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Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections
antibiotics
Article
Evaluation of Benzguinols as Next-Generation Antibiotics for
the Treatment of Multidrug-Resistant Bacterial Infections
...
(approval number S-2015-151) reviewed and approved all animal experiments. The study was
conducted in compliance with the Australian Code of
Genomics Market Newer Segments of Application 2030
Introduction:
Genomics refers to the study of structure, function and inheritance of the genome of an organism. Genomic technology offer ...
By Application:
Drug Discovery and Development
Diagnostics
Agriculture and Animal Research
Other Applications
By End User:
Hospitals and
Pics: Meet the 30 finalists vying for the Miss Ireland 2021 crown
© Provided by Extra.ie
The announcement of the finalists for the Miss Ireland 2021 was a rainbow of colours.
This year’s contestants ...
in UCD with the goal of going on to study Veterinary or move into animal research.
Miss Kildare North – Alannah Pardy
© Provided by Extra.ie
Development of Radiofluorinated Nicotinamide/Picolinamide Derivatives as Diagnostic Probes for the Detection of Melanoma
Regarding the increased incidence and high mortality rate of malignant melanoma, practical early-detection methods are essential to improve ...
4.7. Establishment of Melanoma-Bearing Mouse Models
All animal experiments were approved by the Institutional Animal Care and Use Committee
A Candidate Gene Association Study for Economically Important Traits in Czech Dairy Goat Breeds
Milk production is influenced by many factors, including genetic and environmental factors and their interactions. Animal health, ...
GAJU028/2019/ Z.
Institutional Review Board Statement
All animal experiments were under the supervision of the Institutional Animal Care and
Pharmacokinetics in Zebrafish Embryos (ZFE) Following Immersion and Intrayolk Administration: A Fluorescence-Based Analysis
Zebrafish embryos (ZFE) have increasingly gained in popularity as a model to perform safety screenings of compounds. Although immersion of ...
]. Moreover, this model adheres to the 3Rs principle of animal experimentation by providing refinement and partial replacement over higher
Nucleic Acid Isolation and Purification Market to Register Unwavering Growth During 2030
Nucleic Acid Isolation and Purification Market: Overview
The growing influence of technology across the life science research, molecular ...
acid isolation and purification process in diagnostics, agriculture research, animal research, precision medicine, drug discovery, drug
PICS: From GAA stars to showjumpers, here are the Miss Ireland 2021 finalists
© Provided by Evoke.ie
This year’s Miss Ireland 2021 finalists have finally been unveiled.
A beautiful outdoor show will take place on 5 ...
UCD with the goal of someday going on to study veterinary or go into animal research.
Miss Laois
© Provided by Evoke.ie
Miss Ireland 2021
Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccine
Abstract
Inactivated poultry vaccines are subject to routine potency testing for batch release, requiring large numbers of animals. The ...
/63/EU) experiments with embryonated chicken eggs are not considered animal experiments, the study was carried out in compliance with the
A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models
Abstract
CRISPR/Cas9 represents a valuable tool to determine protein function, but technical hurdles limit its use in challenging settings ...
with the current ethical standards of the official committee on animal experimentation (written approval by the Regierung von Oberbayern,
Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration
Abstract
Caspase-6 (Casp6) is implicated in Alzheimer disease (AD) cognitive impairment and pathology. Hippocampal atrophy is associated ...
, Ipswich, MA, USA) as described46.
Electrophysiology
All animal experimentation was approved by the McGill University Animal Care Committee
A distributed saccade-associated network encodes high velocity conjugate and monocular eye movements in the zebrafish hindbrain
Abstract
Saccades are rapid eye movements that redirect gaze. Their magnitudes and directions are tightly controlled by the oculomotor ...
out on the tuning curves using the Matlab command ttest2.
Animal experiments and all experimental protocols were approved by the responsible
Hypoxic–ischemic injury causes functional and structural neurovascular degeneration in the juvenile mouse retina
Abstract
Ischemic stroke is a major cause of long-term disabilities, including vision loss. Neuronal and blood vessel maturation can affect ...
the National Institutes of Health Guide for the Care and Use of Laboratory Animals and approved by the Institutional Animal Care and Use
Interventricular Differences of Signaling Pathways-Mediated Regulation of Cardiomyocyte Function in Response to High Oxidative Stress in the Post-Ischemic Failing Rat Heart
antioxidants
Article
Interventricular Differences of Signaling Pathways-Mediated
Regulation of Cardiomyocyte Function in Response to High
...
.
2. Materials and Methods
2.1. Animal Model
Animal experimental procedures were permitted by the Animal Care Committee
of the University of
Blockade of HVEM for Prostate Cancer Immunotherapy in Humanized Mice
The herpes virus entry mediator (HVEM) delivers a negative signal to T cells mainly through the B and T lymphocyte attenuator (BTLA) ...
European legislation. All protocols were approved by the Ethics Committee for Animal Experimentation Charles Darwin (Ce5/2012/025).
Informed
Superoxide Dismutase 3-Transduced Mesenchymal Stem Cells Preserve Epithelial Tight Junction Barrier in Murine Colitis and Attenuate Inflammatory Damage in Epithelial Organoids
Superoxide dismutase 3 (SOD3), also known as extracellular superoxide dismutase, is an enzyme that scavenges reactive oxygen species (ROS ...
animal research was conducted in accordance with the Laboratory Animals Welfare Act, the guide for the care and use of laboratory animals,
Simulation-based optimisation to quantify heterogeneity of specific ventilation and perfusion in the lung by the Inspired Sinewave Test
Abstract
The degree of specific ventilatory heterogeneity (spatial unevenness of ventilation) of the lung is a useful marker of early ...
Altman, D. G. Improving bioscience research reporting: The arrive guidelines for reporting animal research. Animals 4, 35–44 (2013).
Article
Preclinical study to improve microbubble-mediated drug delivery in cancer using an ultrasonic probe with an interchangeable acoustic lens
Abstract
Focused ultrasound with microbubbles (FUS-MBs) has shown that it can lead to an efficient drug delivery system (DDS) involving the ...
MB destruction, promoting the DDS even under fluidic conditions. In the animal experiment, the UUS-MBs in the acoustic lens treatment group
Toxicity evaluation of ConvitVax breast cancer immunotherapy
Abstract
ConvitVax is a personalized vaccine for the treatment of breast cancer, composed of autologous tumor cells, bacillus Calmette- ...
by Instituto de Estudios Avanzados (IDEA) and maintained in the animal research facility of Fundación Jacinto Convit (FJC) in computerized
Evidence of a new hidden neural network into deep fasciae
Abstract
It is recognized that different fasciae have different type of innervation, but actually nothing is known about the specific ...
of the Italian Department of Health, and in compliance with the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines. The
Null cyp1b1 Activity in Zebrafish Leads to Variable Craniofacial Defects Associated with Altered Expression of Extracellular Matrix and Lipid Metabolism Genes
CYP1B1 loss of function (LoF) is the main known genetic alteration present in recessive primary congenital glaucoma (PCG), an infrequent ...
All animal husbandry and experiments were approved by the Institutional Animal Research Committee of the University of Castilla–La Mancha (
Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus
Abstract
Aims/hypothesis
People with diabetes have an increased cardiovascular risk with an accelerated development of atherosclerosis and ...
the Care and Use of Laboratory Animals of the National Institutes of Health (Bethesda, MD, USA). All animal experiments were approved by the
Dietary Vitamin C and Age-Induced Lipid and Hormonal Metabolic Changes in a Humanized Mouse Model Not Synthesizing Vitamin C and Producing Lipoprotein(a) [Gulo (−/−); Lp(a)+]
AbstractThe lack of ability to produce vitamin C innately and the ability to synthesize human lipoprotein(a) (Lp(a)) are two unique ...
-PCR at Transnetyx (Cordova, TN) using mouse tail clips. All animal experiments were conducted with humane and customary care and followed a
A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study
Engineered nanomaterials (ENMs) are of significant relevance due to their unique properties, which have been exploited for widespread ...
, 120, S1–S7. [Google Scholar] [CrossRef]
Ipsos. Public Attitudes to Animal Research in 2018. 2018, pp. 1–36. Available online: https://www
Using the Tea Bag Index to determine how two human pharmaceuticals affect litter decomposition by aquatic microorganisms
Abstract
This study demonstrates that independent additive effects of two human pharmaceuticals, the antibiotic trimethoprim and the ...
The authors declare no competing interests.
Animal research
No animals were used in
Transdifferentiation of Human Fibroblasts into Skeletal Muscle Cells: Optimization and Assembly into Engineered Tissue Constructs through Biological Ligands
The development of robust skeletal muscle models has been challenging due to the partial recapitulation of human physiology and ...
vitro human skeletal muscle model, as an alternative to animal experimentation that more closely represents human physiology, necessitates
A review of proficiency exercises offered by the Veterinary Laboratory Investigation and Response Network (Vet-LIRN) and Moffett Proficiency Testing Laboratory from 2012 to 2018
Abstract
The Food and Drug Administration’s Veterinary Laboratory Investigation and Response Network is comprised of more than 40 animal ...
with the principles stated in the Guide for the Care and Use of Laboratory Animals [18]. The contaminated catfish were prepared by feeding
Inhibition of c-Fos expression attenuates IgE-mediated mast cell activation and allergic inflammation by counteracting an inhibitory AP1/Egr1/IL-4 axis
Abstract
Background
Activator protein-1 (AP1), a c-Fos–JUN transcription factor complex, mediates many cytobiological processes. c-Fos has ...
Balb/c mice (6–8 weeks, 18–20 g) from Guangdong Medical Laboratory Animal Center (Benxi, Liaoning, China) were bred in an aseptic-specified
Cancer cells fight for their footing by using an ageing gene
Researchers at the University of Helsinki and the Beatson Institute for Cancer Research in Glasgow have discovered how mutated cells ...
led by Katajisto has previously used a compound for this purpose in aged research animals to enhance the function of aged stem cells. In the
Mathematical Model Predicts that Acceleration of Diabetic Wound Healing is Dependent on Spatial Distribution of VEGF-A mRNA (AZD8601)
Abstract
Introduction
Pharmacologic approaches for promoting angiogenesis have been utilized to accelerate healing of chronic wounds in ...
(Approved Protocol #3459) or the Local Ethics Committee on Animal Experiments in Gothenburg, Sweden.
Author information
Author notes
S.
Evaluation of efficacy and toxicity of nivolumab combined with or without docetaxel in patients with advanced NSCLC
Abstract
Background
The combination of PD-1/PD-L1 inhibitor and chemotherapy has been clinically confirmed to be beneficial as the first- ...
outlined in the Declaration of Helsinki for all human or animal experimental investigations.
Additional information
Publisher's Note
Ureteroscopic Cryoablation for Patients with Upper Tract Urothelial Carcinoma of a Solitary Kidney: A Porcine Model and Our Pilot Clinical Experience
Abstract
Purpose
To investigate the safety and efficacy of ureteroscopic cryoablation by a liquid-nitrogen system in a porcine model and ...
site accurately.
Before the clinical study, we performed an animal experiment to evaluate the safety of cryotherapy for ureter and obtained
Alzheimer disease research results over-hyped if science papers omit mice from the title
Scientists call for accurate reporting of animal studies to avoid misleading the public with exaggerated news headlines
A study of media ...
.
This is of concern because scientific findings obtained from animal experiments should be reported with caution due to their limited
Alzheimer's research gets more attention if scientists leave out the word 'mice' from study titles
News media are more likely to report on a novel scientific finding about Alzheimer’s disease if the authors fail to disclose in their paper ...
mainstream media to ensure the public understands that the results of animal experiments may have little to no relevance to human patients,’
News media are 30% more likely to report on Alzheimer's research if scientists leave out the word 'mice' from study titles
If a study title fails to include that Alzheimer's research was done in mice, the study tends to get more media attention, a new pape found ...
careful in communicating results to the public.
'The reporting of animal research needs to be addressed with far greater caution and more
A broadly cross-reactive monoclonal antibody against hepatitis E virus capsid antigen
Abstract
To generate a hepatitis E virus (HEV) genotype 3 (HEV-3)–specific monoclonal antibody (mAb), the Escherichia coli–expressed ...
with good animal practice as defined by the Federation of European Laboratory Animal Science Associations (FELASA). All animal protocols
Elevated Anti-Müllerian Hormone Levels in Newborns of Women with Polycystic Ovary Syndrome: a Systematic Review and Meta-analysis Based on Observational Studies
Abstract
We performed this updated systematic review and meta-analysis to evaluate anti-Müllerian hormone levels (AMH) in newborns of ...
excluded if they (1) were letters, case reports, editorials, animal experiments, or conference abstracts; (2) included individuals of twin
Veterinary Teleradiology Market Value Predicted To Reach US$ 437.6 Million By 2027 Covering COVID-19 Impact: Acumen Research and Consulting
Acumen Research and Consulting, a global provider of market research studies, in a recently published report titled “Veterinary ...
in the United States and Canada, and increased healthcare spending on animal research. During the forecast period, these factors are also
PFOS Inhibited Normal Functional Development of Placenta Cells via PPARγ Signaling
Perfluorooctane sulfonic acid (PFOS), a persistent environmental pollutant, has adverse effects on gestation pregnancy. Peroxisome ...
for the Care and Use of Laboratory Animals released by the US National Institute of Health. Animal experiments and procedures were approved
Breeding and Maintenance of Immunodeficient Mouse Lines under SPF Conditions—A Call for Individualized Severity Analyses and Approval Procedures
In the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience ...
the EU, the breeding of genetically modified laboratory animals is, by definition, an animal experiment if the offspring may experience pain
molecules-1247276
Molecules 2021, 26, 3660. https://doi.org/10.3390/molecules26123660 www.mdpi.com/journal/molecules
Article
Phytochemical and In‐ ...
reviewed the man‐
uscript; Z.Y.A. performed the animal experiments and data curation. All authors have read and
agreed to the published
Case reportDeaths Due to Mixed Infections with Passalurus ambiguus
Pathogens 2021, 10, 756. https://doi.org/10.3390/pathogens10060756 www.mdpi.com/journal/pathogens
Case Report
Deaths Due to Mixed ...
in recent years [1], while
they continue to be used as laboratory animals in experiments [2]. Commercially, rabbits
are farmed for their
ijms-1241787
Int. J. Mol. Sci. 2021, 22, 6418. https://doi.org/10.3390/ijms22126418 www.mdpi.com/journal/ijms
Review
Pathophysiological ...
treatments for TBI‐induced cytotoxic edema.
A large number of animal experiments have been performed to develop novel therapeu‐
tic drugs
ijms-1217028-fc done
Int. J. Mol. Sci. 2021, 22, 6416. https://doi.org/10.3390/ijms22126416 www.mdpi.com/journal/ijms
Article
Is PTSD‐Phenotype ...
and
guidelines of the NIH Guide for the Care and Use of Laboratory Animals. All treatment
and testing procedures were approved by the
Microbots Gene Delivery System Based on Bifidobacteria in a Tumor Model
In cancer, the use of microbots based on anaerobic bacteria as specific transporters targeting tumor tissues has been explored since most ...
-ZOO-1999, technical specifications for the production care, and use of laboratory animals.
2.7. Fluorescence and Luminescence Analysis
NCs
Protective Effect of Lutein/Zeaxanthin Isomers in Traumatic Brain Injury in Mice
Abstract
Previous studies revealed that oxidative stress and inflammation are the main contributors to secondary injury after traumatic ...
Participate
The experimental protocol was approved by the Animal Research Ethics Committee of Istanbul Medipol University (37
molecules-1209726 - revised
Molecules 2021, 26, 3654. https://doi.org/10.3390/molecules26123654 www.mdpi.com/journal/molecules
Article
Anti‐Helicobacter ...
protocols were approved by
the Ethics Committee for the Care and Use of Laboratory Animals, Faculty of Medicine,
UNAM, Mexico City, Mexico
A Novel Model for Nephrotic Syndrome Reveals Associated Dysbiosis of the Gut Microbiome andExtramedullary Hematopoiesis
cells
Article
A Novel Model for Nephrotic Syndrome Reveals Associated
Dysbiosis of the Gut Microbiome and
Extramedullary Hematopoiesis
...
S.Z.; Chang, K.T. Extramedullary hematopoiesis (emh) in laboratory
animals: Offering an insight into stem cell research. Cell Transpl. 2015,
PDLIM2 Suppression Inhibit Proliferation and Metastasis in Kidney Cancer
We evaluated the expression of PDLIM2 in human kidney cancer cell lines from primary or metastatic origins and found that PDLIM2 expression ...
at 20× magnification.
4.7. Animal Studies
All animal experiments were performed in accordance with the Seoul National University Hospital
Inhibitory control in neuronal networks relies on the extracellular matrix integrity
Abstract
Inhibitory control is essential for the regulation of neuronal network activity, where excitatory and inhibitory synapses can act ...
2010/63/EU) guidelines for the care and use of laboratory animals.
Additional information
Publisher's Note
Springer Nature remains neutral
Next Generation Sequencing Market Predicted to Exhibit Explosive Growth in Near Future
The global Next Generation Sequencing market which projected a CAGR of approximately 18% in the midst of the estimate time span of 2020- ...
Personalized Medicine and Genetic Screening
Disease Diagnosis
Agriculture and Animal Research
Others
By End User:
Hospital
Research Centers
Effects of Exogenous 6-Phytase (EC 3.1.3.26) Supplementation on Performance, Calcium and Phosphorous Digestibility, and Bone Mineralisation and Density in Weaned Piglets
animals
Article
Effects of Exogenous 6-Phytase (EC 3.1.3.26) Supplementation
on Performance, Calcium and Phosphorous Digestibility, and
...
Agrifood Research & Technology (IRTA) after approval by IRTA’s Ethical Committee on
Animal Experimentation (CEEA); Experiment codes P-504/P-
Viable 3D bioprinted tissues: an animal testing substitute or still years from reality?
Over the last decade, 3D bioprinting has come on leaps and bounds, with significant advances being made in the development of viable, ...
cell-culturing microstructures, which could help reduce the number of animal experiments behind clinical trials in the longer term.
In fact
Osteoclast-Mediated Cell Therapy as an Attempt to Treat Elastin Specific Vascular Calcification
Inflammation and stiffness in the arteries is referred to as vascular calcification. This process is a prevalent yet poorly understood ...
were performed according to protocols approved by the Clemson University Animal Research Committee. Animal care was provided by trained
Peptides from Liza aurata: Natural Source Attenuate Paracetamol Induced Nephrotoxicity by Modulation of the Inflammatory Response and DNA Damage
Abstract
The present study investigates the nephroprotective and the molecular mechanisms effects of Liza aurata protein hydrolysates ( ...
3.5, PB No 1171-14, 3000, Sfax, Tunisia
Sabah Dhibi
Laboratory Animal Eco Physiology, Faculty of Sciences, Sidi Ahmed Zarrouk, PB 11, 2112
ijms-1231808-FC done
Int. J. Mol. Sci. 2021, 22, 6399. https://doi.org/10.3390/ijms22126399 www.mdpi.com/journal/ijms
Article
Cardioprotective ...
Use of Laboratory Animals’’ published by US National Institutes of Health (NIH, Guide,
NRC 2011) and the ‘‘Principles of laboratory animal
Comparative Pathogenesis, Genomics and Phylogeography of Mousepox
viruses
Article
Comparative Pathogenesis, Genomics and Phylogeography
of Mousepox
Carla Mavian 1,† , Alberto López-Bueno 1, Rocío Martín 1 ...
-B-I00).
Institutional Review Board Statement: All animal experiments were performed with special efforts
to minimize animal suffering, in
Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1β-induced inflammation
Abstract
We recently reported that cyclin-dependent kinase inhibitor 1 (p21) deficiency induces osteoarthritis susceptibility. Here, we ...
with the recommendations of the Guide for the Care and Use of Laboratory Animals published by the National Institutes of Health (Bethesda,
Fish From Toxic Water Pass Down Epigenetic Mutations to Freshwater Offspring
You can take a fish out of toxic water, but its epigenetic mutations will remain for at least two generations.
A research team led by ...
in the Galapagos and the New Zealand mud snail as well as laboratory animals, showing that epigenetic changes resulting from environmental
Vimentin Promotes the Aggressiveness of Triple Negative Breast Cancer Cells Surviving Chemotherapeutic Treatment
Tremendous data have been accumulated in the effort to understand chemoresistance of triple negative breast cancer (TNBC). However, ...
were handled according to the European Union guidelines for the handling of laboratory animals (Directive 2010/63/EU of the European
SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury
Abstract
In the adult pancreas, the presence of progenitor or stem cells and their potential involvement in homeostasis and regeneration ...
. All experimental protocols were also approved by Zhejiang University Animal Experiment Facility. We confirm that all experiments were
Deficiency of myostatin protects skeletal muscle cells from ischemia reperfusion injury
Abstract
Ischemia reperfusion (IR) injury plays a pivotal role in many diseases and leads to collateral damage during surgical ...
(5′-FAM GAT GGG CTG GCA AGT GAT AAC BHQ1-3′).
All animal experiments were approved by the IACUC LANUV NRW (The Ministry for Environment,
Fatty acids suppress the steroidogenesis of the MA-10 mouse Leydig cell line by downregulating CYP11A1 and inhibiting late-stage autophagy
Abstract
Obese men have lower circulating testosterone than men with an optimal body mass index. Elevated fatty acids (FAs) caused by ...
Reagent (Thermo).
Male ICR mice obtained from the Laboratory Animal Center of the College of Medicine at National Taiwan University were
CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma
Abstract
Malignant mesothelioma is a cancer with a poor survival rate. It is difficult to diagnose mesotheliomas because they show a ...
for Medical and Health Research involving Human Subjects.
Animal experiments
The experiments conducted using animals strictly adhered to the
Lack of detectable genetic isolation in the cyclic rodent Microtus arvalis despite large landscape fragmentation owing to transportation infrastructures
Abstract
Although roads are widely seen as dispersal barriers, their genetic consequences for animals that experience large fluctuations in ...
and in compliance with the ARRIVE guidelines for how to report animal experiments.
Total genomic DNA was extracted from tissue samples using
Plasma metabolomic profiles as affected by diet and stress in Spanish goats
Abstract
The effects of high-condensed tannin (CT) diet combined with preslaughter stress have not been studied at the metabolome level in ...
. The animal care protocols were approved by the FVSU Agricultural and Laboratory Animal Care and Use Committee prior to beginning of the
Determining the effect of aging, recovery time, and post-stroke memantine treatment on delayed thalamic gliosis after cortical infarct
Abstract
Secondary injury following cortical stroke includes delayed gliosis and eventual neuronal loss in the thalamus. However, the ...
in accordance with NIH guidelines for the care and use of laboratory animals and were approved by the Institutional Animal care and use
Functional ultrasound imaging of the spreading activity following optogenetic stimulation of the rat visual cortex
Abstract
Optogenetics has revolutionized neurosciences by allowing fine control of neuronal activity. An important aspect for this control ...
carried out in compliance with the ARRIVE guidelines.
Animals
All animal experiments and procedures were approved by the Local Animal Ethics
Measurement of S-glutathionylated proteins by HPLC
Abstract
S-glutathionylated proteins (GSSP), i.e., protein-mixed disulfides with glutathione (GSH), are considered a suitable biomarker of ...
in accordance with the European Community guidelines for the use of laboratory animals. The experiments were authorized by the local ethical
Neuronal variability reflects probabilistic inference tuned to natural image statistics
The neural sampling theory suggests that neuronal variability encodes the uncertainty of probabilistic inferences. This paper shows that ...
States Public Health Service Guide for the Care and Use of Laboratory Animals.
Visual stimuli
Visual stimuli were generated with custom
Intertypic reassortment of mammalian orthoreovirus identified in wastewater in Japan
Abstract
Mammalian orthoreovirus (MRV), a non-enveloped virus with a ten-segmented double-stranded RNA genome, infects virtually all ...
Kitamura & Tomoichiro Oka
Management Department of Biosafety and Laboratory Animal, National Institute of Infectious Diseases, Tokyo, 208-
Acrolein contributes to human colorectal tumorigenesis through the activation of RAS-MAPK pathway
Abstract
Colorectal cancer (CRC) is one of the most well-known malignancies with high prevalence and poor 5-year survival. Previous studies ...
out in accordance with the Declaration of Helsinki principles. All animal experiments were approved by the Institutional Animal Care and Use
Clinical Characteristics, Treatments and Outcomes of 18 Lung Transplant Recipients with COVID-19
We report clinical features, treatments and outcomes in 18 lung transplant recipients with laboratory confirmed SARS-CoV-2 infection. We ...
of the paucity of clinical data in this group of patients. In animal experiments, remdesivir has been shown to be nephrotoxic in monkeys and
(-)-Englerin-A Has Analgesic and Anti-Inflammatory Effects Independent of TRPC4 and 5
Recently, we found that the deletion of TRPC5 leads to increased inflammation and pain-related behaviour in two animal models of arthritis ...
, D.G. Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. Osteoarthr. Cartil. 2012, 20, 256–260.
Serosurvey of Nonhuman Primates in Costa Rica at the Human–Wildlife Interface Reveals High Exposure to Flaviviruses
Arthropod-borne viruses belonging to the flavivirus genus possess an enormous relevance in public health. Neotropical non-human primates ( ...
11501-2060, Costa Rica
2
Department of Ethology, Wildlife and Laboratory Animals, School of Veterinary and Zootechnics, National Autonomous
Evaluation of sex steroid hormones and reproductive irregularities in diethyl phthalate-exposed premature mice: modulatory effect of raw honey against potential anomalies
Abstract
Phthalates, plasticizing chemicals, are top-rated environmental contaminants. Diethyl phthalate (DEP), a chief member of this ...
use of mice was following NIH Publication “Guide for the Care and Use of Laboratory Animals” (NRC 2004) and with the approval by the local
Lyme Neuroborreliosis: Mechanisms of B. burgdorferi Infection of the Nervous System
brain
sciences
Review
Lyme Neuroborreliosis: Mechanisms of B. burgdorferi Infection
of the Nervous System
Lenzie Ford 1,* and Danielle M. ...
tissues and long-term mechanistic studies can be carried out
in laboratory animals. Combined, these works have the potential to influence
Egg White Protein Feeding Facilitates Skeletal Muscle Gain in Young Rats with/without Clenbuterol Treatment
Based on the Digestible Indispensable Amino Acid Score (DIAAS), egg white protein (EGG) has an excellent score, comparable to that of whey ...
.K. (Keiichi Koshinaka), R.I., Y.M. and A.S. performed the animal experiments, and K.K. (Keiichi Koshinaka), A.H. and K.K. (Kentaro Kawanaka
Pointing Out Some Issues Regarding Reproduction Management in Murciano-Granadina Goats
Two of the most important problems in high-yielding dairy goat farms are early and accurate pregnancy diagnosis and the appropriate dry off ...
qualified as exempt from experimental protocols by the Committee in Animal Experimentation of the Universitat Politècnica de València.
Data
NLRP3 Inflammasome Promotes the Progression of Acute Myeloid Leukemia via IL-1β Pathway
NLRP3 inflammasome has been reported to be associated with the pathogenesis of multiple solid tumors. However, the role of NLRP3 ...
Model
Female WT C57BL/6J mice were obtained from the Laboratory Animal Center, Shandong University. C1498 cells were intravenously injected
A Novel Orthotopic Implantation Technique for Osteosarcoma Produces Spontaneous Metastases and Illustrates Dose-Dependent Efficacy of B7-H3-CAR T Cells
The outcome for metastatic pediatric osteosarcoma (OS) remains poor. Thus, there is an urgent need to develop novel therapies, and ...
-H3-CAR T cells), we felt that it was not justified to perform additional animal experiments at lower Ctrl-CAR T cell doses.
The most common
Water Extract of Mixed Mushroom Mycelia Grown on a Solid Barley Medium Is Protective against Experimental Focal Cerebral Ischemia
Although the individual consumption of medicinal mushrooms, including Phellinus linteus (PL), Ganoderma lucidum (GL), and Inonotus obliquus ...
the Care and Use of Laboratory Animals (National Institutes of Health publication, 8th Edition, 2011) [39]. Animal experiments in this study
Lanolin-Based Synthetic Membranes for Transdermal Permeation and Penetration Drug Delivery Assays
membranes
Article
Lanolin-Based Synthetic Membranes for Transdermal
Permeation and Penetration Drug Delivery Assays
Cristina Alonso , ...
the Care and Use of Laboratory Animals; National Research Council. Guide for the
Care and Use of Laboratory Animals; The National Academic
The Nevada Biotechnology & Health Science Consortium is Recognizing Dr. Marc Kahn as Medical Professional of the Year and Daniel C. Montano as the Biotech Entrepreneur of the Year
LAS VEGAS, June 15, 2021 (GLOBE NEWSWIRE) -- The Nevada Biotechnology & Health Science Consortium (NevBio) was founded in 2007 to ...
, the number one cause of death in the world. In animal experiments, monkeys given experimental Parkinson’s disease, then treated with
Oxidative Stress Signaling in Blast TBI-Induced Tau Phosphorylation
Traumatic brain injury caused by blast is associated with long-term neuropathological changes including tau phosphorylation and pathology. ...
the National Institutes of Health Guide for the Care and Use of Laboratory Animals. Experiment group sample sizes, consisting of at least n
Enantiomer distribution of major chiral volatile organic compounds in botrytized grapes and wines
Abstract
In this study, volatile organic compounds in healthy and botrytized grape berries, as well as highly botrytized wines (Tokaj ...
This study did not contain any studies with human participants or animal experiments performed by any of the authors.
Additional information
BAFF signaling drives interstitial transformation of mouse renal tubular epithelial cells in a Pin1-dependent manner
Abstract
Aberrant expression of B cell–activating factor belonging to TNF superfamily (BAFF) and its receptors results in abnormal ...
light-dark cycle with ad libitum access to food and water. Animal experiments were approved by the Academic Committee of Soochow University.
Effect of Landiolol Hydrochloride on Hemodynamics in a Histamine-Induced Shock Model
Abstract
Background and Objective
Anaphylactic shock is a serious adverse drug reaction that can occur in response to contrast media used ...
temperature was 24 ± 2 °C during the experiment. All animal experiments were approved by the Ethical Committee of Ono Pharmaceutical Co.,
MicroRNA-1178-3p suppresses the growth of hepatocellular carcinoma by regulating transducin (beta)-like 1 X-linked receptor 1
Abstract
MicroRNAs (miRNAs) are implicated in various cancer-relevant cellular processes, including cell proliferation, migration, invasion ...
number: AF-OG-03-1.0-02. All animal research were carried out following approval by the Institutional Animal Care and Use Committee of First
Supplementing lycopene combined with corn improves circulating IgG concentration in pregnant ewes and their lambs
Abstract
Lycopene (C40H56, a non-provitamin A carotenoid) is a lipid-soluble pigment and a natural antioxidant with immunomodulatory ...
A., 2011. Management effects on colostrogenesis in small ruminants: a review, Journal of Applied Animal Research, 39(2), 85-93. https://doi.
viruses-1257540
Viruses 2021, 13, 1143. https://doi.org/10.3390/v13061143 www.mdpi.com/journal/viruses
Case Report
SARS‐CoV‐2 Antigenemia as a ...
No. 317/12‐06‐2020). Finally, all animal experiments were performed in accord‐
ance with ethical standards of the responsible committee on
Effects of dietary active soybean trypsin inhibitors on pancreatic weights, histology and expression of STAT3 and receptors for androgen and estrogen in different tissues of rats
Abstract
Our previous study showed that soy milks could contain high levels of active soybean trypsin inhibitors (SBTI) if they were not ...
Food Directorate, Health Canada for their assistance during the animal experimentation phase.
Funding
This research was supported by Health
Traceable metallic antigen release for enhanced cancer immunotherapy
Abstract
Tumor vaccine has shown outstanding advantages and good therapeutic effects in tumor immunotherapy. However, antigens in tumor ...
to Medical Comprehensive Experimental Center of Hebei University for the animal experiment.
Funding
This work was supported by the Natural
Myocardial remote ischemic preconditioning: from cell biology to clinical application
Abstract
Remote ischemic preconditioning (rIPC) is a cardioprotective phenomenon where brief periods of ischemia followed by reperfusion of ...
and were in compliance with the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health in 2011.
A Comparative Review of the Extrinsic and Intrinsic Factors Regulating Lactose Synthesis
Abstract
Milk is critical for the survival of all mammalian offspring, where its production by a mammary gland is also positively ...
the biology of milk synthesis [200].
These various animal experiments highlight the potential importance of regulatory elements within the 5
materials-1195963
Materials 2021, 14, 3292. https://doi.org/10.3390/ma14123292 www.mdpi.com/journal/materials
Article
Structural, Thermal, and ...
to a lot of research, could positively influence the immune response in laboratory animals
and humans [4], boost physical and mental
ijms-1241068
Int. J. Mol. Sci. 2021, 22, 6363. https://doi.org/10.3390/ijms22126363 www.mdpi.com/journal/ijms
Article
Influence of Paclitaxel ...
and 568/2009 of Slovak Republic for the Care and Use of Laboratory
Animals. The experiment was licensed by the State Veterinary and Food
Fifty-nine labs around world handle the deadliest pathogens – only a quarter score high on safety
A virologist stands between rows of cages for laboratory animals in the new high security laboratory (biosafety level 4) at the Bernhard ...
A virologist stands between rows of cages for laboratory animals in the new high security laboratory (biosafety level 4) at the Bernhard
Fodringsforsøg med krydsningskvier på Danmarks Kvægforskningscenter
I efteråret 2019 blev der indsat 62 kviekalve på Danmarks Kvægforskningscenter (DKC) ved AU Foulum. Kalvene indgår i et fodringsforsøg, som ...
, men vi søger ekstra midler, så vi kan få det maksimale ud af forsøgsdyrene ved at kunne beholde dem 2. laktation ud. Derved kan vi få
3D-Printed Barrier Membrane Using Mixture of Polycaprolactone and Beta-Tricalcium Phosphate for Regeneration of Rabbit Calvarial Defects
Background: Polycarprolactone and beta tricalcium phosphate (PCL/β-TCP) are resorbable biomaterials that exhibit ideal mechanical ...
were according to the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) guidelines and approved
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