We report clinical features, treatments and outcomes in 18 lung transplant recipients with laboratory confirmed SARS-CoV-2 infection. We ...
of the paucity of clinical data in this group of patients. In animal experiments, remdesivir has been shown to be nephrotoxic in monkeys and
(-)-Englerin-A Has Analgesic and Anti-Inflammatory Effects Independent of TRPC4 and 5
Recently, we found that the deletion of TRPC5 leads to increased inflammation and pain-related behaviour in two animal models of arthritis ...
, D.G. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. Osteoarthr. Cartil. 2012, 20, 256–260.
Serosurvey of Nonhuman Primates in Costa Rica at the Human–Wildlife Interface Reveals High Exposure to Flaviviruses
Arthropod-borne viruses belonging to the flavivirus genus possess an enormous relevance in public health. Neotropical non-human primates ( ...
11501-2060, Costa Rica
2
Department of Ethology, Wildlife and Laboratory Animals, School of Veterinary and Zootechnics, National Autonomous
Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate-exposed premature mice: modulatory effect of raw honey against potential anomalies
Abstract
Phthalates, plasticizing chemicals, are top-rated environmental contaminants. Diethyl phthalate (DEP), a chief member of this ...
the local bioethical committee of the University on animal experimentation.
Consent to participate
Lyme Neuroborreliosis: Mechanisms of B. burgdorferi Infection of the Nervous System
brain
sciences
Review
Lyme Neuroborreliosis: Mechanisms of B. burgdorferi Infection
of the Nervous System
Lenzie Ford 1,* and Danielle M. ...
tissues and long-term mechanistic studies can be carried out
in laboratory animals. Combined, these works have the potential to influence
Egg White Protein Feeding Facilitates Skeletal Muscle Gain in Young Rats with/without Clenbuterol Treatment
Based on the Digestible Indispensable Amino Acid Score (DIAAS), egg white protein (EGG) has an excellent score, comparable to that of whey ...
.K. (Keiichi Koshinaka), R.I., Y.M. and A.S. performed the animal experiments, and K.K. (Keiichi Koshinaka), A.H. and K.K. (Kentaro Kawanaka
Pointing Out Some Issues Regarding Reproduction Management in Murciano-Granadina Goats
Two of the most important problems in high-yielding dairy goat farms are early and accurate pregnancy diagnosis and the appropriate dry off ...
qualified as exempt from experimental protocols by the Committee in Animal Experimentation of the Universitat Politècnica de València.
Data
NLRP3 Inflammasome Promotes the Progression of Acute Myeloid Leukemia via IL-1β Pathway
NLRP3 inflammasome has been reported to be associated with the pathogenesis of multiple solid tumors. However, the role of NLRP3 ...
Model
Female WT C57BL/6J mice were obtained from the Laboratory Animal Center, Shandong University. C1498 cells were intravenously injected
A Novel Orthotopic Implantation Technique for Osteosarcoma Produces Spontaneous Metastases and Illustrates Dose-Dependent Efficacy of B7-H3-CAR T Cells
The outcome for metastatic pediatric osteosarcoma (OS) remains poor. Thus, there is an urgent need to develop novel therapies, and ...
-H3-CAR T cells), we felt that it was not justified to perform additional animal experiments at lower Ctrl-CAR T cell doses.
The most common
Water Extract of Mixed Mushroom Mycelia Grown on a Solid Barley Medium Is Protective against Experimental Focal Cerebral Ischemia
Although the individual consumption of medicinal mushrooms, including Phellinus linteus (PL), Ganoderma lucidum (GL), and Inonotus obliquus ...
the Care and Use of Laboratory Animals (National Institutes of Health publication, 8th Edition, 2011) [39]. Animal experiments in this study
Lanolin-Based Synthetic Membranes for Transdermal Permeation and Penetration Drug Delivery Assays
membranes
Article
Lanolin-Based Synthetic Membranes for Transdermal
Permeation and Penetration Drug Delivery Assays
Cristina Alonso , ...
the Care and Use of Laboratory Animals; National Research Council. Guide for the
Care and Use of Laboratory Animals; The National Academic
The Nevada Biotechnology & Health Science Consortium is Recognizing Dr. Marc Kahn as Medical Professional of the Year and Daniel C. Montano as the Biotech Entrepreneur of the Year
LAS VEGAS, June 15, 2021 (GLOBE NEWSWIRE) -- The Nevada Biotechnology & Health Science Consortium (NevBio) was founded in 2007 to ...
, the number one cause of death in the world. In animal experiments, monkeys given experimental Parkinson’s disease, then treated with
Oxidative Stress Signaling in Blast TBI-Induced Tau Phosphorylation
Traumatic brain injury caused by blast is associated with long-term neuropathological changes including tau phosphorylation and pathology. ...
food and water access in an Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC)-accredited specific antigen-free
Enantiomer distribution of major chiral volatile organic compounds in botrytized grapes and wines
Abstract
In this study, volatile organic compounds in healthy and botrytized grape berries, as well as highly botrytized wines (Tokaj ...
This study did not contain any studies with human participants or animal experiments performed by any of the authors.
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