Blood sampling microsite

This microsite provides information on blood sampling from animals to help laboratory staff choose the most appropriate technique for removal of blood in an humane and efficient manner.

This microsite provides information on blood sampling from animals to help laboratory staff choose the most appropriate technique for removal of blood in an humane and efficient manner. The original material was collated by GlaxoSmithKline and donated to the NC3Rs. It has been edited and expanded with assistance from colleagues from the Institute of Animal Technology, academia, industry and animal welfare organisations.

The microsite contains information on surgical, non-surgical and terminal methods, including removal of blood from veins, arteries, by cannulation, by cardiac puncture and by decapitation, as appropriate for the species.
It aims to assist with refinement by:
  • Setting out general principles for refinement of blood sampling
  • Highlighting advantages and disadvantages for most of the available techniques
  • Highlighting potential adverse effects and control measures
  • Collating references for further reading
  • Presenting images and video for training purposes (new video clips added January 2009)
  • Presenting decision trees for sampling from the mouse and sampling from the rat and information on safe blood sample volumes.
Inclusion of a particular technique in this microsite should not be seen as endorsement of its use by the NC3Rs.
This page was updated on 15 September 2022

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