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Secondary metabolites from acridocarpus orientalis inhibits 4T1 cells and promotes mesenchymal stem cells (MSCs) proliferation
Abstract
Among medicinal plants, Acridocarpus orientalis (AO) possesses a remarkable anti-cancer potential, possibly because of its anti-...
Research involving human and animals rights
The animal experiments were done according to the guidelines of the ...
Standardized Extract of Atractylodis Rhizoma Alba and Fructus Schisandrae Ameliorates Coughing and Increases Expectoration of Phlegm
Cough and phlegm frequently occur in respiratory diseases like upper respiratory tract infections, acute bronchitis, and chronic ...
302, Anton Paar, Graz, Austria).
4.7. Animals
The animal experiments were performed according to the U.S. National Institutes of...
STAT2 Limits Host Species Specificity of Human Metapneumovirus
The host tropism of viral infection is determined by a variety of factors, from cell surface receptors to innate immune signaling. Many ...
).
2.8. In Vivo Infection and Serial Passage
For all animal experiments, mice were anesthetized with ketamine-xylazine (mouse ...
Medical breakthrough could help farmers breed healthier pigs
The most accurate map of the genetic code of pigs yet produced may pave the way for farmers to breed healthier and more productive animals...
Department of Agriculture’s (USDA) Agricultural Research Service Meat Animal Research Centre and involved 40 scientists from 15 ...
nutrients-849345
Nutrients 2020, 12, 1988; doi:10.3390/nu12071988 www.mdpi.com/journal/nutrients
Article
L‐Theanine Reduced the Development of Knee
...
.
All animal experiments were carried out in accordance with the guidelines of the China Ethical
Committee for Animal...
Combination Antioxidant/NSAID Therapies and Oral/Topical Ocular Delivery Modes for Prevention of Oxygen-Induced Retinopathy in a Rat Model
Given the complexity of oxygen-induced retinopathy (OIR), we tested the hypothesis that combination therapies and modes of administration ...
Department of Agriculture and the Guide for the Care and Use of Laboratory Animals. Certified infection-free, timed-pregnant ...
Behavioral Methods for Severity Assessment
It has become mandatory for the application for allowance of animal experimentation to rate the severity of the experimental procedures. In...
animal experimentation to rate the severity of the experimental procedures. In order to minimize suffering related to animal ...
animals-834974
Animals 2020, 10, 1136; doi:10.3390/ani10071136 www.mdpi.com/journal/animals
Review
Behavioral Methods for Severity Assessment
Pia ...
possibility to better understand laboratory animals in their entirety, which can also lead to better
animal research
Marine Excitatory Amino Acids: Structure, Properties, Biosynthesis and Recent Approaches to Their Syntheses
This review considers the results of recent studies on marine excitatory amino acids, including kainic acid, domoic acid, dysiherbaine, and...
, and to evaluate efficiency of various therapeutic interventions on laboratory animals with simulated diseases [29,30,31].
The ...
animals-786801
Animals 2020, 10, 1133; doi:10.3390/ani10071133 www.mdpi.com/journal/animals
Article
Dietary Preference of Newly Weaned Pigs and
...
Materials and Methods
2.1. Ethics Statement
All animal experimentation procedures were approved by the Ethics Committee...
Location, location, location: Even gut immune response is site-specific
Why is it that some chronic inflammatory bowel diseases, such as Crohn's, affect both the small intestine and the colon, while others, like...
between humans and animals, organoids can help to reduce animal experiments and illuminate uniquely human diseases. They also play...
MiR-1976 knockdown promotes epithelial–mesenchymal transition and cancer stem cell properties inducing triple-negative breast cancer metastasis
Abstract
Triple-negative breast cancer (TNBC), characterized by high aggression and invasiveness, has a worse prognosis than other subtypes...
activity/Renilla Luciferase activity.
Animal models
All animal experiments were approved by the Nanjing Medical University ...
Using Epo to treat COVID-19
Erythropoietin (Epo) is actually a medication for anemia. According to researchers at the Max Planck Institute of Experimental Medicine in ...
have now summarized the various studies on the effects of Epo. Animal experiments suggest that Epo acts on areas of the brain stem...
French business leaders support new animal welfare campaign
Three high-profile business founders in France have come out in support of holding a referendum on animal welfare issues - including the ...
the end of battery and intensive farming, the use of fur, and animal experimentation.
Xavier Niel, the founder of internet firm ...
Subtyping analysis reveals new variants and accelerated evolution of Clostridioides difficile toxin B
Shen et al. compare the amino acid sequences of bacterial toxins TcdA and TcdB from 3,269 Clostridioides difficile genomes to identify four...
, male, specific-pathogen-free) were purchased from the Laboratory Animal Resources Center at Westlake University (Hangzhou, China...
Task rule and choice are reflected by layer-specific processing in rodent auditory cortical microcircuits
Marina M. Zempeltzi et al. show that task- and choice-related information is encoded by layer-specific population activity in the primary ...
presented in this study were conducted in accordance with ethical animal research standards defined by the German Law and approved...
Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures
Wallén-Mackenzie et al. investigate anatomical–functional organization of the subthalamic nucleus in mice, using single-nuclei RNA ...
were conducted with permission from the local Animal Ethical Committee (Uppsala Djurförsöksetiska Nämnd, Uppsala, Sweden).
...
Supplementation of 17-Estradiol Normalizes Rapid Gastric Emptying by Restoring Impaired Nrf2 and nNOS Function in Obesity-Induced Diabetic Ovariectomized Mice
antioxidants
Article
Supplementation of 17β-Estradiol Normalizes Rapid
Gastric Emptying by Restoring Impaired Nrf2 and
nNOS Function in ...
of the National Institutes
of Health (NIH) Guide for the Care and Use of Laboratory Animals. Adult female C57BL/6J (12–15
weeks ...
Investigations of an inducible intact dystrophin gene excision system in cardiac and skeletal muscle in vivo
Abstract
We sought here to induce the excision of a large intragenic segment within the intact dystrophin gene locus, with the ultimate ...
(NIH) guidelines, standards of the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC International), ...
A Cu9S5 nanoparticle-based CpG delivery system for synergistic photothermal-, photodynamic- and immunotherapy
CpG oligonucleotides can stimulate an anticancer immune response. Zhou et al. now develop nanoparticles that can deliver CpG, which ...
).
Female Balb/c mice (4–5 weeks) were purchased from Shanghai Laboratory Animal Center (SLAC, Shanghai, China) and bred in a ...
Increased Alcohol Consumption in Mice Lacking Sodium Bicarbonate Transporter NBCn1
Abstract
The previous reports on an addiction vulnerability marker in the human SLC4A7 gene encoding the Na/HCO3 transporter NBCn1 suggest ...
the National Institute of Health Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Animal ...
IgM antibodies against malondialdehyde and phosphorylcholine in different systemic rheumatic diseases
Abstract
IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) may have protective properties in cardiovascular...
of dead and dying cell26, this notion is in line with animal experiments showing increased uptake of apoptotic cells by IgM anti-...
Oat and Rye Bran Boost Gut Microbiome and Benefit Health
In a newly published experimental study, the consumption of dietary fibre from oat and rye brans supported the growth of beneficial gut ...
and improved glucose, lipid and adipose tissue metabolism in human and animal experimental research. In addition, they have been ...
A novel silkworm infection model with fluorescence imaging using transgenic Trichosporon asahii expressing eGFP
Abstract
Trichosporon asahii is a pathogenic fungus that causes deep mycosis in patients with neutropenia. Establishing an experimental ...
by T. asahii, however, remain unclear. Establishing a simple animal experimental system for systemic infection with hyphal ...
Hope for new antibiotic that was discovered by accident
Cancer researcher Marit Otterlei made a chance discovery of a brand new antibiotic that has proven effective after several experiments.
...
, like a wound ointment, you have to start all over with new animal experiments to develop the peptide into something that could ...
Molecular Cloning, Characterization, and Expression Regulation of Acyl-CoA Synthetase 6 Gene and Promoter in Common Carp Cyprinus carpio
Omega-3 long chain polyunsaturated fatty acids (n-3 LC-PUFA), particularly docosahexaenoic acids (22:6n-3, DHA), have positive effects on ...
following the National Institutes of Health guide for the care and use of laboratory animals (NIH Publications No. 8023, revised ...
Roslin Institute-led research decodes pigs’ genetic make-up
Stock photo.
The findings could help improve selective breeding and enable more accurate use of gene-editing technologies to develop pigs ...
and the US Department of Agriculture’s Agricultural Research Service Meat Animal Research Centre, and involved 40 scientists from ...
MicroRNA-375 represses tumor angiogenesis and reverses resistance to sorafenib in hepatocarcinoma
Abstract
Sorafenib was originally identified as an inhibitor of multiple oncogenic kinases and remains the first-line systemic therapy for ...
Beijing Vital River Laboratory Animal Technology Co., Ltd. and bred under pathogen-free conditions. All animal experiments
Oat and rye bran fibres alter gut microbiota, reducing weight gain and hepatic inflammation
In a newly published experimental study, the consumption of dietary fiber from oat and rye brans supported the growth of beneficial gut ...
to supplementation with oat and rye bran fibers.
The study was an animal experiment during which mice were fed a high-fat Western...
July infringements package: key decisions
Overview by policy area
In its regular package of infringement decisions, the European Commission pursues legal action against Member ...
on the protection of laboratory animals
The Commission is urging Poland to ensure compliance with the Laboratory Animals ...
animals-819064
Animals 2020, 10, 1128; doi:10.3390/ani10071128 www.mdpi.com/journal/animals
Article
Genomic Analysis of Staphylococcus aureus Strains
...
of the dermis, but also could be the origin
of the disease. Animal experimental models [29,30] could decide this question, ...
nutrients-800569
Nutrients 2020, 12, 1973; doi:10.3390/nu12071973 www.mdpi.com/journal/nutrients
Review
The Effectiveness of Probiotics in the Treatment...
‐17 and protected from the colitis induced by Helicobacter hepaticus in an animal
experimental model [53]. Atarashi and ...
Bifidobacterium longum subsp. longum OLP-01 Supplementation during Endurance Running Training Improves Exercise Performance in Middle- and Long-Distance Runners: A Double-Blind Controlled Trial
Bifidobacterium longum subsp. longum Olympic No. 1 (OLP-01) has been shown in previous animal experiments to improve exercise endurance ...
Olympic No. 1 (OLP-01) has been shown in previous animal experiments to improve exercise endurance performance, but this effect ...
Xtalks Announces Its Life Science Webinar Calendar for July 2020
Xtalks Announces Its Life Science Webinar Calendar for July 2020
from Exploratory Research to Clinical Trials
July 15- The Role of the Laboratory Animal Diet in Shaping the Gut Microbiota
July ...
Nitric Oxide-Releasing S-Nitrosoglutathione- Conjugated Poly(Lactic-Co-Glycolic Acid) Nanoparticles for the Treatment of MRSA-Infected Cutaneous Wounds
pharmaceutics
Article
Nitric Oxide-Releasing S-Nitrosoglutathione-
Conjugated Poly(Lactic-Co-Glycolic Acid)
Nanoparticles for the Treatment...
.1. Macroscopic Assessment: Wound Size Reduction
All animal experiments were approved by Pusan National University Institutional ...
animals-828431
Animals 2020, 10, 1126; doi:10.3390/ani10071126 www.mdpi.com/journal/animals
Review
MicroRNA Milk Exosomes: From Cellular Regulator
to ...
studies have been reported on milk‐derived EXO, of human and laboratory animal
origin, with both in vitro and in vivo ...
animals-833663
Animals 2020, 10, 1127; doi:10.3390/ani10071127 www.mdpi.com/journal/animals
Article
Differential Dynamics of the Ruminal Microbiome of...
S.T.; Clark, R.A. The Design and Statistical Analysis of Animal Experiments; Cambridge University Press:
Cambridge, UK, 2014.
35...
Effect of Social Rank upon Estrus Induction and Some Reproductive Outcomes in Anestrus Goats Treated With Progesterone + eCG
We evaluated the possible role of the social rank [R] (i.e., low—LSR, middle—MSR, or high—HSR) in anestrus goats exposed ...
NAM-National Academy of Medicine. Guide for the Care and Use of Laboratory Animals. Co-Produced by the National Academy of ...
Tetanus insensitive VAMP2 differentially restores synaptic and dense core vesicle fusion in tetanus neurotoxin treated neurons
Abstract
The SNARE proteins involved in the secretion of neuromodulators from dense core vesicles (DCVs) in mammalian neurons are still ...
were produced as described before58.
Laboratory animals, primary neuron cultures and infection
All animal experiments ...
GoldenBiotech wins FDA approval to begin Phase 2 trial of Antroquinonol in COVID-19 patients in the US
Taiwanese biopharmaceutical company Golden Biotechnology Corp disclosed on Wednesday the receipt of approval from the US FDA for its ...
nucleic acid replication and viral protein synthesis in both cell and animal experiments. Prevention of organ and tissue damage ...
Enhanced Notch3 signaling contributes to pulmonary emphysema in a Murine Model of Marfan syndrome
Abstract
Marfan syndrome (MFS) is a heritable disorder of connective tissue, caused by mutations in the fibrillin-1 gene. Pulmonary ...
of Nebraska Medical Center Animal Care Committee for the use and care of laboratory animals. Heterozygous mutant mice (Fbn1mgR/+ ...
Hepatic regeneration following radiation-induced liver injury is associated with increased hepatobiliary secretion measured by PET in Göttingen minipigs
Abstract
Normal liver tissue is highly vulnerable towards irradiation, which remains a challenge in radiotherapy of hepatic tumours. Here, ...
and all experiments were performed according to the current law on animal experimentation and ethics. The environmental conditions...
Effects of pirfenidone targeting the tumor microenvironment and tumor-stroma interaction as a novel treatment for non-small cell lung cancer
Abstract
Targeting cancer-associated fibroblasts (CAFs), as well as the crosstalk between stroma and cancer cells, could be of value in ...
immunohistochemical analyses. All animal studies were approved by the Osaka University Animal Experiment Committee (Approval No. ...
Tofacitinib treatment aggravates Staphylococcus aureus septic arthritis, but attenuates sepsis and enterotoxin induced shock in mice
Abstract
Tofacitinib, a janus kinase inhibitor, is a novel immunosuppressive drug for treatment of rheumatoid arthritis (RA). Septic ...
. Experiments were approved by the Animal Research Ethical Committee of Gothenburg, and animal experimentation guidelines...
Variability and sex-dependence of hypothermic neuroprotection in a rat model of neonatal hypoxic–ischaemic brain injury: a single laboratory meta-analysis
Abstract
Therapeutic hypothermia (HT) is standard care for term infants with hypoxic–ischaemic (HI) encephalopathy. However, the efficacy ...
and severity of injury.
References
1.
Franco, N. H. Animal experiments in biomedical research: a historical perspective. Animals...
The anterior and medial thalamic nuclei and the human limbic system: tracing the structural connectivity using diffusion-weighted imaging
Abstract
The limbic system is a phylogenetically old, behaviorally defined system that serves as a center for emotions. It controls the ...
whose components have evolved and increased over time. Previous animal research indicates that the anterior nuclear group of the ...
Quantification of muco-obstructive lung disease variability in mice via laboratory X-ray velocimetry
Abstract
To effectively diagnose, monitor and treat respiratory disease clinicians should be able to accurately assess the spatial ...
is shown by the characterisation of CF-like lung disease in small laboratory animals at high resolution using a synchrotron-based ...
EpCAM-Binding DARPins for Targeted Photodynamic Therapy of Ovarian Cancer
Ovarian cancer is the most lethal gynecological malignancy due to late detection associated with dissemination throughout the abdominal ...
in accordance with the guidelines of the Revised Dutch Act on Animal Experimentation.
5. Conclusions
DARPin-IRDye 700DX ...
Influenza virus infection affects insulin signaling, fatty acid-metabolizing enzyme expressions, and the tricarboxylic acid cycle in mice
Abstract
Although the severity of influenza virus infections has been associated with host energy metabolism, the related mechanisms have ...
following the Fundamental Guidelines for Proper Conduct of Animal Experiment and Related Activities in Academic Research ...
Extremely preterm children exhibit altered cortical thickness in language areas
Abstract
Children born extremely preterm (< 28 weeks gestation, EPT) are at increased risk for language and other neurocognitive deficits ...
proliferative zones occurs from approximately 10–25 weeks, and animal experiments suggest that an increase in this neurogenesis ...
Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: what is the best choice?
Abstract
Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that ...
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nutrients-838984 final1
Nutrients 2020, 12, 1967; doi:10.3390/nu12071967 www.mdpi.com/journal/nutrients
Article
Collagen Extract Derived from Yeonsan Ogye
...
manufacturer’s instructions.
2.7. Animals and Diet
All animal experiments were approved by the Institutional Animal Care and Use...
Regulatory Effect of Lactobacillus brevis Bmb6 on Gut Barrier Functions in Experimental Colitis
The integrity of gut barrier functions is closely associated with the pathogenesis of colitis. It is speculated that Lactobacillus brevis ...
2.6. Induction and Assessment of DSS-Induced Colitis
All animal experiments were approved and performed in accordance with the ...
Oat and rye bran fibres alter gut microbiota, reducing weight gain and hepatic inflammation
In a newly published experimental study, the consumption of dietary fibre from oat and rye brans supported the growth of beneficial gut ...
to supplementation with oat and rye bran fibres.
The study was an animal experiment during which mice were fed a high-fat ...
Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer’s disease model by increasing the expression of microRNA-146a in hippocampus
Abstract
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β and tau. We previously reported that administration of ...
Animals
All methods for animal experiments were performed in accordance with the approved guidelines of the Animal Experiment...
Anti-viral and Anti-Inflammatory Response: GoldenBiotech's Antroquinonol Receives FDA Approval on COVID-19 Phase 2 Trial in USA
Update! FirstWord is updating its Privacy Policy as of May 25, 2018 to reflect changes in global data protection and data privacy laws, ...
nucleic acid replication and viral protein synthesis in both cell and animal experiments. Prevention of organ and tissue damage ...
Findings From "Mini-brain" Study Suggest SARS-CoV-2 Can Infect Human Brain Cells
A multidisciplinary team from two Johns Hopkins University institutions, including neurotoxicologists and virologists from the Bloomberg ...
online June 26, 2020, in the journal ALTEX: Alternatives to Animal Experimentation.
Early reports from Wuhan, China, the origin ...
Anti-viral and Anti-Inflammatory Response: GoldenBiotech's Antroquinonol Receives FDA Approval on COVID-19 Phase 2 Trial in USA
TAIPEI, July 1, 2020 /PRNewswire/ -- Golden Biotechnology Corp. (GoldenBiotech, 4132.TWO), a leading Taiwanese biopharmaceutical company, ...
nucleic acid replication and viral protein synthesis in both cell and animal experiments. Prevention of organ and tissue damage ...
Protective Effects of Dietary Grape on UVB-Mediated Cutaneous Damages and Skin Tumorigenesis in SKH-1 Mice
Non-melanoma skin cancers (NMSCs) are the most diagnosed cancers in the US and occur more frequently in males. We previously demonstrated ...
is equivalent to one ¾ cup serving of whole grapes.
All animal experiments were approved by the University of Wisconsin ...
Lab-grown 'mini-brains' can be infected by SARS-CoV-2 virus
Reviewed by James Ives, M.Psych. (Editor)Jul 1 2020
A multidisciplinary team from two Johns Hopkins University institutions, including ...
online June 26, 2020, in the journal ALTEX: Alternatives to Animal Experimentation.
Early reports from Wuhan, China, the origin of...
animals-822319
Animals 2020, 10, 1124; doi:10.3390/ani10071124 www.mdpi.com/journal/animals
Technical Note
Glucocorticoid Receptor Agonists to Improve ...
Chapter 11: Swine. In Guide for the Care and Use of Laboratory Animals;
Federation of Animal Science Societies: Champaign, IL, ...
How lab animals have fared in the coronavirus crisis
The current pandemic has impacted lab animals, with US research labs culling thousands of mice. Germany has coped somewhat better, but the ...
bracing himself for the coronavirus pandemic to hit Germany.
As the animal research and welfare officer at the Max Planck Society...
The Impact of Sugar-Sweetened Beverage Consumption on the Liver: A Proteomics-based Analysis
Cardiometabolic complications such as the metabolic syndrome and Type 2 Diabetes Mellitus (T2DM) are major causes of global morbidity and ...
handling were in agreement with the Guide for the Care and Use of Laboratory Animals of the National Academy of Science (NIH ...
Anti-viral and Anti-Inflammatory Response: GoldenBiotech's Antroquinonol Receives FDA Approval on COVID-19 Phase 2 Trial in USA
PR Newswire
TAIPEI, July 1, 2020
TAIPEI, July 1, 2020 /PRNewswire/ -- Golden Biotechnology Corp. (GoldenBiotech, 4132.TWO), a leading ...
nucleic acid replication and viral protein synthesis in both cell and animal experiments. Prevention of organ and tissue damage ...
ArticleTargeted Brain Tumor Therapy by Inhibiting MDM
Cells 2020, 9, 1592; doi:10.3390/cells9071592 www.mdpi.com/journal/cells
Article
Targeted Brain Tumor Therapy by Inhibiting the
MDM2 ...
with DAB chromogen according to the
manufacturer’s instructions (DACO Animal Research Kit). The final step involved light
...
Anti-viral and Anti-Inflammatory Response: GoldenBiotech's Antroquinonol Receives FDA Approval on COVID-19 Phase 2 Trial in USA
Anti-viral and Anti-Inflammatory Response: GoldenBiotech's Antroquinonol Receives FDA Approval on COVID-19 Phase 2 Trial in USA
nucleic acid replication and viral protein synthesis in both cell and animal experiments. Prevention of organ and tissue damage ...
The effect of a diet based on rice straw co-fermented with probiotics and enzymes versus a fresh corn Stover-based diet on the rumen bacterial community and metabolites of beef cattle
Abstract
Improvement of the food value of rice straw is urgently required in rice crop growing areas to mitigate pollution caused by rice ...
care and sampling were approved by the Ethics Committee for Animal Experimentation of Jiangxi Agricultural University and all ...
Injury intensifies T cell mediated graft-versus-host disease in a humanized model of traumatic brain injury
Abstract
The immune system plays critical roles in promoting tissue repair during recovery from neurotrauma but is also responsible for ...
appears as a single data point in graphical displays. All animal experiments were approved by and conducted in compliance with ...
Perinatal exposure to diets with different n-6:n-3 fatty acid ratios affects olfactory tissue fatty acid composition
Abstract
The olfactory mucosa (OM) and the olfactory bulb (OB) are responsible for the detection and processing of olfactory signals. Like ...
in accordance with the guidelines of the European Community for the use and care of laboratory animals (2010/63/EU). It was ...
Nusinersen ameliorates motor function and prevents motoneuron Cajal body disassembly and abnormal poly(A) RNA distribution in a SMA mouse model
Abstract
Spinal muscular atrophy (SMA) is a devastating autosomal recessive neuromuscular disease characterized by degeneration of spinal ...
guidelines of the European Commission for the Accommodation and Care of Laboratory Animals (revised in Appendix A of the Council ...
Disorganization of chondrocyte columns in the growth plate does not aggravate experimental osteoarthritis in mice
Abstract
Osteoarthritis (OA) is a multifactorial joint disease mainly affecting articular cartilage (AC) with a relevant biomechanical ...
Spanish Regulations and the Guidelines for the Care and Use of Laboratory Animals drawn up by the National Institutes of Health (...
Germ cell depletion in recipient testis has adverse effects on spermatogenesis in orthotopically transplanted testis pieces via retinoic acid insufficiency
Abstract
Germ cell depletion in recipient testes is indispensable for successful transplantation of spermatogonial stem cells. However, we ...
animal care and use committee of Shinshu University approved all animal experimentation protocols (Approval Nos. 260013, 280120, ...
Modulation of acoustic navigation behaviour by spatial learning in the echolocating bat Rhinolophus ferrumequinum nippon
Abstract
Using echolocation, bats receive acoustic information on their surroundings, which is assumed to help them sophisticatedly ...
were conducted correctly in accordance with Japanese law for animal experimentation. In addition, all experimental procedures ...
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
Osteocytes are mechanoresponsive within skeletal tissue. Here, the authors show that class IIa histone deacetylases are phosphorylated by ...
all experiments were approved by the hospital’s Subcommittee on Research Animal Care. The following published genetically modified...
Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish
Abstract
Emerging findings point to a role for brain-derived neurotrophic factor (BDNF) on feeding in mammals. However, its role on energy ...
Council for Animal Care, and were approved by the University of Saskatchewan Animal Research Ethics Board (Protocol Number 2012–...
The place Ought to Covid-19 Vaccines Be Examined? It is a Transferring Goal – NEWPAPER24
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advertising
A phrase about how medical trials work. Candidate vaccines and potential medicine spend years progressing via lab ...
and potential medicine spend years progressing via lab research, then animal research, after which assessments in people. The ...
Human papillomavirus vaccine-associated premature ovarian insufficiency and related adverse events: data mining of Vaccine Adverse Event Reporting System
Abstract
We detected disproportionate reports of premature ovarian insufficiency (POI) and related events, including amenorrhea, ...
response, but it may have potential adverse effect. According to animal experiments, aluminum could accumulate in the ovary, ...
Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation
Abstract
Nurr1, a transcription factor belonging to the orphan nuclear receptor, has an essential role in the generation and maintenance of...
out in accordance with the guidelines for the Care and Use of Laboratory Animals published by the US National Institutes of Health...
Electroacupuncture at Zusanli and at Neiguan characterized point specificity in the brain by metabolomic analysis
Abstract
Different point stimulations can induce brain activity in specific regions, and however whether these stimulations affect unique ...
in
PubMed Google Scholar
Contributions
U.-R.J. performed animal experiments; D.-Y.L. performed metabolomic...
A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection
Abstract
Autophagy is a conserved process that delivers cytosolic substances to the lysosome for degradation, but its direct role in the ...
experiments; P.H., K.Y., P.J. and Z.L. performed the animal experiments and viral infections; L.L., J.L. and Y.L. completed the ...
Chondroitin polymerizing factor (CHPF) promotes development of malignant melanoma through regulation of CDK1
Abstract
Chondroitin polymerizing factor (CHPF) is an important member of glycosyltransferases involved in the biosynthesis of chondroitin ...
of the Z score greater than 2 is considered meaningful.
All animal experiments performed here were approved by the Institutional ...
Esteemed award for young scientist focusing on pig welfare
Dr Irene Camerlink has been awarded the Young Animal Welfare Scientist of the Year 2020.
science degree in 2007, after which she commenced an MSc on Research Animal Sciences in Wageningen University (The Netherlands). ...
RNA molecule identified as a growth driver in various types of cancer
A special RNA molecule ensures faster growth and stops cell ageing in many types of cancer. This was discovered by scientists from the ...
membranes in incubated chicken eggs to avoid the use of laboratory animals.
The examination of tissue samples from numerous types...
Lab-grown 'mini-brains' suggest COVID-19 virus can infect human brain cells
A multidisciplinary team from two Johns Hopkins University institutions, including neurotoxicologists and virologists from the Bloomberg ...
online June 26, 2020, in the journal ALTEX: Alternatives to Animal Experimentation.
Early reports from Wuhan, China, the origin ...
Development and characterization of microsatellite markers in Rosy-faced and other lovebirds ( Agapornis spp.) using next-generation sequencing
Abstract
Agapornis are a group of small African parrots that are heavily traded around the world. They are invasive species in many places...
Committee on the Use of Live Animals in Teaching and Research (CULATR) in the Laboratory Animal Unit, HKU (CULATR Approval Number...
Implantat skal forhindre lækage efter tarmoperation
Et danskudviklet 3D-printet implantat har i dyreforsøg vist sig i stand til at styrke sammensyningen af tarme.
Universitet udviklet et lille 3D-printet implantat, som i indledende dyreforsøg har vist lovende resultater.
"Idéen opstod efter ...
Lab-grown ‘mini-brains’ suggest COVID-19 virus can infect human brain cells
Credit: Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health
A multidisciplinary team from two...
online June 26, 2020, in the journal ALTEX: Alternatives to Animal Experimentation.
Early reports from Wuhan, China, the origin ...
Dual Network Hydrogels Incorporated with Bone Morphogenic Protein-7-Loaded Hyaluronic Acid Complex Nanoparticles for Inducing Chondrogenic Differentiation of Synovium-Derived Mesenchymal Stem Cells
Alginate-poloxamer (ALG-POL) copolymer with optimal POL content was synthesized, and it was combined with silk fibroin (SF) for building ...
tissues were aseptically excised from the knee joints of rats. All animal experiments were approved by the Animal Care and Use ...
Study Shows Bioengineered Uteri Support Pregnancy in an Animal Model
In new research from the Wake Forest Institute for Regenerative Medicine (WFIRM), scientists have shown that bioengineered uteri supported ...
regeneration studies as they have a relatively large uterus compared with other laboratory animals. The female rabbit's uterus is ...
Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants
Abstract
While the etiology of non-familial Parkinson’s disease (PD) remains unclear, there is evidence that increased levels of tissue ...
exposure and disease has been found both in epidemiological studies and in animal experiments (Greenamyre and Hastings 2004; ...
Global Next-generation Sequencing Market By Product, By Technology, By End User, By Application, By Region, Competition, Forecast & Opportunities, 2025
Global Next-generation Sequencing Market By Product, By Technology, By End User, By Application, By Region, Competition, Forecast & ...
o Diagnostics
o Reproductive Health
o Personalized Medicine
o Agriculture & Animal Research
o Other Applications
Market, By ...
Gode nyheter for forsøksdyr! - Dyrebeskyttelsen Norge
Det er svært gledelig at Forsøksdyrkomiteen setter et klart fokus på de tre R-ene i sitt arbeid med en uttalelse om dagens ...
smerte). Forsøksdyrkomiteen jobber nå med tydelige anbefalinger til Landbruksministeren, og setter dyrevelferden til ...
'Curing Cancer without Surgery'
Return to all news
"Successful disappearance of tumors in subjects upon administering the pain-free anticancer drug, Polytaxel, without ...
chemotherapy drugs such as Nab-paclitaxel or Docetaxel showed efficacy in animal experiments when dosed within NOAEL.
CNPharm's ...
Cellular decoys distract coronavirus
Wrapping polymer nanoparticles in membranes from human lung epithelial type II cells and immune cells creates a biomimetic system that can ...
the target the virus aims at.
The next step is to evaluate the putative therapy in laboratory animals and then move on to human ...
Chinese Firm Claims Positive Results With COVID Jab In Human Trials
Ad5-nCoV is one of China's vaccine candidates approved for human trials that cleared Phase 1 and 2 clinical trials before receiving ...
April says, "Refinement of the CoroFlu vaccine concept and testing in laboratory animal models at UW-Madison is expected to take ...
Effects of novel non-thermal atmospheric plasma treatment of titanium on physical and biological improvements and in vivo osseointegration in rats
Abstract
Titanium (Ti) has achieved extensive applications due to its excellent biocompatibility and mechanical properties. Plasma can ...
Google Scholar
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miRNA–mRNA network regulation in the skeletal muscle fiber phenotype of chickens revealed by integrated analysis of miRNAome and transcriptome
Abstract
Skeletal muscle fibers are primarily categorized into oxidative and glycolytic fibers, and the ratios of different myofiber types ...
quality traits in chickens.
Materials and methods
Ethics statement
All animal experiments were approved by the Animal Care and Use...
Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78)
Abstract
Abnormal cardiac fibrosis indicates cardiac dysfunction and poor prognosis in myocardial infarction (MI) patients. Many studies ...
University, which conforms to the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health (NIH ...
Transcriptomic analysis of the mechanisms of alleviating renal interstitial fibrosis using the traditional Chinese medicine Kangxianling in a rat model
Abstract
Renal interstitial fibrosis (RIF) is currently recognized as a crucial mechanism of the pathogenesis of chronic kidney disease (...
Renal fibrosis rat model
The study was approved by the Animal Research Ethics Committee of the Shanghai University of Traditional ...
Blast-induced hearing impairment in rats is associated with structural and molecular changes of the inner ear
Abstract
Auditory dysfunction is the most prevalent injury associated with blast overpressure exposure (BOP) in Warfighters and civilians, ...
to principles stated in the Guide for the Care and Use of Laboratory Animals with an Institutional Animal Care and Use Committee ...
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