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New nano particles suppress resistance to cancer immunotherapy
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A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage ...
-2021-002852
Method of Research
Experimental study
Subject of Research
Animals
Article Title
STING agonist loaded lipid
Colonic inflammation induces changes in glucose levels through modulation of incretin system - Pharmacological Reports
Abstract
Background
The role of the incretin hormone, glucagon-like peptide (GLP-1), in Crohn’s disease (CD), is still poorly understood. ...
. All experiments involving animals were accepted by the Local Ethical Committee for Animal Experiments (Protocol #64/LB03/2015). Groups of
Protocol for cryoinjury model in neonatal mice for heart regeneration and repair research
Highlights
•
Low-maternal cannibalization and reproducible cryoinjury model in neonatal mice
•
Tissue processing and sectioning for Masson' ...
in quantification of heart cryoinjury
Summary
The variability of animal experimental groups and high maternal cannibalization are two major
Det skal være slut med forsøgskaniner - og dyreforsøg generelt
Det skal være slut med forsøgskaniner - og dyreforsøg generelt
The Two Faces of Estrogen in Experimental Hemorrhagic Stroke - Translational Stroke Research
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national guidelines for the care and use of laboratory animals were followed.
Conflict of Interest
Effect of marker dosage frequency and spot fecal sampling frequency in the prediction accuracy of fecal output using chromic oxide and titanium dioxide in grazing BON steers - Tropical Animal Health and Production
Abstract
This study aimed to evaluate the effect of two marker dosage frequencies and two spot fecal sampling frequencies on the ...
as inert markers for calculating apparent digestibility in sheep. Journal of Applied Animal Research, 45(1), 275–279.
CAS
Article
Seroprevalence of bovine viral diarrhea virus (BVDV) infection in cattle population in Iran: a systematic review and meta-analysis - Tropical Animal Health and Production
Abstract
Bovine viral diarrhea virus (BVDV) is an important pathogen correlated with reproductive, respiratory, and gastrointestinal ...
leukaemia virus in Iranian cattle and associations among studied agents Journal of Applied Animal Research, 43, 22–25 (Taylor & Francis)
Treatment of Glaucoma Patients with Flammer Syndrome
Flammer syndrome (FS) describes a phenotype characterized by the presence of primary vascular dysregulation along with a number of symptoms ...
or nonexistent in patients who already have low BP; (c) animal experiments have shown that nifedipine increases ocular blood flow, even when
Glycolytic Reprogramming in Silica-Induced Lung Macrophages and Silicosis Reversed by Ac-SDKP Treatment
Glycolytic reprogramming is an important metabolic feature in the development of pulmonary fibrosis. However, the specific mechanism of ...
with the US National Institutes of Health Guide for the Care and Use of Laboratory Animals [3]. Specific pathogen-free (SPF) adult male
Effect of Lactic Acid Bacteria on the Pharmacokinetics and Metabolism of Ginsenosides in Mice
This study aims to investigate the effect of lactic acid bacteria (LAB) on in vitro and in vivo metabolism and the pharmacokinetics of ...
Institutes of Health guidelines for the care and use of laboratory animals.
Informed Consent Statement
Not applicable.
Data Availability
Stellate Ganglion Block Improves the Proliferation and Function of Splenic CD4 + T Cells Through Inhibition of Posthemorrhagic Shock Mesenteric Lymph–Mediated Autophagy - Inflammation
Abstract—
Severe hemorrhagic shock leads to excessive inflammation and immune dysfunction, which results in high mortality ...
.Z., H.Z., Z.Z., and Z.L. performed majority of the animal experiment and laboratory work; Y.L. acquired and analyzed the data; C.N. and Z.Z
Investigating the Central Nervous System Disposition of Actinomycin D: Implementation and Evaluation of Cerebral Microdialysis and Brain Tissue Measurements Supported by UPLC-MS/MS Quantification
Actinomycin D is a potent cytotoxic drug against pediatric (and other) tumors that is thought to barely cross the blood–brain barrier. To ...
Statement
Animal experiments were performed in accordance with national and European guidelines for the care and use of laboratory animals (
European Parliament Votes In Favour Of Plan To End Animal Experiments
The European Parliament has adopted a resolution vote calling on the European Commission to establish an EU-wide Action Plan to replace the ...
Humane Society International/Europe, the European Coalition to End Animal Experiments and PETA, representing over 100 organisations from 24
VKNG-1 Antagonizes ABCG2-Mediated Multidrug Resistance via p-AKT and Bcl-2 Pathway in Colon Cancer: In Vitro and In Vivo Study
The emergence of multidrug resistance (MDR) to chemotherapeutic drugs is a major problem in the therapy of cancer. Knowledge of the ...
and the National Institutes of Health guide for the care and use of laboratory animals.
4.4. Determination of Cytotoxicity by MTT Assay
It
EU-Parlamentet presser på for at afskaffe dyreforsøg i forskning
Der er forskningsområder, hvor vi kan undgå at bruge dyr til forsøg, siger ekspert.
metoderne med dyreforsøg i disse tilfælde, siger Axel Kornerup Hansen.
© Scanpix
Forsøgsdyr i Danmark
I Danmark findes der både forsøgsdyr
Effects of Controlled Generator Fume Emissions on the Levels of Troponin I, C-Reactive Protein and Oxidative Stress Markers in Dogs: Exploring Air Pollution-Induced Cardiovascular Disease in a Low-Resource Country - Cardiovascular Toxicology
Abstract
Exhaust fumes from petrol/diesel-powered electric generators contribute significantly to air pollution in many developing ...
National Research Council: Institute for Laboratory Animal Research. (2011). The guide for the care and use of laboratory animals (8th ed.).
Ladostigil Attenuates Induced Oxidative Stress in Human Neuroblast-like SH-SY5Y Cells
A hallmark of the aging brain is the robust inflammation mediated by microglial activation. Pathophysiology of common neurodegenerative ...
completed CITI program ethical course for good practice in human and animal research. The study is limited to research on established cell
Oxidant-antioxidants and trace mineral status in Coccidiosis affecting buffalo calves - Comparative Clinical Pathology
Abstract
A major cause of economic losses among cattle breeders is calf diarrhea; bovine coccidiosis can cause a severe constriction on ...
Surai FP (2018) Antioxidant systems in poultry biology: superoxide dismutase. Journal of Animal Research and Nutrition 01(01):1–17. https://
The anti-tumour effect of induced pluripotent stem cells against submandibular gland carcinoma in rats is achieved via modulation of the apoptotic response and the expression of Sirt-1, TGF-β, and MALAT-1 in cancer cells - Molecular and Cellular Biochemistry
Abstract
The era of induced pluripotent stem cells (iPSCs) was used as novel biotechnology to replace embryonic stem cells bypassing the ...
Scholar
11.
NIH (2011) Guide for the care and use of laboratory animals, 8th edn. National Academies Press, New York, USA
Methyl Brevifolincarboxylate Attenuates Free Fatty Acid-Induced Lipid Metabolism and Inflammation in Hepatocytes through AMPK/NF-κB Signaling Pathway
The prevalence of non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases worldwide. This study ...
-free grade, weight 18–22 g), were provided by the National Laboratory Animal Center (NLAC) (Nangang, Taipei, Taiwan). Mice maintained on a
Anti-Inflammatory Effect of Charantadiol A, Isolated from Wild Bitter Melon Leaf, on Heat-Inactivated Porphyromonas gingivalis-Stimulated THP-1 Monocytes and a Periodontitis Mouse Model
Porphyromonas gingivalis has been identified as one of the major periodontal pathogens. Activity-directed fractionation and purification ...
the experiments. All animal experiments were conducted in accordance with the Guide for the Care and Use of Laboratory Animals and were
Polyvinyl Alcohol/Chitosan and Polyvinyl Alcohol/[email protected] Bilayer Hydrogel for Tissue Engineering Applications
In this paper, polyvinyl alcohol/Ag-Metal-organic framework (PVA/[email protected]) and polyvinyl alcohol/chitosan (PVA/CS) were used as ...
of the Declaration of Helsinki, and approved by the Laboratory Animal Ethics Committee of Chinese Medicine Sciences (protocol code P20190515
Radiotherapy Combined with PD-1 Inhibition Increases NK Cell Cytotoxicity towards Nasopharyngeal Carcinoma Cells
Background: Nasopharyngeal carcinoma (NPC) in endemic regions and younger patients is characterized by a prominent lymphomononuclear ...
and xenografts were reviewed and approved by the Ethics Committee for animal experimentation n°26 (Gustave Roussy, Villejuif, France), in
'Fearful-place' coding in the amygdala-hippocampal network
Animals seeking survival needs must be able to assess different locations of threats in their habitat. However, the neural integration of ...
or the decision to submit the work for publication.
Ethics
Animal experimentation: All experiments in this study were performed in strict
Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice
Adzuki bean consumption has many health benefits, but its effects on obesity and regulating gut microbiota imbalances induced by a high-fat ...
and Diets
Four-week-old male C57BL/6 mice was purchased from Vital River Laboratory Animal Technology Co., Ltd. (Beijing, China). Mice were
Et mulig skritt på veien i kampen mot antibiotikaresistens
Kjemiingeniør Florian Weber har forsket på alternative måter å forebygge og bekjempe infeksjoner på. Selv om mye ser lovende ut, spør ...
, men det er også strengt av en grunn. Først måtte man ha gjennomført dyreforsøk. Også her spiller etikk en viktig rolle.Forskeren sier det
The Effect of Feeding Hens a Peanut Skin-Containing Diet on Hen Performance, and Shell Egg Quality and Lipid Chemistry
Peanut skins are a considerable waste product with little current economic value or use. We aimed to determine the dietary effects of ...
diet.
Author Contributions
All authors actively contributed to the care and husbandry of all research animals, while co-authors O.T., R.M.
Metabolomic Profiling in Lung Cancer: A Systematic Review
Lung cancer continues to be a significant burden worldwide and remains the leading cause of cancer-associated mortality. Two considerable ...
who may benefit from platinum-based CT [33].
Animal experimental models reported an antineoplastic effect of caffeine, inducing cell
Fagpressen med hederlig omtale til forskning.nos Ingrid Spilde
– Det er et imponerende stykke journalistisk arbeid – særlig fordi journalisten er en mester i å fortelle de mest kompliserte tingene på en ...
siden ser to norske professorer kreftsvulster krympe og forsvinne. De ser forsøksdyr overleve dødelige infeksjoner.
Og alt på grunn av et
Synthetic Antiferromagnetic Gold Nanoparticles as Bimodal Contrast Agents in MRI and CT—An Experimental In Vitro and In Vivo Study
The use of multimodal contrast agents can potentially overcome the intrinsic limitations of individual imaging methods. We have validated ...
used BLI but has also the potential to be used for larger laboratory animals or in the clinic due to unlimited depth penetration. We thus
Galaxaura elongata Extract (GE) Modulates Vanadyl Sulfate-Induced Renal Damage via Regulating TGF-β/Smads and Nrf2/NF-κB Pathways - Biological Trace Element Research
Abstract
Nephrotoxicity becomes a provoked problem as the kidneys are the target of many chemotherapies. For this reason, we aimed to study ...
National Institutes of Health (NIH) guide for the care and use of laboratory animals (NIH Publications No. 8023, revised 1978), Approval No.
Lipid-Based Drug Delivery Systems in Regenerative Medicine
The most important goal of regenerative medicine is to repair, restore, and regenerate tissues and organs that have been damaged as a ...
blood–spinal cord barrier and effectively treat spinal cord injury. In animal experiments, the cyclosporin A-loaded liposomes resulted in a
Effects of a Mixed Limosilactobacillus fermentum Formulation with Claimed Probiotic Properties on Cardiometabolic Variables, Biomarkers of Inflammation and Oxidative Stress in Male Rats Fed a High-Fat Diet
High-fat diet (HFD) consumption has been linked to dyslipidemia, low-grade inflammation and oxidative stress. This study investigated the ...
were in accordance with the National Council for Control of Animal Experimentation (CONCEA), and International Principles for Biomedical
Transovarial Transmission of Borrelia hermsii by Its Tick Vector and Reservoir Host Ornithodoros hermsi
Transovarial passage of relapsing fever spirochetes (Borrelia species) by infected female argasid ticks to their progeny is a widespread ...
Use of Laboratory Animals, and the Guide for the Care and Use of Laboratory Animals, United States Institute of Laboratory Animal Resources,
Radiation-Induced Emesis (RIE) in Extended-Field Radiotherapy for Gynecological Malignancies: Dosimetric and Non-Dosimetric Factors
Radiation-induced emesis (RIE) is usually noted during abdominal-pelvic radiotherapy. In gynecological malignancies, it is usually noted in ...
SB accounts for about 90% of the whole body [8]. Animal experiments have found that cisplatin induces a vomiting pattern, and serotonin is
Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain - Scientific Reports
Abstract
Maladaptive adult neurogenesis in the mammalian brain has been associated with diverse behaviors including disrupted learning, ...
< 0.05 was considered significant in all tests.
All animal experimental procedures in this study were performed in accordance to the ethical
Dietary tomato inhibits angiogenesis in TRAMP prostate cancer but is not protective with a Western-style diet in this pilot study - Scientific Reports
Abstract
Prostate cancer (PCa) remains the second most diagnosed cancer worldwide. Higher body weight is associated with chronic ...
National Institutes of Health Guide for the Care and Use of Laboratory Animals and reported according to the ARRIVE guidelines. Male C57Bl/6
Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts - Scientific Reports
Abstract
The liver is an important metabolic organ that controls homeostasis in the body. Moreover, it functions as a hematopoietic organ, ...
mice were purchased from Nihon SLC (Shizuoka, Japan). Animal experiments were performed with the approval of the Institutional Animal Care
Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity - Nature Communications
PTEN copy number loss is found in 25% of fusion-negative rhabdomyosarcomas (FN-RMS). Here, the authors use a Hedgehog-driven FN-RMS mouse ...
to feel for tumors and scored when first felt. All animal experiments were reviewed and approved by the SJCRH Institutional Animal Care and
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery - Nature Communications
Drug and target discovery for advanced liver disease are hampered by a lack of suitable models for clinical translation. Here the authors ...
wrote the manuscript. B.C.F. and K.K.T. supervised animal experiments (fibrosis/NASH/HCC models). Y.H. supervised the bioinformatic analyses
Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence - Nature Communications
How the bone marrow microenvironment evolves during induction chemotherapy to facilitate acute lymphoblastic leukaemia (ALL) survival ...
Analyser v1.13.5.1 (Bruker microCT, Kontich).
All animal experiments were performed under license PPL 70/8540 approved by the Home Office of
Multiscale computational modeling of cancer growth using features derived from microCT images - Scientific Reports
Abstract
Advances in medical imaging technologies now allow noninvasive image acquisition from individual patients at high spatiotemporal ...
Google Scholar
Percie du Sert, N. et al. Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 20. PLoS Biol. 18
Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex
We hypothesized that an interplay between aryl hydrocarbon receptor (AhR) and cysteine-related thiolome at the kidney cortex underlies the ...
the ethical use of animals were followed, according to the NIH Principles of Laboratory Animal Care (NIH Publication 85-23, revised 1985),
Adipose Tissue Macrophages Modulate Obesity-Associated β Cell Adaptations through Secreted miRNA-Containing Extracellular Vesicles
Obesity induces an adaptive expansion of β cell mass and insulin secretion abnormality. Expansion of adipose tissue macrophages (ATMs) is a ...
, San Diego Research Guidelines for the Care and Use of Laboratory Animals and all animals were randomly assigned to cohorts when used.
2.2
Application of LDH assay for therapeutic efficacy evaluation of ex vivo tumor models - Scientific Reports
Abstract
The current standard preclinical oncology models are not able to fully recapitulate therapeutic targets and clinically relevant ...
Use of Laboratory Animals guidelines in a facility accredited by the Association for the Assessment and Accreditation of Laboratory Animal
DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis - Scientific Reports
Abstract
Leydig cells in the testes produce testosterone in the presence of gonadotropins. Therefore, male testosterone levels must ...
Institutes of Health (NIH) guidelines for the care and use of laboratory animals. This study was also carried out in compliance with the
Gut Microbiome Composition and Metabolic Status Are Differently Affected by Early Exposure to Unhealthy Diets in a Rat Model
Childhood is a critical stage of development during which diet can have profound influence on the microbiota–host interactions, leading to ...
all the procedures were performed by licensed users of Federation of Laboratory Animal Science Associations (FELASA) and in accordance with
Walking patterns of movement disorders shared among worms, mice, and humans
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Osaka, Japan – Scientists from the Graduate School of Information Science and Technology at Osaka ...
Method of Research
Computational simulation/modeling
Subject of Research
Animals
Article Title
Cross-species behavior analysis
Animal testing in NI should be 'urgently addressed', say USPCA
There were almost 30,000 experiments on animals here in 2019 - including 28 beagles and 21 cats
from the practice in the EU.
In 2019 alone, almost 30,000 animal experiments were carried out in labs across Northern Ireland which were ‘
Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring - Scientific Reports
Abstract
“Western diet” containing high concentrations of sugar and fat consumed during pregnancy contributes to development of obesity and ...
8 software (GraphPad Software, San Diego, USA).
The animal experiments were approved by the Animal Ethics Committee at the Poznan University
Dynamic Expression of Membrane Type 1-Matrix Metalloproteinase (Mt1-mmp/Mmp14) in the Mouse Embryo
MT1-MMP/MMP14 belongs to a subgroup of the matrix metalloproteinases family that presents a transmembrane domain, with a cytosolic tail and ...
institutional guidelines. Animal studies were approved by the CNIC Animal Experimentation Ethics Committee and by the Community of Madrid (
Histological Evaluation of Porous Additive-Manufacturing Titanium Artificial Bone in Rat Calvarial Bone Defects
Jaw reconstruction using an additive-manufacturing titanium artificial bone (AMTAB) has recently attracted considerable attention. The ...
The protocol of this study was reviewed and approved by the Animal Research Committee of Osaka Medical College (approval number: 30014).
Assessing CYP2C8-Mediated Pharmaceutical Excipient-Drug Interaction Potential: A Case Study of Tween 80 and Cremophor EL−35
Pharmaceutical excipients (PEs) are substances included in drug formulations. Recent studies have revealed that some PEs can affect the ...
the plasma or liver. Therefore, the results of cell and animal experiments are not sufficient to predict the potential interaction of PEs in
Metformin and Dichloroacetate Suppress Proliferation of Liver Cancer Cells by Inhibiting mTOR Complex 1
The Warburg effect is important for cancer cell proliferation. This phenomenon can be flexible by interaction between glycolysis and ...
the “Guide for the Care and Use of Laboratory Animals” issued by the Institute of Laboratory Animal Resources Commission on Life Science, US
BREAKING: EU votes to end cruel lab animal experiments
“A coherent approach is essential to achieve safety and sustainability, without animal testing. We need to use science. Not animals.”
end the use and misuse of animals for scientific purposes.
“Animal experiments are still used in many different areas of the Commission’s
Enterocytes in Food Hypersensitivity Reactions
Food hypersensitivity reactions are adverse reactions to harmless dietary substances, whose causes are hidden within derangements of the ...
the question of compliance with ethical standards in research work with laboratory animals. It should be emphasized that animals do suffer
EU Lawmakers Seek To Intensify Efforts To Protect Animals Used - London Daily
The European Parliament aimed to make necessary animal testing regimes more humane, and phase
EU lawmakers said they "understood that there are cases where animal experiments are still needed to gain scientific insights for certain
In-Vitro Visualization of Thrombus Growth in Artificial Lungs Using Real-Time X-Ray Imaging: A Feasibility Study - Cardiovascular Engineering and Technology
Abstract
Purpose
Extracorporeal membrane oxygenation has gained increasing attention in the treatment of patients with acute and chronic ...
from three healthy Border Leicester Merino crossbreed sheep from the Monash Animal Research Platform (MARP, Monash University, Clayton/
Current status of xylanase for biofuel production: a review on classification and characterization - Biomass Conversion and Biorefinery
Abstract
Strengthening green alternative energy sources has been enforced due to hydrocarbon fuels’ consequential harmful impacts. Climate ...
Shailendra Kumar Arya.
Ethics declarations
Animal research
Not applicable.
Oncosuppressive role of MicroRNA-205–3p in gastric cancer through inhibition of proliferation and induction of senescence: Oncosuppressive role of MicroRNA-205 in gastric cancer
Highlights
•
The molecular mechanism of miR-205-3p in inhibiting the proliferation and invasion of GC was elucidated in animal and cell ...
methods, like immunohistochemistry, flow cytometry and SA-β-gal in animal experiments.
Results
Based on the study, it is found that the
RIOK2 Inhibitor NSC139021 Exerts Anti-Tumor Effects on Glioblastoma via Inducing Skp2-Mediated Cell Cycle Arrest and Apoptosis
Up to now, the chemotherapy approaches for glioblastoma were limited. 1-[2-Thiazolylazo]-2-naphthol (named as NSC139021) was shown to ...
/L6 mouse (10–12 weeks) were obtained from Beijing Vital River Laboratory Animal Technology Co., Ltd., and all mice were housed in barrier
Tanshinone I restrains osteosarcoma progression by regulating circ_0000376/miR-432-5p/BCL2 axis - Molecular and Cellular Biochemistry
Abstract
Circular RNAs (circRNAs) have been identified as important regulators in cancer progression. Nevertheless, little is known about ...
were in strict conformity to the guidelines on the use of laboratory animals and approved by China-Japan Union Hospital Jilin University.
Motivation matters: lighter littermates of the domestic cat compete more successfully for meat at weaning - Behavioral Ecology and Sociobiology
Abstract
Widespread recognition of the contribution of individual differences in behavioral phenotype to evolutionary processes raises ...
and according to the National Guide for the Production, Care and Use of Laboratory Animals, Mexico (Norma Oficial Mexicana NOM-062–200-1999)
Increase of serum uric acid levels associated with APOE ε2 haplotype: a clinico-genetic investigation and in vivo approach - Human Cell
Abstract
Elevated serum uric acid (SUA)—hyperuricemia—is caused by overproduction of urate or by its decreased renal and/or intestinal ...
and Cardiovascular Center Research Institute) for skilled technical assistance in the animal experiments. We are indebted to J. Abe, M.
A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice - Transgenic Research
Abstract
Tryptophan 2,3-dioxygenase (TDO2) was an initial rate-limiting enzyme of the kynurenine (Kyn) pathway in tryptophan (Trp) ...
of the laboratory animal care guidelines. The present study complied with principles and standards for reporting animal experiments in
The time-dependent variations of zebrafish intestine and gill after polyethylene microplastics exposure - Ecotoxicology
Abstract
Microplastics (MPs) are common environmental contaminants that present a growing health concern due to their increasing presence ...
the National Institutes of Health Guide for the Care and Use of Laboratory Animals (China).
Additional information
Publisher’s note Springer
Mouse resources at the RIKEN BioResource Research Center and the National BioResource Project core facility in Japan - Mammalian Genome
Abstract
The RIKEN BioResource Research Center (BRC) was established in 2001 as a comprehensive biological resource center in Japan. The ...
animal experiments. In general, commercial breeders have established global standards and contributed to high-quality animal experiments in
Involvement of the nociceptin opioid peptide receptor in morphine-induced antinociception, tolerance and physical dependence in female mice - Metabolic Brain Disease
Abstract
Nociceptin opioid peptide (NOP) receptor modulates pain transmission and is considered a prospective target for pain management. ...
with the National Institutes of Health’s Guide for the Care and Use of Laboratory Animals (NIH Publication No. 80 − 23). None of the authors
European Parliament calls for faster end to use of laboratory animals
On Thursday 16 September, the European Parliament called on the European Union to speed up the transition to a research system that no ...
European Parliament calls for faster end to use of laboratory animals
Can fruit fly research help improve survival of cancer patients?
The experience of a fruit fly dying from cancer may seem worlds away from that of a human with a life-threatening tumor, yet University of ...
concerns prevent researchers from allowing vertebrates to suffer, so research animals are euthanized before they die naturally, preventing a
Development of ELISA Using Recombinant Proteins for the Diagnosis of Mycoplasma hyopneumoniae Infection - Indian Journal of Microbiology
Abstract
In order to develop a more sensitive and reliable method for detection of serum antibodies against Mycoplasma hyopneumoniae ...
accredited by the Brazilian National Council for Animal Experimentation Control (CONCEA).
Consent
Gα13 Contributes to LPS-Induced Morphological Alterations and Affects Migration of Microglia - Molecular Neurobiology
Abstract
Microglia are the resident immune cells of the CNS that are activated in response to a variety of stimuli. This phenotypical ...
.
Ethics declarations
Ethics Approval
All animal experiments have been carried out
6 Omega 6-Rich Foods You Should Be Eating
They seem like the outcast of the family of fats, but omega-6 fatty acids deserve to share the spotlight. After all, you'll find notable ...
risk of colorectal cancer. And there's more good news. Animal research in Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Link between inflammation and pancreatic cancer development uncovered
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HOUSTON ― A new discovery from researchers at The University of Texas MD Anderson Cancer Center has ...
.abj0486
Method of Research
Experimental study
Subject of Research
Animals
Article Title
Epithelial memory of resolved
The Pathobiology of H7N3 Low and High Pathogenicity Avian Influenza Viruses from the United States Outbreak in 2020 Differs between Turkeys and Chickens
An outbreak caused by H7N3 low pathogenicity avian influenza virus (LPAIV) occurred in commercial turkey farms in the states of North ...
between the US 2020 H7N3 LPAIVs and HPAIV used as inoculum for the animal experiments. na: not applicable.
LPAIV-1LPAIV-2HPAIVPositionAmino
Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice - Microbiome
Background
Non-alcoholic liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, and it can progress to non-alcoholic ...
the Institutional Guidelines on Animal Experimentation at Keio University or the Guidelines for the Proper Conduct of Animal Experiments (
Adding New Pieces to the Puzzle of Karyotype Evolution in Harttia (Siluriformes, Loricariidae): Investigation of Amazonian Species
A remarkable morphological diversity and karyotype variability can be observed in the Neotropical armored catfish genus Harttia. These ...
followed the ethical conduct approved by the Ethics Committee on Animal Experimentation of the Universidade Federal de São Carlos (Process
Effect of the Non-Immunosuppressive MPT Pore Inhibitor Alisporivir on the Functioning of Heart Mitochondria in Dystrophin-Deficient mdx Mice
Supporting mitochondrial function is one of the therapeutic strategies that improve the functioning of skeletal muscle in Duchenne muscular ...
M.V.D.
Institutional Review Board Statement
The study with laboratory animals was carried out in accordance with the European Convention for
Co-Treatment with the Epigenetic Drug, 3-Deazaneplanocin A (DZNep) and Cisplatin after DZNep Priming Enhances the Response to Platinum-Based Therapy in Chondrosarcomas
Background: We have previously shown that 3-Deazaneplanocin A (DZNep) induces apoptosis in chondrosarcomas. Herein, we tested whether the ...
Ligue Contre le Cancer.
Institutional Review Board Statement
Animal experimental procedures were performed according to local legislation,
Newly discovered two-cell color detection system of lamprey as clue to the evolution of color vision
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Most non-mammalian vertebrates have a color detection system in the pineal organ of the brain that is ...
-1
Method of Research
Experimental study
Subject of Research
Animals
Article Title
Insights into the evolutionary origin
A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo
Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting annually in ~219,000 deaths and a societal cost of ...
the regulations of the European Union (EU) concerning the welfare of laboratory animals as declared in Directive 2020/569/EU. All procedures
MEPs call for EU timeline on reduction of animal research
Push “threatens the future of effective biomedical research in Europe”, says advocacy organisation
The European Parliament has called ...
MEPs call for EU timeline on reduction of animal research
Historic Vote: Overwhelming Majority of MEPs Vote Yes on Plan to End Animal Experiments
PETA
Vote: Overwhelming Majority of MEPs Vote Yes on Plan to End Animal Experiments
London –- In a monumental move for animals in European Union
Influence of HFD-induced precocious puberty on neurodevelopment in mice
BackgroundPrecocious puberty is frequently associated with obesity, which will lead to long-term effects, especially on growth and ...
the test, food and water were provided ad libitum. The animal experiments approved by a regulatory institution and performed according to
Researchers explore promising new stem cell treatment for MRSA superbug
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Durham, NC – A study released in STEM CELLS Translational Medicine (SCTM), by researchers at the Baker ...
21-0058
Method of Research
Experimental study
Subject of Research
Animals
Article Title
Mesenchymal stromal cell-secreted
Constitutive BAK/MCL1 complexes could predict sensitivity of chemotherapy drugs, research shows
A research team led by Prof. DAI Haiming from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences (CAS) ...
, and their combination. Further studies on PDX models and animal experiments also illustrate the predictive effect of the BAK/MCL1 complex.
Methodology of Selecting the Optimal Receptor to Create an Electrochemical Immunosensor for Equine Arteritis Virus Protein Detection
The study reports a methodology of selecting the optimal receptor to create an electrochemical immunosensor for equine arteritis virus (EAV ...
, Munich, Germany) when necessary. Animal experiments obtained approval from the Local Ethics Committee for Animal Experiments (No. 76/2016)
European Parliament votes for EU-wide plan to phase out animal testing
Members of the European Parliament (MEPs) have adopted a resolution vote calling on the European Commission to establish an EU-wide action ...
vote was important in the context of the wider fight against animal experiments, but also in the cosmetic industry’s fight to protect its
Identification of circulating sphingosine kinase-related metabolites for prediction of type 2 diabetes - Journal of Translational Medicine
AbstractBackgroundSphingosine Kinase (SphK) that catalyzes sphingosine (Sph) to sphingosine 1-phosphate (S1P), plays a key role in both ...
and Human Services Public Health Service Policy on Humane Care and Use of Laboratory Animals (NIH publication No. 15-8013; Bethesda, MD, USA
Cell Properties of Lung Tissue-Resident Macrophages Propagated by Co-Culture with Lung Fibroblastic Cells from C57BL/6 and BALB/c Mice
Tissue-resident macrophages (Mø) originating from foetal precursors are maintained by self-renewal under tissue/organ-specific ...
7–8 weeks were used in this study. The animal experimentation protocol was approved by the Animal Research Committee of the Osaka Prefecture
MEPs call for a complete end to animal testing in EU
Members of the European Parliament have called on the EU to bring an end to testing on laboratory animals.
The use of animals for the ...
Parliament have called on the EU to bring an end to testing on laboratory animals.
The use of animals for the testing of cosmetics safety
Giant Waikato penguin: school kids discover new species
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A giant fossilized penguin discovered by New Zealand school children has been revealed as a new species ...
.1953047
Method of Research
Observational study
Subject of Research
Animal tissue samples
Article Title
A giant Oligocene
FDA's Centre for Veterinary Medicine deems TriviumVet's feline HCM program eligible for expanded conditional approval pathway
FDA's Centre for Veterinary Medicine deems TriviumVet's feline HCM program eligible for expanded conditional approval pathway
formulation (Felycin) in treating HCM. Results of previous laboratory animal studies and effects observed in human organ transplant patients
EU lawmakers seek end to science experiments on animals
The European Union should intensify efforts to phase out the use of animals in scientific research, lawmakers have said in a resolution.
and suffering" inflicted on animals.
Current conditions for animal experiments
Current EU legislation strives to protect the welfare of
Development of CIDEA reporter mouse model and its application for screening thermogenic drugs - Scientific Reports
Abstract
Cell death-inducing DNA fragmentation factor-like effector A (CIDEA) is a lipid droplet-associated protein and is a known marker ...
CideaLuc2-tdT) mouse strain.
Animal experiments
All of the protocols related to animal experiments were approved by the Institutional Animal
European Parliament votes to replace animal testing with modern science
The European Parliament has voted to replace barbaric animal experiments with cutting-edge science, saving nearly 10 million animals a year ...
The European Parliament has voted to replace barbaric animal experiments with cutting-edge science, saving nearly 10 million animals a year.
Protective mechanism of Erigeron breviscapus injection on blood–brain barrier injury induced by cerebral ischemia in rats - Scientific Reports
Abstract
This study investigates the protective effect of Erigeron breviscapus injection, a classic traditional Chinese medicine most ...
to participate
Our animal experiments were approved by Chengdu Dashuo Biotechnology Co., Ltd. and bearing laboratory animal production
EU-parlamentet vil ha skjerpet kamp mot dyreforsøk
© (NTB scanpix)
Store forskingsframskritt er gjort ved hjelp av dyreforsøk. Nå blir EU-kommisjonen bedt om å utarbeide en plan for hvordan ...
er gjort ved hjelp av dyreforsøk. Nå blir EU-kommisjonen bedt om å utarbeide en plan for hvordan dyreforsøkene kan avvikles. Foto: Ned Alley
Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits - Nature Communications
In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal ...
protocols were approved by the British National Committee for Ethics in Animal Research.
Brain slices were prepared from P30-40 male mice.
Transformation of tenofovir into stable ProTide nanocrystals with long-acting pharmacokinetic profiles - Nature Communications
Antiretroviral therapy (ART) for the treatment of HIV-1 requires life-long daily adherence to supress viral replication, and nucleoside ...
Medical Center (UNMC) laboratory animal facility according to the American Animal Association and Laboratory Animal Care guidance. All
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